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Volumn 4, Issue 6, 1994, Pages 285-299

Biochemistry and molecular biology of the human CYP2C subfamily

Author keywords

[No Author keywords available]

Indexed keywords

3 NAPHTHYLOXYLACTIC ACID; BARBITURIC ACID DERIVATIVE; CYCLOGUANIL; CYTOCHROME P450 ISOENZYME; DIAZEPAM; DICLOFENAC; DRONABINOL; DRUG METABOLITE; HEXOBARBITAL; IBUPROFEN; IMIPRAMINE; MEFENAMIC ACID; MEPHENYTOIN; NAPHTHOXYLACTIC ACID; NAPROXEN; NONSTEROID ANTIINFLAMMATORY AGENT; OMEPRAZOLE; PHENYTOIN; PIROXICAM; PROGUANIL; PROPRANOLOL; SULFAPHENAZOLE; TENOXICAM; TIENILIC ACID; TOLBUTAMIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG; WARFARIN;

EID: 0028590127     PISSN: 0960314X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008571-199412000-00001     Document Type: Article
Times cited : (525)

References (99)
  • 1
    • 0025196013 scopus 로고
    • Cytochrome b5 potentiation of cytochrome P-4 50 catalytic activity demonstrated by a vaccinia virusmediate in situ reconstitution system
    • Aoyama T, Nagata K, Yamazoe Y, Kato R, Matsunaga K, Gelboin HV, Gonzalez FJ. Cytochrome b5 potentiation of cytochrome P-4 50 catalytic activity demonstrated by a vaccinia virusmediate in situ reconstitution system. Proc Natl Acad Sci USA 1990: 87. 5425-5429.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 5425-5429
    • Aoyama, T.1    Nagata, K.2    Yamazoe, Y.3    Kato, R.4    Matsunaga, K.5    Gelboin, H.V.6    Gonzalez, F.J.7
  • 2
    • 0028207548 scopus 로고
    • Stereoselective disposition of hexobarbital and its metabolites: Relationship to the S-mephenytoin polymorphism in Caucasian and Chinese subjects
    • Adedoyin A, Prakash C, O’Shea D, Blair IA, Wilkinson GR. Stereoselective disposition of hexobarbital and its metabolites: relationship to the S-mephenytoin polymorphism in Caucasian and Chinese subjects. Pharmacogenetics 1994: 4, 27-38.
    • (1994) Pharmacogenetics , vol.4 , pp. 27-38
    • Adedoyin, A.1    Prakash, C.2    O’Shea, D.3    Blair, I.A.4    Wilkinson, G.R.5
  • 3
  • 5
    • 0022692071 scopus 로고
    • Amitriptyline pharmacokinetics and clinical response. II. Metabolic polymorphism assessed by hydroxylation of debrisoquine and mephenytoin
    • Baumann P, Jonzier-Perez M, Kerb L, Küpfer A, Tingueley D, Schöpf, J. Amitriptyline pharmacokinetics and clinical response. II. Metabolic polymorphism assessed by hydroxylation of debrisoquine and mephenytoin. Int Clin Psychopharmacol 1986: 1. 102-112.
    • (1986) Int Clin Psychopharmacol , vol.1 , pp. 102-112
    • Baumann, P.1    Jonzier-Perez, M.2    Kerb, L.3    Küpfer, A.4    Tingueley, D.5    Schöpf, J.6
  • 6
    • 0242668517 scopus 로고
    • Human anti-endoplasmic reticulum autoantibodies appearing in a drug-induced hepatitis are directed against a human liver cytochrome P-450 that hydroxylates the drug
    • Beaune P, Dansette PM, Mansuy D, Kiffel L, Finck M, Amar C, Leroux JP, Homberg JC. Human anti-endoplasmic reticulum autoantibodies appearing in a drug-induced hepatitis are directed against a human liver cytochrome P-450 that hydroxylates the drug. Proc Natl Acad Sci USA 1987: 84, 551-555.
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 551-555
    • Beaune, P.1    Dansette, P.M.2    Mansuy, D.3    Kiffel, L.4    Finck, M.5    Amar, C.6    Leroux, J.P.7    Homberg, J.C.8
  • 8
    • 0027208084 scopus 로고
    • Why are diazepam metabolism and polymorphic S-mephenytoin hydroxylation associated with each other in white and Korean populations but not in Chinese populations
    • Bertilsson L, Kalow W. Why are diazepam metabolism and polymorphic S-mephenytoin hydroxylation associated with each other in white and Korean populations but not in Chinese populations. Clin Pharmacol Ther 1993: 53, 608-610.
    • (1993) Clin Pharmacol Ther , vol.53 , pp. 608-610
    • Bertilsson, L.1    Kalow, W.2
  • 9
    • 0024580554 scopus 로고
    • Importance of genetic factors in the regulation of diazepam metabolism: Relationship to S-mephenytoin but not debrisoquine hydroxylation phenotype
    • Bertilsson L, Henthorn TK, Sanz F, Tybring G, Säwe J, Villen T. Importance of genetic factors in the regulation of diazepam metabolism: relationship to S-mephenytoin but not debrisoquine hydroxylation phenotype. Clin Pharmacol Ther 1989: 45, 348-355.
    • (1989) Clin Pharmacol Ther , vol.45 , pp. 348-355
    • Bertilsson, L.1    Henthorn, T.K.2    Sanz, F.3    Tybring, G.4    Säwe, J.5    Villen, T.6
  • 10
    • 0026586613 scopus 로고
    • Human hepatic microsomal metabolism of A'-tetrahydrocannabinol
    • Bornheim LM, Lasker JM, Raucy JL. Human hepatic microsomal metabolism of A'-tetrahydrocannabinol. Drug Metab Dispos 1992: 20, 241-246.
    • (1992) Drug Metab Dispos , vol.20 , pp. 241-246
    • Bornheim, L.M.1    Lasker, J.M.2    Raucy, J.L.3
  • 11
    • 0027272518 scopus 로고
    • Proguanil metabolism is determined by the mephenytoin oxidation polymorphism in Vietnamese living in Denmark
    • Brosen K, Skjelbo E, Flachs H. Proguanil metabolism is determined by the mephenytoin oxidation polymorphism in Vietnamese living in Denmark. Br J Clin Pharmacol 1993: 36, 105-108.
    • (1993) Br J Clin Pharmacol , vol.36 , pp. 105-108
    • Brosen, K.1    Skjelbo, E.2    Flachs, H.3
  • 12
    • 0024354143 scopus 로고
    • Expression of a human liver cytochrome P-450 protein with tolbutamide hydroxylase activity in Saccharomyces cerevisiae
    • Brian WR, Srivastava PK, Umbenhauer DR, Lloyd RS, Guengerich FP. Expression of a human liver cytochrome P-450 protein with tolbutamide hydroxylase activity in Saccharomyces cerevisiae. Biochemistry 1989: 28, 4993-4999.
    • (1989) Biochemistry , vol.28 , pp. 4993-4999
    • Brian, W.R.1    Srivastava, P.K.2    Umbenhauer, D.R.3    Lloyd, R.S.4    Guengerich, F.P.5
  • 13
    • 0027514164 scopus 로고
    • Hepatic microsomal tolbutamide hydroxylation in Japanese: In vitro evidence for rapid and slow metabolizers
    • Chen L-S, Yasumori T, Yamazoe Y, Kato R. Hepatic microsomal tolbutamide hydroxylation in Japanese: in vitro evidence for rapid and slow metabolizers. Pharmacogenetics 1993: 3, 77-85.
    • (1993) Pharmacogenetics , vol.3 , pp. 77-85
    • Chen, L.-S.1    Yasumori, T.2    Yamazoe, Y.3    Kato, R.4
  • 14
    • 0028029165 scopus 로고
    • A transcriptional regulatory element common to a large family of hepatic cytochrome P450 genes is a functional binding site of the orphan receptor HNF-4
    • Chen D, Lepar G, Kemper B. A transcriptional regulatory element common to a large family of hepatic cytochrome P450 genes is a functional binding site of the orphan receptor HNF-4. J Biol Chem 1994: 269. 5420-5427.
    • (1994) J Biol Chem , vol.269 , pp. 5420-5427
    • Chen, D.1    Lepar, G.2    Kemper, B.3
  • 15
    • 0028214359 scopus 로고
    • The role of S-mephenytoin 4'-hydroxylase in imipramine metabolism by human liver microsomes: A two-enzyme kinetic analysis of N-demethylation and 2-hydroxylation
    • Chiba K, Saitoh A, Koyama F, Tani M, Hayashi M, Ishizaki T. The role of S-mephenytoin 4'-hydroxylase in imipramine metabolism by human liver microsomes: a two-enzyme kinetic analysis of N-demethylation and 2-hydroxylation. Br J Clin Pharmacol 1994: 37, 237-242.
    • (1994) Br J Clin Pharmacol , vol.37 , pp. 237-242
    • Chiba, K.1    Saitoh, A.2    Koyama, F.3    Tani, M.4    Hayashi, M.5    Ishizaki, T.6
  • 19
    • 0025344378 scopus 로고
    • Cytochrome P450 isozymes, epoxide hydrolase and glutathione transferases in rat and human hepatic and extrahepatic tissues
    • de Waziers I, Cugnenc PH, Leroux J-P, Beaune PH. Cytochrome P450 isozymes, epoxide hydrolase and glutathione transferases in rat and human hepatic and extrahepatic tissues. J Pharmacol Exp Ther 1990: 253, 387-393.
    • (1990) J Pharmacol Exp Ther , vol.253 , pp. 387-393
    • De Waziers, I.1    Cugnenc, P.H.2    Leroux, J.-P.3    Beaune, P.H.4
  • 20
    • 0020493643 scopus 로고
    • Identification of rabbit microsomal cytochrome P-450 isozyme, form 1, as a hepatic progesterone 21-hydroxylase
    • Dieter HH, Müller-Eberhard U, Johnson EF. Identification of rabbit microsomal cytochrome P-450 isozyme, form 1, as a hepatic progesterone 21-hydroxylase. Biochem Biophys Res Commun 1982: 105, 515.
    • (1982) Biochem Biophys Res Commun , vol.105 , pp. 515
    • Dieter, H.H.1    Müller-Eberhard, U.2    Johnson, E.F.3
  • 22
    • 0026582038 scopus 로고
    • Relation between chloroguanide bioactivation to cycloguanil and the genetically determined metabolism of mephenytoin in humans
    • Funck-Brentano C, Bosco O, Jacqz-Aigrain E, Keundjian A, Jaillon P. Relation between chloroguanide bioactivation to cycloguanil and the genetically determined metabolism of mephenytoin in humans. Clin Pharmacol Ther 1992: 51, 507-512.
    • (1992) Clin Pharmacol Ther , vol.51 , pp. 507-512
    • Funck-Brentano, C.1    Bosco, O.2    Jacqz-Aigrain, E.3    Keundjian, A.4    Jaillon, P.5
  • 23
    • 0025948746 scopus 로고
    • Polymerase chain reaction-directed identification cloning and quantification of human CYP2C18 mRNA
    • Furuya H, Meyer UA, Gelboin HV, Gonzalez FJ. Polymerase chain reaction-directed identification cloning and quantification of human CYP2C18 mRNA. Mol Pharmacol 1991: 40, 375-382.
    • (1991) Mol Pharmacol , vol.40 , pp. 375-382
    • Furuya, H.1    Meyer, U.A.2    Gelboin, H.V.3    Gonzalez, F.J.4
  • 24
    • 0027468338 scopus 로고
    • Human-liver cytochromes P-450 expressed in yeast as tools for reactive-metabolite formation studies. Oxidative activation of tienilic acid by cytochromes P-4502C9 and 2C10
    • Garcia MPL, Dansette PM, Valadon P, Amar C, Beaune P. Guengerich FP, Mansuy D. Human-liver cytochromes P-450 expressed in yeast as tools for reactive-metabolite formation studies. Oxidative activation of tienilic acid by cytochromes P-4502C9 and 2C10. Eur J Biochem 1993: 213, 223-232.
    • (1993) Eur J Biochem , vol.213 , pp. 223-232
    • Garcia, M.1    Dansette, P.M.2    Valadon, P.3    Amar, C.4    Beaune, P.5    Guengerich, F.P.6    Mansuy, D.7
  • 25
    • 0025971582 scopus 로고
    • Isolation of the human cytochrome P-450 UC8 gene: Multiple glucocorticoid responsive elements in the 5'-region
    • Ged C, Beaune, P. Isolation of the human cytochrome P-450 UC8 gene: multiple glucocorticoid responsive elements in the 5'-region. Biochim Biophys Acta 1991: 1088, 433-435.
    • (1991) Biochim Biophys Acta , vol.1088 , pp. 433-435
    • Ged, C.1    Beaune, P.2
  • 26
    • 0026878914 scopus 로고
    • Partial sequence and polymerase chain reactionmediated analysis of expression of the human CYP2C18 gene
    • Ged C, Beaune, P. Partial sequence and polymerase chain reactionmediated analysis of expression of the human CYP2C18 gene. Pharmacogenetics 1992: 2, 109-113.
    • (1992) Pharmacogenetics , vol.2 , pp. 109-113
    • Ged, C.1    Beaune, P.2
  • 27
  • 29
    • 0017641799 scopus 로고
    • Plasma level monitoring of tricyclic antidepressant therapy
    • Gram IT. Plasma level monitoring of tricyclic antidepressant therapy. Clin Pharmacokinet 1977: 2, 237-251.
    • (1977) Clin Pharmacokinet , vol.2 , pp. 237-251
    • Gram, I.T.1
  • 30
    • 0022916809 scopus 로고
    • Mephenytoin-type polymorphism of drug oxidation: Purification and characterization of a human liver cytochrome P-450 isozyme catalyzing microsomal mephenytoin hydroxylation
    • Gut J, Meier UT, Catin T, Meyer UA. Mephenytoin-type polymorphism of drug oxidation: purification and characterization of a human liver cytochrome P-450 isozyme catalyzing microsomal mephenytoin hydroxylation. Biochem Biophys Acta 1986: 884, 435-447.
    • (1986) Biochem Biophys Acta , vol.884 , pp. 435-447
    • Gut, J.1    Meier, U.T.2    Catin, T.3    Meyer, U.A.4
  • 31
    • 0023261541 scopus 로고
    • Kinetics of hexobarbital and dipyrone in critical care patients receiving high-dose pentobarbital
    • Heinemeyer G, Gramm HJ, Simgen W, Denhardt R, Roots I. Kinetics of hexobarbital and dipyrone in critical care patients receiving high-dose pentobarbital. Eur J Clin Pharmacol 1987: 32, 273-277.
    • (1987) Eur J Clin Pharmacol , vol.32 , pp. 273-277
    • Heinemeyer, G.1    Gramm, H.J.2    Simgen, W.3    Denhardt, R.4    Roots, I.5
  • 32
    • 0027267722 scopus 로고
    • Thijssen HHW. Human liver microsomal metabolism of the enantiomers of warfarin and acenocoumarol: P450 isozyme diversity determines the differences in their pharmacokinetics
    • Hermans JJR, Thijssen HHW. Human liver microsomal metabolism of the enantiomers of warfarin and acenocoumarol: P450 isozyme diversity determines the differences in their pharmacokinetics. Br I Pharmacol 1993: 100, 482-490.
    • (1993) Br I Pharmacol , vol.100 , pp. 482-490
    • Hermans, J.1
  • 33
    • 0022503196 scopus 로고
    • Family studies of mephenytoin hydroxylation deficiency
    • Inaba T, Jurima M, Kalow, W. Family studies of mephenytoin hydroxylation deficiency. Am J Hum Genet 1986: 38, 768-772.
    • (1986) Am J Hum Genet , vol.38 , pp. 768-772
    • Inaba, T.1    Jurima, M.2    Kalow, W.3
  • 34
    • 0025266722 scopus 로고
    • Phenytoin: Pharmacogenetic polymorphism of 4’-hydroxylation
    • Inaba T. Phenytoin: Pharmacogenetic polymorphism of 4’-hydroxylation. Pharmacol Tiler 1990: 46, 341-347.
    • (1990) Pharmacol Tiler , vol.46 , pp. 341-347
    • Inaba, T.1
  • 35
    • 0021895443 scopus 로고
    • The interaction of cytochrome b5 with four cytochrome P-450 enzymes from the untreated rat
    • Jansson I, Tamburini PP, Favreau LV, Schenkman JB. The interaction of cytochrome b5 with four cytochrome P-450 enzymes from the untreated rat. Drug Metab Dispos 1985: 13, 453-458.
    • (1985) Drug Metab Dispos , vol.13 , pp. 453-458
    • Jansson, I.1    Tamburini, P.P.2    Favreau, L.V.3    Schenkman, J.B.4
  • 36
    • 0023461586 scopus 로고
    • Inverse relationship between cytochrome P-450 phosphorylation and complexation with cytochrome b5
    • Jansson I, Kpstein PM, Bains S, Schenkman JB. Inverse relationship between cytochrome P-450 phosphorylation and complexation with cytochrome b5. Arch Biochem Biophgs 1987: 259. 441-448.
    • (1987) Arch Biochem Biophgs , vol.259 , pp. 441-448
    • Jansson, I.1    Kpstein, P.M.2    Bains, S.3    Schenkman, J.B.4
  • 37
    • 0027452620 scopus 로고
    • Correlation of human P4502C substrate specificities with primary structure-warfarin as a probe
    • Kaminsky I.S, de Morais SMF, Faletto MB, Dunbar D, Goldstein JA. Correlation of human P4502C substrate specificities with primary structure-warfarin as a probe. Mol Pharmacol 1993: 43, 234-239.
    • (1993) Mol Pharmacol , vol.43 , pp. 234-239
    • Kaminsky, I.S.1    De Morais, S.2    Faletto, M.B.3    Dunbar, D.4    Goldstein, J.A.5
  • 38
    • 0023650353 scopus 로고
    • CDNA and amino acid sequences of two members of the human P450I1C gene subfamily
    • Kimura S, Pastewka J, Gelboin HV, Gonzalez FJ. cDNA and amino acid sequences of two members of the human P450I1C gene subfamily. Nucleic Acids Res 1987: 15, 10053-10054.
    • (1987) Nucleic Acids Res , vol.15 , pp. 10053-10054
    • Kimura, S.1    Pastewka, J.2    Gelboin, H.V.3    Gonzalez, F.J.4
  • 39
    • 0023355128 scopus 로고
    • Hepatic metabolism of tolbutamide: Characterization of the form of cytochrome P-450 involved in methyl hydroxylation and relationship to in vivo disposition
    • Knodell RG, Hall SD, Wilkinson GR, Guengerich FP. Hepatic metabolism of tolbutamide: characterization of the form of cytochrome P-450 involved in methyl hydroxylation and relationship to in vivo disposition. J Pharmacol Exp Titer 1987: 241, 1112-1119.
    • (1987) J Pharmacol Exp Titer , vol.241 , pp. 1112-1119
    • Knodell, R.G.1    Hall, S.D.2    Wilkinson, G.R.3    Guengerich, F.P.4
  • 40
    • 0023928098 scopus 로고
    • Oxidative metabolism of hexobarbital in human liver: Relationship to polymorphic S-mephenytoin 4'-hydroxylation
    • Knodell RG, Dubey RK, Wilkinson GR, Guengerich FP. Oxidative metabolism of hexobarbital in human liver: relationship to polymorphic S-mephenytoin 4'-hydroxylation. J Pharmacol Exp Ther 1988: 245, 845-849.
    • (1988) J Pharmacol Exp Ther , vol.245 , pp. 845-849
    • Knodell, R.G.1    Dubey, R.K.2    Wilkinson, G.R.3    Guengerich, F.P.4
  • 41
    • 0021237993 scopus 로고
    • Pharmacogenetics of mephenytoin: A new drug hydroxylation polymorphism in man
    • Küpfer A, Preisig R. Pharmacogenetics of mephenytoin: a new drug hydroxylation polymorphism in man. Eur J Clin Pharmacol 1984: 26, 753-759.
    • (1984) Eur J Clin Pharmacol , vol.26 , pp. 753-759
    • Küpfer, A.1    Preisig, R.2
  • 42
    • 0022212549 scopus 로고
    • Stereoselective mephobarbital hydroxylation cosegregates with mephenytoin hydroxylation
    • Küpfer A, Branch RA. Stereoselective mephobarbital hydroxylation cosegregates with mephenytoin hydroxylation. Clin Pharmacol Ther 1985: 38. 414-418.
    • (1985) Clin Pharmacol Ther , vol.38 , pp. 414-418
    • Küpfer, A.1    Branch, R.A.2
  • 43
    • 0000966446 scopus 로고
    • Insufficient parahydroxylation as the cause of diphenylhydantoin toxicity
    • Kutt H, Wolk M, Scherman R, McDowell F. Insufficient parahydroxylation as the cause of diphenylhydantoin toxicity. Neurology 1964: 14, 542-548.
    • (1964) Neurology , vol.14 , pp. 542-548
    • Kutt, H.1    Wolk, M.2    Scherman, R.3    McDowell, F.4
  • 44
    • 0027739383 scopus 로고
    • A major role for cytochrome P450TB (CYP2C subfamily) in the actions of non-steroidal antiinflammatory drugs
    • Leemann TD, Transon C, Bonnabry P, Dayer P. A major role for cytochrome P450TB (CYP2C subfamily) in the actions of non-steroidal antiinflammatory drugs. Drugs Exp Clin Res 1993a: 19, 189-195.
    • (1993) Drugs Exp Clin Res , vol.19 , pp. 189-195
    • Leemann, T.D.1    Transon, C.2    Bonnabry, P.3    Dayer, P.4
  • 45
    • 0027264432 scopus 로고
    • Cytochrome P450TB (CYP2C): A major monooxygenase catalyzing diclofenac 4'-hydroxylation in human liver
    • Leeman T, Transon C, Dayer P. Cytochrome P450TB (CYP2C): A major monooxygenase catalyzing diclofenac 4'-hydroxylation in human liver. Life Sci 1993b: 52. 29-34.
    • (1993) Life Sci , vol.52 , pp. 29-34
    • Leeman, T.1    Transon, C.2    Dayer, P.3
  • 49
    • 0024976419 scopus 로고
    • Alteration of mouse cytochrome P450coh substrate specificity by mutation of a single aminoacid residue
    • Lindberg RLP, Negishi M. Alteration of mouse cytochrome P450coh substrate specificity by mutation of a single aminoacid residue. Nature 1989: 339, 632-634.
    • (1989) Nature , vol.339 , pp. 632-634
    • Lindberg, R.1    Negishi, M.2
  • 52
    • 0022253112 scopus 로고
    • The site of cyclic AMP-dependent protein kinase catalyzed phosphorylation of cytochrome P-450 LM2
    • Muller R, Schmidt WK, Stier A. The site of cyclic AMP-dependent protein kinase catalyzed phosphorylation of cytochrome P-450 LM2. FEBS Lett 1985: 187, 21-24.
    • (1985) FEBS Lett , vol.187 , pp. 21-24
    • Muller, R.1    Schmidt, W.K.2    Stier, A.3
  • 53
    • 0022178173 scopus 로고
    • Interethnic differences in genetic polymorphism of debrisoquine and mephenytoin hydroxylation between Japanese and Caucasian populations
    • Nakamura K, Goto F, Ray WA, McAllister GB, Jacqz K, Wilkinson GR. Interethnic differences in genetic polymorphism of debrisoquine and mephenytoin hydroxylation between Japanese and Caucasian populations. Clin Pharmacol Ther 1985: 38, 402-408.
    • (1985) Clin Pharmacol Ther , vol.38 , pp. 402-408
    • Nakamura, K.1    Goto, F.2    Ray, W.A.3    McAllister, G.B.4    Jacqz, K.5    Wilkinson, G.R.6
  • 56
    • 0025014594 scopus 로고
    • Tolbutamide and mephenytoin hydroxylation by human cytochrome P450s in the CYP2C subfamily
    • Relling MV, Aoyama T, Gonzalez FJ, Meyer UA. Tolbutamide and mephenytoin hydroxylation by human cytochrome P450s in the CYP2C subfamily. J Pharmacol Exp Ther 1990: 252, 442-447.
    • (1990) J Pharmacol Exp Ther , vol.252 , pp. 442-447
    • Relling, M.V.1    Aoyama, T.2    Gonzalez, F.J.3    Meyer, U.A.4
  • 59
    • 0025763625 scopus 로고
    • Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily
    • Romkes M, Faletto MB, Blaisdell JA, Raucy JL, Goldstein JA. Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily. Biochemistry 1991: 30, 3247-3255.
    • (1991) Biochemistry , vol.30 , pp. 3247-3255
    • Romkes, M.1    Faletto, M.B.2    Blaisdell, J.A.3    Raucy, J.L.4    Goldstein, J.A.5
  • 61
    • 0018395301 scopus 로고
    • Pharmacogenetics of tolbutamide metabolism in humans
    • Scott J, Poffenbarger PL. Pharmacogenetics of tolbutamide metabolism in humans. Diabetes 1979: 28, 41-51.
    • (1979) Diabetes , vol.28 , pp. 41-51
    • Scott, J.1    Poffenbarger, P.L.2
  • 62
    • 0027406781 scopus 로고
    • Inhibition by barbiturates of the binding of the Bm3Rl repressor to its operator site on the barbiturate-inducible cytochrome P4 50BM3 gene of Bacillus megaterium
    • Shaw G-C, Fulco A. Inhibition by barbiturates of the binding of the Bm3Rl repressor to its operator site on the barbiturate-inducible cytochrome P4 50BM3 gene of Bacillus megaterium. J Biol Client 1993: 268, 2997-3004.
    • (1993) J Biol Client , vol.268 , pp. 2997-3004
    • Shaw, G.-C.1    Fulco, A.2
  • 63
    • 0022574425 scopus 로고
    • Human liver microsomal cytochrome P-450 mephenytoin 4-hydroxylase, a prototype of genetic polymorphism in oxidative drug metabolism: Purification and characterization of two similar forms involved in the reaction
    • Shimada T, Misono KS, Guengerich FP. Human liver microsomal cytochrome P-450 mephenytoin 4-hydroxylase, a prototype of genetic polymorphism in oxidative drug metabolism: purification and characterization of two similar forms involved in the reaction. J Biol Chem 1986: 261, 909-921.
    • (1986) J Biol Chem , vol.261 , pp. 909-921
    • Shimada, T.1    Misono, K.S.2    Guengerich, F.P.3
  • 64
    • 0027472058 scopus 로고
    • Pharmacokinetics of citalopram in relation to the sparteine and the mephenytoin oxidation polymorphisms
    • Sindrup SH, Brosen K, Hansen MGJ, Aaes-Jorgensen T, Overo KF, Gram LF. Pharmacokinetics of citalopram in relation to the sparteine and the mephenytoin oxidation polymorphisms. Ther Drug Monit 1993: 13. 11-17.
    • (1993) Ther Drug Monit , vol.13 , pp. 11-17
    • Sindrup, S.H.1    Brosen, K.2    Hansen, M.3    Aaes-Jorgensen, T.4    Overo, K.F.5    Gram, L.F.6
  • 65
    • 0025964524 scopus 로고
    • The mephenytoin oxidation polymorphism is partially responsible for the Ndemethylation of imipramine
    • Skjelbo R, Brosen K, Hallas J, Gram LF. The mephenytoin oxidation polymorphism is partially responsible for the Ndemethylation of imipramine. Clin Pharmacol Ther 1991: 49, 18-23.
    • (1991) Clin Pharmacol Ther , vol.49 , pp. 18-23
    • Skjelbo, R.1    Brosen, K.2    Hallas, J.3    Gram, L.F.4
  • 66
    • 0027389155 scopus 로고
    • The N-demethylation of imipramine correlates with the oxidation of S-mephenytoin (S/R ratio). A population study
    • Skjelbo E, Gram LF, Brosen K. The N-demethylation of imipramine correlates with the oxidation of S-mephenytoin (S/R ratio). A population study. Br J Clin Pharmacol 1993: 35. 331-334.
    • (1993) Br J Clin Pharmacol , vol.35 , pp. 331-334
    • Skjelbo, E.1    Gram, L.F.2    Brosen, K.3
  • 67
    • 0025690311 scopus 로고
    • Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily
    • Sladek FM, Zhong W, Lai E, Darnell JE Jr. Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily. Genes Dev 1990: 4, 2353-2565.
    • (1990) Genes Dev , vol.4 , pp. 2353-2565
    • Sladek, F.M.1    Zhong, W.2    Lai, E.3    Darnell, J.E.4
  • 68
    • 0026806412 scopus 로고
    • Disposition kinetics and metabolism of omeprazole in extensive and poor metabolizers of S-mephenytoin 4'-hydroxylation recruited from an oriental population
    • Sohn D-R, Kobayashi K, Chiba K, Lee K-H, Shin S-G, Ishizaki T. Disposition kinetics and metabolism of omeprazole in extensive and poor metabolizers of S-mephenytoin 4'-hydroxylation recruited from an oriental population. J Phtmtacol Exp Ther 1992a: 262, 1195-1202.
    • (1992) J Phtmtacol Exp Ther , vol.262 , pp. 1195-1202
    • Sohn, D.-R.1    Kobayashi, K.2    Chiba, K.3    Lee, K.-H.4    Shin, S.-G.5    Ishizaki, T.6
  • 69
    • 0026705708 scopus 로고
    • Incidence of S-mephenytoin hydroxylation deficiency in a Korean population and the interphenotypic differences in diazepam pharmacokinetics
    • Sohn D-R, Kusaka M, Ishizaki T, Shin S-G, Jang I-J, Chiba K. Incidence of S-mephenytoin hydroxylation deficiency in a Korean population and the interphenotypic differences in diazepam pharmacokinetics. Clin Pharmacol Ther 1992b: 52, 160-169.
    • (1992) Clin Pharmacol Ther , vol.52 , pp. 160-169
    • Sohn, D.-R.1    Kusaka, M.2    Ishizaki, T.3    Shin, S.-G.4    Jang, I.-J.5    Chiba, K.6
  • 70
    • 0025916087 scopus 로고
    • Separation of human liver microsomal tolbutamide hydroxylase and (S)-mephenytoin 4'-hydroxylase cytochrome P-450 enzymes
    • Srivastava PK, Yun C-H, Beaune PH, Ged C, Guengerich FP. Separation of human liver microsomal tolbutamide hydroxylase and (S)-mephenytoin 4'-hydroxylase cytochrome P-450 enzymes. Mol Pharmacol 1991: 40, 69-79.
    • (1991) Mol Pharmacol , vol.40 , pp. 69-79
    • Srivastava, P.K.1    Yun, C.-H.2    Beaune, P.H.3    Ged, C.4    Guengerich, F.P.5
  • 71
    • 0021962433 scopus 로고
    • Chemical characterization of protein-protein interactions between cytochrome P-450 and cytochrome b5
    • Tamburini PP, White RH, Schenkman JB. Chemical characterization of protein-protein interactions between cytochrome P-450 and cytochrome b5. J Biol Client 1985: 260, 4007-4015.
    • (1985) J Biol Client , vol.260 , pp. 4007-4015
    • Tamburini, P.P.1    White, R.H.2    Schenkman, J.B.3
  • 72
    • 0023121619 scopus 로고
    • Cloning and sequence determination of a complementary DNA related to human liver microsomal cytochrome P-450 S-mephenytoin 4'-hydroxylase
    • Umbenhauer DR, Martin MV, Floyd RS, Guengerich FP. Cloning and sequence determination of a complementary DNA related to human liver microsomal cytochrome P-450 S-mephenytoin 4'-hydroxylase. Biochemistry 1987: 26, 1094-1099.
    • (1987) Biochemistry , vol.26 , pp. 1094-1099
    • Umbenhauer, D.R.1    Martin, M.V.2    Floyd, R.S.3    Guengerich, F.P.4
  • 73
    • 0018853387 scopus 로고
    • Inheritance of phenytoin hypometabolism: A kinetic study of one family
    • Vasko MR, Bell RD, Daly DD, Pippenger CE. Inheritance of phenytoin hypometabolism: a kinetic study of one family. Clin Pharmacol Ther 1980: 27, 96-103.
    • (1980) Clin Pharmacol Ther , vol.27 , pp. 96-103
    • Vasko, M.R.1    Bell, R.D.2    Daly, D.D.3    Pippenger, C.E.4
  • 74
    • 0026786805 scopus 로고
    • Transcriptional regulatory elements for basal expression of cytochrome P450IIC genes
    • Venepally P, Chen D, Kemper B. Transcriptional regulatory elements for basal expression of cytochrome P450IIC genes. J Biol Client 1992: 267, 17333-17338.
    • (1992) J Biol Client , vol.267 , pp. 17333-17338
    • Venepally, P.1    Chen, D.2    Kemper, B.3
  • 77
    • 0027529381 scopus 로고
    • Tolbutamide hydroxylation in humans: Lack of bimodality in 106 healthy subjects
    • Veronese ME, Miners JO, Rees DTP, Birkett DJ. Tolbutamide hydroxylation in humans: lack of bimodality in 106 healthy subjects. Pharmacoyenetics 1993a: 3, 86-93.
    • (1993) Pharmacoyenetics , vol.3 , pp. 86-93
    • Veronese, M.E.1    Miners, J.O.2    Rees, D.3    Birkett, D.J.4
  • 79
    • 0018877218 scopus 로고
    • Purification of human liver cytochrome P-450 and comparison to the enzyme isolated from rat liver
    • Wang P, Mason PS, Guengerich FP. Purification of human liver cytochrome P-450 and comparison to the enzyme isolated from rat liver. Arch Biochem Biophys 1980: 199. 206-219.
    • (1980) Arch Biochem Biophys , vol.199 , pp. 206-219
    • Wang, P.1    Mason, P.S.2    Guengerich, F.P.3
  • 82
    • 0024534047 scopus 로고
    • Propranolol's metabolism is determined by both mephenytoin and debrisoquin hydroxylase activities
    • Ward SA, Walle T, Walle UK, Wilkinson GR, Branch RA. Propranolol's metabolism is determined by both mephenytoin and debrisoquin hydroxylase activities. Clin Pharmacol Ther 1989a: 45, 72-79.
    • (1989) Clin Pharmacol Ther , vol.45 , pp. 72-79
    • Ward, S.A.1    Walle, T.2    Walle, U.K.3    Wilkinson, G.R.4    Branch, R.A.5
  • 84
    • 0025735576 scopus 로고
    • The activation of the biguanide antimalarial proguanil co-segregates with the mephenytoin oxidation polymorphism a panel study
    • Ward SA, Helsby NA, Skjelbo E, Brosen K. Gram EF, Breckenridge AM. The activation of the biguanide antimalarial proguanil co-segregates with the mephenytoin oxidation polymorphism a panel study. Br J Clin Pharmacol 1991: 31, 639-692.
    • (1991) Br J Clin Pharmacol , vol.31 , pp. 639-692
    • Ward, S.A.1    Helsby, N.A.2    Skjelbo, E.3    Brosen, K.4    Gram, E.F.5    Breckenridge, A.M.6
  • 86
    • 0021684926 scopus 로고
    • Mephenytoin hydroxylation deficiency in Caucasians: Frequency of a new oxidative drug metabolism polymorphism
    • Wedlund PJ, Aslanian WS, McAllister CB, Wilkinson GR, Branch RA. Mephenytoin hydroxylation deficiency in Caucasians: Frequency of a new oxidative drug metabolism polymorphism. Clin Pharmacol Ther 1984: 36, 773-780.
    • (1984) Clin Pharmacol Ther , vol.36 , pp. 773-780
    • Wedlund, P.J.1    Aslanian, W.S.2    McAllister, C.B.3    Wilkinson, G.R.4    Branch, R.A.5
  • 88
    • 0023574855 scopus 로고
    • Purification of a human liver cytochrome P-450 immunochemically related to several cytochromes P-450 purified from untreated rats
    • Wrighton SA, Thomas PE, Willis P, Maines SE, Watkins PB, Eevin W, Guzelian PS. Purification of a human liver cytochrome P-450 immunochemically related to several cytochromes P-450 purified from untreated rats. J Clin Invest 1987: 80, 1017.
    • (1987) J Clin Invest , vol.80 , pp. 1017
    • Wrighton, S.A.1    Thomas, P.E.2    Willis, P.3    Maines, S.E.4    Watkins, P.B.5    Eevin, W.6    Guzelian, P.S.7
  • 89
    • 0027445449 scopus 로고
    • Isolation and characterization of human liver cytochrome P450 2C19: Correlation between 2C19 and S-mephenytoin 4'-hydroxylation
    • Wrighton SA, Stevens JC, Becker GW, Van den Branden M. Isolation and characterization of human liver cytochrome P450 2C19: Correlation between 2C19 and S-mephenytoin 4'-hydroxylation. Arch Biochem Biophys 1993: 306, 240-245.
    • (1993) Arch Biochem Biophys , vol.306 , pp. 240-245
    • Wrighton, S.A.1    Stevens, J.C.2    Becker, G.W.3    Van Den Branden, M.4
  • 90
    • 0026736112 scopus 로고
    • Role of the liver-enriched transcription factor DBP in expression of the cytochrome P450 CYP2C6 gene
    • Yano M, Falvey E, Gonzalez FJ. Role of the liver-enriched transcription factor DBP in expression of the cytochrome P450 CYP2C6 gene. Mol Cell Biol 1992: 12, 2847-2854.
    • (1992) Mol Cell Biol , vol.12 , pp. 2847-2854
    • Yano, M.1    Falvey, E.2    Gonzalez, F.J.3
  • 91
    • 0023443243 scopus 로고
    • Nucleotide sequence of a human liver cytochrome P-450 related to the rat male specific form
    • Yasumori TS, Kawano K, Nagata M, Shimada Y, Yamazoe Y, Kato R. Nucleotide sequence of a human liver cytochrome P-450 related to the rat male specific form. J Biochem (Tokyo) 1987: 102, 1075-1082.
    • (1987) J Biochem (Tokyo) , vol.102 , pp. 1075-1082
    • Yasumori, T.S.1    Kawano, K.2    Nagata, M.3    Shimada, Y.4    Yamazoe, Y.5    Kato, R.6
  • 92
    • 0025253095 scopus 로고
    • Polymorphism in hydroxylation of mephenytoin and hexobarbital stereoisomers in relation to hepatic P-450 human 2
    • Yasumori T, Murayama N, Yamazoe Y, Kato R. Polymorphism in hydroxylation of mephenytoin and hexobarbital stereoisomers in relation to hepatic P-450 human 2. Clin Pharmacol Ther 1990: 47, 313-322.
    • (1990) Clin Pharmacol Ther , vol.47 , pp. 313-322
    • Yasumori, T.1    Murayama, N.2    Yamazoe, Y.3    Kato, R.4
  • 93
    • 0025761936 scopus 로고
    • Cytochrome P-450 human-2 (P-4501IC9) in mephenytoin hydroxylation polymorphism in human livers: Differences in substrate and stereoselectivities among microheterogeneous P-450IIC species expressed in yeasts
    • Yasumori T, Yamazoe Y, Kato R. Cytochrome P-450 human-2 (P-4501IC9) in mephenytoin hydroxylation polymorphism in human livers: differences in substrate and stereoselectivities among microheterogeneous P-450IIC species expressed in yeasts. J Biochem 1991: 109, 711-717.
    • (1991) J Biochem , vol.109 , pp. 711-717
    • Yasumori, T.1    Yamazoe, Y.2    Kato, R.3
  • 94
    • 0027744044 scopus 로고
    • Cytochrome P450 mediated metabolism of diazepam in human and rat: Involvement of human CYP2C in N-demethylation in the substrate concentration dependent manner
    • Yasumori T, Nagata K, Yang SK, Chen E-S, Murayama N, Yamazoe Y, Kato R. Cytochrome P450 mediated metabolism of diazepam in human and rat: involvement of human CYP2C in N-demethylation in the substrate concentration dependent manner. Pharmacoyenetics 1993: 3, 291-301.
    • (1993) Pharmacoyenetics , vol.3 , pp. 291-301
    • Yasumori, T.1    Nagata, K.2    Yang, S.K.3    Chen, E.-S.4    Murayama, N.5    Yamazoe, Y.6    Kato, R.7
  • 95
    • 0026633834 scopus 로고
    • Roles of human liver cytochrome P4502C and 3A enzymes in the 3-hydroxylation of benzo(A)pyrene
    • Yun C-H, Shimada T, Guengerich FP. Roles of human liver cytochrome P4502C and 3A enzymes in the 3-hydroxylation of benzo(a)pyrene. Cancer Res 1992: 52, 1868-1874.
    • (1992) Cancer Res , vol.52 , pp. 1868-1874
    • Yun, C.-H.1    Shimada, T.2    Guengerich, F.P.3
  • 96
    • 0025223056 scopus 로고
    • Diazepam metabolism in native Chinese poor and extensive hydroxylators of S-mephenytoin: Interethnic differences in comparison with white subjects
    • Zhang Y, Reviriego J, Eou VQ, Sjöqvist F, Bertilsson L. Diazepam metabolism in native Chinese poor and extensive hydroxylators of S-mephenytoin: interethnic differences in comparison with white subjects. Clin Pharmacol Ther 1990: 48, 496-502.
    • (1990) Clin Pharmacol Ther , vol.48 , pp. 496-502
    • Zhang, Y.1    Reviriego, J.2    Eou, V.Q.3    Sjöqvist, F.4    Bertilsson, L.5
  • 97
    • 0026696993 scopus 로고
    • In vitro oxidation of oxicam NSAIDS by a human liver cytochrome P450
    • Zhao J, Eeemann T, Dayer P. In vitro oxidation of oxicam NSAIDS by a human liver cytochrome P450. Life Sci 1992: 51, 575-581.
    • (1992) Life Sci , vol.51 , pp. 575-581
    • Zhao, J.1    Eeemann, T.2    Dayer, P.3
  • 98
    • 0025005022 scopus 로고
    • Induction of polymorphic 4'-hydroxylation of S-mephenytoin by rifampicin
    • Zhou HE, Anthony EB, Wood AJ, Wilkinson GR. Induction of polymorphic 4'-hydroxylation of S-mephenytoin by rifampicin. Br J Clin Pharmacol 1990: 30, 471-475.
    • (1990) Br J Clin Pharmacol , vol.30 , pp. 471-475
    • Zhou, H.E.1    Anthony, E.B.2    Wood, A.J.3    Wilkinson, G.R.4
  • 99
    • 0016758480 scopus 로고
    • Induction of drug metabolism in man after rifampicin treatment measured by increased hexobarbital and tolbutamide clearance
    • Zilly W, Breimer DD, Richter E. Induction of drug metabolism in man after rifampicin treatment measured by increased hexobarbital and tolbutamide clearance. Eur J Clin Pharmacol 1975: 9, 219-227.
    • (1975) Eur J Clin Pharmacol , vol.9 , pp. 219-227
    • Zilly, W.1    Breimer, D.D.2    Richter, E.3


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