Inhibition of Human Neutrophil Elastase with Peptidyl Electrophilic Ketones. 2. Orally Active PG-Val-Pro-Val Pentafluoroethyl Ketones

Journal of Medicinal Chemistry

Volumn 37, Issue 26, 1994, Pages 4538-4553

  Angelastro, Michael R ^a   Baugh, Larry E ^a   Bey, Philippe ^a   Burkhart, Joseph P ^a   Chen, Teng Man ^a   Durham, Sherrie L ^a   Hare, C Michelle ^a   Hube, Edward W ^a   Janusz, Michael J ^a   Koehl, Jack R ^a   Marquart, Angela L ^a   Mehdi, Shujaath ^a   Peet, Norton P ^a  

^a Merrell Dow Research Institute   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ELASTASE; KETONE; LEUKOCYTE ENZYME; MDL 101146; MDL 103139; MDL 103542; N [4 (MORPHOLINOCARBONYL)BENZOYL]VALYL N [3,3,4,4,4 PENTAFLUORO 1 ISOPROPYL 2 OXOBUTYL]PROLINAMIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIASTEREOISOMER; DRUG BIOAVAILABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; EXPERIMENTAL MODEL; HAMSTER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIPOPHILICITY; LUNG HEMORRHAGE; NEUTROPHIL; NONHUMAN; ORAL DRUG ADMINISTRATION; PHYSICAL PARAMETERS; RAT;

ADMINISTRATION, ORAL; AMINO ACID SEQUENCE; ANIMAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HAMSTERS; HEMORRHAGE; HUMAN; KETONES; LEUKOCYTE ELASTASE; MOLECULAR SEQUENCE DATA; PANCREATIC ELASTASE; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0028569229     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00052a013     Document Type: Article

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