Cancer Genetics: Is p53 the only real tumor suppressor gene?

Current Biology

Volumn 4, Issue 2, 1994, Pages 137-139

  Berns, Anton ^a  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL; CELL DIFFERENTIATION; CELL DIVISION; GENETICS; HETEROZYGOTE; HOMOZYGOTE; HUMAN; MOUSE; NEOPLASM; PHENOTYPE; REVIEW; TUMOR SUPPRESSOR GENE;

ANIMAL; CELL DIFFERENTIATION; CELL DIVISION; GENES, P53; GENES, TUMOR SUPPRESSOR; HETEROZYGOTE; HOMOZYGOTE; HUMAN; MICE; NEOPLASMS; PHENOTYPE;

ANIMALIA;

EID: 0028372234     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(94)00031-X     Document Type: Article

References (13)

1. Worrying about p53
2. The p53-mdm-2 autoregulatory feedback loop
3. WAF-1, a potential mediator of p53 tumor suppression
4. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin- dependent kinases
5. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumors
6. Tumor spectrum analysis in p53-mutant mice
7. High incidence of lung, bone and lymphoid tumors in transgenic mice overexpressing mutant alleles of the p53 oncogene
8. Spontaneous and carcinogen-induced tumorigenesis in p53-deficient mice
9. Genetic background alters the spectrum of tumors that develop in p53-deficient mice
10. Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors
11. Mice with DNA repair gene (ERCC-1) deficiency have elevated levels of p53, liver nuclear abnormalities and die before weaning
12. The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer
13. Molecule of the year