P450 in the rat and man: Methods of investigation, substrate specificities and relevance to cancer

Xenobiotica

Volumn 24, Issue 12, 1994, Pages 1151-1175

  Nedelcheva, V ^a   Gut, I ^a  

^a NATIONAL INSTITUTE OF PUBLIC HEALTH   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; AMINOPHENAZONE; ANDROSTENEDIONE; BARBITURIC ACID DERIVATIVE; BENZPHETAMINE; CAFFEINE; CARCINOGEN; CHLORZOXAZONE; CYTOCHROME P450; DAPSONE; DEBRISOQUINE; DEXTROMETHORPHAN; ERYTHROMYCIN; ESTRADIOL; HYDROCORTISONE; ISONIAZID; LIDOCAINE; MEPHENYTOIN; MUTAGENIC AGENT; NIFEDIPINE; PARACETAMOL; PHENACETIN; PROGESTERONE; RIFAMPICIN; SENECIONINE; SPARTEINE; TOBACCO SMOKE; UNINDEXED DRUG;

ARTICLE; CANCER; DETOXIFICATION; ENZYME SPECIFICITY; HUMAN; METABOLIC ACTIVATION; METHODOLOGY; NONHUMAN; OXIDATION; RAT; SPECIES DIFFERENCE;

ANIMAL; CARCINOGENS; COMPARATIVE STUDY; CYTOCHROME P-450 ENZYME SYSTEM; DNA, COMPLEMENTARY; FEMALE; GENE EXPRESSION; HUMAN; MALE; MUTAGENS; NEOPLASMS; RATS; SPECIES SPECIFICITY; SUBSTRATE SPECIFICITY; XENOBIOTICS;

EID: 0028662025     PISSN: 00498254     EISSN: None     Source Type: Journal    
DOI: 10.3109/00498259409038673     Document Type: Article

References (136)

1. Mutagenic activation of 2-amino-3-methylimidazo(4,5-f)-quinoline by complementary DNA expressed human liver cytochromes P450
2. Metabolic oxidation phenotypes as markers for susceptibility to lung cancer
3. In vitro inhibition studies of tolbutamide hydroxylase activity of human liver microsomes by azoles, sulphonamides and quinolines
4. Carcinogen metabolism and DNA adducts in human lung tissues as affected by tobacco smoking or metabolic phenotype: a case control study on lung cancer patients
5. Induction of P4502E1 and P4502B1 by secondary ketones and the role of P4502E1 in chloroform metabolism
6. Effect of disulfiram on hepatic P4502E1 and other microsomal enzymes and hepatotoxicity in rats
7. Catalytic activities of human liver cytochrome P450 3A4 expressed in Saccharomyces cerevisiae
8. Expression of a human liver cytochrome P450 protein with tolbutamide hydroxylase activity in Saccharomyces cerevisiae
9. Human, cytochrome P450PA, the phenacetine-O-deethylase is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines
10. Ethoxy-, penthoxy- and benzyloxy-phenoxazones and homologues: a series of substrates to distinguish between different induced cytochromes P450
11. Induction of microsomal cytochrome P450 enzymes: the first Bernard Brodie award lecture in Pensylvania State University
12. Stable expression of human P450 cDNAs in human lymphoblastoid cells
13. Human cytochrome P450 1A3: cDNA sequence, role of the enzyme in the metabolic activation of promutagens, comparison to the nitrosamine activation by human cytochrome P4502E1
14. 17β-Estradiol 2- and 4-hydroxylation catalyzed by rat hepatic P450: roles of individual forms, inductive effects, developmental patterns and alternations by gonadectomy and hormone replacement
15. Dextramethorphan O-demethylation in liver microsomes as a prototype reaction to monitor cytochrome db1 activity
16. Human Liver microsome P4502E1. Immunological evaluation of its contribution to microsomal ethanol oxidation, carbon tetrachloride reduction and NADPH oxidase activity
17. Separation and purification of a novel form of P450 from rats treated with pregnenolone 16α- carbonitrile
18. Inhibition of microsomal oxidation of ethanol by pyrazole and 4-methyrpyrazole in vitro. Increased effectiveness after induction by pyrazole and 4-methylpyrazole
19. Human liver N-hydroxylation of dapsone by P4503A4
20. Xenobiotic and endobiotic inhibitors of cytochrome P450db1 function, the target of the debrizoquine-sparteine type polymorphism
21. Simultaneous purification of multiple forms of rat liver microsomal P450 by HPLC
22. Purification and characterization of liver microsomal P450 from untreated male rats
23. The increase of urinary excression of 6β-hydroxycortisol as a marker of human hepatic cytochrome P4503A induction
24. Characterization of cDNAs, mRNAs and protein related to human liver microsomal P450-S mephenytoin-4'hydroxylase
25. The effects of cigarette smoke compared to 3-methylhoianthrene and phenobarbitone on alkoxyresorufin metabolism by lung and liver microsomes from rats
26. Evidence that CYP2C19 is the major (S)-mephenytoin 4'-hydroxylase in humans
27. The molecular biology of cytochrome P450
28. Molecular genetics of the P450 superfamily
29. Analysis and characterization of enzymes
30. Mechanism based inactivation of human liver microsomal P450IIIA4 by gestodene
31. Metabolism of 17α-ethynylestradiol in humans
32. Oxidation of sparteins by cytochrome P450: evidence against the formation of N-oxides
33. Oxidation of dihidropyridine calcium channel blockers and analogues by human liver cytochrome P450 3A4
34. Purification and characterization of rat liver microsomal cytochromes P450: electrophoretic, spectral, catalytic and immunochemical properties and inducibility of 8 isozymes isolated from rats treated with phenobarbital or β-naphtoflavone
35. Human Liver cytochromes involved in polymorphisms of drug oxidation
36. In vitro inhibition of dihidropyridine oxidation and aflatoxin B1 oxidation in human liver microsomes by naringenin and other flavonoids
37. Role of human P4502E1 in the oxidation of many low molecular weight cancer suspects
38. Characterization of rat and human microsomal P450 forms involved in the nifedipine oxidation—a prototype for genetic polymorphism in oxidative drug metabolism
39. Improved HPLC determination of chlorzoxazone and its hydroxymetabolite in human serum and urine
40. Reconstituion of testosterone oxidation by purified rat cytochrome P4503A1 (p)
41. Metabolic oxidation of carcinogenic arylamines by rat, dog and human hepatic microsomes and by purified flavin containing cytochrome P450 monooxygenases
42. The human CYP2D lokus associated with a common genetic defect in drug oxidation: a G1934–a base change in intron 3 of a mutant CYP2D6 allele results in an aberrant 3' splice recognition site
43. Cytochrome P450 isozyme selectivity in the oxidation of acetaminophen
44. Heterogeneity of CYP3A isoforms metabolizing erythromycin and cortisol
45. Lidocaine metabolism of human cytohrome P450s purified from hepatic microsomes: comparison with rat hepatic cytochrome P450s
46. Purification and characterization of six P450 from hepatic microsomes of immature female rats
47. Induction of cytochrome P4501 as an indicator of potential chemical carcinogenesis
48. Characterization of a new form (RLM2) of liver microsomal cytochrome P450 from untreated rats
49. Benzene metabolism by ethanol- acetone- and benzene inducible cytochrome P450 IIE1 in rat and rabbit liver microsomes
50. Cytochromes P450 as determinants of susceptibility to carcinogenesis is by aromatic amines and nitroaromatic hydrocarbons
51. Genetic predisposition to Bladder cancer: ability to hydroxylate debrisoquine and mephenytoin as risk factor
52. Use of caffeine metabolite ratios to explore CYP1A2 and xanthine oxidase activities
53. Sex differences of P450 in the rat: purification, characterization and quantitation of constitutive forms of P450 from liver microsomes of male and female rats
54. Expression and characterization of human fetal liver cytochrome P450 (P4503A7)
55. The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene and a pseudogene
56. Differential Inhibition of individual human liver P450 by cimetidine
57. Oxidative metabolism of hexobarbital in human liver: relationship to polymorphic S-mephemytoin 4-hydroxylation
58. Cyclosporin metabolism in human liver. Identification of a cytochrome 3 gene family as the major cyclosporin metabolizing enzyme explains interactions of cyclosporin with other drugs
59. Purification and characterization of the rat liver microsomal P450 involved in the 4-hydroxylation of debrizoquine, a prototype for the genetic variation in oxidative drug metabolism
60. Purification and characterization of human liver cytochrome P450ALC
61. Metabolism of retinol and retinolic acid by human liver cytochrome P4502C8
62. The erythromycin breath test selectively measures P450IIIA in patients with severe liver disease
63. Metabolism of 2-acetylaminofluorene and benzo(a)pyrene and activation of food derived heterocyclic amine mutagens by human cytochromes P450
64. Dangerous properties of petroleum refining products: benzene—health effects
65. Characterization of cytochrome 2B6 in human liver microsomes
66. Role of P4503A4 in the metabolism of the pyrrazolidine alkaloid senecionine in human liver
67. Metabolism of chlorzoxazone in rat brain
68. Sexual differentiation of cytochrome P450 in rat liver
69. Selectivity in the inhibition of mammalian cytochromes P450 by chemical agents
70. A comparative study on the contribution of cytochrom P450 isozymes to metabolism of benzene, toluene and trichloroethylene in rat liver
71. Cytochrome P450 isozymes involved in the metabolic activation of Δ-tetrahydrocannabinol by rat liver microsomes
72. The P450 superfamily: updated listing of all genes and recommended nomenclature for the chromosomal loci
73. The P450 superfamily: update on new sequences, gene mapping and recommended literature
74. The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature
75. Stable expression of human P450IIE1 in mammalian cells: metabolic activation of nitroso dimethylamine and formation of adducts with cellular DNA
76. Urinary excretion of 6β-hydroxycortisol and the time course measurement of enzyme induction in man
77. Enzyme induction in the cytochrome P450 system
78. Use of quinidine inhibition to define the role of the sparteine/debrisoquine cytochrome P450 in metoprolol oxidation by human liver microsomes
79. Characterization and identification of a pyrazole inducible form of cytochrome P450
80. Preparation and characterization of monoclonal antibodies to pregnenolone 16α carbonitrile inducible rat liver cytochrome P450
81. Comparative effects of rifabulin and rifampicin on hepatic microsomal enzyme activity in normal subjects
82. Hydroxylation of chlorzoxazone as a specific probe for human liver P4502E1
83. Specifity of rat liver cytochrome P450 isozymes in the mutagenic activation of benzo(a)pyrene, aromatic amines and aflatoxin B1
84. Cloning and expression of complementary cDNAs for multiple members of the human cytochrome P450 IIC subfamily
85. Characterization of three highly purified P450 from hepatic microsomes of adult male rats
86. Evidence that izoniazid and ethanol induce the same microsomal P450 in rat liver, an isozyme homologous to rabbit liver P450 isozyme 3a
87. Purification and characterisation of hepatic microsomal cytochrome P450
88. Separation and characterization of highly purified forms of liver microsomal cytochrome P450 from rats treated with polychlorinated biphenyls phenobarbital, and 3-methylcholanthrene
89. Purification, characterization and regulation of 5 rat hepatic microsomal cytochrome P450 enzymes
90. GC determination of sparteine and 2- and 5-dehydrosparteine in plasma and urine
91. Purification of a previously unreported form of P448 from the liver of #-methylcholantrene pretreated rat
92. A form of P450 in man, orthologous to form d in the rat catalyses the O-deethylation of phenacetine and is inducible by cigarette smoking
93. Furafylline is a potent and selective inhibitor of cytochrome P4501A2 in man
94. Steroid metabolism by constitutive forms of P450
95. Participation of a form of rat liver microsomal cytochrome P450 induced by pregnenolone 16α carbonitrile in the 4-hydroxylation of mephenytoin, a prototype of genetic polymorphism of oxidative drug metabolism
96. Evidence for the cytochrome P450NF, the nifedipine oxidase, being the principle enzyme involved in the bioactivation of aflatoxins in human liver
97. Inactivation of 1·3-, 1,6- and 1,8-Dinitropyrene by P450 enzymes in human and rat liver microsomes
98. Human liver microsomal P450 enzymes involved in the bioactivation of procaracinogens detected by umu-gene response in Salmonella typhimurium TA1535 pSK1002
99. Roles of individual human P450 enzymes in the bioactivation of benzo(a)pyrene-7,8-dehidroxy-7,8-dihidro-benzo(a)pyrene and other dihidrodiol derivatives of PAH
100. Cytochrome P450 mediated activation of procarcinogens and promutagens to DNA damaging products by measuring expression of umu-gene in Salmonella typhimurium TA1535
101. Genotoxic and mutagenic activation of aflatoxin B1 by constitutive forms of P450 in rat liver microsomes
102. Interindividual variation in human liver cytochrome P450 enzymes involved in the oxidation of drugs, carcinogens, and toxic chemicals: studies with liver microsomes of 30 japanese and 30 caucasians
103. Ethanol increases cytochromes P4502E, 2B1/2 and 3A in cultured rat hepatocytes
104. Selective mutagenic activation by cytochrome P3450 of carcinogenic arylamines found in foods
105. P450 in rat: structures, functions properties and relevant human forms
106. Debrisoquine oxidation phenotype and susceptibility to lung cancer
107. Separation of human liver microsomal tolbutamide hydroxylase and (S)-mephenytoin 4'hydroxylase cytochrome P450 enzymes
108. Characterization of nine monoclonal antibodies against rat hepatic cytochrome P450
109. Differential rates of metabolic activation and detoxication of the food mutagen 2-amino-6-phenyl-imidazo[4,5-b]pyridine by different P450
110. Human liver microsomal steroid metabolism: identification of the major microsome steroid hormone 6β-hydroxylase cytochrome P450 enzyme
111. Rat hepatic cytochrome P450 isoenzyme 2c: identification as a male specific developmentally induced steroid 16α-hydrolase and comparison to female specific cytochrome P450 enzyme
112. Cytochrome P450 isozyme 1 from phenobarbital induced rat liver: purification, characterization and interactions with metyrapone and cytochrome b5
113. Immunochemical analysis of cytochrome P4501A1 homologue in human lung microsomes
114. Bioactivation and detoxification of the pyrrolizidine alkaloid senecionine by P450s in rat liver
115. Studies on the expression and the metabolic capabilities of human liver P4503A5 (HLp3)11
116. The CYP2A3 gene product catalyses coumarin 7-hydroxylation in human liver microsomes
117. Participation of rat liver cytochrome P4502E1 in the activation of N-nitrosodimethylamine and N-nitrosodiethylamine to products genotoxic in an acetyltransferase overexpressing Salmonella typhimurium strain
118. Specifity of four forms of P450 in the metabolic activation of several aromatic amines and benzo(a)pyrene
119. Induction, purification and characterization of P4502E1
120. Cytochrome P4502E1: roles in nitrosamine metabolism and mechanism of regulation
121. Expression of a human P450IIC gene in yeast cells using galactose unducible expression system
122. Metabolism of N-nitrosodiakylamines by human liver microsomes
123. Purification and characterization of a human liver microsomal cytochrome P450 2A6
124. Roles of cytochromes 2C11 and 3A enzymes in the 3'-hydroxylation of benzo(a)pyrene
125. Induction by rifampin of genetically determined 4-hydroxylation of S-mephenytoin in man
126. Studies on the expression and the metabolic capabilities of human liver P4503A5 (HLp3)11
127. The CYP2A3 gene product catalyses coumarin 7-hydroxylation in human liver microsomes
128. Participation of rat liver cytochrome P4502E1 in the activation of N-nitrosodimethylamine and N-nitrosodiethylamine to products genotoxic in an acetyltransferase overexpressing Salmonella typhimurium strain
129. Specifity of four forms of P450 in the metabolic activation of several aromatic amines and benzo(a)pyrene
130. Induction, purification and characterization of P4502E1
131. Cytochrome P4502E1: roles in nitrosamine metabolism and mechanism of regulation
132. Expression of a human P450IIC gene in yeast cells using galactose unducible expression system
133. Metabolism of N-nitrosodiakylamines by human liver microsomes
134. Purification and characterization of a human liver microsomal cytochrome P450 2A6
135. Roles of cytochromes 2C11 and 3A enzymes in the 3'-hydroxylation of benzo(a)pyrene
136. Induction by rifampin of genetically determined 4-hydroxylation of S-mephenytoin in man