Nodularin, a Potent Inhibitor of Protein Phosphatases 1 and 2A, Is a New Environmental Carcinogen in Male F344 Rat Liver

Cancer Research

Volumn 54, Issue 24, 1994, Pages 6402-6406

  Carmichael, Wayne W ^d   Sueoka, Eisaburo ^a   Iida, Naoyuki ^a   Komori, Atsumasa ^a   Suganuma, Masami ^a   Nishiwaki, Rie ^a   Fujiki, Hirota ^a  

^a SAITAMA CANCER CENTER   (Japan)

^b AICHI CANCER CENTER HOSPITAL   (Japan)

^c NATIONAL CANCER INSTITUTE   (United States)

^d WRIGHT STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NODULARIN; PHOSPHOPROTEIN PHOSPHATASE;

ANIMAL EXPERIMENT; ARTICLE; CANCER PREVENTION; CANCER RISK; CHINA; CYANOBACTERIUM; DRUG POTENCY; DRUG PROTEIN BINDING; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; INHIBITION KINETICS; LIVER CANCER; LIVER CARCINOGENESIS; LIVER TOXICITY; MALE; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; RISK ASSESSMENT;

ANIMAL; BACTERIAL TOXINS; CARCINOGENS; DIETHYLNITROSAMINE; IMMEDIATE-EARLY PROTEINS; KERATIN; LIVER; LIVER NEOPLASMS, EXPERIMENTAL; MALE; PEPTIDES, CYCLIC; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-FOS; PROTO-ONCOGENE PROTEINS C-JUN; RATS; RATS, INBRED F344; RNA, MESSENGER; SUPPORT, NON-U.S. GOV'T;

EID: 0028650326     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Rinehart, K.L. Harada, K.L., Namikoshi, M. Chen, C. and Harvis, C.A. Nodularin, microcystin, and the configuration of Adda. J. Am. Chem. Soc. 110: 8557-8558, 1988.
2. Carmichael, W.W. Eschedor, J.T. Patterson, G.M.L. and Moore, R.E. Toxicity and partial structure of a hepatotoxic peptide produced by the cyanobacterium Nodularia spumigena Mertens emend. L575 from New Zealand. Appl. Environ. Microbiol. 54: 2757-2763, 1988.
3. Yoshizawa S. Matsushima, R. Watanabe, M.F. Harada, K.L., Ichihara, A. Carmichael, W.W. and Fujiki, H. Inhibition of protein phosphatases by microcystin and nodularin associated with hepatotoxicity. J. Cancer Res. Clin. Oncol. 116: 609-614, 1990.
4. Suganuma, M. Fujiki, H. Okabe, S. Nishiwaki, S. Brautigan, D. Ingebritsen, T.S. and Rosner, M.R. Structurally different members of the okadaic acid class selectively inhibit protein serine/threonine but not tyrosine phosphatase activity. Toxicon, 30: 873-876, 1992.
5. Quinn, R.J. Taylor, C. Suganuma, M. and Fujiki, H. The conserved acid binding domain model of inhibitors of protein phosphatases 1 and 2A: molecular modeling aspects. Biomed. Chem. Lett. 6: 1029-1034, 1993.
6. de Silva, E.D. Williams, D.E. Andersen, R.J. Klix, H. Holmes, C.F.B. and Allen, T.M. Motuporin, a potent protein phosphatase inhibitor isolated from the Papua New Guinea sponge Theonella swinhoei Gray. Tetrahedron Lett. 33: 1561-1564, 1992.
7. Nishiwaki-Matsushima, R. Ohta, T. Nishiwaki, S. Suganuma, M. Kohyama, K. Ishikawa, T. Carmichael, W.W. and Fujiki H. Liver tumor promotion by the cyanobacterial cyclic peptide toxin microcystin-LR.J. Cancer Res. Clin. Oncol. 118: 420-424, 1992.
8. Krishnamurthy, T. Carmichael, W.W. and Sarver, E.W. Toxic peptides from fresh water cyanobacteria (blue-green algae). Isolation, purification and characterization of peptides from Microcystis aeruginosa and Anabena flos-aquae. Toxicon, 24: 865-873, 1986.
9. Ito, N. Tsuda, H. Tatematsu, M. Inoue, T. Tagawa, Y. Aoki, T. Uwagawa, S. Kagawa, M. Ogiso, T. Imada, K. Fukushima, S. and Asamoto, M. Enhancing effect of various hepatocarcinogens on induction of preneoplastic glutathione 5-transferase placental form positive foci in rats-an approach for a new medium-term bioassay system. Carcinogenesis (Lond.), 9: 387-394, 1988.
10. Ogiso, T. Tatematsu, M. Tamano, S. Tsuda, H. and Ito, N. Comparative effects of carcinogens on the induction of placental glutathione S-transferase-positive liver nodules in a short-term assay and of hepatocellular carcinomas in a long-term assay. Toxicol. Pathol. 13: 257-265, 1985.
11. Ogiso, T. Tatematsu, M. Tamano, S. Hasegawa, R. and Ito, N. Correlation between medium-term liver bioassay system data and results of long-term testing in rats. Carcinogenesis (Lond.), 11: 561-566, 1990.
12. Campbell, H.A. Pitot, H.C. Potter, V.R. and Laishes, B.A. Application of quantitative stereology to the evaluation of enzyme-altered foci in rat liver. Cancer Res. 42: 465-472, 1982.
13. Ohta, T. Nishiwaki, R. Yatsunami, J. Komori, A. Suganuma, M. and Fujiki, H. Hyperphosphorylation of cytokeratins 8 and 18 by microcystin-LR, a new liver tumor promoter, in primary cultured rat hepatocytes. Carcinogenesis (Lond.), 13: 2443-2447, 1992.
14. Chomczynski, P. and Sacchi, N. Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162: 156-159, 1987.
15. Th6venin, C. Kim, S.J. and Kehrl, J.H. Inhibition of protein phosphatases by okadaic acid induces AP-1 in human T cells. J. Biol. Chem. 266: 9363-9369, 1991.
16. Yatsunami, J. Fujiki, H. Suganuma, M. Yoshizawa, S. Eriksson, J.E. Olson, M.O.J. and Goldman, R.D. Vimentin is hyperphosphorylated in primary human fibroblasts treated with okadaic acid. Biochem. Biophys. Res. Commun. 107: 1165-1170, 1991.
17. Yatsunami, J. Komori, A. Ohta, T. Suganuma, M. and Fujiki, H. Hyperphosphorylation of cytokeratins by okadaic acid class tumor promoters in primary human keratinocytes. Cancer Res. 53: 992-9%, 1993.
18. Sassa, T. Richter, W.W. Uda, N. Suganuma, M. Suguri, H. Yoshizawa, S. Hirota, M. and Fujiki, H. Apparent “activation” of protein kineses by okadaic acid class rumor promoters. Biochem. Biophys. Res. Commun. 159: 939-944, 1989.
19. Eriksson, J.E. Brautigan, D.L. Vallee, R. Olmsted, J. Fujiki, H. and Goldman, R.D. Cytoskeletal integrity in interphase cells requires protein phosphatase activity. Proc. Natl. Acad. Sci. USA, 89: 11093-11097, 1992.
20. Holladay, K. Fujiki, H. and Bowden, G.T. Okadaic acid induces expression of both early and secondary response genes in mouse keratinocytes. Mol. Carcinogen. 5: 16-24, 1992.
21. Park, K. Chung, M. and Kim, S.J. Inhibition of myogenesis by okadaic acid, an inhibitor of protein phosphatases 1 and 2A, correlates with the induction of AP-1. J. Biol. Chem. 267: 10810-10815, 1992.
22. Taylor, C. Quinn, R.J. McCulloch, R. Nishiwaki-Matsushima, R. and Fujiki, H. An alternative computer model of the 3-dimensional structures of microcystin-LR and nodularin rationalizing their interactions with protein phosphatases 1 and 2A. BioMed. Chem. Lett. 2: 299-302, 1992.
23. Nishiwaki-Matsushima, R. Fujiki, H. Harada, K.I., Taylor, C. and Quinn, R.J. The role of arginine in interactions of microcystins with protein phosphatases 1 and 2A. BioMed. Chem. Lett. 2: 673-676, 1992.
24. Nishiwaki-Matsushima, R. Nishiwaki, S. Ohta, T. Yoshizawa, S. Suganuma, M. Harada K.I. Watanabe, M.F. and Fujiki H. Structure-function relationships of microcystins, liver tumor promoters, in interaction with protein phosphatase. Jpn. J. Cancer Res. 82: 993-996, 1991.
25. Matsushima R. Yoshizawa S. Watanabe M.F. Harada K. Furusawa M. Carmichael W.W. and Fujiki H. In vitro and in vivo effects of protein phosphatase inhibitors, microcystins and nodularin, on mouse skin and fibroblasts. Biochem. Biophys. Res. Commun. 171: 867-874, 1990.
26. Fujiki, H. and Suganuma, M. Tumor promotion by inhibitors of protein phosphatases 1 and 2A: the okadaic acid class of compounds. Adv. Cancer Res. 61: 143-194, 1993.
27. Akashi, M. Shaw, G. Gross, M. Saito, M. and Koeffler, P. Role of AUUU sequences in stabilization of granulocyte-macrophage colony-stimulating factor RNA in stimulated cells. Blood, 78: 2005-2012, 1991.
28. Schönthal, A. Tsukitani, Y. and Feramisco, J.R. Transcriptional and post-transcrip-tional regulation of c-fos expression by the tumor promoter okadaic acid. Oncogene, 6: 423-430, 1991.
29. Komori, A. Yatsunami, J. Suganuma, M. Okabe, S. Abe, S. Sakai, A. Sasaki, K. and Fujiki, H. Tumor necrosis factor acts as a tumor promoter in BALB/3T3 cell transformation. Cancer Res. 53: 1982-1985, 1993.
30. Michael, L.K. Netpen liver disease (NLD) of salmonid fishes reared in sea water: species susceptibility, recovery, and probable cause. Dis. Aquat. Org. 8: 21-28, 1990.
31. Yu, S.Z. Drinking water and primary liver cancer. In: Z.Y. Tang, M.C. Wu, and S.S. Xia (eds.), Primary Liver Cancer, pp. 30-37. Berlin: Springer-Verlag, China Academic Publishers, Beijing, 1989.
32. Nishiwaki R. Ohta, T. Sueoka, E. Suganuma, M. Harada K.I. Watanabe, M.F. and Fujiki, H. Two significant aspects of microcystin-LR: Specific binding and liver specificity. Cancer Lett. 83: 283-289, 1994.