The relationship between phosphorylation potential and redox state in the isolated working rabbit heart

Journal of Molecular and Cellular Cardiology

Volumn 26, Issue 12, 1994, Pages 1525-1536

  Laughlin, Maren R ^a   Heineman, Frederick W ^a  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

Aminooxy acetate; Fluorescence; Lactate; NADH; NMR; Pyruvate; Redox state; hydroxybutyrate

Indexed keywords

EID: 0028651917     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmcc.1994.1173     Document Type: Article

References (40)

1. Balaban RS, Kantor HL, Katz LA, Briggs RW, 1986. Relation between work and phosphate metabolite in the in vivo paced mammalian hearts. Science 232: 1121-1123.
2. Berry MN, 1980. The function of energy-dependent redox reactions in cell metablism. FEB.'? Lett 117(Suppl.): K106-K119.
3. Bucher T, Hohorts H-J, 1963. Dihydroxyacetone Phosphate, Fructose-1, 6-diphosphate and D-gly-ceraldehyde-3-phosphate, In: HU Bergmeyer ed. Methods of Enzymatic Analysis. New York, Academic Press, 246-252.
4. Bunger R, Glanert S, Sommer O, Gereach E, 1980. Inhibition by (Aminooxy)acetate of the malate-as-partate cycle in the isolated working guinea pig heart. Hoppe-Seyler’s Z Physiol Chem 361: 907-914.
5. Bunger R, Mallet RE, Hartman DA, 1989. Pyruvate-enchanced phosphorylation potential and inotropism in normoxic and postischemic isolated working heart. Ear J Biochem 180: 221-233.
6. Bunger R, Mukohara N, Kang Y-H, Mallet RT, 1991. Combined glyceraldehyde-3-phosphate dehydrogenase/phosph’oglycer ate kinase in catecholamine-stimulated guinea-pig cardiac muscle. Eur/Biochem 202: 913-921.
7. Czok R, Eckert h, 1963. d-3-phosphoglycerate, D-2-phos-phoglycerate, phosphoenolpyruvate, In: HU Bergmeyer ed. Methods of Enzymatic Analysis, New York, Academic Press, 224-228.
8. Dennis SC, Padma A, DeBuysere MS, Olson MS, 1979. Studies on the regulation of pyruvate dehydrogenase in the isolated perfused rat heart./Bio Chem 254: 1252-1258.
9. Erecinska M, 1982. Regulation of cellular energy metabolism. j Membrane Biol 70: 1-14.
10. From AHL, Zimmer SD, Michiirski SP, Mohana-krishnan P, Ulstad VK, Thoma WJ, Ugurbil K, 1990. Regulation of the oxidative phosphorylation rate in the intact cell. Biochemistry 29: 3731-3743.
11. Hassinen I. Ito K, Nioka S, Chance B. 1990. Mechanism of fatty acid effect on myocardial ocygen consumption. A phosphorus NMR study. Biochim Biopys Acta 1019: 73-80.
12. 31P magnetic resonance study. Magn Reson Med 12: 328-338.
13. Heineman FW, Balaban RS, 1993. Effects of afterload and heart rate on NAD(P)H redox state in the isolated rabbit heart, Am J Physiol 264: H433-H440.
14. Heineman FW, Eng J, Berkowitz, BA, Balaban RS, 1990. NMR spectral analysis of kinetic data using natural lineshapes. Magn Res Med 13: 490-497.
15. Heineman FW, Kupriyanov VV, Marshall R, Fralix TA, Balaban RS, 1992. Myocardial oxygenation in the isolated working rabbit heart as a function of work. Am J Physiol 262: H255-267.
16. Hohorst H-J, 1963. L-(-)-glycero 1-1-phosphate, In: HU Bergmeyer ed. Methods of Enzymatic Analysis, New York, Academic Press, 21 5-219.
17. Katz LA, Koretsky AP, Balaban RS, 1987. Respiratory control in the glucose perfused heart. i'EBS Lett 221: 270-276.
18. Katz LA, Swain JA, Portman MA, Balaban RS, 1989. Relation between phosphate metabolites and oxygen consumption of heart in vivo. Am J Physiol 256: H265-274.
19. Kim DK, Heineman FW, Balaban RS, 1991. Effects of p-hydroxybutyrate on oxidative metabolism and phosphorylation potential in canine heart in vivo. Am J Physiol 260: H1767-H1773.
20. Koretsky AP, Balaban RS, 1987. Changes in pyridine nucleotide levels alter oxygen consumption and extra-mitochondrial phosphates in isolated mitochondria: a 31P-NMR and NAD(P)H fluorescence study. Biochim Biophys Acta 893: 398-408.
21. LaNoije KF, Bryla J, Williamson R, 1972. Feedback interactions in the control of citric acid cycle activity in rat heart mitochondria. J Biol Chem 247: 667-679.
22. Laughlin MR, Taylor J, Chesnick AS, DeCroot M, Balaban RS, 1993. Pyruvate and lactate metabolism in the in vivo dog heart. Am J Physiol 264: H2068-112079.
23. 2+ on the K^, of the creatine kinase reaction and other phosphate hydrolyses and phosphate transfer reactions. J Biol Chem 254: 6528-6537.
24. Mallet RT, Hartman DA, Bunger R, 1990. Glucose requirement for postischemic recovery of perfused working heart. Eur j Biochem 188: 481-493.
25. J1P-NMR study of some metabolic and functional effects of the inotropic agents epinephrine and ouabain, and the ionophore R02-2985 (X537A) in the isolated, perfused rat heart. Biochim Biophys Acta 720: 163-171.
26. 2+ homeostasis during p-adrenergic stimulation. Am J Physiol 164: H670-H678.
27. Owen P, Dennis S, Opie LH, 1990. Glucose flux rate regulates onset of ischemic contracture in globally underperfused rat hearts. Circ Res 66: 344-354.
28. Russell RR, Taegtmeyer HJ, 1991. Changes in citric acid cycle flux and anaplerosis antedate the functional decline in isolated rat hearts utilizing acetoacetate. Clin Invest 87: 384-390
29. Russell RR, Taegtmeyer HJ, 1992. Coenzyme A sequestration in rat hearts oxidizing ketone bodies. J. Clin Invest 89: 968-973
30. Safer B, Smith CM, Williamson JR, 1971. Control of the transport of reducing equivalents across the mitochondrial membrane in perfused rat heart. J Mol Cell Cardiol 2: 111-124.
31. Sholz T, Laughlin MR, Kuprianov VV, Balaban RS, Heineman FW, 1994. Effect of substrate on mitochondrial NADH, cytosolic redox state and phos-phorylated compounds in the working, isolated heart. AmJ Physiol (in press).
32. Sistar FD, Haynes RC Jr, 1985. The interaction between the cytosolic pyridine nucleotide redox potential and gluconeogenesis from lactate/pyruvate in isolated rat hepatocytes. J Biol Chem 260: 12748-12753.
33. Starnes JW, Wilson DF, Erecinska M, 1985. Substrate dependence of metabolic state and coronary flow in perfused rat heart. Am J Physiol 249: H799-806.
34. Tilton WM, Seaman C, Carriero D, Piomelli S, 1991. Regulation of glycolysis in the erythrocyte; role of the lactate/pyruvate and NAD/NADH ratios. J Lab Clin Med 118: 146-152.
35. Veech RL, Raijman L, Krebs HA, 1979. Cytosolic phosphorylation potential. J Biol Chem 254: 6538-6547.
36. Veech RL, Raijman L, Krebs HA, 1970. Equilibrium relations between the cytoplasmic adenine nucleotide system and nicotinamide-adenine nucleotide system in rat liver. Biochem J 117: 499-503.
37. Weiss J, Hiltbrand B, 1985. Functional com-partmentation of glycolytic versus oxidative metabolism in isolated rabbit heart. J Clin Invest 75: 436-447.
38. Williamson JR, Saver B, LaNoue KF, Smith CM, Wa-lajtys H, 1973. Mitochondrial-cytosolic interactions in cardiac tissue: role of the malate-aspartate cycle in the removal of glycolytic NADH from the cytosol. Symp Soc Exptl Biol 27: 241-281.
39. Wilson, DF, Stubbs M, Veech RL, Erecinska M, Krebs HA, 1974, Equilibrium relations between the oxidation-reduction reactions and the adenosine triphosphate synthesis in suspensions of isolated liver cells. Biochem I 140: 57-64.
40. Zweier JL, Jacobus WE, 1987. Substrate-induced alterations of high energy phosphate metabolism and contractile function in the perfused heart. J Biol Chem 262: 8015-8021.