Atomic structure of the trypsin-A90720A complex: a unified approach to structure and function

Chemistry and Biology

Volumn 1, Issue 2, 1994, Pages 113-117

  Y Lee, Angela ^a   A Smitka, Tim ^b   Bonjouklian, Rosanne ^b   Clardy, Jon ^a  

^a Department of Molecular Biology and Genetics   (United States)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

crystal structure; cyclic peptide; Microchaete loktakensis; proteinase inhibitor; serine proteinase

Indexed keywords

ALGAE; BOVINAE; CHLOROPHYTA; CYANOBACTERIA; MICROCHAETE; ANIMALIA; BOS TAURUS;

A 90720A; CYCLOPEPTIDE; TRYPSIN; TRYPSIN INHIBITOR;

ANIMAL; ARTICLE; CATTLE; CHEMISTRY; CONFORMATION; SOLUBILITY; X RAY CRYSTALLOGRAPHY;

ANIMALS; CATTLE; CRYSTALLOGRAPHY, X-RAY; MOLECULAR CONFORMATION; PEPTIDES, CYCLIC; SOLUBILITY; TRYPSIN; TRYPSIN INHIBITORS;

EID: 0028518887     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/1074-5521(94)90049-3     Document Type: Article

References (24)

1. The mechanism of fibrin-polymer formation in solution
2. Strategies for inhibiting the effects of thrombin
3. Hirudin: clinical potential of a thrombin inhibitor
4. Conjunctive antithrombotic and thrombolytic therapy for coronary occlusion
5. Ambiguine isonitriles, fungicidal hapalindole-type alkaloids from three genera of blue-green algae belonging to the stigonemataceae
6. A90720A, A serine protease inhibitor isolated from a terrestrial blue-green alga Microchaete loktakensis
7. Isolation and structure of the cytostatic depsipeptide dolastatin 13 from the sea hare Dolabella auricularia
8. Occurrence of four depsipeptides, aeruginopeptins, together with microcystins from toxic cyanobacteria
9. Cyanopeptolins, new depsipeptides from the cyanobacterium Microcystis sp. PCC 7806
10. Microcystolide A: a novel cell-differentiation-promoting depsipeptide from Microcystis aeruginosa NO-15-1840
11. Micropeptins A and B, plasmin and trypsin inhibitors from the blue-green Alga Microcystis aeruginosa
12. Introduction to the protein inhibitors: X-ray crystallography
13. Ligand binding: proteinase-protein inhibitor interactions
14. Natural protein proteinase inhibitors and their interaction with proteinases
15. Atomic structure of the trypsin-cyclotheonamide A complex: lessons for the design of serine protease inhibitors
16. Fusetani N.
17. Inhibition of thrombin and other trypsin-like serine proteinases by cyclotheonamide A
18. Protein inhibitors of proteinases
19. Solvent content of crystals
20. Slow-cooling protocols for crystallographic refinement by simulated annealing
21. CHAIN — A crystallographic modeling program
22. A fast algorithm for rendering space-filling molecule pictures