-
1
-
-
85022279551
-
A Program for the Evaluation of Metabolic Transformation of Chemicals
-
preceding paper in this issue
-
Klopman, G.; Dimayuga, M.; Talafous, J. META. 1. A Program for the Evaluation of Metabolic Transformation of Chemicals, preceding paper in this issue
-
META
, vol.1
-
-
Klopman, G.1
Dimayuga, M.2
Talafous, J.3
-
3
-
-
84988074876
-
Computer Simulation of Metabolic Transformation
-
Tinker, J. F.; Gelemter, H. Computer Simulation of Metabolic Transformation. J. Comput. Chem. 1986, 7, 657—665
-
(1986)
J. Comput. Chem.
, vol.7
, pp. 657-665
-
-
Tinker, J.F.1
Gelemter, H.2
-
4
-
-
0024027564
-
Predicting metabolic pathways by logic programming
-
Darvas, F. Predicting metabolic pathways by logic programming. J. Mol. Graphics 1988, 6, 80—86
-
(1988)
J. Mol. Graphics
, vol.6
, pp. 80-86
-
-
Darvas, F.1
-
5
-
-
0026201671
-
A graph-theoretic approach to modeling metabolic pathways
-
Gifford, E.; Johnson, M.; Tsai, C.-c. A graph-theoretic approach to modeling metabolic pathways. J. Comput. Aided Mol. Des. 1991, 5, 303-322
-
(1991)
J. Comput. Aided Mol. Des.
, vol.5
, pp. 303-322
-
-
Gifford, E.1
Johnson, M.2
Tsai, C.-C.3
-
8
-
-
0002701332
-
-
Eds.; American Chemical Society: Washington, DC
-
Xenobiotic Conjugation Chemistry; Paulson, G. D., Caldwell, J., Hutson, D., Menn, J. J., Eds.; American Chemical Society: Washington, DC, 1986; Vol. 299
-
(1986)
Xenobiotic Conjugation Chemistry
, pp. 299
-
-
Paulson, G.D.1
Caldwell, J.2
Hutson, D.3
Menn, J.J.4
-
9
-
-
84908820072
-
-
3rd ed.; Foye, W. O., Lea & Febiger: Philadelphia
-
Williams, D. A. In Principles of Medicinal Chemistry, 3rd ed.; Foye, W. O., Lea & Febiger: Philadelphia, 1989; pp 79-117
-
(1989)
Principles of Medicinal Chemistry
, pp. 79-117
-
-
Williams, D.A.1
-
11
-
-
0004225779
-
-
3rd ed.; Pratt, W. B., Taylor, P.; Eds.; Churchill Livingstone: New York
-
Alvares, A. P.; Pratt, W. B. In Principles of Drug Action, 3rd ed.; Pratt, W. B., Taylor, P.; Eds.; Churchill Livingstone: New York, 1990
-
(1990)
Principles of Drug Action
-
-
Alvares, A.P.1
Pratt, W.B.2
-
16
-
-
0025784027
-
Cytochrome P-450. Multiplicity of Isoforms, Substrates, and Catalytic and Regulatory Mechanisms
-
Porter, T. D.; Coon, M. J. Cytochrome P-450. Multiplicity of Isoforms, Substrates, and Catalytic and Regulatory Mechanisms. J. Biol. Chem. 1991, 266, 13469-13472
-
(1991)
J. Biol. Chem.
, vol.266
, pp. 13469-13472
-
-
Porter, T.D.1
Coon, M.J.2
-
17
-
-
0001803615
-
-
J. B., Greim, H. Eds.; Springer-Verlag: Berlin
-
Guengerich In Cytochrome P450; Schenkman, J. B., Greim, H. Eds.; Springer-Verlag: Berlin, 1993; Vol. 105, pp 89—103
-
(1993)
Cytochrome P450
, vol.105
, pp. 89-103
-
-
Guengerich1
-
18
-
-
0027321139
-
Cytochromes P450: Their Active-Site Structure and Mechanism of Oxidation
-
Koymans, L.; Donne-op, G. M.; Kelder, D.; Te, J. M. K.; Vermeulen, N. P. E. Cytochromes P450: Their Active-Site Structure and Mechanism of Oxidation. Drug Metab. Rev. 1993, 25, 325—387
-
(1993)
Drug Metab. Rev.
, vol.25
, pp. 325-387
-
-
Koymans, L.1
Donne-op, G.M.2
Kelder, D.3
Te, J.M.K.4
Vermeulen, N.P.E.5
-
19
-
-
0027216023
-
Regioselectivity of Cytochrome P-450 Catalyzed Hydroxylation of Fluorobenzenes Predicted by Calculated Frontier Orbital Substrate Characteristics
-
Rietjens, I. M. C.; Soffers, A. E. M. F.; Veejer, C.; Vervoort, J. Regioselectivity of Cytochrome P-450 Catalyzed Hydroxylation of Fluorobenzenes Predicted by Calculated Frontier Orbital Substrate Characteristics. Biochemistry 1993, 32, 4801—4812
-
(1993)
Biochemistry
, vol.32
, pp. 4801-4812
-
-
Rietjens, I.M.C.1
Soffers, A.E.M.F.2
Veejer, C.3
Vervoort, J.4
-
20
-
-
0019519171
-
Searches for Ultimate Chemical Carcinogens and Their Reactions with Cellular Macromolecules
-
Miller, E. C.; Miller, J. A. Searches for Ultimate Chemical Carcinogens and Their Reactions with Cellular Macromolecules. Cancer 1981, 47, 2327-2345
-
(1981)
Cancer
, vol.47
, pp. 2327-2345
-
-
Miller, E.C.1
Miller, J.A.2
-
21
-
-
0020570301
-
Chemical mechanism of halocarbon metabolism
-
MacDonald, T. L. Chemical mechanism of halocarbon metabolism. CRC Crit. Rev. Toxicol. 1983, 11, 85-120
-
(1983)
CRC Crit. Rev. Toxicol.
, vol.11
, pp. 85-120
-
-
MacDonald, T.L.1
-
22
-
-
0004039284
-
-
Ed.; Academic Press: New York
-
The Enzymes; Boyer, P. D., Ed.; Academic Press: New York, 1975; Vol. XIIb
-
(1975)
The Enzymes
, vol.12 b
-
-
Boyer, P.D.1
-
23
-
-
0015272484
-
Diamine Oxidase: Specificity and Mechanism
-
Zeller, E. A. Diamine Oxidase: Specificity and Mechanism. Adv. Biochem. Psychopharmacol. 1972, 5, 167—171
-
(1972)
Adv. Biochem. Psychopharmacol.
, vol.5
, pp. 167-171
-
-
Zeller, E.A.1
-
24
-
-
4444284036
-
-
Ed.; Taylor & Francis: London
-
Biological Oxidation of Nitrogen in Organic Molecules; Bridges, J. W., Gorrod, J. W., Parke, D. V., Ed.; Taylor & Francis: London, 1972
-
(1972)
Biological Oxidation of Nitrogen in Organic Molecules
-
-
Bridges, J.W.1
Gorrod, J.W.2
Parke, D.V.3
-
25
-
-
0023894686
-
Flavin-containing Monooxygenases: Catalytic Mechanism and Substrate Specificities
-
Ziegler, D. M. Flavin-containing Monooxygenases: Catalytic Mechanism and Substrate Specificities. Drug Metab. Rev. 1988, 19, 1-32
-
(1988)
Drug Metab. Rev.
, vol.19
, pp. 1-32
-
-
Ziegler, D.M.1
-
26
-
-
0019990422
-
Cytochrome P-450- and Flavin-Containing Monooxygenase-catalyzed Formation of the Carcinogen N-hydroxy-2-aminofluorene and Its Covalent Binding to Nuclear DNA
-
Frederick, C. B.; Mays, J. B.; Ziegler, D. M.; Guengerich, F. P.; Kadlubar, F. F. Cytochrome P-450- and Flavin-Containing Monooxygenase-catalyzed Formation of the Carcinogen N-hydroxy-2-aminofluorene and Its Covalent Binding to Nuclear DNA. Cancer Res. 1982, 42, 2671-2676
-
(1982)
Cancer Res.
, vol.42
, pp. 2671-2676
-
-
Frederick, C.B.1
Mays, J.B.2
Ziegler, D.M.3
Guengerich, F.P.4
Kadlubar, F.F.5
-
27
-
-
0022392309
-
The Early History of Xenobiotic Sulfoxidation
-
Mitchell, S. C.; Waring, R. H. The Early History of Xenobiotic Sulfoxidation. Drug Metab. Rev. 1986, 16, 255—284
-
(1986)
Drug Metab. Rev.
, vol.16
, pp. 255-284
-
-
Mitchell, S.C.1
Waring, R.H.2
-
28
-
-
0025609128
-
Metabolism of Thioamide Antithyroid Durgs
-
Sitar, D. S. Metabolism of Thioamide Antithyroid Durgs. Drug Metab. Rev. 1990, 22, 477-502
-
(1990)
Drug Metab. Rev.
, vol.22
, pp. 477-502
-
-
Sitar, D.S.1
-
30
-
-
0024452316
-
Xenobiotic Oxidation Catalyzed by Aldehyde Dehydrogenases
-
Sladek, N. E.; Manthey, C. L.; Maki, P. A.; Zhang, Z.; Landkamer, G. J. Xenobiotic Oxidation Catalyzed by Aldehyde Dehydrogenases. Drug. Metab. Rev. 1989, 20, 697—720
-
(1989)
Drug. Metab. Rev.
, vol.20
, pp. 697-720
-
-
Sladek, N.E.1
Manthey, C.L.2
Maki, P.A.3
Zhang, Z.4
Landkamer, G.J.5
-
32
-
-
0016540289
-
The Carboxylesterases/Amidases of Mammalian Liver and Their Possible Significance
-
Junge, W.; Krisch, K. The Carboxylesterases/Amidases of Mammalian Liver and Their Possible Significance. CRC Crit. Rev. Toxicol. 1974, 3, 371-434
-
(1974)
CRC Crit. Rev. Toxicol.
, vol.3
, pp. 371-434
-
-
Junge, W.1
Krisch, K.2
-
33
-
-
0020590702
-
Structure-activity Relationships for the Deacetylation of a Homologous Series of Phenacetin Analogs and Their N-hydroxy Derivatives
-
Estus, G. S.; Mieyal, J. J. Structure-activity Relationships for the Deacetylation of a Homologous Series of Phenacetin Analogs and Their N-hydroxy Derivatives. Drug. Metab. Dispos. 1983, 11, 471 —476
-
(1983)
Drug. Metab. Dispos.
, vol.11
, pp. 471-476
-
-
Estus, G.S.1
Mieyal, J.J.2
-
34
-
-
0004027866
-
-
Ed.; Plenum Press: New York
-
Molecular Aspects of Monooxygenases and Bioactivation of Toxic Compounds; Arinc, E., Schenkman, J. B., Hodgon, E., Ed.; Plenum Press: New York, 1989
-
(1989)
Molecular Aspects of Monooxygenases and Bioactivation of Toxic Compounds
-
-
Arinc, E.1
Schenkman, J.B.2
Hodgon, E.3
-
35
-
-
0020431144
-
Induction of Microsomal Enzymes by Foreign Chemicals and Carcinogenesis by Polycyclic Aromatic Hydrocarbons: G. H. A. Clowes Memorial Lecture
-
Conney, A. H. Induction of Microsomal Enzymes by Foreign Chemicals and Carcinogenesis by Polycyclic Aromatic Hydrocarbons: G. H. A. Clowes Memorial Lecture. Cancer Res. 1982, 42, 4875-4917
-
(1982)
Cancer Res.
, vol.42
, pp. 4875-4917
-
-
Conney, A.H.1
-
36
-
-
84915713141
-
-
Ed.; Alan, R. Liss, Inc.: New York
-
Enzymology of Carbonyl Metabolism 2; Aldehyde Dehydrogenase, Aldo-Ketoreductase, and Alcohol Dehydrogenase; Flynn, T. G., Weiner, H., Ed.; Alan, R. Liss, Inc.: New York, 1985
-
(1985)
Enzymology of Carbonyl Metabolism 2; Aldehyde Dehydrogenase, Aldo-Ketoreductase, and Alcohol Dehydrogenase
-
-
Flynn, T.G.1
Weiner, H.2
-
37
-
-
0025860841
-
Metabolism of Azo Dyes: Implication for Detoxification and Activation
-
Levine, W. G. Metabolism of Azo Dyes: Implication for Detoxification and Activation. Drug Metab. Rev. 1991, 23, 253—309
-
(1991)
Drug Metab. Rev.
, vol.23
, pp. 253-309
-
-
Levine, W.G.1
-
38
-
-
0020579326
-
Reductive Drug Metabolism
-
McLane, K. E.; Fisher, J.; Ramakrishnan, K. Reductive Drug Metabolism. Drug. Metab. Rev. 1983, 14, 741-799
-
(1983)
Drug. Metab. Rev.
, vol.14
, pp. 741-799
-
-
McLane, K.E.1
Fisher, J.2
Ramakrishnan, K.3
-
39
-
-
0020415697
-
Conjugation Reactions in Foreign-Compound Metabolism: Definition, Consequences, and Species Variations
-
Caldwell, J. Conjugation Reactions in Foreign-Compound Metabolism: Definition, Consequences, and Species Variations. Drug Metab. Rev. 1982, 13, 745-777
-
(1982)
Drug Metab. Rev.
, vol.13
, pp. 745-777
-
-
Caldwell, J.1
-
41
-
-
0025663358
-
The Pharmacology, Metabolism, Analysis, and Applications of Coumarin and Coumarin-related compounds
-
Egan, D.; O'Kennedy, R.; Moran, E.; Cox, D.; Prosser, E.; Thornes, R. D. The Pharmacology, Metabolism, Analysis, and Applications of Coumarin and Coumarin-related compounds. Drugs Metab. Rev. 1990, 22, 503-529
-
(1990)
Drugs Metab. Rev.
, vol.22
, pp. 503-529
-
-
Egan, D.1
O'Kennedy, R.2
Moran, E.3
Cox, D.4
Prosser, E.5
Thornes, R.D.6
-
42
-
-
0024345871
-
N-Acetyltransferase
-
Price-Evans, D. A. N-Acetyltransferase. Pharmacol. Ther. 1989, 42, 157-234
-
(1989)
Pharmacol. Ther.
, vol.42
, pp. 157-234
-
-
Price-Evans, D.A.1
-
43
-
-
0017066187
-
Identification of Separate Acyl-CoA: Glycine and Acyl-CoA: L-Acyltransferase Activities in Mitochondrial Fractions from Liver of Rhesus Monkey and Man
-
Webster, L. T., Jr.; Sibbiqui, U. A.; Lucas, S. V.; Strong, J. M.; Mieyal, J. J. Identification of Separate Acyl-CoA: Glycine and Acyl-CoA: L-Acyltransferase Activities in Mitochondrial Fractions from Liver of Rhesus Monkey and Man. J. Biol. Chem. 1976, 251, 3352—3358
-
(1976)
J. Biol. Chem.
, vol.251
, pp. 3352-3358
-
-
Webster, L.T.1
Sibbiqui, U.A.2
Lucas, S.V.3
Strong, J.M.4
Mieyal, J.J.5
-
44
-
-
0026707265
-
Glutathione-dependent toxicity
-
Anders, M. W.; Dekant, W.; Vamvakas, S. Glutathione-dependent toxicity. Xenobiotica 1992, 22, 1135—1145
-
(1992)
Xenobiotica
, vol.22
, pp. 1135-1145
-
-
Anders, M.W.1
Dekant, W.2
Vamvakas, S.3
-
46
-
-
0015370292
-
Catechol O-methyltransferase IV. Factors Affecting m- and p-Methylation of Substituted Catechols
-
Creveling, C. R.; Morris, N.; Shimizu, H.; Ong, H. H.; Daly, J. Catechol O-methyltransferase IV. Factors Affecting m- and p-Methylation of Substituted Catechols. Mol. Pharmacol. 1972, 8, 398-409
-
(1972)
Mol. Pharmacol.
, vol.8
, pp. 398-409
-
-
Creveling, C.R.1
Morris, N.2
Shimizu, H.3
Ong, H.H.4
Daly, J.5
-
48
-
-
0039306168
-
Detoxication mechanisms in man
-
Williams, R.T. Detoxication mechanisms in man. Clin. Pharmacol. Ther. 1962, 4, 234-254
-
(1962)
Clin. Pharmacol. Ther.
, vol.4
, pp. 234-254
-
-
Williams, R.T.1
-
49
-
-
85022301085
-
Pharmacology
-
Little, Brown and Company: Boston
-
Levine, R. R. Pharmacology. Drug Actions and Reactions; Little, Brown and Company: Boston, 1983
-
(1983)
Drug Actions and Reactions
-
-
Levine, R.R.1
-
50
-
-
0019276096
-
Prodrugs and Site-Specific Drug Delivery
-
Stella, V. J.; Himmelstein, K. J. Prodrugs and Site-Specific Drug Delivery. J. Med. Chem. 1980, 23, 1275-1282
-
(1980)
J. Med. Chem.
, vol.23
, pp. 1275-1282
-
-
Stella, V.J.1
Himmelstein, K.J.2
-
51
-
-
0019719023
-
The Current Status of Attempts to Predict Species Differences in Drug Metabolism
-
Caldwell, J. The Current Status of Attempts to Predict Species Differences in Drug Metabolism. Drug Metab. Rev. 1981, 12, 221-237
-
(1981)
Drug Metab. Rev.
, vol.12
, pp. 221-237
-
-
Caldwell, J.1
-
52
-
-
0000455616
-
The Comparative Carcinogenicities of 2-Acetylaminofluorene and Its N-Hydroxy Metabolite in Mice, Hamsters, and Guinea Pigs
-
Miller, E. C.; Miller, J. A.; Hartman, H. A. The Comparative Carcinogenicities of 2-Acetylaminofluorene and Its N-Hydroxy Metabolite in Mice, Hamsters, and Guinea Pigs. Cancer Res. 1963, 24, 2018-2032
-
(1963)
Cancer Res.
, vol.24
, pp. 2018-2032
-
-
Miller, E.C.1
Miller, J.A.2
Hartman, H.A.3
-
53
-
-
0026346879
-
Consideration of the Target Organ Toxicity in Terms of Metabolite Toxicity and Pharmacokinetics
-
Davidson, I. W. F.; Beliles, R. P. Consideration of the Target Organ Toxicity in Terms of Metabolite Toxicity and Pharmacokinetics. Drugs Metab. Rev. 1991, 23, 493-599
-
(1991)
Drugs Metab. Rev.
, vol.23
, pp. 493-599
-
-
Davidson, I.W.F.1
Beliles, R.P.2
-
54
-
-
0024349630
-
Biochemical mechanism of action of the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
-
Sayre, L. M. Biochemical mechanism of action of the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Toxicol. Lett. 1989, 48, 121-149
-
(1989)
Toxicol. Lett.
, vol.48
, pp. 121-149
-
-
Sayre, L.M.1
-
55
-
-
0021529312
-
Artificial Intelligence Approach to Structure-Activity Studies. Computer Automated Structure Evaluation of Biological Activity of Organic Molecules
-
Klopman, G. Artificial Intelligence Approach to Structure-Activity Studies. Computer Automated Structure Evaluation of Biological Activity of Organic Molecules. J. Am. Chem. Soc. 1984,106, 7315-7320
-
(1984)
J. Am. Chem. Soc.
, vol.106
, pp. 7315-7320
-
-
Klopman, G.1
|