Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions

Cell

Volumn 76, Issue 5, 1994, Pages 821-828

  Shuai, Ke ^a   Horvath, Curt M ^a   Huang, Linda H Tsai ^a   Qureshi, Sajjad A ^a   Cowburn, David ^a   Darnell Jr , James E ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; DNA; GAMMA INTERFERON; PEPTIDE; TRANSCRIPTION FACTOR;

ARTICLE; CYTOPLASM; DIMERIZATION; DISSOCIATION; DNA BINDING; DNA SEQUENCE; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION;

EID: 0028349904     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(94)90357-3     Document Type: Article

References (36)

1. Modulation of the dimerization of a transcriptional antiterminator protein by phosphorylation
2. Structure of an SH2 domain of the p85α subunit of phosphatidylinositol-3-OH kinase
3. Molecular weights of protein multimers from polyacrylamide gel electrophoresis
4. Rapid activation by interferon α of a latent DNA-binding protein present in the cytoplasm of untreated cells
5. Cytoplasmic activation of GAF an IFN-γ regulated DNA binding factor
6. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
7. Recognition of a high affinity phosphotyrosyl peptide by Src homology 2 domain of p56lck
8. SH2 domains exhibit high-affinity binding to tyrosine-phosphorylated peptides yet also exhibit rapid dissociation and exchange
9. A transcription factor with SH2 and SH3 domains is directly activated by an interferon α-induced cytoplasmic protein tyrosine kinase(s)
10. Transcription factor p91 interacts with the epidermal growth factor receptor and mediates activation of the c-fos gene promoter
11. ISGF3 the transcriptional activator induced by interferon α consists of multiple interacting polypeptide chains
12. The proteins of ISGF-3 the interferon α-induced transcriptional activator define a gene family involved in signal transduction
13. Transcriptional regulation by dimerization two sides to an incestuous relationship
14. Interferon-α regulates nuclear translocation and DNA-binding affinity of ISGF-3 a multimeric transcriptional activator
15. Induction of the Ly-6A/E gene by interferon α/β and γ requires a DNA element to which a tyrosine-phosphorylated 91-kDa protein binds
16. SH2 and SH3 domains elements that control interactions of signal protein
17. Tyrosine phosphorylation of DNA-binding proteins by multiple cytokines
18. Cytoplasmic activation of ISGF3 the positive regulator of interferon-α-stimulated transcription reconstituted in vitro
19. High frequency mutagenesis of human cells and characterization of a mutant unresponsive to both α and β interferons
20. Characterization of a cofactor that regulates dimerization of a mammalian homeodomain protein
21. Complementation of a mutant cell line central role of the 91-kDa polypeptide of ISGF3 in the interferon-α and -γ signal transduction pathway
22. Secondary structure of Src homology 2 domain of c-abl by heteronuclear NMR spectroscopy in solution
23. Three-dimensional solution structure of the src homology 2 domain of c-abl
24. SH2 and SH3 domains
25. Interferon γ-induced transcription of the high-affinity Fc receptor for IgG requires assembly of a complex that includes the 91-kDa subunit of transcription factor ISGF3
26. Induction by EGF and interferon-γ of tyrosine phosphorylated DNA binding proteins in mouse liver nuclei
27. A common nuclear signal transduction pathway activated by growth factor and cytokine receptors
28. Proteins of transcription factor ISGF-3 one gene encodes the 91 and 84 kDA ISGF-3 proteins that are activated by inteferon-α
29. Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor
30. Activation of transcription by IFN-γ tyrosine phosphorylation of a 91 kD DNA binding protein
31. A single phosphotyrosine residue of Stat91 required for gene activation by interferon-γ
32. Polypeptide signaling to the nucleus through tyrosine phosphorylation of JAK and STAT proteins
33. Ras-independent growth factor signaling by transcription factor tyrosine phosphorylation
34. SH2 domains recognize specific phosphopeptide sequences
35. Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA-binding protein
36. Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides