Effect of chronic administration of selective 5-hydroxytryptamine and noradrenaline uptake inhibitors on a putative index of 5-HT 2C 2B receptor function

Neuropharmacology

Volumn 33, Issue 12, 1994, Pages 1581-1588

  Kennett, G A ^a   Lightowler, S ^a   De Biasi, V ^a   Stevens, N C ^a   Wood, M D ^a   Tulloch, I F ^a   Blackburn, T P ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

5 HT2B receptor; 5 HT2C receptor; selective 5 hydroxytryptamine reuptake inhibitors (SSRIs)

Indexed keywords

(3 CHLOROPHENYL)PIPERAZINE; CLOMIPRAMINE; DESIPRAMINE; FLUOXETINE; PAROXETINE; RECEPTOR SUBTYPE; SEROTONIN 2 RECEPTOR; SEROTONIN AGONIST;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; INTRAPERITONEAL DRUG ADMINISTRATION; LOCOMOTION; MALE; NONHUMAN; NORADRENALIN UPTAKE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; SEROTONIN UPTAKE;

ANIMAL; BRAIN; CLOMIPRAMINE; DESIPRAMINE; FLUOXETINE; MALE; MOTOR ACTIVITY; NOREPINEPHRINE; PAROXETINE; PIPERAZINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, SEROTONIN; SEROTONIN UPTAKE INHIBITORS; TIME FACTORS;

EID: 0028608831     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/0028-3908(94)90133-3     Document Type: Article

References (50)

1. Differential effects of clomipramine given locally or systemically on extracellular 5-hydroxytryptamine in raphe nuclei and frontal cortex
2. Drug-Induced Priapism Its Aetiology, Incidence and Treatment
3. Fluvoxamine preferentially increases extracellular 5-hydroxytryptamine in the raphe nuclei: an in vivo microdialysis study
4. 1C receptor mediated behaviour in rats following chronic treatment with 5-HT receptor agonists, antagonists or anti-depressants
5. 1C receptor agonists in piglet choroid plexus
6. Effects of short- and long-term administration of fluoxetine on the monoamine content of rat brain
7. Monoamine oxidase inhibitors increase preferentially extracellular 5-hydroxytryptamine in the midbrain raphe nuclei. A brain microdialysis study in the awake rat
8. Characterization of 5-hydroxytryptamine receptors in rat stomach fundus
9. Long term clorgyline treatment antagonizes the eating and motor function responses to m-chlorophenylpiperazine
10. 1C) receptors
11. 2-mediated behaviour in the rat following noradrenergic or serotonergic denervation
12. Sertraline as a treatment for panic disorder
13. Serotonergic and noradrenergic sensitivity in obsessive-compulsive disorder: behavioural findings
14. Effects of chronic fluoxetine treatment on behavioral and neuroendocrine responses to meta-chloro-phenylpiperazine in obsessive-compulsive disorder
15. Serotonin function in obsessive-compulsive disorder. Behavioural and neuroendocrine responses to oral m-chlorophenylpiperazine and fenfluramine in patients and healthy volunteers
16. 2 receptors in rat brain: an autoradiological study
17. New pharmacological approaches to obsessive compulsive disorder
18. 1C receptors in the antiserotonergic properties of some antidepressant drugs
19. Neuroendocrine evidence for serotonin receptor supersensitivity in patients with panic disorder
20. 1C receptors
21. 1C receptors and their therapeutic relevance
22. 2C receptor antagonist, on two conflict models of anxiety
23. 2C/2B receptor antagonist
24. 2C receptors
25. 2-like receptor: expression in brain, heart and intestine
26. Effect of 1-(m-chlorophenyl)piperazine and 1-(m-trifluoromethylphenyl) piperazine on locomotor activity
27. Effects of sertraline and citalopram given repeatedly on the responsiveness of 5-HT receptor populations
28. Effects of paroxetine, on 5-HT-induced head twitches and phosphatidylinositol hydrolysis in mice
29. A competitive examination of a role for serotonin in obsessive compulsive disorder, panic disorder and anxiety
30. Pharmacological effects of paroxetine after repeated administration to animals
31. Long term antidepressant treatment decreases spiroperidol-labeled serotonin receptor binding
32. Serotonin-releasing effects of substituted piperazines in vitro
33. Metergoline blocks the behavioral and neuroendocrine effects of orally administered m-chlorophenylpiperazine in patients with obsessive-compulsive disorder
34. 2C receptors
35. 2 receptor
36. Acute uptake inhibition increases extracellular serotonin in the rat forebrain
37. Sertraline-induced desensitization of the serotonin 5-HT-2 receptor transmembrane signaling system
38. 2B serotonin receptor
39. Fluoxetine in panic disorder
40. 1B receptor ligands exist?
41. Effects of ritanserin on the behavioural neuroendocrine and cardiovascular responses to meta chlorophenylpiperazine in healthy subjects
42. 3H]-spiperone binding in rat frontal cortex and serotonin receptor mediated behaviour
43. Biochemical effects of the antidepressant paroxetine, a specific 5-hydroxytryptamine uptake inhibitor
44. The pharmacologie profile of paroxetine, a new selective serotonin reuptake inhibitor
45. Serotonin-influencing drugs in the treatment of panic disorder
46. Affinities of fluoxetine, its enantiomers, and other inhibitors of serotonin uptake for subtypes of serotonin receptors
47. Hyperthermia induced by mCPP in the rat and its modification by antidepressant treatments
48. Obsessive compulsive disorder: psychobiological approaches to diagnosis, treatment, and pathophysiology
49. 5HT, obsessive-compulsive disorders and anxiety
50. Serotonergic responsivity in obsessive compulsive disorder: effects of chronic clomipramine treatment