p53 immunohistochemical positivity as a prognostic marker in intracranial tumours

APMIS

Volumn 102, Issue 7-12, 1994, Pages 786-792

  SOINI, YLERMI ^a   NIEMELÄ, ASKO ^a   KAMEL, DIA ^a   HERVA, RIITTA ^a   BLOIGU, RISTO ^a   PÄÄKKÖ, PAAVO ^a   VÄHÄKANGAS, KIRSI ^a  

^a UNIVERSITY OF OULU   (Finland)

Author keywords

Brain; brain tumours; cytoplasmic p53 staining; immunocytochemistry; p53

Indexed keywords

PROTEIN P53;

AGE; ARTICLE; ASTROCYTOMA; CONTROLLED STUDY; EPENDYMOMA; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTRACRANIAL TUMOR; MAJOR CLINICAL STUDY; OLIGODENDROGLIOMA; PRIORITY JOURNAL; SURVIVAL;

ADULT; ASTROCYTOMA; BRAIN NEOPLASMS; GLIOMA; HUMAN; IMMUNOHISTOCHEMISTRY; PROGNOSIS; PROTEIN P53; SUPPORT, NON-U.S. GOV'T; SURVIVAL ANALYSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 0028555778     PISSN: 09034641     EISSN: 16000463     Source Type: Journal    
DOI: 10.1111/j.1699-0463.1994.tb05235.x     Document Type: Article

References (41)

1. Heterogeneity of subcellular localization of p53 protein in human glioblastomas
2. p53 protein expression in central nervous system neoplasms
3. Aberrant expression of the p53 oncoprotein is a common feature of a wide spectrum of human malignancies
4. p53 protein alterations in human testicular cancer including pre‐invasive intratubular germ‐cell neoplasia
5. Immunocytochemical detection of p53 in human gliomas
6. Involvement of multiple chromosome 17p loci in medulloblastoma tumorigenesis
7. Grading of astrocytomas. A simple and reproducible method
8. Expression of the p53 protein in a spectrum of astrocytic tumours
9. Wild‐type p53 activates transcription in vitro
10. Activating mutations for transformation by p53 produce a gene product that forms an hsc‐70‐p53 complex with an altered half‐life
11. p53 mutation and loss of heterozygosity on chromosomes 17 and 10 during human astrocytoma progression
12. Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specific for the mutant form
13. Interaction of heat‐shock protein 70 with p53 translated in vitro: evidence for interaction with dimeric p53 and for a role in the regulation of p53 conformation
14. p53 mutations in human cancers
15. Use of avidin‐biotin‐peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabelled antibody (PAP) procedures
16. Increased expression of mutant forms of p53 oncogene in primary lung cancer
17. Prognostic implications of p53 protein, epidermal growth factor receptor, and Ki‐67 labelling in brain tumours
18. p53, guardian of the genome
19. Comparative study of p53 gene and protein alterations in human astrocytic tumors
20. High frequency of p53 gene alterations associated with protein overexpression in human squamous cell carcinoma of the larynx
21. Detection of p53 gene mutations in human brain tumours by single‐strand conformation polymorphism analysis of polymerase chain reaction products
22. Expression of human p53 in bacteria: application to the analysis of p53 expression in human tumors
23. Human p53 gene localized to short arm of chromosome 17
24. Biochemical properties of the growth suppressor/oncoprotein p53
25. Mutations in the p53 gene occur in diverse human tumour types
26. p53 mutations in nonastrocytic human brain tumors
27. Amplification of a gene encoding a p53‐associated protein in human sarcomas
28. Specific interaction between the p53 cellular tumour antigen and major heat shock proteins
29. Alterations of the TP53 gene in human gliomas
30. p53 mutations in colorectal cancer
31. Infrequent p53 gene mutations in medulloblastomas
32. The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53
33. p53 expression in lymphatic malignancies
34. Comparative analysis of p53 protein immunoreactivity in prostatic, lung and breast carcinomas
35. p53 immunohistochemistry in malignant fibrous histiocytomas and other mesenchymal tumours
36. Prognostic significance of cytoplasmic p53 oncoprotein in colorectal adenocarcinoma
37. p53 protein expression in lymphomas and reactive lymphoid tissue
38. p53 function and dysfunction
39. P53 mutations are associated with 17p allelic loss in grade II and grade III astrocytoma
40. Mutations of p53 and ras in radon‐associated lung cancer from uranium miners