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So, what about the molecular clock hypothesis?
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Li1
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Codon usage in the G+C-rich Streptomyces genome
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A novel operon organization involving the genes for chorismate synthase (aromatic biosynthesis pathway) and ribosomal GTPase center proteins (L11, L1, L10, L12: rpIKAJL) in Cyanobacterium Synechocystis PCC 6803
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of special interest, A bacterial species in which natural selection has not biased codon usage in highly expressed genes.
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J Biol Chem
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Schmidt1
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Science
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Sharp1
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Li4
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14
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Reduced synonymous substitution rate at the start of enterobacterial genes
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of special interest, Silent sites near the start of E. coli genes evolve differently from those in the rest of the gene — why?
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Nucleic Acids Res
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Eyre-Walker1
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15
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Synonymous codon usage in Saccharomyces cerevisiae
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Yeast
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Sharp1
Cowe2
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17
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0027161465
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Regional base composition variation along yeast chromosome III: evolution of chromosome primary structure
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of special interest, The first direct demonstration of large-scale GC content variation along a chromosome.
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(1993)
Nucleic Acids Res
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Sharp1
Lloyd2
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20
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0028351792
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Sequence comparison of the ARG4 chromosomal regions from the two related yeasts, Saccharomyces cerevisiae and Saccharomyces douglasii
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Yeast
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Adjiri1
Chanet2
Mezard3
Fabre4
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21
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0024497416
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Mutation rates differ among regions of the mammalian genome
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Nature
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Wolfe1
Sharp2
Li3
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23
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0027485310
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Synonymous codon usage in Kluyveromyces lactic
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(1993)
Yeast
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Lloyd1
Sharp2
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28
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0024591558
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On the rate of DNA sequence evolution in Drosophila
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Sharp1
Li2
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Rates of synonymous substitution and base composition of nuclear genes in Drosophila
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Genetics
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Moriyama1
Gojobori2
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30
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0028220048
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Synonymous codon usage in Drosophila melanogaster: natural selection and translational accuracy
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of outstanding interest, Persuasive evidence that codon usage in Drosophila is selected because of its effect on the accuracy of translation.
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(1994)
Genetics
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Akashi1
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31
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0028347758
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The molecular evolution of the alcohol dehydrogenase and alcohol dehydrogenase-related genes in the Drosophila melanogaster species subgroup
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(1994)
Mol Biol Evol
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Jeffs1
Holmes2
Ashburner3
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32
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0027471782
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Low codon bias and high rates of synonymous substitution in Drosophila hydei and D. melanogaster histone genes
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(1993)
Mol Biol Evol
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Fitch1
Strausbaugh2
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33
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0027383354
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Reduced natural selection associated with low recombination in Drosophila melanogaster
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of outstanding interest, Population genetics theory indicates that selection should be less effective in regions of reduced recombination, and codon usage bias is found to be lower in such regions — indirect evidence that natural selection can indeed discriminate among synonymous codons in Drosophila.
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(1993)
Mol Biol Evol
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Kliman1
Hey2
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34
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The effects of mutation and natural selection on codon bias in the genes of Drosophila
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Genetics
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Kliman1
Hey2
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35
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0027311934
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Compositional heterogeneity and patterns of molecular evolution in the Drosophila genome
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of special interest, Using a new technique to estimate GC content in large DNA fragments, it is shown that base composition varies considerably among segments of the Drosophila genome.
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(1993)
Genetics
, vol.134
, pp. 837-845
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Carulli1
Krane2
Hard3
Ochman4
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36
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Codon usage bias and base composition of nuclear genes in Drosophila
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(1993)
Genetics
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Moriyama1
Hard2
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45
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0027422858
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Mammalian gene evolution: nucleotide sequence divergence between mouse and rat
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of special interest, Characterization of the relative amounts of sequence divergence for 〉350 genes compared between a single pair of closely related species.
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(1993)
J Mol Evol
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Wolfe1
Sharp2
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47
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Synonymous nucleotide substitution rates in mammalian genes: implications for the molecular dock and the relationships of mammalian orders
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edn 1
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Proc Natl Acad Sci USA
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Bulmer1
Wolfe2
Sharp3
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49
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0028002346
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Organization of mutations along the genome: a prime determinant of genome evolution
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of special interest, A review of hypotheses explaining why mutation patterns might vary around the mammalian genome.
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(1994)
Trends Ecol Evol
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Holmquist1
Filipski2
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50
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0028123674
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DNA mismatch repair and synonymous codon evolution in mammals
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(1994)
Mol Biol Evol
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Eyre-Walker1
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51
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0028216326
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A model for the correlation of mutation-rate with GC content and the origin of GC-rich isochores
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J Mol Evol
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Gu1
Li2
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53
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0027506873
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Region-specific rates of molecular evolution: a fourfold reduction in the rate of accummulation of ‘silent’ mutations in transcribed versus nontranscribed regions of homologous DNA fragments derived from two closely related mouse species
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(1993)
J Mol Evol
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Turker1
Cooper2
Bishop3
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54
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0027346997
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Codon usage in mammalian genes is biased by sequence slippage mechanisms
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DNA Seq
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Bains1
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58
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0028088517
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Hydrophobicity, expressivity and aromaticity are the major trends of amino-acid usage in 999 Escherichia coli chromosome-encoded genes
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Selection for translationally optimal codons seems to bias protein sequences.
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Nucleic Acids Res
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Lobry1
Gautier2
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59
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0027461794
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Relationship between G+C in silent sites of codons and amino acid composition of human proteins
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(1993)
J Mol Evol
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Collins1
Jukes2
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60
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0028301837
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Nucleotide composition as a driving force in the evolution of retroviruses
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(1994)
J Mol Evol
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Bronson1
Anderson2
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61
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0028229543
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The unusual nucleotide content of the HIV RNA genome results in a biased amino acid composition of HIV proteins
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Nucleic Acids Res
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, pp. 1705-1711
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Berkhout1
van Hemert2
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63
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0027910749
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Compositional compartmentalization of the nuclear genomes of Trypanosorna brucei and Trypanosoma equiperdum
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FEBS Left
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, pp. 181-183
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Isacchi1
Bernardi2
Bernardi3
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66
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0028370010
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Patterns in the genome
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of special interest, An interesting attempt to correlate observations of regional GC effects in the genomes of yeast, Drosophila and mammals.
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(1994)
Curr Biol
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, pp. 182-184
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Charlesworth1
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