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Volumn 4, Issue 13, 1994, Pages 1565-1570

Synthesis and antitumor properties of novel 14-β-hydroxytaxol and related analogues

Author keywords

[No Author keywords available]

Indexed keywords

10 ACETYL 14BETA HYDROXYTAXOTERE; 14BETA HYDROXYTAXOL; 14BETA HYDROXYTAXOTERE; ANTINEOPLASTIC AGENT; DOCETAXEL; PACLITAXEL; PACLITAXEL DERIVATIVE; TUBULIN; UNCLASSIFIED DRUG;

EID: 0028361548     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)80567-9     Document Type: Article
Times cited : (14)

References (26)
  • 4
    • 84908840958 scopus 로고    scopus 로고
    • For recent reviews: Georg, G.I.; Boge, T.C.; Cheruvallath, Z.S.; Clowers, J.S.; Harriman, G.C.B.; Hepperle, M.; Park., H. The Medicinal Chemistry of Taxol. In Taxol: Science and Application; Suffness, M., Ed., CRC: Boca Raton, FL, in press.
  • 12
    • 0003463148 scopus 로고
    • A variety of protecting groups were evaluated to protect the diol system, as illustrated below: Under literature conditions, Wiley, New York, we were unable to remove the acetonide (16) or phenyl boronate (17) without sacrificing the oxetane ring. The 14-β-hydroxyl group can be easily protected as siyl ethers (triethylsiyl ether 18 or trimethylsilyl ether 19), but we were unable to introduce the amino acid side chain at C-13 on these C-14 silyl ethers employing the β-lactam chemistry.
    • (1991) Protective Groups in Organic Synthesis:
    • Greene1    Wuts2
  • 14
    • 84908840954 scopus 로고    scopus 로고
    • ORGN 0355. Holton R.A. U.S. Patent 5,015,744 (1991) and U.S. Patent 5, 136, 060 (1992).
  • 18
    • 84908840953 scopus 로고    scopus 로고
    • All new compounds were characterized by NMR spectroscopy and combustion analyses and/or high resolution mass spectroscopy.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.