The effect on synaptic physiology of synaptotagmin mutations in drosophila

Neuron

Volumn 12, Issue 4, 1994, Pages 909-920

  DiAntonio, Aaron ^a   Schwarz, Thomas L ^a  

^a STANFORD UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MEMBRANE PROTEIN; SYNAPTOTAGMIN;

ANIMAL CELL; ARTICLE; CELL MUTANT; DROSOPHILA MELANOGASTER; EVOKED RESPONSE; GENE MUTATION; NEUROMUSCULAR SYNAPSE; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; SYNAPSE VESICLE; SYNAPTIC POTENTIAL; SYNAPTIC TRANSMISSION;

ANIMAL; DROSOPHILA MELANOGASTER; EVOKED POTENTIALS; LARVA; MEMBRANE GLYCOPROTEINS; MUTATION; NERVE TISSUE PROTEINS; NEUROMUSCULAR JUNCTION; NEUROTRANSMITTERS; OCULAR PHYSIOLOGY; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; SYNAPSES; SYNAPTIC TRANSMISSION;

EID: 0028351171     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/0896-6273(94)90342-5     Document Type: Article

References (43)

1. Alien intracellular calcium chelators attenuate neurotransmitter release at the squid giant synapse
2. Divalent cations differentially support transmitter release at the squid synapse
3. The molecular machinery for secretion is conserved from yeast to neurons
4. Syntaxin: a synaptic protein implicated in docking of synaptic vesicles at presynaptic active zones
5. Botulinum neurotoxin A selectively cleaves the synaptic protein SNAP-25
6. Inhibition of neurotransmitter release by C2-domain peptides implicates synaptotagmin in exocytosis
7. Synaptotagmin: a calcium sensor on the synaptic vesicle surface
8. Altered branching of serotonin-containing neurons in Drosophila mutants unable to synthesize serotonin and dopamine
9. Morphological plasticity of motor axons in Drosophila mutants with altered excitability
10. Genetic and molecular identification of a Drosophila histidine decarboxylase gene required in photoreceptor transmitter synthesis
11. 2+-dependent translocation domain with homology to PKC and GAP
12. Opioid inhibition of GABA release from presynaptic terminals of rat hippocampal interneurons
13. Donnees ultrastructurales et cytochimiques sur le mechanisme de liberation de l'acetylcholine dans la transmission synaptique
14. Synaptotagmin and neurotransmitter release
15. Statistical factors involved in neuromuscular facilitation and depression
16. Synaptic transmission persists in synaptotagmin mutants of Drosophila
17. Identification and characterization of Drosophila genes for synaptic vesicle proteins
18. A role for synaptotagmin (p65) in regulated exocytosis
19. Properties of the larval neuromuscular junction in Drosophila melanogaster
20. Antibodies to horseradish peroxidase as specific neuronal markers in Drosophila and in grasshopper embryos.
21. Stereotypic morphology of glutarnatergic synapses on identified muscle cells of Drosophila larvae
22. Storage and release of neurotransmitters
23. 2+-activated neurotransmitter release
24. Expression of synaptotagmin in Drosophila reveals transport and localization of synaptic vesicles to the synapse
25. A further study of the statistical composition of the endplate potential
26. Activation of transmitter release by strontium and calcium ions at the neuromuscular junction
27. Multiple calcium-dependent processes related to secretion in bovine chromaffin cells
28. Synaptic function is impaired but not eliminated in C. elegans mutants lacking synaptotagmin
29. Molecular genetic studies of photoreceptor function using Drosophila mutants
30. Phospholipid binding by a synaptic vesicle protein homologous to the regulatory region of protein kinase C
31. Structural and functional conservation of synaptotagmin (p65) in Drosophila and humans
32. Binding of synaptotagmin to the a-latrotoxin receptor implicates both in synaptic vesicle exocytosis
33. Synaptotagmin: a calciumsensitive inhibitor of exocytosis?
34. Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin
35. Tetanus toxin is a zinc protein and its inhibition of neurotransmitter release and protease activity depend on zinc
36. Rabphilin-3A, a putative target protein for smg p25A/rab3A p25 small GTPbinding protein related to synaptotagmin
37. Neurotransmitter release from synaptotagmin-deficient clonal variants of PC12 cells
38. Properties of potassium currents and their role in membrane excitability in Drosophila larval muscle fibers
39. SNAP receptors implicated in vesicle targeting and fusion
40. A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusion
41. A Ca-dependent step in the releaseofcatecholamines from adrenal chromaffin cells
42. Differential expression of the p65 gene family