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Volumn 35, Issue 25, 1994, Pages 4351-4354

Synthesis of deoxy analogs of HEPT involving a palladium (0) catalyzed coupling

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; THYMIDINE DERIVATIVE;

EID: 0028357926     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(00)73352-1     Document Type: Article
Times cited : (51)

References (17)
  • 7
    • 84912902079 scopus 로고    scopus 로고
    • 1-alkyl 6-(phenylthio)thymine derivatives (methyl ethyl, and butyl) have been reported in ref.5 and it has been shown that introduction of an ethyl or butyl group into the N-1 position, significantly contributes to an anti-HIV-1 activity.
  • 8
    • 0027381149 scopus 로고
    • It should be also of great interest to ascertain if these new compounds retain marked activity against HIV-1 mutant strains that are resistant to other HIV-1 specific inhibitors as pointed out for HEPT derivatives themselves in
    • (1993) Molecular Pharmacol. , vol.44 , pp. 694-701
    • Balzarini1    Karlsson2    De3
  • 11
    • 84912899423 scopus 로고    scopus 로고
    • 1 alkylation was based on comparison of the UV spectra in neutral vs 0.1 N NaOH (Baker B.R.; Kawazu, M.; Santi, D.V.; Schwan, T.J. J. Med. Chem., 1967, 10, 304–311) which shows less than a 2-mμ shift.
  • 13
    • 85081225068 scopus 로고
    • Expanding Industrial Applications of Palladium Catalysts
    • (1990) Synthesis , pp. 739-749
    • Tsuji1
  • 14
    • 84912946848 scopus 로고    scopus 로고
    • 5
  • 15
    • 85082673916 scopus 로고
    • Reduction of Symmetric and Mixed Anhydrides of Carboxylic Acids by Sodium Borohydride with Dropwise Addition of Methanol
    • Acetates 15–17 were prepared from the corresponding acrylic acid derivatives through reduction of the mixed carbonic anhydrides by sodium borohydride according to
    • (1987) Synthesis , pp. 647-648
    • Soai1    Yokohama2    Mochida3
  • 16
    • 84912917715 scopus 로고    scopus 로고
    • 2S : C, 68.55; H, 5.18; N, 7.99. Found : C, 68.60; H, 5.24; N, 8.17.
  • 17
    • 84912942960 scopus 로고    scopus 로고
    • Catalyst poisoning interfered with the hydrogenation of the CC bond in compounds 4a–7a necessitating a change in catalyst part way through the experiment.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.