메뉴 건너뛰기




Volumn 4, Issue 9, 1994, Pages 1161-1166

Synthesis and FKBP binding of small molecule mimics of the tricarbonyl region of FK506

Author keywords

[No Author keywords available]

Indexed keywords

1 (3,4,5 TRIMETHOXYPHENYLGLYXOLY) PIPECOLIC ACID 4 (4 METHOXYPHENYL) BUTYL ESTER; BINDING PROTEIN; FK 506 BINDING PROTEIN; HYBRID PROTEIN; PIPECOLIC ACID DERIVATIVE; TACROLIMUS; UNCLASSIFIED DRUG;

EID: 0028350462     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)80248-1     Document Type: Article
Times cited : (14)

References (22)
  • 7
    • 84908854276 scopus 로고    scopus 로고
    • Armistead,D.M.; Boger, J.S.; Myers,H. V.; Saunders, J. O.; Tung, R.D. WO 92/00278, 1992.
  • 15
    • 84908854275 scopus 로고    scopus 로고
    • Werner, S.; Alfred, M. German Patent P33 17 356.7
  • 18
    • 84908854274 scopus 로고    scopus 로고
    • 18 An ascomycin conjugate of alkaline phosphatase was prepared by reaction of a C22 active ester of ascomycin with alkaline phosphatase (ascomycin-AP).In the assay, FKBP-CKS fusion protein was dissolved at 10–35 μg/ml in 20 mM sodium phosphate buffer, pH 7.4, and adsorbed to the wells of an Immuno Plate Maxisorp™ (Nunc, Naperville, IL) by incubation at ambient temperature for 2 hr. A solution o phosphate buffered saline (PBS), pH 7.4, containing 2 % bovine serum albumin (BSA) and 0.2 % Tween 20 was added to the wells to reduce nonspecific binding of the ascomycin-AP. After rising the wells with 0.2 % Tween 20 in PBS, the test compound in the PBS/BSA/Tween 20 buffer, or buffer alone, was added to the wells. [[Truncated]]


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.