Regulation of tone in penile cavernous smooth muscle - Established concepts and new findings

World Journal of Urology

Volumn 12, Issue 5, 1994, Pages 249-261

  Andersson, K E ^a   Holmquist, F ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; ARGIPRESSIN; CALCITONIN GENE RELATED PEPTIDE; ENDOTHELIN; HISTAMINE; NEUROPEPTIDE Y; NITRIC OXIDE; PROSTAGLANDIN; SUBSTANCE P; VASOACTIVE INTESTINAL POLYPEPTIDE;

ANIMAL; DRUG EFFECT; HUMAN; INNERVATION; MALE; METABOLISM; MUSCLE CONTRACTION; MUSCLE RELAXATION; MUSCLE TONE; NEUROMUSCULAR SYNAPSE; PENIS; PENIS ERECTION; PHYSIOLOGY; REVIEW; SYNAPTIC TRANSMISSION; VASCULAR ENDOTHELIUM; VASCULAR SMOOTH MUSCLE; VASCULARIZATION;

ADENOSINE TRIPHOSPHATE; ANIMAL; ARGIPRESSIN; CALCITONIN GENE-RELATED PEPTIDE; ENDOTHELINS; ENDOTHELIUM, VASCULAR; HISTAMINE; HUMAN; MALE; MUSCLE CONTRACTION; MUSCLE RELAXATION; MUSCLE TONUS; MUSCLE, SMOOTH, VASCULAR; NEUROMUSCULAR JUNCTION; NEUROPEPTIDE Y; NITRIC OXIDE; PENILE ERECTION; PENIS; PROSTAGLANDINS; SUBSTANCE P; SYNAPTIC TRANSMISSION; VASOACTIVE INTESTINAL PEPTIDE;

EID: 0028695162     PISSN: 07244983     EISSN: 14338726     Source Type: Journal    
DOI: 10.1007/BF00191204     Document Type: Article

References (201)

1. Quantification of prostaglandin receptors in cavernous tissue of men, monkeys and dogs
2. Effects of histamine on the human penis muscle in vitro
3. Is vasoactive intestinal polypeptide the principal transmitter involved in human penile erection?
4. Physiopharmacology of human penile erection — autonomic/nitrergic neurotransmission and receptors of the human corpus cavernosum
5. Neuropeptide Y in the human male genital tract
6. The pharmacology of lower urinary tract smooth muscles and penile erectile tissues
7. Mechansims for contraction and relaxation of human penile smooth muscle
8. Relaxation of isolated human corpus spongiosum induced by vasoactive intestinal polypeptide, substance P, carbachol and electrical field stimulation
9. Characterization of immunoreactive arginine vasopressin (AVP) in and effects of AVP on isolated human penile erectile tissue
10. Hemodynamics of pelvic nerve induced penile erection in the dog: possible mediation by vasoactive intestinal polypeptide
11. Quantitative analysis of outflow pathway of corpora cavernosa by pressure flow technique
12. Hypercholesterolemia impairs endothelium-dependent relaxation of rabbit corpus cavernosum smooth muscle
13. Diabetes mellitus impairs neurogenic and endothelium-dependent relaxation of rabbit corpus cavernosum smooth muscle
14. Endothelium-derived nitric oxide and cyclooxygenase products modulate corpus cavernosum smooth muscle tone
15. Recherches sur la physiologie et al pharmacologie du système nerveux autonome. XII. Nature cholinergique et adrénergique des diverses innervations vasomotrices du pénis chez la chien
16. Inositol trisphosphate and diacylglycerol: two interacting second messengers
17. Thromboxane B2 production during erection
18. Changes in penile hemodynamics after intracavernous injection of prostaglandin E1 and prostaglandin I2 in pigtailed monkeys
19. Cyclic GMP mediates neurogenic relaxation in the bovine retractor penis muscle
20. Neurogenic vasodilatation in isolated bovine and canine penil arteries
21. Vasopressin promotes neurite growth in cultured embryonic neurons
22. Intracavernous sodium nitroprusside: inappropriate impotence treatment
23. In-vitro contractile response of the rabbit corpus cavernosa to field stimulation and autonomic agonists and antagonists: a qualitative study
24. Anoxia and corporeal smooth muscle dysfunction: a model for ischemic priapism
25. Nitric oxide: a physiologic mediator of penile erection
26. Immunohistochemical localization of nitric oxide synthase in the autonomic innervation of the human penis
27. Nitric oxide is a potent relaxant of human and rabbit corpus cavernosum
28. Comparison of nonadrenergic, noncholinergic- and nitric oxide-mediated relaxation of corpus cavernosum
29. Biosynthesis of nitric oxide and citrulline from L-arginine by constitutive nitric oxide synthase present in rabbit corpus cavernosum
30. The role of histamine in the cardiovascular system
31. Gap junctions formed of connexin43 found between smooth muscle cells of human corpus cavernosum
32. Autonomic control of penile erection in dogs
33. Vascular changes during erection in the dog
34. Pharmacological studies of human erectile tissue: characteristics of spontaneous contractions and alterations in α-adrenoceptor responsiveness with age and disease in isolated tissues
35. Intercellular communication through gap junctions: a potential role in pharmacomechanical coupling and syncytial tissue contraction in vascular smooth muscle isolated from the human corpus cavernosum
36. Gap junction-mediated intercellular diffusion of Ca2+ in cultured human corporal smooth muscle
37. The role of gap junctions and ion channels in the modulation of electrical and chemical signals in human corpus cavernosum smooth muscle
38. Neurotransmitter receptors and phosphoinositide turnover
39. Transcutaneous nitroglycerin therapy in the treatment of impotence
40. Immunohistochemical study of neuropeptide Y-containing nerve fibers in the human clitoris and penis
41. L'érection du pénis humaine et ses bases morphologico-vasculaires
42. Adrenergic receptors on smooth muscle cells isolated from human penile corpus cavernosum
43. Human calcitonin gene-related peptide activates adenylate cyclase and releases prostacyclin from human umbilical vein endothelial cells
44. Vasoactive intestinal polypeptide-like immunoreactive nerves in the diabetic penis: a comparison between streptozotocin-treated rats and man
45. The human penis: an unusual penetration of NPY-immunoreactive nerves within the medial muscle coat of the deep dorsal vein
46. Sodium nitroprusside and neurostimulation cause increased levels of cylcic guanosine monophosphate and not cyclic adenosine monophosphate during canine penile erection
47. Localization of vasoactive intestinal polypeptide in penile erectile tissue and in the major pelvic ganglion of the rat
48. Responses of smooth muscle strips from penile erectile tissue to drugs and transmural nerve stimulation
49. Neural control of penile erection
50. The effect of papaverine on arterial and venous hemodynamics of erection
51. Comparison of the penile erection induced by intracavernous injection of papaverine and histamine in patients with psychogenic erection
52. Muscular cavernous single cell analysis in patients with venoocclusive dysfunction
53. Followup results of a combination of calcitonin gene-related peptide and prostaglandin E1 in the treatment of erectile dysfunction
54. Hemodynamic mechanisms of erection in the canine penis
55. Secretory mechanism of immunoreactive endothelin in cultured bovine endothelial cells
56. The biochemical pathways of nitric oxide formation from nitrovasodilators: appropriate choice of exogenous NO donors and aspects of preparation and handling of aqueous NO solutions
57. Evidence for a role of EDRF in penile erection
58. Inhibition of nerve stimulation-induced vasodilatation in corpora cavernosa of the pithed rat by blockade of nitric oxide synthase
59. Isoforms of nitric oxide synthase
60. Mechanisms of venous occlusion during canine penile erection: an anatomic demonstration
61. Effects of some calcium channel blockers on isolated human penile erectile tissue
62. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine
63. Antierectile role of the sympathetic nervous system in rats
64. Multiple neuropeptide Y receptors are involved in cardiovascular regulation. Peripheral and central mechanisms
65. Peptidergic innervation of the human male genital tract
66. Decrease of vasoactive intestinal polypeptide (VIP) in the penises from impotent men
67. Vasoactive intestinal polypeptide and norepinephrine concentration in the corpora cavernosa of impotent men
68. Synthetic nitrovasodilators are effective, in vitro, in relaxing penile tissue from impotent men: the findings and their implications
69. Topical glyceryltrinitrate causes measurable penile arterial dilatation in impotent men
70. Comparison of the responses to drugs acting on adrenoceptors and muscarinic receptors in human isolated corpus cavernosum and cavernous artery
71. Effects of some peptides on isolated human penile erectile tissue and cavernous artery
72. Contraction and relaxation induced by some prostanoids in isolated human penile erectile tissue and cavernous artery
73. Characterization of contraction-mediating prostanoid receptors in human penile erectile tissues
74. Effect of the thromboxane receptor antagonist AH 23848 on human isolated corpus cavernosum
75. Localization and effects of pituitary adenylate cyclase-activating polypeptide (PACAP) in human penile erectile tissues
76. Effects of nicorandil on human isolated corpus cavernosum and cavernous artery
77. On the mechanism of erection
78. Effects of pinacidil on isolated human corpus cavernosum penis
79. Actions of endothelin on isolated corpus cavernosum from rabbit and man
80. Gl- N-nitro arginine inhibits non-adrenergic, non-cholinergic relaxation of human isolated corpus cavernosum
81. G-nitro-lEffects of the nitric oxide synthase inhibitor N-arginine on the erectile response to cavernous nerve stimulation in the rabbit
82. Characterization of inhibitory neurotransmission in the isolated corpus cavernosum from rabbit and man
83. Functional effects, binding sites and immunolocalization of endothelin-1 in isolated penile tissues from man and rabbit
84. Phospholipase C activation by endothelin-1 and noradrenaline in isolated penile erectile tissue from rabbit
85. Actions of 3-morpholinosydnonimin (SIN-1) on rabbit isolated penile erectile tissue
86. Targeted disruption of the neuronal nitric oxide synthase gene
87. The structure and specificity of endothelin receptors: their importance in physiology and medicine
88. Biosynthesis and metabolism of endothelium-derived nitric oxide
89. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide
90. Nitric oxide and cyclic GMP formation upon electrical field stimulation cause relaxation of corpus cavernosum smooth muscle
91. Prostacyclin synthesis by the corpora cavernosa of the human penis: evidence for muscarinic control and pathological implications
92. Pharmacotherapy of impotence: where are we going?
93. Pharmacotherapy of erectile dysfunction: a review
94. Further evidence of venous outflow restriction during erection
95. Interaction of VIP and acetylcholine on the relaxation of human corpus cavernosal tissue
96. A possible neural source of nitric oxide in the rat penis
97. Immunohistochemical characterization of pelvic neurons which project to the bladder, colon, or penis in rats
98. Studies on intracavernosal VIP levels during pharmacologically induced penile erections
99. Penile response to intracavernosal vasoactive intestinal polypeptide alone and in combination with other vasoactive agents
100. A nitric oxide-like factor mediates nonadrenergic-noncholinergic neurogenic relaxation of penile corpus cavernosum smooth muscle
101. Oxygen tension regulates the nitric oxide pathway. Physiological role in penile erection
102. Endothelium dependent relaxation of human corpus cavernosum by bradykinin
103. Effects of noradrenaline, 5-hydroxytryptamine and histamine on human penile cavernous tissue and circumflex veins
104. Neuropeptide Y (NPY) in human penile corpus cavernosum and circumflex veins
105. Vasoactive intestinal polypeptide (VIP) and peptide histidine methionine (PHM) in human penile corpus cavernosum tissue and circumflex veins: localization and in vitro effects
106. Role of the l-arginine/nitric oxide pathway in relaxation of isolated human penile cavernous tissue and circumflex veins
107. Suppression of the excitatory adrenergic neurotransmission; a possible role of cholinergic nerves in the retractor penis muscle
108. Basal and acetylcholine-stimulated nitric oxide formation mediates relaxation of rabbit cavernous smooth muscle
109. Nitric oxide mediates relaxation in rabbit and human corpus cavernosum smooth muscle
110. Nitric oxide mediates neurogenic relaxation induced in rabbit cavernous smooth muscle by eletric field stimulation
111. Release of immunoreactive endothelin from porcine aortic strips
112. Characterization of cyclic nucleotide and inositol 1,4,5-trisphosphate-sensitive calcium-exchange activity of smooth muscle cells cultured from the human corpora cavernosa
113. Occurrence, distribution and origin of peptide-containing nerves of guinea-pig and rat male genitalia and the effects of denervation on sperm characteristics
114. Vasoactive intestinal polypeptide (VIP) in the male genitourinary tract, concentration and motor effect
115. Effect of endothelin-1 on the human corpus cavernosum and penile vasculature
116. A review of erectile dysfunction: new insights and more questions
117. Changes in the VIPergic, cholinergic and adrenergic innervation of human penile tissue in diabetic and non-diabetic impotent males
118. Neuropeptides and impotence
119. Physiology of erection and pharmacological management of impotence
120. Hemodynamics of erection in the monkey
121. Role of endotheliumformed nitric oxide on vascular responses
122. Endothelium-derived relaxing factors. A perspective from in vivo data
123. Cyclic guanosine monophosphate mediates penile erection in the rat
124. Physiology and pharmacology of endothelins
125. Experimental study of erection ejaculation reflex
126. Inhibition of adrenergic neurotransmission in canine vascular smooth muscle by histamine: mediation by H2-receptors
127. Non-invasive management of impotence with trancutaneous nitroglycerin
128. Intracavernous injection of cGMP in impotent man
129. Modulation of noradrenaline release in human corpus cavernosum by presynaptic prostaglandin receptors
130. Arachidonic acid metabolites and the interactions between platelets and blood-vessel walls
131. An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation
132. Biosynthesis of nitric oxide from L-arginine
133. Gap junctions between human corpus cavernosum smooth muscle cells: gating properties and unitary conductance
134. Levels of nitric oxide metabolites do not increase during penile erection
135. Mast cells, histamine and penile erection
136. Immunocytochemical localization of endothelin in cultured bovine endothelial cells
137. Penile erection: possible role for vasoactive intestinal polypeptide as a neurotransmitter
138. Topical nitroglycerin: a potential treatment for impotence
139. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
140. Acetylcholine, histamine, 5-hydroxytryptamine and catecholamine contents of mammalian penile erectile and urethral tissue
141. The effect of inhibitors of nitric oxide biosynthesis and cyclic GMP formation on nerve-evoked relaxation of human cavernosal smooth muscle
142. Evidence against vasoactive intestinal polypeptide as the relaxant neurotransmitter in human cavernosal smooth muscle
143. Vipergic nerves in the penis
144. Prostaglandin E1 bei erektiler Dysfunktion
145. Prostaglandin E1 and the nitric oxide donor linsidomine for erectile failure: a diagnostic comparative study of 40 patients
146. Nitric oxide as a mediator of relaxation of the corpus cavernosum on response to nonadrenergic, noncholinergic neurotransmission
147. Evidence for endothelin-1 release from resistance vessels of rats in response to hypoxia
148. The calcium messenger system
149. Ability of human corpora cavernosa muscle to generate prostaglandins and thromboxanes in vitro
150. Prostaglandin 15-hydroxydehydrogenase activity in human penile corpora cavernosa and its significance in prostaglandin-mediated penile erection
151. A clinical trial of intracavernous vasoactive intestinal peptide to induce penile erection
152. Cholinergic neurotransmission in human corpus cavernosum. I. Responses of isolated tissue
153. Impaired neurogenic and endothelium-mediated relaxation of penile smooth muscle from diabetic men with impotence
154. Endothelin: localization, synthesis, activity, and receptor types in human penile corpus cavernosum
155. Endothelium-derived contractile factors
156. Fine structure of the human corpus cavernosum
157. Vasoactive intestinal polypeptide (VIP)- and neuropeptide Y (NPY)-containing nerve fibres in the penile cavernous tissue of green monkeys Cercopithecus aethiops
158. Content and distribution of vasoactive intestinal polypeptide (VIP) in cavernous tissues of human penis
159. Principal mechanisms controlling penile retraction and protrusion in rabbits
160. Endothelins and sarafotoxins: physiological regulation, receptor subtypes and transmembrane signaling
161. Use of methylene blue and selective embolization of the pudendal artery for high flow priapism refractory to medical and surgical treatments
162. Anatomical localization and some pharmacological effects of vasoactive intestinal polypeptide in human and monkey corpus cavernosum
163. Acetylcholine as a possible neurotransmitter in penile erection
164. Preliminary report on the effect of the nitric oxide (NO) donor SIN-1 on human cavernous tissue in vivo
165. Calcitonin-gene-related peptide: a possible role in human penile erection and its therapeutic application in impotent patients
166. Trancutaneous registration of cavernous smooth muscle electrical activity: noninvasive diagnosis of neurogenic autonomic impotence
167. Preliminary results with the nitric oxide donor linsidomine chlorhydrate in the treatment of human erectile dysfunction
168. Calcitonin gene-related peptide: possibly neurotransmitter contributes to penile erection in monkeys
169. Effect of intracavernous simultaneous injection of acetylcholine and vasoactive intestinal polypeptide on canine penile erection
170. Effects of adenosine triphosphate on canine penile erection
171. Effects of adenosine on canine penile erection
172. Correlations of purinergic, cholinergic and adrenergic functions in rabbit corporal cavernosal tissue
173. Nitric oxide and cGMP: mediators of pelvic nerve-stimulated erection in dogs
174. The role of cyclic adenosine monophosphate, cyclic guanosine monophosphate, endothelium and nonadrenergic, noncholinergic neurotransmission in canine penile erection
175. Intracellular mechanism of penile erection in monkeys
176. Vasoactive intestinal polypeptide release during penile erection in man
177. The effect of atropine and α-and β-blockers on human penile erection: a controlled pilot study
178. Intracavernous injection of vasoactive intestinal polypeptide (VIP) does not induce erection in man per se
179. Electrical activity of corpus cavernosum during flaccidity and erection of the human penis: a new diagnostic method?
180. Neuropeptide Y-related peptides and their receptors — are the receptors potential therapeutic drug targets?
181. Penile erections induced by vasoactive intestinal peptide and sodium nitroprusside
182. Nitric oxide mediates penile erection in cats
183. Study of neuropeptide Y-containing nerve fibers in the human penis
184. Vasoactive intestinal polypeptide (VIP) as a possible neurotransmitter involved in penile erection
185. Vasoactive intestinal polypeptide (VIP) as a putative neurotransmitter in penile erection
186. Effects of purines on rabbit corpus cavernosum contractile activity
187. The coexistence of neuropeptide Y and norepinephrine in rabbit corpus cavernosum penis: an in vitro study
188. A novel potent vasoconstrictor peptide produced by vascular endothelial cells
189. Peptide histidine methionine (PHM) and the human male genitalia