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Volumn 4, Issue 11, 1994, Pages 1385-1390

New dipeptide isosteres useful for the inhibition of HIV-1 protease

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; N TERT BUTYL 2 [2 HYDROXY 4 PHENYL 3 [[N (2 QUINOLYLCARBONYL)ASPARAGINYL]AMINO]BUTYL]BENZAMIDE; PROTEINASE; PROTEINASE INHIBITOR; ZIDOVUDINE;

EID: 0028362882     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)80367-X     Document Type: Article
Times cited : (36)

References (22)
  • 9
    • 84908835138 scopus 로고    scopus 로고
    • A reviewer has suggested the name Pheψ[CH(OH)CH2]Aba to describe these dipeptide isosteres.
  • 16
    • 84908835137 scopus 로고    scopus 로고
    • 1H NMR, FAB exact MS or elemental analysis, IR, OR) and were homogeneous by TLC and/or HPLC. Full experimental data will be made available in a subsequent report. b) In exploratory reactions, an excess of dianion (2–3 equiv.) was utilized relative to N-methoxy-N-methyl amide to simultaneously deprotonate the CbzNH.
  • 20
    • 84908835136 scopus 로고    scopus 로고
    • Published (ref. 5a), data for Ro-31-8959: HIVP IC50 = <0.4 nM; antiviral IC50 = 2 nM; AZT antiviral IC50 = 3–30 nM.
  • 21
    • 84908835135 scopus 로고    scopus 로고
    • Testing performed at Southern Research Institute, Birmingham, Al according to the method of Weislow, O.S.; Kiser, R.; Fine, D.L. et al. J. Natl. Cancer Inst. 1989, 81(8), 577–586. In contrast to the antiviral IC50 values for the HIV-1 protease inhibitors described in this paper, the antiviral IC50 values for AZT can vary widely in this assay, making even side-by-side comparison difficult.
  • 22
    • 84908835134 scopus 로고    scopus 로고
    • Schevitz, R.W.; Very, J.-P.; Clawson, D.K.(Lilly Research Laboratories), and Appelt, K. (Agouron Pharmceuticals, Inc.), unpublished results. Details will be reported in a separate paper.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.