The retinoid signaling pathway: Molecular and genetic analyses

Seminars in Cell and Developmental Biology

Volumn 5, Issue 2, 1994, Pages 115-125

  Chambon, Pierre ^a  

^a INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

Embryonic development; Homologous recombination; Knock out mutants; Retinoid receptors; Vad syndromes

Indexed keywords

RETINOIC ACID RECEPTOR; RETINOID;

ANIMAL; GENETICS; HUMAN; PHYSIOLOGY; REVIEW; SIGNAL TRANSDUCTION;

ANIMAL; HUMAN; RECEPTORS, RETINOIC ACID; RETINOIDS; SIGNAL TRANSDUCTION; SUPPORT, NON-U.S. GOV'T;

EID: 0028419153     PISSN: 10849521     EISSN: None     Source Type: Journal    
DOI: 10.1006/scel.1994.1015     Document Type: Article

References (58)

1. Wolbach SB, Howe PR (1925) Tissue changes following deprivation of fat-soluble vitamin A. J Exp Med 42:753-777
2. Sporn MB, Roberts AB, Goodman DS (eds) (1994) The Retinoids, 2nd edn. Raven Press, New York
3. Underwood BA (1994) Vitamin A in human nutrition: Public health considerations, in The Retinoids, 2nd edn (Sporn MB, Roberts AB, Goodman DS, eds), pp 211-227. Raven Press, New York
4. Wilson JG, Roth CB, Warkany J (1953) An analysis of the syndrome of malformations induced by maternal vitamin A deficiency. Effects of restoration of vitamin A at various times during gestation. Am J Anat 92:189-217
5. Wald G (1968) Molecular basis of visual excitation. Science 162:230-239
6. Van Pelt AMM, De Rooij DG (1991) Retinoic acid is able to reinitiate spermatogenesis in vitamin A-deficient rats and high replicate doses support the full development of spermatogenic cells. Endocrinology 128:697-704
7. Kessel M (1992) Respecification of vertebral identities by retinoic acid. Development 115:487-501
8. Morriss-Kay G (1993) Retinoic acid and cranofacial development: Molecules and morphogenesis. BioEssays 15:9-15
9. Tabin CJ (1991) Retinoids, homeoboxes, and growth factors: Toward molecular models for limb development. Cell 66:199-217
10. Giguère V, Ong ES, Segui P, Evans RM (1987) Identification of a receptor for the morphogen retinoic acid. Nature 330:624-629
11. Petkovich M, Brand NJ, Krust A, Chambon P (1987) A human retinoic acid receptor which belongs to the family of nuclear receptors. Nature 330:444-450
12. Leid M, Kastner P, Chambon P (1992) Multiplicity generates diversity in the retinoic acid signalling pathways. Trends Biochem Sci 17:427-433
13. Evans RM (1988) The steroid and thyroid hormone receptor superfamily. Science 240:889-895
14. Beato M (1989) Gene regulation by steroid hormones. Cell 56:335-344
15. Green S, Chambon P (1988) Nuclear receptors enhance our understanding of transcription regulation. Trends Genet 4:309-314
16. Linney E (1992) Retinoic acid receptors: Transcription factors modulating gene regulation, development, and differentiation. Curr Topics Dev Biol 27:309-350
17. Kastner P, Leid M, Chambon P (1994) The role of nuclear retinoic acid receptors in the regulation of gene expression, in Vitamin A in Health and Disease (Blomhoff R, ed). Marcel Dekker, New York, in press
18. Leid M, Kastner Ph, Lyons R, Nakshatri H, Saunders M, Zacharewski T. Chen JY, Staub A, Gamier JM, Mader S, Chambon P (1992) Purification, cloning and RXR identity of the HeLa cell factor with which RAR or TR hetero-dimerizes to bind target sequences eflirientiy. Cell 68:377-395
19. Mangelsdorf DJ, Borgmeyer U, Heyman RA, Zhou JY, Ong ES, Oro AE, Kakizuka A, Evans RM (1992) Characterization of three RXR genes that mediate the action of 9-cis retinoic acid. Genes Dev 6:329-344
20. Allenby G, Bocquel MT, Saunders M, Kazmer S, Speck J, Rosenberger M, Lovey A, Kastner P, Grippo JF, Chambon, P, Levin AA (1993) Retinoic acid receptors and retinoid X receptors: Interactions with endogenous retinoic acids. Proc Natl Acad Sci USA 90:30-34
21. Mangelsdorf DJ, Umesono K, Evans RM (1994) The retinoid receptors, in The Retinoids, 2nd edn (Sporn MB, Roberts AB, Goodman DS, eds), pp 319-349. Raven Press, New York
22. Dolle P, Ruberte E, Kastner P, Petkovich M, Stoner CM, Gudas LJ, Chambon P (1989) Differential expression of the genes encoding the retinoic acid receptors a, 0 and 7 and CRABP in the developing limbs of the mouse. Nature 342:702-705
23. Dolle P, Ruberte E, Leroy P, Morriss-Kay G, Chambon P (1990) Retinoic acid receptors and cellular binding proteins. I. A systematic study of the differential pattern of transcription during mouse organogenesis. Development 110:1133-1151
24. Ruberte E, Dolle P, Krust A, Zelent A, Morriss-Kay G, Chambon P (1990) Specific spatial and temporal distribution of retinoic acid gamma transcripts during mouse embryogenesis, Development 108:213-222
25. Ruberte E, Dolle P, Chambon P, Morriss-Kay G (1991) Retinoic acid receptors and cellular retinoid binding proteins. II. Their differential pattern of transcription during early morphogenesis in mouse embryos. Development 111:45-60
26. Dolle P, Fraulob V, Kastner Ph, Chambon P (1994) Developmental expression of murine retinoid X receptor (RXR) genes. Mech Dev 45:91-104
27. Nagpal S, Saunders M, Kastner P, Durand B, Nakshatri H, Chambon P (1992) Promoter context and response element-dependent specificity of the transcriptional activation and modulating functions of retinoic acid receptors. Cell 70:1007-1019
28. Nagpal S, Friant S, Nakshatri H, Chambon P (1993) RARs and RXRs: Evidence for two autonomous transactivation functions (AF-1 and AF-2) and heterodimerization in vivo. EMBOJ 12:2349-2360
29. Durand B, Saunders M, Leroy P, Leid M, Chambon P (1992) All-trans and 9-cis retinoic acid inducation of CRABPII transcription is mediated by RAR/RXR hetero-dimers bound to DR1 and DR2 repeated motifs. Cell 71:73-85
30. Kurokawa R, Yu VC, Naar A, Kyakumoto S, Han Z, Silverman S, Rosenfeld MG, Glass CK (1993) Differential orientations of the DNA-binding domain and carboxy-terminal dimerization interface regulate binding site selection by nuclear receptor heterodimers. Genes Dev 7:1423-1435
31. Mader S, Chen JY, Chen Z, White J, Chambon P, Gronemeyer H (1993) The patterns of binding of RAR, RXR and TR homo- and heterodimers to direct repeats are dictated by the binding specificities of the DNA binding domains. EMBOJ 12:5029-5041
32. Mader S, Leroy P, Chen JY, Chambon P (1993) Multiple parameters control the selectivity of nuclear receptors for their response elements. J Biol Chem 268:591-600
33. Perlmann T, Rangarajan PN, Umesono K, Evans RM (1993) Determinants for selective RAR and TR recognition of direct repeat HREs. Genes Dev 7:1411-1422
34. Zechel C, Shen X-Q, Chambon P, Gronemeyer H (1994) Dimerization interfaces formed between the DNA binding domains determine the cooperative binding of RXR/RAR and RXR/TR heterodimers to DR5 and DR4 elements. EMBO J, in press
35. Zechel C, Shen X-Q, Chen JY, Chen YZ, Chambon P, Gronemeyer H (1994) The dimerization interfaces formed between the DNA binding domains of RXR, RAR and TR determine the binding specificity and polarity of the full-length receptors to direct repeats. EMBO J, in press
36. Au-Fliegner M, Helmer E, Casanova J, Raaka BM, Samuels HH (1993) The conserved ninth C-terminal heptad in thyroid hormone and retinoic acid receptors mediates diverse responses by affecting heterodimer but not homo-dimer formation. Mol Cell Biol 13:5725-5737
37. Tini M, Otulakowski G, Breitman ML, Tsui L-C, Giguere V (1993) An everted repeat mediates retinoic acid induction of the γF-crystallin gene: Evidence of a direct role for retinoids in lens development. Genes Dev 7:295-307
38. Leroy P, Krust A, Zelent A, Mendelsohn C, Gamier J M, Kastner P, Dierich A, Chambon P (1991) Multiple isoforms of the mouse retinoic acid receptor α are generated by alternative splicing and differential induction by retinoic acid. EMBOJ 10:59-69
39. Leroy P, Nakshatri H, Chambon P (1991) Mouse retinoic acid receptor α2 isoform is transcribed from a promoter that contains a retinoic acid response element. Proc Natl Acad Sci USA 88:10138-10142
40. Mendelsohn C, Ruberte E, LeMeur M, Morriss-Kay G, Chambon P (1991) Developmental analysis of the retinoic acid-inducible RAR-β2 promoter in transgenic animals. Development 113:723-734
41. Zelent A, Mendelsohn C, Kastner P, Krust A, Gamier JM, Ruffenach F, Leroy P, Chambon P (1991) Differentially expressed isoforms of the mouse retinoic acid receptor β are generated by usage of two promoters and alternative splicing. EMBO J 10:71-81
42. Ruberte E, Friederich V, Chambon P, Morriss-Kay G (1993) Retinoic acid receptors and cellular retinoid binding proteins. Ill Their differential transcript distribution during mouse nervous system development. Development 118:267-282
43. Kastner P, Krust A, Mendelsohn C, Garnier JM, Zelent A, Leroy P, Staub A, Chambon P (1990) Murine isoforms of retinoic acid receptor γ with specific patterns of expression. Proc Natl Acad Sci USA 87:2700-2704
44. Cappechi MR (1989) Altering the genome by homologous recombination. Science 244:1288-1292
45. Lufkin T, Lohnes D, Mark M, Dierich A, Gorry P, Gaub MP, LeMeur M, Chambon P (1993) High postnatal lethality and testis degeneration in retinoic acid receptor α mutant mice. Proc Natl Acad Sci USA 90:7225-7229
46. Li E, Sucov HM, Lee K-F, Evans RM, Jaenisch R (1993) Normal development and growth of mice carrying a targeted disruption of the αl retinoic acid receptor gene. Proc Natl Acad Sci USA 90:1590-1594
47. Mendelsohn C, Mark M, Dolle P, Dierich A, Gaub MP, Krust A, Lampron C, Chambon P (1994) Retinoic acid receptor β2 (RAR β2) null mutant mice appear normal. Submitted
48. Lohnes D, Kastner P, Dierich A, Mark M, LeMeur M, Chambon P (1993) Function of retinoic acid receptor γ in the mouse. Cell 73:643-658
49. Howell JM, Thompson JN, Pitt GA (1963) Histology of the lesions produced in the reproductive tract of animals fed a diet deficient in vitamin A Acid. I. The male rat. J Reprod Fert 5: 159-167
50. Shingleton JL, Skinner MK, Ong DE (1989) Retinol csterification in Sertoli by lecitihLn—retinol acyltransferase. Biochemistry 28:9641-9647
51. Ramirez-Solis R, Zheng H, Whiting J, Krumlauf R, Bradley A (1993) Hoxb-4 (Hox-2.6) mutant mice show homeotic transformation of a cervical vertebra and defect in the closure of the sternal rudiments. Cell 73:279-294
52. Conlon RA, Rossant J (1992) Exogenous retinoic acid rapidly induces anterior ectopic expression of murine Hox-2 genes in vivo. Development 116:357-368
53. Tautz D (1992) Redundancies, development and the flow of information. BioEssays 14:263-266
54. Kimura M (1962) On the probability of fixation of mutant genes in a population. Genetics 47:713-719
55. Ko MSH (1992) Induction mechanism of a single gene molecule: Stochastic or deterministic? BioEssays 14:341-346
56. Sucov HM, Murakami KK, Evans RM (1990) Characterization of an autoregulated response element in the mouse retinoic acid receptor type β gene. Proc Natl Acad Sci USA 87:5392-5396
57. de The, Vivanco-Ruiz M, Tiollais P, Stunncnbcrg H, Dejean A (1990) Identification of a retinoic acid responsive element in the retinoic acid receptor β gene. Nature 343:177-180
58. Lehmann JM, Zhang X-K, Pfahl M (1992) RAR-γ2 expression is regulated through a retinoic acid response element embedded in Spl sites. Mol Cell Biol 12:2976-2985