Ectopic Adrenocorticotropic Hormone Syndrome

Endocrine Reviews

Volumn 15, Issue 6, 1994, Pages 752-787

  Leo Wajchenberg, Bernardo ^a   Campos Carneiro, Paulo ^b,d   Wakamatsu, Alda ^c   Kirschner, Marvin A ^e   Albergaria Pereira, Maria A ^f  

^a Endocrine Section ^*  (Brazil)

^b Pathology Division of HFA   (Brazil)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

^d INSTITUTO ADOLFO LUTZ   (Brazil)

^e NEWARK BETH ISRAEL MEDICAL CENTER   (United States)

^f NONE

Author keywords

[No Author keywords available]

Indexed keywords

5 HYDROXYINDOLEACETIC ACID; ALPHA INTERFERON; AMINOGLUTETHIMIDE; ANDROSTENEDIONE; CALCITONIN; CATECHOLAMINE; CHROMOGRANIN; CISPLATIN; CORTICOTROPIN RELEASING FACTOR; CYCLOPHOSPHAMIDE; DEOXYCORTICOSTERONE; DOXORUBICIN; ENOLASE; FLUOROURACIL; LOMUSTINE; METYRAPONE; MIFEPRISTONE; MITOTANE; OCTREOTIDE; PRASTERONE; SEMUSTINE; SOMATOSTATIN; SOMATOSTATIN RECEPTOR; STREPTOZOCIN; SYNAPTOPHYSIN; VINCRISTINE;

APUDOMA; ARTICLE; CARCINOID; CLINICAL FEATURE; CORTICOTROPIN RELEASE; CUSHING DISEASE; DEXAMETHASONE SUPPRESSION TEST; DIAGNOSTIC APPROACH ROUTE; HORMONE INHIBITION; HUMAN; HYDROCORTISONE RELEASE; HYPOPHYSIS ADENOMA; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IMMUNOTHERAPY; LIVER METASTASIS; LUNG SMALL CELL CANCER; PANCREAS ISLET CELL CARCINOMA; PRIORITY JOURNAL; THYROID MEDULLARY CARCINOMA; TREATMENT PLANNING;

ACTH SYNDROME, ECTOPIC; ADOLESCENT; ADULT; AGED; CHILD, PRESCHOOL; FEMALE; HUMAN; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGE; PREVALENCE; TOMOGRAPHY, X-RAY COMPUTED; TUMOR MARKERS, BIOLOGICAL;

EID: 0028606917     PISSN: 0163769X     EISSN: 0163769X     Source Type: Journal    
DOI: 10.1210/edrv-15-6-752     Document Type: Article

References (236)

1. Odell WD, Wolfsen AR, Yoshimoto Y, Weitzman R, Hirose F 1977 Ectopic peptide synthesis a universal concomitant of neoplasia. Trans Assoc Am Physicians 90:204-227
2. Meador CK, Liddle GW, Island DP, Nicholson WE, Lucas CP, Nuckton JG, Luetscher JA 1962 Cause of Cushing’s syndrome in patients with tumors arising from nonendocrine tissue. J Clin Endocrinol Metab 22:693-703
3. Liddle GW, Island DP, Ney RL, Nicholson WE, Shimizu N 1963 Nonpituitary neoplasms and Cushing’s syndrome. Arch Intern Med 11:471-475
4. Amatruda Jr TT, Mulrow PJ, Gallagher JC, Sawyer WH 1963 Carcinoma of the lung with inappropriate antidiuresis. Demon-stration of antidiuretic-hormone-like activity in tumor extract. N Engl J Med 269:544-549
5. Odell WD, Appleton WS 1992 Humoral manifestations of cancer. In: Wilson JD, Foster DW (eds) Williams Textbook of Endocrinology, ed 8. WB Saunders, Philadelphia, pp 1599-1617
6. Baylin SB, Mendelsohn G 1980 Ectopic (inappropriate) hormone production by tumors: mechanisms involved and the biological and clinical implications. Endocr Rev 1:45-77
7. Bailey RE 1971 Periodic hormogenesis a new phenomenon. Periodicity in function of a hormone-producing tumor in man. J Clin Endocrinol Metab 32:317-327
8. Brown WH 1928 A case of pluriglandular syndrome: diabetes of bearded women. Lancet 2:1022-1023
9. Liddle GW, Nicholson WE, Island DP, Orth DN, Abe K, Lowder SC 1969 Clinical and laboratory studies of ectopic humoral syndromes. Recent Prog Horm Res 25:283-324
10. Ratdiffe JG, Knight RA, Besser GM, Landon J, Stansfeld AG 1972 Tumor and plasma ACTH concentrations in patients with and without the ectopic ACTH syndrome. Clin Endocrinol (Oxf) 1:27-44
11. Gewirtz G, Yalow RS 1974 Ectopic ACTH production in carcinoma of the lung. J Clin Invest 53:1022-1032
12. Wolfsen AR, Odell WD 1979 ProACTH: use for early detection for lung cancer. Am J Med 66:765-772
13. Odell WD, Saito E 1983 Protein hormone-like mateials from normal and cancer cells –ectopic— hormone production. In: Mirand EA, Hutchinson WB, Mihich E (eds) 13th International Cancer Congress, Part E: Cancer Management. Alan R. Liss, New York, pp 247-258
14. Yalow RS, Berson SA 1971 Size heterogeneity of immunoreactive human ACTH in plasma and in extracts of pituitary gland and ACTH-producing thymomas. Biochem Biophys Res Commun 44:439-445
15. Orwoll ES, Kendall JW 1980 β-endorphin and adrenocorticotropin in extrapituitary sites: gastrointestinal tract. Endocrinology 107:438-442
16. Saito E, Iwasa S, Odell WD 1983 Widespread presence of large molecular weight adrenocorticotropin-like substances in normal rat extrapituitary. Endocrinology 113:1010-1019
17. Saito E, Odell WD 1983 Corticotropin/lipotropin common precursor-like material in normal rat extrapituitary tissues. Proc Natl Acad Sci USA 80:3792-3796
18. DeBold CR, Menefee JK, Nicholson WE, Orth DN 1988 Proopiomelanocortin gene is expressed in many normal human tissues and in tumors not associated with ectopic adrenocorticotropin syndrome. Mol Endocrinol 2:862-870
19. Chen CL, Mather JP, Morris PL, Bardin CW 1984 Expression of proopiomelanocortin-like gene in the testis and epididymis. Proc Natl Acad Sci USA 81:5672-5675
20. Jingami H, Nakanishi S, Imura I, Numa S 1987 Tissue distribution of messenger RNAs coding for opioid peptide precursors and related RNA. Eur J Biochem 142:441-447
21. Lacaze-Masmonteil T, de Keyzer Y, Luton J-P, Kahn A, Bertagna X 1987 Characterization of POMC transcripts in human nonpituitary tissues. Proc Natl Acad Sci USA 84:7261-7265
22. Jeannotte L, Burbach JPH, Drouin J 1987 Unusual proopiomelanocortin ribonucleic acids in extrapituitary tissues: intronless transcripts in testis and long poly (A)+ tail in hypothalamus. Mol Endocrinol 1:749-754
23. DeBold CR, Nicholson WE, Orth DN 1988 Immunoreactive proopiomelanocortin (POMC) peptides and POMC-like messenger ribonucleic acid are present in many rat nonpituitary tissues. Endocrinology 122:2648-2657
24. Clark AJL, Stewart MF, Lavender PM, Coates P, Johnson MR, Rees LH 1990 In vitro and in vivo analysis of the peptide products of the short pro-opiomelanocortin mRNA. Mol Endocrinol 4:1737-1743
25. de Keyser Y, Bertagna X, Lenne F, Girard F, Luton J-P, Kahn A 1985 Altered proopiomelanocortin gene expression in adrenocorticotropin-producing nonpituitary tumors. J Clin Invest 76:1892-1898
26. de Keyser Y, Rousseau-Merck M-F, Luton J-P, Girard F, Kahn A, Bertagna X 1989 Proopiomelanocortin gene expression in human pheochromocytomas. J Mol Endocrinol 2:175-181
27. de Keyser Y, Bertagna X, Luton J-P, Kahn A 1989 Variable modes of proopiomelanocortin gene transcription in human tumors. J Mol Endocrinol 3:215-223
28. Texier P-L, de Keyser Y, Lacave R, Vieau D, Lenne F, RojasMiranda A, Verley JM, Luton J-P, Kahn A, Bertagna X 1991 Proopiomelanocortin gene expression in normal and tumoral human lung. J Clin Endocrinol Metab 73:414-420
29. White A, Clark AJL 1993 The cellular and molecular basis of the ectopic ACTH syndrome. Clin Endocrinol (Oxf) 39:131-141
30. Stewart PM, Gibson S, Crosby SR, Penn R, Holder R, Ferry D, Thatcher N, Phillips P, London DR, White A 1994 ACTH precursors characterize the ectopic ACTH syndrome. Clin Endocrinol (Oxf) 40:199-204
31. Clark AJL, Stewart MF, Lavender PM, Farrell W, Crosby SR, Rees LH, White A 1990 Defective glucocorticoid regulation of proopiomelanocortin gene expression and peptide secretion in a small cell lung cancer cell line. J Clin Endocrinol Metab 70:485490
32. Farrell WE, Stewart MF, Clark AJL, Crosby SK, Davis JRE, White A 1993 Glucocorticoid inhibition of ACTH peptides: small cell lung cancer cell lines are more resistant than pituitary corticotroph adenoma cells. J Mol Endocrinol 10:25-32
33. Howlett TA, Drury PL, Perry L, Doniach I, Rees LH, Besser GM 1986 Diagnosis and management of ACTH-dependent Cushing’s syndrome: comparison of the features in ectopic and pituitary ACTH production. Clin Endocrinol (Oxf) 24:699-713
34. Carpenter PC 1988 Diagnostic evaluation of Cushing’s syndrome. Endocrinol Metab Clin North Am 17:455-472
35. Oldfield EH, Doppman JL, Nieman LK, Chrousos GP, Miller DL, Katz DA, Cutler Jr GB, Loriaux DL 1991 Petrosal sinus sampling with and without corticotropin-releasing hormone for the differential diagnosis of Cushing’s syndrome. N Engl J Med 325:897-905
36. Imura H, Nakai Y, Nakao K, Oki S, Matsukura S, Hirata Y, Fukase M, Hattori M, Yoshmimi H, Sueoka S 1978 Functioning tumors with special reference to ectopic hormone producing tumors. Protein Nucleic Acid Enzyme 23:641-656
37. Kato Y, Ferguson TB, Bennett DE, Burford TH 1969 Oat cell carcinoma of the lung. A review of 138 cases. Cancer 23:517-524
38. Shepherd FA, Laskey J, Evans WK, Goss PE, Johansen E, Khamsi F 1992 Cushing’s syndrome associated with ectopic corticotropin production and small-cell lung cancer. J Clin Oncol 10:21-27
39. Delisle L, Boyer MJ, Warr D, Killinger D, Payne D, Yeoh JL, Feld R 1993 Ectopic corticotropin syndrome and small cell carcinoma of the lung. Clinical features, outcome and complications. Arch Intern Med 153:746-752
40. Jex RK, van Heerden JA, Carpenter PC, Grant CS 1985 Ectopic ACTH syndrome. Diagnostic and therapeutic aspects. Am J Surg 149:276-282
41. Doppman JL, Nieman L, Miller DL, Pass HI, Chang R, Cutler GB, Schaaf M, Chrousos GP, Norton JA, Ziessman HA, Oldfield EH, Loriaux DL 1989 Ectopic adrenocorticotropic hormone syndrome: localization studies in 28 patients. Radiology 172:115-124
42. Findling JW, Tyrrell JB 1986 Occult ectopic secretion of corticotropin. Arch Intern Med 146:929-933
43. Doppman JL 1992 The search for occult ectopic ACTH-producing tumors. Endocrinologist 2:41-46
44. Maton PN, Gardner JD, Jensen RT 1986 Cushing’s syndrome in patients with the Zollinger-Ellison syndrome. N Engl J Med 315:15
45. Rude RK, Singer FR 1977 Comparison of serum calcitonin levels after an 1-minute calcium injection and after pentagastrin injection in the diagnosis of medullary thyroid carcinoma. J Clin Endocrinol Metab 44:980-983
46. Graham SM, Genel M, Touloukian RJ, Barwick KW, Gertner JM, Toroany C 1987 Provocative testing for occult medullary carcinoma of the thyroid: findings in seven children with multiple endocrine neoplasia type Ila. J Pediatr Surg 22:501-503
47. Carey RM, Orth DN, Hartmann WH 1973 Malignant melanoma with ectopic production of adrenocorticotropic hormones: palliative treatment with inhibitors of adrenal steroid biosynthesis. J Clin Endocrinol Metab 36:482-487
48. Aron DC, Findling JW, Fitzgerald PA, Forsham PH, Wilson CB, Tyrrell JB 1982 Cushing’s syndrome: problems in management. Endocr Rev 3:229-244
49. Pfluger KH, Gramse M, Gropp C, Havemann K 1981 Ectopic ACTH production with autoantibody formation in a patient with acute myeloblastic leukemia. N Engl J Med 305:1632-1636
50. Dupont AG, Somers G, Van Steirteghem AC, Warson F, Vanhaelst L 1984 Ectopic adrenocorticotropin production: disappearance after removal of inflammatory tissue. J Clin Endocrinol Metab 58:654-658
51. Blalock JE 1987 New concepts in endocrinology: neuroendocrine and immune system interactions. In: Bagdade Jd (ed) Year Book of Endocrinology 1987. Year Book Medical Publishers Inc, Chicago, pp 15-28
52. Olsen NJ, Nicholson WE, De Bold CR, Orth DN 1992 Lymphocyte-derived adrenocorticotropin is insufficient to stimulate adrenal steroidogenesis in hypophysectomized rats. Endocrinology 130:2113-2119
53. Van Woudenberg AD, Metzelaar MJ, va der Kley AAM, de Wied D, Burbach JPH, Wiegant VM 1993 Analysis of proopiomelanocortin (POMC) messenger ribonucleic acid and POMCderived peptides in human peripheral blood mononuclear cells: no evidence for a lymphocyte-derived POMC system. Endocrinology 133:1922-1933
54. Levine RJ, Metz SA 1974 A classification of ectopic hormoneproducing tumors. Ann NY Acad Sci 230:533-546
55. Pearse AGE, Polak JM 1981 Neural crest origin of the endocrine polypeptide (APUD) cell of the gastrointestinal tract and pancreas. Gut 12:783-788
56. Pearse AGE 1980 The APUD concept and hormone production. Clin Endocrinol Metab 9:211-222
57. Lamberts SWJ, Krenning EP, Reubi J-C 1991 The role of somatostatin and its analogues in the diagnosis and treatment of tumors. Endocr Rev 12:450-482
58. Wajchenberg BL, Mendonca BB, Liberman B, Pereira MAA, Carneiro PC, Wakamatsu A, Kirschner MA The changing picture of ectopic ACTH syndrome. J Steroid Biochem Mol Biol, in press
59. Pereira MAA, Jugue SM, Moura OMD, Gross K, Halpern A, Nicolau W, Liberman B, Bloise W, Mendonca B, Cabral ND, Marino Jr R, Wajchenberg BL 1992 Cushing’s disease: diagnostic, therapeutic and prognostic evaluation. Rev Assoc Med Bras 20:4854
60. Crane MG, Harris JJ 1966 Deoxycorticosterone secretion rates in hyperadrenocorticism. J Clin Endocrinol Metab 26:1135-1143
61. Kater CE, Biglieri EG, Brust N, Chang B, Hirai J 1982 Regulation of the mineralocorticoid hormones in adrenocortical discorders with adrenocorticotropin excess. Clin Exp Hypertens A4(9 and 10): 1749-1758
62. Ulick S, Wang JE, Blumefeld JD, Pickering TG 1992 Cortisol inactivation overload: a mechanism of mineralocorticoid hypertension in the ectopic ACTH syndrome. J Clin Endocrinol Metab 74:963-967
63. Walker BR, Jill CC, Fraser R, Stewart PM, Edwards RW 1992 Mineralocorticoid excess and inhibition of 11β-hydroxy steroid dehydrogenase in patients with ectopic ACTH syndrome. Clin Endocrinol (Oxf) 37:483-492
64. Silber RH, Porter CC 1954 The determination of 17, 21-dihydroxy-20-ketosteroids in urine and plasma. J Biol Chem 21:262-265
65. Crapo L 1979 Cushing’s syndrome: a review of diagnostic tests. Metabolism 28:955-977
66. Orth DN, Kovacs WJ, DeBold CR 1992 The adrenal cortex In: Wilson JD, Foster DW (eds) Williams Textbook of Endocrinology, ed 8. WB Saunders, Philadelphia, pp 489-619
67. Kuhn JM, Proeschel MF, Seurin DJ, Bertagna XY, Luton J-P, Girard FL 1989 Comparative assessment of ACTH and lipoprotein plasma levels in the diagnosis and follow-up of patients with Cushing’s syndrome: a study of 210 cases. Am J Med 86:678-684
68. Tabarin A, Corcuff JB, Rashedi M, Navarranne A, Ducassou D, Roger P 1992 Comparative value of plasma ACTH and betaendorphin measurement with three different commercial kits for the etiological diagnosis of ACTH-dependent Cushing’s syndrome. Acta Endocrinol (Copenh) 126:308-314
69. Crosby SR, Stewart MF, Ratcliffe JG, White A 1988 Direct measurement of the precursors of adrenocorticotropin in human plasma by two-site immunoradiometric assay. J Clin Endocrinol Metab 67:1272-1277
70. Liddle GW 1960 Tests of pituitary-adrenal suppressibility in the diagnosis of Cushing’s syndrome. J Clin Endocrinol Metab 20:1539-1560
71. Kennedy L, Atkinson AB, Johnston H, Sheridan B, Hadden DR 1984 Serum cortisol concentrations during low-dose dexamethasone suppression test to screen for Cushing’s syndrome. Br Med J [Clin Res] 289:1189-1191
72. Kaye TB, Crapo L 1990 Cushing’s syndrome: an update on diagnostic tests. Ann Intern Med 112:435-444
73. Schteingart DE, Lloyd RV, Akil H, Chandler WF, Ibarra-Perez G, Rosen SG, Ogltree R 1986 Cushing’s syndrome secondary to ectopic corticotropin-releasing hormone-adrenocorticotropin secretion. J Clin Endocrinrol Metab 63:770-775
74. Tyrrell JB, Findling JW, Aron DC, Fitzgerald PA, Forsham PH 1986 An overnight high dose dexamethasone suppression test for rapid differential diagnosis of Cushing’s syndrome. Ann Intern Med 104:180-186
75. Grua JR, Nelson DH 1991 ACTH-producing pituitary tumors. Endocrinol Metab Clin North Am 20:319-362
76. Pass HI, Doppman JL, Nieman L, Stovroff M, Vetto J, North JA, Travis W, Chrousos GP, Oldfield EH, Cutler Jr GB 1990 Management of the ectopic ACTH syndrome due to thoracic carcinoids. Ann Thorac Surg 50:52-57
77. Chrousos GP, Schuermeyer TH, Doppman J, Oldfield EH, Schulte HM, Gold PW, Loriaux DL 1985 NIH conference: clinical application of corticotropin-releasing factor. Ann Intern Med 102:344-358
78. Flack MR, Oldfield EH, Cutler Jr GB, Zweig MH, Hailey JD, Chrousos CP, Loriaux DL, Nieman LK 1992 Urine free cortisol in the high-dose dexamethasone suppression test for the differential diagnosis of the Cushing syndrome. Ann Intern Med 116:211-217
79. Ashcraft MW, Van Herle AJ, Vener SL, Geffner DL 1982 Serum cortisol levels in Cushing’s syndrome after lowand high-dose dexamethasone suppression. Ann Intern Med 97:21-26
80. Aron DC, Tyrrell JB, Fitzgerald PA, Findling JW, Forsham PH 1981 Cushing’s syndrome: problems in diagnosis. Medicine (Baltimore) 60:25-35
81. Bruno OD, Rossi MA, Contreras LN, Gomez RM, Galparsoro G, Cazado E, Kral M, Leber B, Arias D 1985 Nocturnal high-dose dexamethasone suppression test in the aetiological diagnosis of Cushing’s syndrome. Acta Endocrinol (Copenh) 109:158-162
82. Spiger M, Jubiz W, Meikle AW, West CD, Tyler FH 1975 Single dose metyrapone test: review of a four year experience. Arch Intern Med 135:698-700
83. Abou-Samra AB, Feore-Montange M, Pugeat M, Dechaud H, Chalendar D, Estour B, Tourniaire J 1984 The value of lipotrophin measurement during the short metyrapone test in patients with pituitary diseases and in Cushing’s syndrome. Acta Endocrinol (Copenh) 105:441-448
84. Boscaro M, Rampazzo A, Sonino N, Merola G, Scanarini M, Mantero F 1987 Corticotropin-releasing hormone stimulation test: diagnostic aspects in Cushing’s syndrome. J Endocrinol Invest 10:298-302
85. Grossman AB, Howlett TA, Perry L, Coy DH, Savage MO, Lavender P, Rees LH, Besser GM 1988 CRF in the differential diagnosis of Cushing’s syndrome. A comparison with the dexamethasone suppression test. Clin Endocrinol (Oxf) 29:167-178
86. Nieman LK, Chrousos GP, Oldfield EH, Avgerinos PC, Cutler Jr GB, Loriaux DL 1986 The ovine corticotropin-releasing hormone stimulation and the dexamethasone suppression test in the differential diagnosis of Cushing’s syndrome. Ann Intern Med 105:862-867
87. Findling JW, Kehoe ME, Shaker JL, Raff H 1991 Routine inferior petrosal sinus sampling in the differential diagnosis of adrenocorticotropin (ACTH)-dependent Cushing’s syndrome; early recognition of occult ectopic ACTH syndrome. J Clin Endocrinol Metab 73:408-413
88. Malchoff D, Orth DN, Abboud C, Carney JA, Pairolero PC, Carey RM 1998 Ectopic ACTH syndrome caused by a bronchial carcinoid tumor responsive to dexamethasone, metyrapone and corticotropin-releasing factor. Am J Med 84:760-764
89. Kubo M, Nakagawa K, Akikawa K, Ishizuka T, Matsubara M 1985 In vivo and in vitro ACTH response to ovine corticotropin releasing factor in a bronchial carcinoid from a patient with ectopic ACTH. Endocrinol Jpn 42:577-581
90. Schteingart DE 1991 Ectopic secretion of peptides of the proopiomelanocortin family. Endocrinol Metab Clin North Am 20:453-471
91. DeBold CR, Jackson RV, Kamilaris TC, Sheldon Jr WR, DeCherney S, Island DP, Orth DN 1989 Effects of ovine corticotropic-releasing hormone on adrenocorticotropin secretion in the absence of glucocorticoid feedback inhibition in man. J Clin Endocrinol Metab 68:431-437
92. Burrow GN, Wortzman G, Newcastle NB, Holgate RC, Kovacs K 1981 Microadenomas of the pituitary and abnormal sellar tomograms in an unselected autopsy series. N Engl J Med 304:156-158
93. Parent AD, Bedin J, Smith RR 1981 Incidental pituitary adenomas. J Neurosurg 54:228-231
94. Brown SB, Irwin KM, Enzmann DR 1983 CT characteristics of the normal pituitary gland. Neuroradiology 24:259-262
95. Malerbi DA, Mendonca BB, Liberman B, Toledo SPA, Corradini MCM, Cunha-Neto MB, Fragoso MCBV, Wajchenberg BL 1993 The desmopressin stimulation test in the differential diagnosis of Cushing’s syndrome. Clin Endocrinol (Oxf) 38:463-472
96. Schulte HM, Allolio B, Gunther RW 1987 Bilateral and simultaneous sinus petrosus inferior catheterization in patients with Cushing’s syndrome: plasma-immunoreactive-ACTH-concentrations before and after administration of CRF. Horm Metab Res 16(Suppl):66-67
97. Scully RE, Mark EJ, McNeely WF, McNeely BU 1987 Case records of the Massachusetts General Hospital weekly clinicopathological exercises. Case 52. N Engl J Med 317:1648-1658
98. Baylin SB 1990 ‘APUD’ cells. Fact and fiction. Trends Endocrinol Metab 1:198-204
99. El-Sachly M, Lundqvist M, Wilander E 1986 Bronchial carcinoids and pheochromocytomas. Acta Pathol Microbiol Immunol Scand 94:229-235
100. Price J, Kruseman AC, Doniach I, Howlett JA, Besser GM, Rees LH 1985 Bombesin-like peptides in human endocrine tumors: quantitation, biochemical characterization, and secretion. J Clin Endocrinol Metab 60:1097-1103
101. Maruno K, Yamaguchi K, Abe K, Siuzuki M, Saijo N, Mishima Y, Yanaihara N, Shimozato Y 1989 Immunoreactive gastrinreleasing peptide as a specific tumor marker in patients with small cell lung carcinoma. Cancer Res 49:629-632
102. Chiang HC-V, O’Dorisio TM, Huang SC, Maton PN, Gardner JD, Jensen KT 1990 Multiple hormone elevations in ZollingerEllison syndrome: prospective study of clinical significance and of the development of a second symptomatic pancreatic endocrine tumor syndrome. Gastroenterology 91:1565-1575
103. Styne DM, Isaac R, Miller WL, Leisti S, Connors M, Conte FA, Grumbach MM 1983 Endocrine, histological and biochemical studies of adrenocorticotropin-producing islet cell carcinoma of the pancreas in childhood with characterization of proopiomelanocortin. J Clin Endocrinol Metab 57:723-731
104. Iwase K, Nagasaka A, Kato K, Ohtani S, Nagatsu I, Ohyama T, Nakai A, Aono T, Nakagawa H, Shinoda S, Inagaki M, Tei T, Miyakawa S, Kawase K, Miura K, Nakamura T, Kanno T, Kuwayama A, Kageyama N 1986 Enolase subunits in patients with neuroendocrine tumors. J Clin Endocrinol Metab 63:94-101
105. Eriksson B, Arnberg H, Oberg K, Heilman V, Lundqvist G, Wernstedt C, Willander E 1990 A polyclonal antiserum against chromogranin A and B a new sensitive marker for neuroendocrine tumors. Acta Endocrinol (Copenh) 122:145-155
106. O’Connor DT, Deftos LJ 1986 Secretion of chromogranin A by peptide-producing endocrine neoplasms. N Engl J Med 314:1145-1151
107. Weiler R, Fischer-Colbrie R, Schmid KW, Feichtinger H, Bussolati G, Grimelius L, Krisch K, Kerl H, O’Connor DL, Winkler H 1988 Immunological studies on the occurrence and properties of chromogranin A and B and secretogranin II in endocrine tumors. Am J Surg Pathol 12:877-884
108. Sobol RE, Memoli V, Deftos LJ 1989 Hormone negative, chromogranin-A positive endocrine tumor. N Engl J Med 320:444-447
109. Takiyyuddin MA, Cervenka JH, Pandian MR, Stuenekel CA, Neumann HPH, O’Connor DT 1990 Neuroendocrine sources of chromogranin-A in normal man: clues from selective stimulation of endocrine glands. J Clin Endocrinol Metab 71:360-369
110. Vieau D, Rojas-Miranda A, Verley JM, Lenne F, Bertagna X The secretory granule peptides 7B2 and CCB are sensitive biochemical markers of neuro-endocrine bronchial tumours in man. Clin Endocrinol (Oxf) 35:319-325
111. Vieau D, Linard CG, Mbikay M, Lenne F, Chretien M, Luton J-P, Bertagna X 1992 Expression of the neuroendocrine cell marker 7B2 in human ACTH secreting tumours. Clin Endocrinol (Oxf) 35:597-603
112. Parker LN 1991 Control of adrenal androgen secretion. Endocrinol Metab Clin N Am 20:401-421
113. Parker L, Lifrak E, Shively J, Lee T, Kaplan B, Walker P, Calaycay J, Florsheim W, Soon-Shiong P, Human adrenal gland cortical androgen-stimulating hormone (CASH) is identical with a portion of the joining peptide of pituitary POMC. Program of the 71st Annual Meeting of The Endocrine Society, Seattle, 1989, p 97 (Abstract 299)
114. Mellon SH, Shively JE, Miller WL 1991 Human proopiomelanocortin (79-96) a proposed androgen stimulatory hormone, does not effect steroidogenesis in cultured human fetal adrenal cells. J Clin Endocrinol Metab 72:19-22
115. Penhoat A, Sanchez P, Jaillard C, Langlois D, Begeot M, Saez JM 1991 Human proopiomelanocortin (79-96), a proposed androgen-stimulating hormone, does not affect steroidogenesis in cultured human adult adrenal cells. J Clin Endocrinol Metab 72:2326
116. Morley JE, Melmed S 1979 Gonadal dysfunction in systemic disorders. Metabolism 28:1051-1073
117. Christy NP, Laragh JH 1961 Pathogenesis of hypokalemic alkalosis in Cushing’s syndrome. N Engl J Med 265:1083-1088
118. Schamberlan M, Slaton Jr PE, Biglieri EG 1971 Mineralocorticoid production in hyperadrenocorticism. Role in pathogenesis of hypokalemic alkalosis. Am J Med 51:299-303
119. Biglieri EG, Chang B, Hirai J, Brust N, Rost CR, Schamberlan M 1979 Adrenocorticotropin inhibition of mineralocorticoid hormone production. Clin Sci 57(Suppl 5):307s-311s
120. Kater CE, Biglieri EG, Wajchenberg BL 1985 Effects of continued adrenocorticotropin stimulation on the mineralocorticcid hormones in classical and nonclassical simple virilizing types of 21-hydroxylase deficiency. J Clin Endocrinol Metab 60:1057-1062
121. Arriza JL, Weinberger C, Cerelli G, Glaser TM, Handelin BI, Housman DE, Evans RM 1987 Cloning of human mineralocorticcid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor. Science 237:268-275
122. Vlicx S, Levine LS, Gunczlea P, Zanconato G, Ramirez LC, Rauk W, Rosslea A, Bradlow HL, New MI 1979 A syndrome of apparent mineralocorticoid excess associated with defects in the peripheral metabolism of cortisol. J Clin Endocrinol Metab 49:757-764
123. Walker BR, Campbell JC, Fraser R, Stewart PM, Edwards CRW Mineralocorticoid excess and inhibition of 11β-hydroxys teroid dehydrogenase in patients with ectopic ACTH syndrome. Clin Endocrinol (Oxf) 37:483-492
124. White FE, White MC, Drury PL, Fry I, Besser GM 1982 Value of computed tomography of the abdomen and chest in investigation of Cushing’s syndrome. Br Med J [Clin Res] 284:771-774
125. Doppman JL, Oldfield EH, Chrousos GP, Nieman L, Udelsman R, Cutler Jr GB, Loriaux DL 1986 Rebound thymic hyperplasia after treatment of Cushing’s syndrome. AJR 147:1145-1147
126. Leinung MC, Young Jr WF, Whitaker MD, Scheithauer BW, Trastek VF, Kvols LK 1990 Diagnosis of corticotropin-producing bronchial carcinoid tumors causing Cushing’s syndrome. Mayo Clin Proc 65:1315-1321
127. Limper AH, Carpenter PC, Scheithauer B, Staats BA 1992 The Cushing syndrome induced by bronchial carcinoid tumors. Ann Intem Med 117:209-214
128. Doppman JL, Pass HI, Nieman LK, Findling JW, Dwyer AJ, Fenerstein IM, Ling A, Travis WD, Cutler Jr GB, Chrousos GP, Loriaux DL 1991 Detection of ACTH-producing bronchial carcinoid tumors: MR imaging vs CT. AJR 156:39-43
129. Doppman JL, Pass HI, Nieman L, Cutler Jr GB, Chrousos GP, Loriaux DL 1989 Failure of bronchial lavage to detect elevated levels of adrenocorticotropin (ACTH) in patients with ACTHproducing bronchial carcinoids. J Clin Endocrinol Metab 69:1302-1304
130. Doppman JL, Reinig JW, Dwyer AJ, Frank JP, Norton J, Loriaux DL, Keiser H 1987 Differentiation of adrenal masses by magnetic resonance imaging. Surgery 102:1018-1026
131. Balthazar EJ, Chaco AC 1990 Computed tomography of pancreatic masses. Am J Gastroenterol 85:343-349
132. Lees WR 1984 Pancreatic ultrasonography. Clin Gastroenterol 13:763-789
133. Warshaw AL, Del Castillo CF 1992 Pancreatic carcinoma. N Engl J Med 326:455-465
134. Mackie CR, Noble HG, Cooper MJ, Collins P, Block GE, Moossa AR 1979 Prospective evaluation of angiography in the diagnosis and management of patients suspected of having pancreatic cancer. Ann Surg 1898:11-17
135. Eriksson B, Arnberg H, Lindgren PG, Lorelius LE, Magnusson A, Lundqvist G, Skogseid B, Wide L, Wilander E, Oberg K 1990 Neuroendocrine pancreatic tumours: clinical presentation, biochemical and histopathological findings in 84 patients. J Intem Med 228:103-113
136. Weil C 1985 Gastroenteropancreatic endocrine tumors. Klin Wochenschr 63:433-459
137. Steiner E, Stark DD, Hahn PF 1989 Imaging of pancreatic neoplasms: comparison of MR and CT. AJR 192:487-491
138. Frucht H, Doppman JL, North JA, Miller DL, Dwyer AJ, Frank JA, Vinayek R, Maton PN, Jensen RT 1989 Gastrinomas: comparison of MR imaging with CT, angiography and US. Radiology 171:713-719
139. Doppman JL, Miller DL, Dwyer AJ, Loughlin T, Nieman L, Cutler Jr GB, Chrousos GP, Oldfield E, Loriaux DL 1988 Macronodular adrenal hyperplasia in Cushing’s disease. Radiology 166:347-352
140. Davies CJ, Joplin GF, Welbourn RB 1982 Surgical management of the ectopic ACTH syndrome. Ann Surg 196:246-258
141. Bergholm V, Adami HO, Bergstrom R 1989 Clinical characteristics in sporadic and familial medullary thyroid carcinoma, a nationwide study of 249 patients in Sweden from 1959 through 1991. Cancer 63:1196-1204
142. Grauer A, Raue F, Gagel RF 1990 Changing concepts in the managment of hereditary and sporadic medullary thyroid carcinoma. Endocrinol Metab Clin N Am 19:613-635
143. Jolivet J, Beauregard H, Somma M, Band PR 1980 ACTH-secreting medullary carcinoma of the thyroid: Monitoring of clinical course with calcitonin and cortisol assays and immunohistochemical studies. Cancer 46:2667-2670
144. Hijazi YM, Nieman LK, Medeiros LJ 1992 Medullary carcinoma of the thyroid as a cause of Cushing’s syndrome: a case with ectopic adrenocorticotropin secretion characterized by double enzyme immunostaining. Hum Pathol 23:592-596
145. Belsky JL, Cuello B, Swanson LW, Simmons DM, Jarret RM, Braza F 1985 Cushing’s syndrome due to ectopic production of corticotropin-releasing factor. J Clin Endocrinol Metab 60:496-500
146. Tourniaire J, Rebattu B, Conte-Devolx B, Trouillas J, Grino M, Berger-Dutrieux N, Peix J-L, Pugeat M 1988 Syndrome de Cushing secondaire a la production ectopique de CRF par un carcinoma medullaire du corps thyroide. Ann d’Endocrinol (Paris) 4:61-67
147. Howlett TA, Price J, Hale AC, Doniach I, Rees LH, Wass JAH, Besser GM 1985 Pituitary ACTH dependent Cushing’s syndrome due to ectopic production of bombesin-like peptide by medullary carcinoma of the thyroid. Clin Endocrinol (Oxf) 22:91-101
148. Lamberts SWJ, Hofland van Koetsveld PM, Reubi J-C, Bruining HA, Bakker WH, Krenning EP 1990 Parallel in vivo and in vitro detection of functional somatostatin receptors in human endocrine pancreatic tumors. Consequences with regard to diagnosis, localization and therapy. J Clin Endocrinol Metab 71:566-574
149. Lamberts SWJ, Bakker WH, Reubi J-C, Krenning EP 1990 Somatostatin-receptor imaging in the localization of endocrine tumors. N Engl J Med 323:1246-1249
150. Krenning EP, Kwekkeboom DJ, Bakker WH, Kooij PP, Oei HY, van Hagen M, Postema PT, de Jong M, Reubi J-C 1993 Somatostatin receptor scintigraphy with (“’In-DTPA-d-Phe1) and (, 23ITyr-3)octreotide: the Rotterdam experience with more than 1000 patients. Eur J Nucl Med 20:716-731
151. Lamberts SWJ, deHerder WW, Krenning EP, Reubi J-C 1994 Editorial: a role of (labeled) somatostatin analogs in the differential diagnosis and treatment of Cushing’s syndrome. J Clin Endocrinol Metab 78:17-19
152. Philipponneau M, Nocaudie M, Epelbaum J, de Keyser Y, Lalau JD, Marchandise X, Bertagna X 1994 Somatostatin analogs for the localization and preoperative treatment of an adrenocorticotropin-secreting bronchial carcinoid tumor. J Clin Endocrinol Metab 78:20-24
153. Gagel RF, Robinson MF, Donovan DT, Alford BR 1993 Medullary thyroid carcinoma: recent progress. J Clin Endocrinol Metab 76:809-814
154. Dimopoulos MA, Fernandez JF, Samaan NA, Holoye PY, Vassilopoulo-Sellin R 1992 Paraneoplastic Cushing’s syndrome as an adverse prognostic factor in patients who die early with small cell lung cancer. Cancer 69:66-71
155. Wick MR, Scott RE, Chin-Yang L, Carney AJ 1980 Carcinoid tumors of the thymus: a clinicopathologic report of seven cases with a review of the literature. Mayo Clin Proc 55:246-254
156. Economopoulos GC, Lewis Jr JW, Lee MW, Silverman NA 1990 Carcinoid tumors of the thymus. Ann Thorac Surg 50:58-61
157. Blumgart LH, Allison DJ 1982 Resection and embolization in the management of secondary hepatic tumors. World J Surg 6:32-45
158. Vetter D, Doffoel M, Wenger JJ, Bergier JM, Reville M, Schmutz G, Bockel R 1992 Arterial embolization, chemoembolization and lipiodolization in the management of hepatocellular carcinoma in cirrhosis. In: Lygidakis NJ, Classen M, Moreno Gonzalez E (eds) Eur Clin Digest Diseases, Suppl-Series-vol 1: Malignancies of the Liver. IGSC Publ, Athens, Greece, pp 133-140
159. Brennan MF, McDonalds JS 1985 Cancer of the endocrine system: treatment. In: DeVita Jr VT, Heilman S, Rosenberg, SA (eds) Cancer Principle and Practice of Oncology, ed 2. JB Lippincott Co, Philadelphia, pp 1226-1230
160. Makowka L, Tzakis AG, Mazzaferro V, Teperman L, Demetris J, Iwatsuki S, Starzl TE 1989 Transplantation of the liver for metastatic endocrine tumors of the intestine and pancreas. Surg Gynecol Obstet 168:107-111
161. Donovan DT, Gagel RF 1990 Medullary thyroid carcinoma and the multiple endocrine neoplasia syndromes. In: Falk J (ed) Thyroid Disease: Endocrinology, Surgery, Nuclear Medicine and Radiotherapy. Raven Press Ltd, New York, pp 501-525
162. Samaan NA, Schultz PN, Hickey RC 1988 Medullary thyroid carcinoma. Prognosis of familial vs. sporadic disease and the role of radiotherapy. J Clin Endocrinol Metab 67:801-805
163. Ajani JA, Legha SS, Karlin DA, Stratton Hill C 1983 Combination chemotherapy of metastatic carcinoid tumors with 5-FU, adriamycin, mitomycin and methyl-CCNU. Proc Am Assoc Clin Oncol 2:124 (Abstract C-486)
164. Bukowski RM, John KG, Peterson RF, Stephens RL, Rivkin SE, Neilan B, Costanzi JH 1987 A phase II trial of combination chemotherapy in patients with metastatic carcinoid tumors. A Southwest Oncology Group Study. Cancer 60:2891-2895
165. Moertel CG, Kvols LK, O’Connell MJ, Rubin J 1991 Treatment of neuroendocrine carcinomas with combined etoposide and cisplatin: evidence of major therapeutic activity in the anaplastic variants of these neoplasms. Cancer 68:227-232
166. Moertel CG, Hanley JA, Johnson LA 1980 Streptozotocin alone compared with streptozotocin plus fluoracil in the treatment of advanced islet-cell carcinoma. N Engl J Med 303:1189-1195
167. Moertel CG 1983 Treatment of carcinoid tumor and the malignant carcinoid syndrome. J Clin Oncol 1:727-732
168. Shimaoka K, Schoenfeld DA, Dewys WD, Creek RH, DeConti R 1985 A randomized trial of doxorubicin us. doxorubicin plus cisplatin in patients with advanced thyroid carcinoma. Cancer 56:2155-2160
169. Samaan NA, Hickey RL 1991 Medullary thyroid carcinoma. In: Bardin CW (ed) Current Therapy in Endocrinology and Metabolism, ed 4. BC Decker Inc, Philadelphia, pp 98-102
170. Oberg K, Norheim I, Alm G 1989 Treatment of malignant carcinoid tumors: a randomized controlled study of streptozotocin plus 5-FU and human leucocyte interferon. Eur J Cancer Clin Oncol 25:1475-1479
171. Eriksson B, Oberg K, Alm G, Karlsson A, Lundqvist G, Andersson T, Wilander E, Wide L 1986 Treatment of malignant endocrine pancreatic tumors with human leucocyte interferon. Lancet 2:1307-1309
172. Ronnblom LE, Alm G, Oberg K 1991 Autoimmunity after alphainterferon therapy for malignant carcinoid tumors. Ann Intern Med 115:178-183
173. Lamberts SWJ, Tilanus HW, Klooswijk AIJ, Bruining HA, van der Lely AJ, de Jong FH 1988 Successful treatment with SMS 201-995 of Cushing’s syndrome caused by ectopic adrenocorticotropin-secretion from a metastatic gastrin-secreting pancreatic islet cell carcinoma. J Clin Endocrinol Metab 67:1080-1083
174. Ruszniewski P, Girard F, Benamouzig R, Mignon M, Bonfils S 1988 Long-acting somatostatin treatment of paraneoplastic Cushing’s syndrome in a case of Zollinger-Ellison syndrome. Gut 29:838-842
175. Bertagna X, Favrod-Coune C, Escourolle H, Beuzeboc P, Christoforov B, Girard F, Luton J-P 1989 Suppression of ectopic adrenocorticotropin secretion by long-acting somatostatin analog octreotide. J Clin Endocrinol Metab 68:988-991
176. Hearn PR, Reynolds CL, Johansen K, Woodhouse NJY 1988 Lung carcinoid with Cushing’s syndrome: control of serum ACTH and cortisol levels using SMS 201-995 (Sandostatin). Clin Endocrinol (Oxf) 28:181-185
177. Moattari AD, Deftos J, Vinik AI 1989 Effect of Sandostatin on plasma chromogranin-A levels in neuroendocrine tumors. J Clin Endocrinol Metab 69:902-905
178. Lamberts SWJ 1988 Somatostatin analogs in the management of gastrointestinal tumors. Horm Res 29:118-120
179. Burrell L, Gray CE, Thomson JA 1989 Failure of somatostatin analogue SMS 201-995 to control Cushing’s syndrome due to ectopic ACTH release from a bronchial carcinoid. Scott Med J 34:533-534
180. Schteingart DE 1989 Cushing’s syndrome. Endocrinol Metab Clin N Am 18:311-338
181. Schteingart DE, Conn JW 1967 Effects of aminoglutethimide upon adrenal function and cortisol metabolism in Cushing’s syndrome. J Clin Endocrinol Metab 27:1657-1666
182. Misbin RI, Canary J, Willard D 1976 Aminoglutethimide in the treatment of Cushing’s syndrome. J Clin Pharmacol 16:645-651
183. Child DF, Burke CW, Busley DM, Rees LH, Fraser TR 1976 Drug control of Cushing’s syndrome. Combined aminoglutethimide and metyrapone therapy. Acta Endocrinol (Copenh) 82:330-341
184. Jeffcoate WJ, Rees LH, Tomlin S, Jones AE, Edwards CRW, Besser GM 1977 Metyrapone in long-term management of Cushing’s disease. Br Med J [Clin Res] 2:215-217
185. Sonino N 1987 The use of ketoconazole as an inhibitor of steroid production. N Engl J Med 317:812-818
186. Feldman D 1986 Ketoconazole and other imidazole derivatives as inhibitors of steroidogenesis. Endocr Rev 7:409-420
187. Couch RM, Muller J, Perry YS, Winter JSD 1987 Kinetic analysis of inhibition of human adrenal steroidogenesis by ketoconazole. J Clin Endocrinol Metab 65:551-554
188. Sonino N, Boscaro M, Merola G, Mantero F 19875 Prolonged treatment of Cushing’s disease by ketoconazole. J Clin Endocrinol Metab 61:718-722
189. Sonino N, Boscaro M, Paoletta A, Mantero F, Ziliotto D 1991 Ketoconazole treatment in Cushing’s syndrome: experience in 34 patients. Clin Endocrinol (Oxf) 35:347-352
190. Tabarin A, Navaranne A, Guerin J, Corcuff J-B, Parneix M, Roger P 1991 Use of ketoconazole in the treatment of Cushing’s disease and ectopic ACTH syndrome. Clin Endocrinol (Oxf) 34:63-69
191. Shepherd FA, Hoffert B, Evans WK, Emery G, Trachtenberg J 1985 Ketoconazole: use in the treatment of ectopic adrenocorticotropic hormone production and Cushing’s syndrome in small-cell lung cancer. Arch Intern Med 145:863-864
192. Farwell AP, Devlin JT, Stewart JA 1988 Total suppression of cortisol excretion by ketoconazole in the therapy of the ectopic adrenocorticotropic hormone syndrome. Am J Med 84:1063-1066
193. Englehardt D, Jacob K, Doerr HG 1989 Different therapeutic efficacy of ketoconazole in patients with Cushing’s syndrome. Klin Wochenschr 67:241-247
194. Cerdas S, Billaud L, Guilhaume B, Laudat MH, Bertagna X, Luton J-P 1989 Effect a court term du ketoconazole dans les syndromes de Cushing. Ann Endocrinol (Paris) 50:489-496
195. Bergenstal DM, Hertz R, Lipsett MB, Moy RH 1960 Chemotherapy of adrenocortical cancer with o.p’DDD. Ann Intern Med 53:672-678
196. Luton J-P, Mahoudeau JA, Bouchard Ph, Thieblot Ph, Hautecouverture M, Simon D, Laudat MH, Touitou Y, Bricaire H 1979 Treatment of Cushing’s disease by o.p’DDD. Survey of 62 cases. N Engl J Med 300:459-464
197. DeStephano DB, Lloyd RV, Schteingart DE 1984 Case studies: Cushing’s syndrome produced by a bronchial carcinoid tumor. Hum Pathol 15:890-892
198. Raux Demay MC, Proeschel MF, de Keyser Y, Bertagna X, Luton J-P, Girard F 1988 Characterization of human corticotrophinreleasing hormone and pro-opiomelanocortin-related peptides in a thymic carcinoid tumor responsible for Cushing’s syndrome. Clin Endocrinol (Oxf) 29:649-657
199. Bertagna X, Bertagna C, Luton J-M, Husson JM, Girard F 1984 The new steroid analog RU 486 inhibits glucocorticoid action in man. J Clin Endocrinol Metab 59:25-28
200. Svec F 1988 Differences in the interaction of RU 486 and ketoconazole with the second binding site of the glucocorticoid receptor. J Clin Endocrinol Metab 123:1902-1906
201. Nieman LK, Chrousos GP, Kellner C, Spitz IM, Nisula BC, Cutler GB, Merriam GR, Bardin CW, Loriaux DL 1985 Successful treatment of Cushing’s syndrome with the glucocorticoid antagonist RU 486. J Clin Endocrinol Metab 61:536-540
202. Spitz IM, Bardin CW 1993 Mifepristone (RU 486) modulator of progestin and glucocorticoid action. N Engl J Med 329:404-412
203. Blunt SB, Pirmohamed M, Chatterjee UKK, Burrin JM, Allison DJ, Joplin GF 1989 Use of adrenal arterial embolization in severe ACTH-dependent Cushing’s syndrome. Postgrad Med J 65:575-579
204. Orth DN, Nicholson WE, Mitchell WM, Island DP, Liddle GW 1973 Biologic and immunologic characterization and physical separation of ACTH and ACTH fragments in ectopic ACTH syndrome. J Clin Invest 58:1757-1769
205. Hale AC, Besser GM, Rees LH 1986 Characterization of proopiomelanocortin-derived peptides in pituitary and ectopic adrenocorticotropin-secreting tumours. J Endocrinol 108:49-56
206. Jessop DS, Cunnah D, Millar JGP, Neville E, Coates P, Doniach I, Besser GM, Rees LH 1987 A pheochromocytoma presenting with Cushing’s syndrome associated with increased concentrations of circulating corticotrophin-releasing factor. J Endocrinol 113:133-138
207. Birkenhager JC, Upton GV, Seldenrath HJ, Krieger DT, Tashjian Jr AH 1976 Medullary thyroid carcinoma: ectopic production of peptides with ACTH-like, corticotrophin releasing factor-like and prolactin production-stimulating activities. Acta Endocrinol (Copenh) 83:280-292
208. Vieau D, Massias J-F, Girard F, Luton J-P, Bertagna X 1989 Corticotrophin-like intermediary lobe peptide as a marker of alternative proopiomelanocortin processing in ACTH-producing nonpituitary tumors. Clin Endocrinol (Oxf) 31:691-700
209. Whitfeld P, Seeburg P, Shine J 1982 The human proopiomelanocortin gene: organization, sequence and interspersion with repetitive DNA. DNA 1:133-134
210. Thomas L, Leduc R, Thorne BA, Smeekens SP, Steiner DF, Thomas G 1991 Kex L-like endoproteases PC2 and PC3 accurately cleave a model prohormone in mammalian cells: evidence for a common core of neuroendocrine processing enzymes. Proc Natl Acad Sci USA 88:5297-5301
211. Benjannet S, Rondeau N, Day R, Chretien M, Seidah NG 1991 PCI and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues. Proc Natl Acad Sci USA 88:3564-3568
212. Bertagna X, Camus F, Lenne F, Girard F, Luton J-P 1988 Human joining peptide: a pro-opiomelancortin product secreted as a homodimer. Mol Endocrinol 2:1108-1114
213. Philipponeau M, Lenne F, Froeschel MF, Girard F, Luton J-P, Bertagna X 1993 Plasma immunoreactive joining peptide in man: a new marker of proopiomelanocortin processing and corticotroph function. J Clin Endocrinol Metab 76:325-329
214. Tanaka I, Nakai Y, Nakao K, Oki S, Fukata J, Imura H 1981 7melanotrophin-like immunoreactivities in human pituitaries, ACTH-producing pitutiary adenomas and ectopic ACTH-producing tumors: evidence for an abnormality of glycosylation in ectopic ACTH-producing tumours. Clin Endocrinol (Oxf) 15:353-361
215. Kannan CR 1992 Paraneoplastic syndromes, islet cell tumors and multiple endocrine neoplasia. In: Bagdade JD (ed) Year Book of Endocrinology. Mosby Year Book, Chicago, pp 231-256
216. Eberlein-Gonska M, Wiedenmann B, Waldherr R 1989 Synaptophysin, Chromogranin und neuronenspezifische enolase als tumor marker bei neuroendokrinen tumoren des gastroeintestinaltraktesfund der Lunge. Eine immunhistochemische Untersuchung. Pathologe 10:228-233
217. Coates PJH, Doniach I, Howlett TA, Rees LH, Besser GM 1986 An immunocytochemical study of 18 tumours causing ectopic Cushing’s syndrome. J Clin Pathol 39:955-960
218. Heitz PU, Kloppel G, Polak JM, Staub JJ 1981 Ectopic hormone production by endocrine tumors: localization of hormones at the cellular level by immunocytochemistry. Cancer 48:2029-2037
219. Boggan JE, Tyrrell JB, Wilson CB 1983 Transsphenoidal microsurgical management of Cushing’s disease: report of 100 cases. J Neurosurg 59:195-200
220. Orth DN 1992 Corticotropin-releasing hormone in humans. Endocr Rev 13:164-191
221. Thorner MO, Martin WH, Ragan GE, MacLeod RM, Eeldman PS, Bruni C, Williamson BRJ, Orth DN 1982 A case of ectopic ACTH syndrome: diagnostic difficulties caused by intermittent hormone secretion. Acta Endocrinol (Copenh) 99:354-370
222. Melchionna RH, Moore RA 1938 The pharyngeal pituitary gland. Am J Pathol 14:743-771
223. Schteingart DE, Chandler WF, Lloyd RV, Ibarra-Perez, 1987 Cushing’s syndrome caused by an ectopic pituitary adenoma. Neurosurgery 21:223-227
224. Kammer H, George R 1981 Cushing’s disease in a patient with an ectopic pituitary adenoma. JAMA 246:2722-2724
225. Burch WM, Kramer RS, Kenan PD, Hammond CB 1985 Cushing’s disease caused by an ectopic pituitary adenoma within the sphenoid sinus. N Engl J Med 587-588
226. Upton GV, Amatruda Jr TT 1971 Evidence for the presence tumor peptides with corticotropin-releasing-factor-like activity in the ectopic ACTH syndrome. N Engl J Med 285:419-424
227. Amatruda Jr TT, Upton GV, Gelfman NA, Orth DN, Partial characterization of ACTH-like peptides in the –ectopic ACTH— syndrome. Program of the 51st Annual Meeting of The Endocrine Society, New York, 1969, p 119 (Abstract)
228. Carey RM, Varma SK, Drake Jr CR, Thorner MO, Kovacs K, Rivier J, Vale W 1984 Ectopic secretion of corticotropin-releasing factor as cause of Cushing’s syndrome. A clinical, morphological and biochemical study. N Engl J Med 311:13-20
229. Asa SL, Kovacs K, Tindall GT, Barrow DL, Horvath E, Vecsei P 1984 Cushing’s disease associated with an intrasellar gangliocytoma producing corticotropin-releasing factor. Ann Intem Med 101:789-793
230. Adams EF, Skrabal F, Carroll D, Loizou M, White MC, Biggins JA, Mashiter K 1987 Ectopic corticotrophin-releasing-factor and growth hormone releasing factor secretion: diagnoses using human pituitary cell culture. Horm Res 25:80-87
231. Fjellestad-Paulsen A, Abrahamsson P-A, Bjartell A, Grino M, Grimelius L, Hedeland H, Falkmer S 1988 Carcinoma of the prostate with Cushing’s syndrome. A case report with histochemical and chemical demonstration of immunoreactive corticotropinreleasing hormone in plasma and tumoral tissue. Acta Endocrinol (Copenh) 119:506-515
232. Hashimoto K, Takahara J, Ogawa N, Yunoki S, Ofuji T, Arata A, Kanda S, Terada K 1980 Adrenocorticotropin, B-lipotropin, Bendorphin, and corticotropin-producing nephroblastoma. J Clin Endocrinol Metab 50:461-465
233. Hashimoto K, Suemaru S, Hattori T, Sugawara M, Ota Z, Takata S, Hamaya K, Doi K, Chretien M 1986 Multiple endocrine neoplasia with Cushing’s syndrome due to paraganglioma producing corticotropin-releasing factor and adrenocorticotropin. Acta Endocrinol (Copenh) 113:189-195
234. Suda T, Kondo M, Totani R, Hashimoto N, Suzuki M, Imaki T, Oba Y, Tomori N, Yajima F, Sumitomo T, Nakagami Y, Ushiyama T, Demura H, Shizume K 1986 Ectopic adrenocorticotropin syndrome caused by lung cancer that responded to corticotropinreleasing hormone. J Clin Endocrinol Metab 63:1047-1051
235. Zarate A, Kovacs K, Flores M, Moran C, Felix L, 1986 ACTH and CRF-producing bronchial carcinoid associated with Cushing’s syndrome. Clin Endocrinol (Oxf) 24:523-529
236. Suda T, Kondo M, Totani R, Hashimoto N, Suzuki M, Imaki T, Oba Y, Tomori N, Yajima F, Sumitomo T, Nakagami Y, Ushiyama T, Demura H, Shizume K 1986 Ectopic adrenocorticotropin syndrome caused by lung cancer that responded to corticotropinreleasing hormone. J Clin Endocrinol 63:1047-1051