Solubility Enhancement of Nucleosides and Structurally Related Compounds by Complex Formation

Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists

Volumn 11, Issue 3, 1994, Pages 398-401

  Chen, Andrew X ^a,b   Zito, S William ^a   Nash, Robert A ^a  

^a ST JOHN'S UNIVERSITY   (United States)

^b ImmuLogic Pharmaceutical Corporation   (United States)

Author keywords

association constant; molecular complex; niacinamide; pyridoxine; solubility

Indexed keywords

ACICLOVIR; ADENINE; ALANINE; AMINO ACID; ASCORBIC ACID; BENZOIC ACID; CAFFEINE; FLAVINE MONONUCLEOTIDE; GUANOSINE; HISTIDINE; MENADIONE; METHYL PARABEN; NICOTINAMIDE; NUCLEOSIDE DERIVATIVE; PHENYLALANINE; PROPYL PARABEN; PYRIDOXINE; SACCHARIN; TRIAMTERENE; TRYPTOPHAN; VANILLIN; VITAMIN;

ARTICLE; COMPLEX FORMATION; DRUG SOLUBILITY; PRIORITY JOURNAL; SOLUBILIZATION;

ADENINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GUANOSINE; HYDROGEN-ION CONCENTRATION; LIGANDS; NUCLEOSIDES; SOLUBILITY; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 0028354962     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1023/A:1018913104383     Document Type: Article

References (9)

1. Solubility enhancement of some developmental anti-cancer nucleoside analogs by complexation with nicotinamide
2. Nucleosides with antiviral activity
3. Quantitative structure-activity relationships (QSARs) or pyridine nucleoside as HIV-1 antiviral agents
4. Water soluble complexes of the antiviral drugs, 9-(4,3-dihydroxy-2-propoxy)methylguanine and acyclovir: the role of hydrophobicity in complex formation
5. The solubility and complexing properties of oxytetracycline and tetracycline III
6. Solubilization of salicylamide and acetaminophen by antihistimines in aqueous solution
7. Phase solubility techniques
8. Alteration of apparent solubility through complexation
9. Binding specificity between small organic solutes in aqueous solution: Classification of some solutes into groups according to binding tendencies