The first highly potent and selective non-peptide neuropeptide Y Y1 receptor antagonist: BIBP3226

European Journal of Pharmacology

Volumn 271, Issue 2-3, 1994, Pages

  Rudolf, Klaus ^a   Eberlein, Wolfgang ^a   Engel, Wolfhard ^a   Wieland, Heike A ^a   Willim, Klaus D ^a   Entzeroth, Michael ^a   Wienen, Wolfgang ^a   Beck Sickinger, Annette G ^b   Doods, Henri N ^a  

^a BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

^b ETH ZURICH   (Switzerland)

Author keywords

BIBP3226; Neuropeptide Y; Neuropeptide Y Y1 receptor antagonist

Indexed keywords

ANGIOTENSIN; IODINE 125; NALPHA (DIPHENYLACETYL) N (4 HYDROXYBENZYL) DEXTRO ARGININAMIDE; NALPHA (DIPHENYLACETYL) N [(4 HYDROXYPHENYL)METHYL]ARGININAMIDE; NEUROPEPTIDE Y; NEUROPEPTIDE Y RECEPTOR; NEUROPEPTIDE Y RECEPTOR ANTAGONIST; NEUROPEPTIDE Y1 RECEPTOR; NEUROPEPTIDE Y1 RECEPTOR ANTAGONIST; NORADRENALIN; RECEPTOR BLOCKING AGENT; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING COMPETITION; BLOOD PRESSURE; BRAIN CORTEX; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; HUMAN; HUMAN CELL; INTRAVENOUS DRUG ADMINISTRATION; KIDNEY BLOOD FLOW; NEUROBLASTOMA CELL; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY;

ANIMAL; ARGININE; BLOOD PRESSURE; CALCIUM; PERFUSION; RATS; RECEPTORS, NEUROPEPTIDE Y;

EID: 0028564783     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(94)90822-2     Document Type: Article

References (8)

1. Structure/activity relationships of C-terminal neuropeptide Y peptide segments and analogues composed of sequence 1–4 linked to 25–36
2. Different NPY-receptor-subtypes in rat and rabbit vas deferens
3. The increase in renal perfusion pressure by neuropeptide Y is mediated via receptors on the Y1 subtype
4. Subtypes of receptors for neuropeptide Y: implications for the targeting of therapeutics
5. Neuropeptide Y:Y1 and Y2 affinities of the complete series of analogues with single D-residue-substitutions
6. 2+ mobilization by NPY
7. Further characterization of neuropeptide Y receptor subtypes using centrally truncated analogs of neuropeptide Y: evidence for subtype-differentiating effects on affinity and intrinsic efficacy
8. Identification of cultured cells selectively expressing Y1-, Y2-, or Y3-type receptors for neuropeptide Y/peptide YY