Structure-function relationships for the EGF/TGF-α family of mitogens

Growth Factors

Volumn 11, Issue 4, 1994, Pages 235-257

  Groenen, Leo C ^a   Nice, Edouard C ^b   Burgess, Antony W ^b  

^a ROYAL MELBOURNE HOSPITAL   (Australia)

^b WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

Amphiregulin; Betacellulin; Biological assays; Epidermal growth factor; HB EGF; Heregulin; Receptor binding; Structure activity relationships; Transforming growth factor alpha; Vaccinia growth factor

Indexed keywords

BLOOD CLOTTING FACTOR; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; GROWTH FACTOR; MITOGENIC AGENT; MUTANT PROTEIN; TRANSFORMING GROWTH FACTOR ALPHA;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; CANCER CELL CULTURE; CANCER GROWTH; CARBOXY TERMINAL SEQUENCE; DRUG ACTIVITY; DRUG DESIGN; HUMAN; HUMAN CELL; HYDROGEN BOND; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN SECONDARY STRUCTURE; PROTEIN STRUCTURE; PROTEIN TERTIARY STRUCTURE; RECEPTOR BINDING; REVIEW; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANIMAL; BINDING SITES; BLOOD COAGULATION FACTORS; COMPARATIVE STUDY; EPIDERMAL GROWTH FACTOR; GROWTH SUBSTANCES; HUMAN; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, NON-U.S. GOV'T; TRANSFORMING GROWTH FACTOR ALPHA;

EID: 0028618937     PISSN: 08977194     EISSN: None     Source Type: Journal    
DOI: 10.3109/08977199409010997     Document Type: Review

References (163)

1. Systematic examination of the role of the disulfide bonds in murine epidermal growth factor (mEGF)
2. Sarcoma growth factor from conditioned medium of virally transformed cells is composed of both type α and type β transforming growth factors
3. Stability of recombinant human epidermal growth factor in various solutions
4. Synthesis and receptor-binding activity of peptide fragments of epidermal growth factor
5. The three-dimensional structure of the first EGF-like module of human factor IX: Comparison with EGF and TGF-α
6. Growth factors and wound healing: Biochemical properties of growth factors and their receptors
7. Growth factors and wound healing: Part II. Role in normal and chronic wound healing
8. NMR restraint analysis of transforming growth factor α: A key component for NMR structure refinement
9. Vaccinia virus encodes a polypeptide homologous to epidermal growth factor and transforming growth factor
10. 1H-NMR assignment and secondary structural elements of human transforming growth factor α
11. Murine epidermal growth factor: Structure and function
12. Structure-function relationships in epidermal growth factor (EGF) and transforming growth factor-alpha (TGF-α)
13. The role of asparagine-32 in forming the receptor-binding epitope of human epidermal growth factor
14. Cumulative effect of double-site mutations of human epidermal growth factor on receptor binding
15. Biochemical properties of site-directed mutants of human epidermal growth factor: Importance of solvent-exposed hydrophobic residues of the amino-terminal domain in receptor binding
16. Evaluation of the role of electrostatic residues in human epidermal growth factor by site-directed mutagenesis and chemical modification
17. The epidermal growth factor family
18. A high resolution 1H NMR study of the solution structure of human epidermal growth factor
19. Semisynthetic peptides and proteins
20. The genome of Shope fibroma virus, a tumorigenic poxvirus, contains a growth factor gene with sequence similarity to those encoding epidermal growth factor and transforming growth factor alpha
21. Requirement for intrinsic protein tyrosine kinase in the immediate and late actions of the EGF receptor
22. Purification of a nerve-growth promoting protein from the mouse salivary gland and its neurocytotoxic antiserum
23. Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal
24. Isolation and biological effects of an epidermal growth-stimulating protein
25. Epidermal growth factor-receptor-protein kinase interactions. Co-purification of receptor and epidermal growth factor-enhanced phosphorylation activity
26. Nuclear-magnetic-resonance studies of human epidermal growth factor
27. The solution structure of human epidermal growth factor
28. Colorectum cell-derived growth factor (CRDGF) is homologous to amphiregulin, a member of the epidermal growth factor family
29. Crystallization and preliminary characterization of three crystal forms of human recombinant transforming growth factor-a
30. Assessment of biological activity of synthetic fragments of transforming growth factor-alpha
31. Growth factors from murine sarcoma virus-transformed cells
32. Proton NMR and photo-chemically induced dynamic nuclear polarization studies of peptide fragments obtained by controlled proteolysis of mouse epidermal growth factor
33. Structure-function analysis of synthetic and recombinant derivatives of transforming growth factor alpha
34. Substitution of lysine for arginine at position 42 of human transforming growth factor-α eliminates biological activity without changing internal disulfide bonds
35. Transforming growth factor α
36. Synthesis of messenger RNAs for transforming growth factors α and β and the epidermal growth factor receptor by human tumors
37. Human Transforming growth factor-a: Precursor structure and expression i
38. Structure-function analysis of epidermal growth factor: Site directed mutagenesis and nuclear magnetic resonance
39. Critical functional requirement for the guanidinium group of the arginine 41 side chain of human epidermal growth factor as revealed by mutagenic inactivation and chemical reactivation
40. Aromaticity at position 37 in human epidermal growth factor is not obligatory for activity
41. Cloning of authentic human epidermal growth factor as a bacterial secretory protein and its initial structure-function analysis by site-directed mutagenesis
42. Human epidermal growth factor. Distinct roles of tyrosine 37 and arginine 41 in receptor binding as determined by site-directed mutagenesis and nuclear magnetic resonance spectroscopy
43. Centrifugation or filtration in quantitative radioreceptor assays
44. Inhibition of epidermal growth factor/ transforming growth factor-α-stimulated cell growth by a synthetic peptide
45. Structural characterisation of native and recombinant forms of the neurotrophic cytokine MK
46. A non-label technology for real-time biospecific interation analysis
47. Structure-function analysis of human transforming growth factor-a by site-directed mutagenesis
48. Protein flexibility and aggregation state of human epidermal growth factor. A time-resolved fluorescence study of the native protein and engineered single-tryptophan mutants
49. Characterization of recombinant human epidermal growth factor produced in yeast
50. Replacement of a labile aspartyl residue increases the stability of human epidermal growth factor
51. Calculation of protein extinction coefficients from amino acid sequence data
52. Assignment of the inter- and intramolecular disulfide linkages in recombinant human macrophage stimulating factor using fast atom bombardment mass spectrometry
53. Isolation and structure of urogastrone and its relationship to epidermal growth factor
54. The contribution of the C-terminal undecapeptide sequence of urogastrone-epidermal growth factor to its biological action
55. Characterization of the interaction between the EGF receptor extracellular domain and TGF-alpha using biospecific interaction analysis (BIA)
56. Affinity ranking of influenza neuraminidase mutants with monoclonal antibodies using an optical biosensor. Comparison with ELISA and slot blot assays
57. The secreted form of the epidermal growth factor receptor. Characterization and crystallization of the receptor-ligand complex
58. Conformational and receptor binding properties of human EGF and TGF-α second loop fragments
59. Conformation of the second disulfide loop in human transforming growth factor-α studied by two-dimensional NMR spectroscopy
60. Solution conformations of the B-loop fragments of human transforming growth factor α and epidermal growth factor by 1H nuclear magnetic resonance and restrained molecular dynamics
61. The solution structure of human transforming growth factor α
62. A synthetic approach to structure-function relationships in the murine epidermal growth factor molecule
63. A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF
64. Identification of immunodominant regions of transforming growth factor α. Implications of structure and function
65. Epidermal growth factor-urogastrone: Biological activity and receptor binding of derivatives
66. Identification of heregulin, a specific activator of p185erbB2
67. Structure-function relationships in human epidermal growth factor studied by site-directed mutagenesis and ‘H NMR
68. Human epidermal growth factor. High resolution solution structure and comparison with human transforming growth factor α
69. Sequence-specific 1H NMR assignments, secondary structure, and location of the calcium binding site in the first epidermal growth factor like domain of blood coagulation factor IX
70. Calcium binding and putative activity of the epidermal growth factor domain of blood coagulation facto
71. Normal mode analysis of mouse epidermal growth factor: Characterization of the harmonic motion
72. Topographic analysis of human epidermal growth factor by monospecific antibodies and synthetic peptides
73. Isolation and sequence analysis of EGF from rabbit urine
74. Schwannoma-derived growth factor must be transported into the nucleus to exert its mitogenic activity
75. Structure, expression and function of a schwannoma-derived growth factor
76. Resolution of high and low affinity epidermal growth factor receptors. Inhibition of high affinity component by low temperature, cycloheximide, and phorbol esters
77. Solution structures of human transforming growth factor a derived from 1H NMR data
78. NMR study on solution structure of the site-specific mutant Leu48-Ala transforming growth factor alpha
79. Tertiary structure of mouse epidermal growth factor determined by two-dimensional 1H NMR
80. Structure of epidermal growth factor bound to perdeuterated dodecylphosphocholine micelles determined by two-dimensional NMR and simulated annealing calculations
81. Three-dimensional nu-clear magnetic resonance structures of mouse epidermal growth factor in acidic and physiological pH solutions
82. A comparative 1H NMR study of mouse α(1–53) and β(2–53) epidermal growth factors
83. Polypeptide chain fold of human transforming growth factor α analogous to those of mouse and human epidermal growth factors as studied by two-dimentional NMR
84. Recognition of an antiparallel β-sheet structure of human epidermal growth factor by its receptor. Site-directed mutagenesis studies of Ala-30 and Asn-32
85. A site-directed mutagenesis study on the role of isoleucine-23 of human epidermal growth factor in the receptor binding
86. Biosynthesis of a protein containing a nonprotein amino acid by Escherichia coli: L-2-aminohexanoic acid at position 21 in human epidermal growth factor
87. Biologically active synthetic fragments of epidermal growth factor: Localization of a major receptor-binding region
88. MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures
89. Chicken epidermal growth factor (EGF) receptor: cDNA cloning, expression in mouse cells, and differential binding of EGF and transforming growth factor alpha
90. Transforming growth factor a: An aromatic side chain at postion 38 is essential for biological activity
91. Transforming growth factor α: Mutation of aspartic acid 47 and leucine 48 results in different biological activities
92. Effects of the extract of the mouse submaxillary salivary glands on the sympathetic system of mammals
93. Synthesis of a biological active tumor growth factor from the predicted DNA sequence of Shope fibroma virus
94. Growth inhibition by vaccinia virus growth factor
95. Synthesis and structure-activity study of myxoma virus growth factor
96. Third loop analogs of epidermal growth factor: Bioassay studies for receptor affinity and tyrosine kinase activation
97. Affinity maturation of human growth hormone by monovalent phage display
98. Proton nuclear magnetic resonance study on the solution conformation of human epidermal growth factor
99. Biospecific interaction analysis using biosensor technology
100. Transforming growth factors produced by retrovirus-transformed rodent fibroblasts and human melanoma cells: Amino acid sequence homology with epidermal growth factor
101. Rat transforming growth factor type 1: Structure and relation to epidermal growth factor
102. Effect of oxidative iodination of epidermal growth factor on its binding and secretion by hepatocytes
103. Analogs of human epidermal growth factor which partially inhibit the growth factor-dependent protein-tyrosine kinase activity of the epidermal growth factor receptor
104. Mutational analysis of leucine 47 in human epidermal growth factor
105. Sequence-specific 1H-NMR assignments and peptide backbone conformation in rat epidermal growth factor
106. Controlled proteolysis of mouse epidermal growth factor
107. Identification of two anti-parallel β-sheet conformations in the solution structure of murine epidermal growth factor by proton magnetic resonance
108. Solution structure of murine epidermal growth factor: Determination of the polypeptide backbone chain-fold by nuclear magnetic resonance and distance geometry
109. Sequence-specific 1H-NMR assignments and identification of two small antiparallel β-sheets in the solution structure of recombinant human transforming growth factor α
110. Solution structure of murine epidermal growth factor determined by NMR spectroscopy and refined by energy minimization with restraints
111. Solution structure of human type-α transforming growth factor determined by heteronuclear NMR spectroscopy and refined by energy minimization with restraints
112. Conformational characterization of a single-site mutant of murine epidermal growth factor (EGF) by 1H NMR provides evidence that leucine-47 is involved in the interactions with the EGF receptor
113. A synthetic fragment of rat transforming growth factor α with receptor binding and antigenic properties
114. Micropreparative LC of proteins
115. Protein engineering by chemical means
116. Synthesis and secretion of human epidermal growth factor b
117. A model system for tumor angiogenesis: Involvement of transforming growth factor-α in tube formation of human microvascular endothelial cells induced by edophageal cancer cells
118. Structure of human des(1–45) factor Xa at 2.2 Å resolution
119. Solution structure and dynamics of epidermal growth factor and transforming growth factor α
120. Synthesis of an active hybrid growth factor (GF) in bacteria: Transforming GF-α/vaccinia GF fusion protein
121. Structure-function studies of murine epidermal growth factor: Expression and site-directed mutagenesis of epidermal growth factor gene
122. Multidomain binding of transforming growth factor a to the epidermal growth factor receptor
123. Preparation and characterization of a bifunctionally spin-labeled mutant of murine epidermal growth factor for saturation-transfer electron paramagnetic resonance studies of the growth factor/receptor complex
124. Epidermal growth factor stimulates the tyrosine phosphorylation of SHC in the mouse
125. Epidermal growth factor. Location of disulfide bonds
126. The primary structure of epidermal growth factor
127. Synthesis of biologically active human transforming growth factor-α by fluorenylmethoxycarbonyl solid phase peptide chemistry
128. Growth factor signalling by receptor tyrosine kinases
129. Pseudomonas exotoxin A-epidermal growth factor (EGF) mutant chimeric protein as an indicator for identifying amino acid residues important in EGF-receptor interaction
130. Betacellulin: A mitogen from pancreatic β cell tumors
131. Structure and function of human amphiregulin: A member of the epidermal growth factor family
132. Rat epidermal growth factor: Complete amino acid sequence
133. Preparation and characterization of monoclonal antibodies specific for human transforming growth factor α
134. Chemical synthesis of human transforming growth factor-α
135. Overproduction of human epidermal growth factor/urogastrone in Escherichia coli and demonstration of its full biological activities
136. The functional importance of hydrophobicity of the tyrosine at position 13 of human epidermal growth factor in receptor binding
137. Mapping the receptor-recognition site of human transforming growth factor-α
138. Synthesis of biologically active rat transforming growth factor I
139. Alpha-transforming growth factor: Biological activity and structure-activity relationships
140. Efficient synthesis of human type α transforming growth factor: Its physical and biological characterization
141. A high-resolution 1H-NMR study of human trans-forming growth factor α
142. Transformation by murine and feline sarcoma viruses specifically blocks binding of epidermal growth factor to cells
143. Chemical synthesis of bovine transforming growth factor-α: Synthesis, characterization and biological activity
144. Three-dimensional structure of the apo form of the N-terminal EGF-like module of blood coagulation factor X as determined by NMR spectroscopy and simulated folding
145. Mapping and sequencing of a gene from Myxoma virus that is related to those encoding epidermal growth factor αnd transforming growth factor alpha
146. Determination of the disulfide bond pairings in bovine transforming growth factor-α
147. Reconstitution of the high affinity epidermal growth factor receptor on cell-free membranes after transmodulation by platelet-derived growth factor
148. Resistance to receptor-mediated degradation of a murine epidermal growth factor αnalogue (EGF-Val-47) potentiates its mitogenic activity
149. High-level production of the mouse epidermal growth factor in a Bacillus brevis expression system
150. Neu differentiaion factor: A transmembrane glycoprotein containing an EGF domain and an immunoglobulin homology unit
151. The purification of fully active recombinant transforming growth factor α produced i
152. Epidermal growth factor and transforming growth factor α bind differently to the epidermal growth factor receptor
153. Use of Bacillus brevis for efficient synthesis and secretion of human epidermal growth factor
154. Contribution of the C-terminal dipeptide of transforming growth factor-α to its activity: Biochemical and pharmacologic profiles
155. Two-step selective formation of three disulfide bridges in the synthesis of the C-terminal epidermal growth factor-like domain in human blood coagulation factor IX
156. Self-phosphorylation of epidermal growth factor receptor: Evidence for a model of intermolecular allosteric activation
157. A nonmitogenic analogue of epidermal growth factor induces early responses mediated by epidermal growth factor
158. Real-time measurements of kinetics of EGF binding to soluble EGF receptor monomers and dimers support the dimerization model for receptor activation
159. Isolation of genomic sequence encoding a biologically active bovine TGF-α protein