Evaluation of the quality of life associated with zidovudine treatment in asymptomatic human immunodeficiency virus infection

New England Journal of Medicine

Volumn 330, Issue 11, 1994, Pages 738-743

  Lenderking, William R ^a   Gelber, Richard D ^a,b   Cotton, Deborah J ^a,d   Cole, Bernard F ^b   Goldhirsch, Aron ^b   Volberding, Paul A ^c,e   Testa, Marcia A ^a  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PLACEBO; ZIDOVUDINE;

ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; FATIGUE; FEVER; HEADACHE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MALAISE; PRIORITY JOURNAL; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; RHEUMATOID ARTHRITIS; SYMPTOMATOLOGY;

CD4-POSITIVE T-LYMPHOCYTES; DOUBLE-BLIND METHOD; HIV INFECTIONS; HUMANS; LEUKOCYTE COUNT; QUALITY OF LIFE; RETROSPECTIVE STUDIES; SURVIVAL ANALYSIS; ZIDOVUDINE;

EID: 0028348683     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJM199403173301102     Document Type: Article

References (19)

1. Fischl MA, Richman DD, Hansen N, The safety and efficacy of zidovudine (AZT) in the treatment of subjects with mildly symptomatic human immunodeficiency virus type 1 (HIV) infection: a double-blind, placebo-controlled trial. Ann Intern Med 1990; 112: 727-737
2. Volberding PA, Lagakos SW, Koch MA, Zidovudine in asymptomatic human immunodeficiency virus infection: a controlled trial in persons with fewer than 500 CD4-positive cells per cubic millimeter. N Engl J Med 1990; 322: 941-949
3. Merigan TC, Amato DA, Balsley J, Placebo-controlled trial to evaluate zidovudine in treatment of human immunodeficiency virus infection in asymptomatic patients with hemophilia: NHF-ACTG 036 Study Group. Blood 1991; 78: 900-906
4. Hamilton JD, Hartigan PM, Simberkoff MS, A controlled trial of early versus late treatment with zidovudine in symptomatic human immunodeficiency virus infection. N Engl J Med 1992; 326: 437-443
5. Aboulker JP, Swart AM Preliminary analysis of the Concorde trial: Concorde Coordinating Committee. Lancet 1993; 341: 889-890
6. Kahn J New developments in the clinical use of didanosine. J Acquir Immune Defic Syndr 1993; 6: Suppl 1: S47-S50
7. Richman DD, Fischl MA, Grieco MH, The toxicity of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. N Engl J Med 1987; 317: 192-197
8. Wu AW, Mathews WC, Brysk LT, Quality of life in a placebo-controlled trial of zidovudine in patients with AIDS and AIDS-related complex. J Acquir Immune Defic Syndr 1990; 3: 683-690
9. Gelber RD, Lenderking WR, Cotton DJ, Quality-of-life evaluation in a clinical trial of zidovudine therapy in patients with mildly symptomatic HIV infection. Ann Intern Med 1992; 116: 961-966
10. Wachtel T, Piette J, Mor V, Stein M, Fleishman J, Carpenter C Quality of life in persons with human immunodeficiency virus infection: measurement by the Medical Outcomes Study instrument. Ann Intern Med 1992; 116: 129-137
11. Rosner BA. Fundamentals of biostatistics. 3rd ed. Boston: PWS-Kent, 1990.
12. Goldhirsch A, Gelber RD, Simes RJ, Glasziou P, Coates AS Costs and benefits of adjuvant therapy in breast cancer: a quality-adjusted survival analysis. J Clin Oncol 1989; 7: 36-44
13. Gelber RD, Goldhirsch A, Cavalli F Quality-of-life-adjusted evaluation of adjuvant therapies for operable breast cancer. Ann Intern Med 1991; 114: 621-628
14. Glasziou PP, Simes RJ, Gelber RD Quality adjusted survival analysis. Stat Med 1990; 9: 1259-1276
15. Cole BF, Gelber RD, Goldhirsch A Cox regression models for quality adjusted survival analysis. Stat Med 1993; 12: 975-987
16. Cohen J Early AZT takes a pounding in French-British Concorde' trial. Science 1993; 260: 157-157
17. Larder BA, Darby G, Richman DD HIV with reduced sensitivity to zidovudine (AZT) isolated during prolonged therapy. Science 1989; 243: 1731-1734
18. Altman LK. Experts change guides for using drugs for HIV. New York Times. June 27, 1993:1, 23.
19. Sande MA, Carpenter CCJ, Cobbs CG, Holmes KK, Sanford JP Antiretroviral therapy for adult HIV-infected patients: recommendations from a state-of-the-art conference. JAMA 1993; 270: 2583-2589