A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family

Cell

Volumn 77, Issue 2, 1994, Pages 261-271

  Ponzetto, Carola ^a   Bardelli, Alberto ^a,b   Zhen, Zhu ^a   Maina, Flavio ^a   dalla Zonca, Paolo ^a   Giordano, Silvia ^a   Graziani, Andrea ^a   Panayotou, George ^b   Comoglio, Paolo M ^a  

^a Department of Biomedical Sciences Oncology University Torino Medical School ^*  (Italy)

^b LUDWIG INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DOCKING PROTEIN; GROWTH FACTOR RECEPTOR; PHOSPHATIDYLINOSITOL KINASE; PHOSPHOLIPASE C; PHOSPHOTYROSINE; PROTEIN KINASE P60; SCATTER FACTOR;

ANIMAL CELL; ARTICLE; CARCINOGENESIS; CELL STRAIN COS1; CONTROLLED STUDY; GENETIC CONSERVATION; NONHUMAN; ONCOGENE RAS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; RECEPTOR AFFINITY; RECEPTOR BINDING; SIGNAL TRANSDUCTION;

EID: 0028351702     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(94)90318-2     Document Type: Article

References (55)

1. Autophosphorylation promotes complex formation of recombinant hepatocyte growth factor receptor with cytoplasmic effectors containing SH2 domains
2. Scatter factor and hepatocyte growth factor activities properties and mechanism
3. Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene
4. Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth
5. Oncogenes and signal transduction
6. Structure, biosynthesis and biochemical properties of the HGF receptor in normal and malignant cells
7. Molecular cloning of a new transforming gene from a chemically transformed human cell line
8. Activation of Src family kinases by colony stimulating factor-1 and their association with its receptor
9. Expression of the Met/HGF receptor in normal and neoplastic human tissues
10. Overexpression of the c-MET/HGF receptor gene in human thyroid carcinomas
11. lck
12. The pathway to signal achievement
13. Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways
14. SH2 domains exhibit high-affinity binding to tyrosine-phosphorylated peptides yet also exhibit rapid dissociation and exchange
15. Identification of the major phosphorylation site of the Met/hepatocyte growth factor receptor tyrosine kinase
16. Hepatocyte growth factor factor-scatter factor mitogen motogen and met
17. Tyrosine kinase receptor indistinguishable from the c-Met protein
18. Transfer of motogenic and invasive response to scatter factor/hepatocyte growth factor by transfection of human MET protooncogene
19. Characterization of the TPR-MET oncogene p65 and the MET proto-oncogene p140 protein tyrosine kinases
20. The tyrosine phosphorylated hepatocyte growth factor/scatter factor receptor associates with phosphatidylinositol 3-kinase
21. Hepatocyte growth factor/scatter factor stimulates the Rasguanine nucleotide exchanger
22. The protooncogene c-sea encodes a transmembrane protein-tyrosine kinase related to the Met/hepatocyte growth factor/scatter factor receptor
23. Phosphorylation sites in the PDGF receptor with different specificities for binding GAP and PI3 kinase in vivo
24. GTPase-activating protein and phosphatidylinositol 3-kinase bind to distinct regions of the platelet-derived growth factor receptor β subunit
25. PDGF stimulation of inositol phospholipid hydrolysis requires PLC-γ1 phosphorylation on tyrosine residues 783 and 1254
26. SH2 and SH3 domains elements that control interactions of cytoplasmic signaling proteins
27. Association between the PDGF receptor and members of the src family of tyrosine kinases
28. Tyrosines 1234–1235 are critical for activation of the tyrosine kinase encoded by the MET protooncogene (HGF receptor)
29. Roles of HGF as a pleiotropic factor in organ regeneration
30. Identification of two juxtamembrane autophosphorylation sites in the PDGF β-receptor; involvement in the interaction with Src family tyrosine kinases
31. The tyrosine kinase encoded by the MET proto-oncogene is activated by autophosphorylation
32. Hepatocyte growth factor (HGF) stimulates the tyrosine kinase activity of the receptor encoded by the proto-oncogene c-MET
33. Two signaling molecules share a phosphotyrosine-containing binding site in the platet-derived growth factor receptor
34. Interactions between SH2 domains and tyrosine-phosphorylated platelet-derived growth factor β-receptor sequences analysis of kinetic parameters by a novel biosensor-based approach
35. Mechanism of met oncogene activation
36. SH2 and SH3 domains
37. MAP kinases charting the regulatory pathways
38. BCR-ABL-induced oncogenesis in mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein
39. c-met is amplified but not mutated in a cell line with an activated Met tyrosine kinase
40. A novel recognition motif for phosphatidylinositol 3-kinase binding mediates its association with the hepatocyte growth factor/scatter factor receptor
41. C-terminal truncated forms of Met the hepatocyte growth factor receptor
42. Dimerization mediated through a leucine zipper activates the oncogenic potential of the met receptor tyrosine kinase
43. Tumorigenicity of the met proto-oncogene and the gene for hepatocyte growth factor
44. Identification of two C-terminal autophosphorylation sites in the PDGF β-receptor involvement in the interaction with phospholipase C-γ
45. A novel putative receptor protein tyrosine kinase of the met family
46. γ
47. SH2 domains recognize specific phosphopeptide sequences
48. Expression of the Met-receptor and its ligand, HGF/SF during mouse embryogenesis
49. Epithelial scatter factor and development of the chick embryonic axis
50. γ and a 64-kilodalton protein, respectively
51. A protein tyrosine phosphatase activity associated with the hepatocyte growth factor/scatter factor receptor
52. Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides
53. Binding of a high affinity phosphotyrosyl peptide in the src SH2 domain crystal structures of the complexed and peptide-free forms
54. Scatter factor molecular characteristics and effect on the invasiveness of epithelial cells
55. The Met receptor tyrosine kinase transduces motility proliferation and morphogenic signals of scatter factor/hepatocyte growth factor in epithelial cells