Imipramine in patients with chest pain despite normal coronary angiograms

New England Journal of Medicine

Volumn 330, Issue 20, 1994, Pages 1411-1417

  Cannon, Richard O ^a   Quyyumi, Arshed A ^a   Mincemoyer, Rita ^a   Stine, Annette M ^a   Gracely, Richard H ^b   Smith, Wendy B ^b   Geraci, Marilla F ^c   Black, Bruce C ^c   Uhde, Thomas W ^c   Waclawiw, Myron A ^a   Maher, Kathleen ^d   Benjamin, Stanley B ^d  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^c NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^d GEORGETOWN UNIVERSITY HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE; CLONIDINE; IMIPRAMINE;

ADULT; AGED; ANGIOCARDIOGRAPHY; ARTICLE; CHRONIC PAIN; CLINICAL TRIAL; CONSCIOUSNESS DISORDER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; ELECTROCARDIOGRAM; ESOPHAGUS MOTILITY; FEMALE; HEART MUSCLE ISCHEMIA; HEART RIGHT VENTRICLE FUNCTION; HUMAN; HUMAN TISSUE; LONG QT SYNDROME; MAJOR CLINICAL STUDY; MALE; PAIN ASSESSMENT; PRIORITY JOURNAL; PSYCHIATRIC DIAGNOSIS; RANDOMIZED CONTROLLED TRIAL; RATING SCALE; THORAX PAIN; VISCERAL PAIN;

ADULT; AGED; CHEST PAIN; CHRONIC DISEASE; CLONIDINE; CORONARY ANGIOGRAPHY; CORONARY DISEASE; DOUBLE-BLIND METHOD; ELECTROCARDIOGRAPHY; EXERCISE TEST; FEMALE; FOLLOW-UP STUDIES; HUMANS; IMIPRAMINE; MALE; MIDDLE AGED;

EID: 0028348491     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJM199405193302003     Document Type: Article

References (54)

1. Proudfit WL, Shirey EK, Sones FM Jr Selective cine coronary arteriography: correlation with clinical findings in 1,000 patients. Circulation 1966; 33: 901-910
2. Kemp HG Jr, Vokonas PS, Cohn PF, Gorlin R The anginal syndrome associated with normal coronary arteriograms: report of a six year experience. Am J Med 1973; 54: 735-742
3. Pasternak RC, Thibault GE, Savoia M, DeSanctis RW, Hutter AM Jr Chest pain with angiographically insignificant coronary arterial obstruction: clinical presentation and long-term follow-up. Am J Med 1980; 68: 813-817
4. Dart AM, Davies HA, Dalal J, Ruttley M, Henderson AH Angina' and normal coronary arteriograms: a follow-up study. Eur Heart J 1980; 1: 97-100
5. Papanicolaou MN, Califf RM, Hlatky MA, Prognostic implications of angiographically normal and insignificantly narrowed coronary arteries. Am J Cardiol 1986; 58: 1181-1187
6. Kemp HG, Kronmal RA, Vlietstra RE, Frye RL Seven year survival of patients with normal or near normal coronary arteriograms: a CASS registry study. J Am Coll Cardiol 1986; 7: 479-483
7. Day LJ, Sowton E Clinical features and follow-up of patients with angina and normal coronary arteries. Lancet 1976; 2: 334-337
8. Ockene IS, Shay MJ, Alpert JS, Weiner BH, Dalen JE Unexplained chest pain in patients with normal coronary arteriograms: a follow-up study of functional status. N Engl J Med 1980; 303: 1249-1252
9. Isner JM, Salem DN, Banas JS Jr, Levine HJ Long-term clinical course of patients with normal coronary arteriography: follow-up study of 121 patients with normal or nearly normal coronary arteriograms. Am Heart J 1981; 102: 645-653
10. Bass C, Cawley R, Wade C, Unexplained breathlessness and psychiatric morbidity in patients with normal and abnormal coronary arteries. Lancet 1983; 1: 605-609
11. Katon W, Hall ML, Russo J, Chest pain: relationship of psychiatric illness to coronary arteriographic results. Am J Med 1988; 84: 1-9
12. Lantinga LJ, Sprafkin RP, McCroskery JH, Baker MT, Warner RA, Hill NE One-year psychosocial follow-up of patients with chest pain and angiographically normal coronary arteries. Am J Cardiol 1988; 62: 209-213
13. Beitman BD, Mukerji V, Lamberti JW, Panic disorder in patients with chest pain and angiographically normal coronary arteries. Am J Cardiol 1989; 63: 1399-1403
14. Brand DL, Martin D, Pope CE II Esophageal manometrics in patients with angina-like chest pain. Am J Dig Dis 1977; 22: 300-304
15. Traube M, Albibi R, McCallum RW High-amplitude peristaltic esophageal contractions associated with chest pain. JAMA 1983; 250: 2655-2659
16. Janssens J, Vantrappen G, Ghillebert G 24-Hour recording of esophageal pressure and pH in patients with noncardiac chest pain. Gastroenterology 1986; 90: 1978-1984
17. Richter JE, Bradley LA, Castell DO Esophageal chest pain: current controversies in pathogenesis, diagnosis, and therapy. Ann Intern Med 1989; 110: 66-78
18. Opherk D, Zebe H, Weihe E, Reduced coronary dilatory capacity and ultrastructural changes of the myocardium in patients with angina pectoris but normal coronary arteriograms. Circulation 1981; 63: 817-825
19. Cannon RO III, Watson RM, Rosing DR, Epstein SE Angina caused by reduced vasodilator reserve of the small coronary arteries. J Am Coll Cardiol 1983; 1: 1359-1373
20. Legrand V, Hodgson JM, Bates ER, Abnormal coronary flow reserve and abnormal radionuclide exercise test results in patients with normal coronary angiograms. J Am Coll Cardiol 1985; 6: 1245-1253
21. Greenberg MA, Grose RM, Neuburger N, Silverman R, Strain JE, Cohen MV Impaired coronary vasodilator responsiveness as a cause of lactate production during pacing-induced ischemia in patients with angina pectoris and normal coronary arteries. J Am Coll Cardiol 1987; 9: 743-751
22. Cannon RO III, Camici PG, Epstein SE Pathophysiological dilemma of syndrome X. Circulation 1992; 85: 883-892
23. Clouse RE, Lustman PJ Psychiatric illness and contraction abnormalities of the esophagus. N Engl J Med 1983; 309: 1337-1342
24. Roy-Byrne PP, Schmidt P, Cannon RO, Diem H, Rubinow DR Microvascular angina and panic disorder. Int J Psychiatry Med 1989; 19: 315-325
25. Cannon RO III, Cattau EL Jr, Yakshe PN, Coronary flow reserve, esophageal motility, and chest pain in patients with angiographically normal coronary arteries. Am J Med 1990; 88: 217-222
26. Shapiro LM, Crake T, Poole-Wilson PA Is altered cardiac sensation responsible for chest pain in patients with normal coronary arteries? Clinical observation during cardiac catheterization. BMJ 1988; 296: 170-171
27. Cannon RO III, Quyyumi AA, Schenke WH, Abnormal cardiac sensitivity in patients with chest pain and normal coronary arteries. J Am Coll Cardiol 1990; 16: 1359-1366
28. Lagerqvist B, Sylven C, Waldenstrom A Lower threshold for adenosine-induced chest pain in patients with angina and normal coronary angiograms. Br Heart J 1992; 68: 282-285
29. Richter JE, Barish CF, Castell DO Abnormal sensory perception in patients with esophageal chest pain. Gastroenterology 1986; 91: 845-852
30. Bruce RA, Hornsten TR Exercise stress testing in evaluation of patients with ischemic heart disease. Prog Cardiovasc Dis 1969; 11: 371-390
31. Bonow RO, Rosing DR, Bacharach SL, Effects of verapamil on left ventricular systolic function and diastolic filling in patients with hypertrophic cardiomyopathy. Circulation 1981; 64: 787-796
32. Schleyer B, Aaronson C, Mannuzza S, Martin LY, Fyer AJ. Schedule for Affective Disorders and Schizophrenia — lifetime version (modified for the study of anxiety disorders) revised [SADS-LA(R)]. New York: New York State Psychiatric Clinic, Anxiety Disorders Clinic, 1990.
33. Mannuzza S, Fyer AJ, Martin LY, Reliability of anxiety assessment. I. Diagnostic agreement. Arch Gen Psychiatry 1989; 46: 1093-1101
34. Diagnostic and statistical manual of mental disorders: DSM-III-R. 3rd ed. rev. Washington, D.C.: American Psychiatric Press, 1987.
35. National Institute of Mental Health. CGI (Clinical Global Impression) Scale. Psychopharmacol Bull 1985; 21: 839-843
36. Spielberger CD, Gorsuch RL, Lushene RE. Manual for the State-Trait Anxiety Inventory. Palo Alto, Calif.: Consulting Psychologists Press, 1970.
37. Zung WWK A rating instrument for anxiety disorders. Psychosomatics 1971; 12: 371-379
38. Bunney WE Jr, Hamburg DA Methods for reliable longitudinal observation of behavior. Arch Gen Psychiatry 1963; 9: 280-294
39. Gracely RH, Dubner R, McGrath PA Narcotic analgesia: fentanyl reduces the intensity but not the unpleasantness of painful tooth pulp sensations. Science 1979; 203: 1261-1263
40. Max MB, Schafer SC, Culnane M, Smoller B, Dubner R, Gracely RH Amitriptyline, but not lorazepam, relieves postherpetic neuralgia. Neurology 1988; 38: 1427-1432
41. SAS user's guide: statistics, version 5 ed. Cary, N.C.: SAS Institute, 1985:433-506.
42. Kvinesdal B, Molin J, Froland A, Gram LF Imipramine treatment of painful diabetic neuropathy. JAMA 1984; 251: 1727-1730
43. Gomez-Perez FJ, Rull JA, Dies H, Rodriguez-Rivera JG, Gonzalez-Barranco J, Lozano-Castaneda O Nortriptyline and fluphenazine in the symptomatic treatment of diabetic neuropathy: a double-blind cross-over study. Pain 1985; 25: 395-400
44. Max MB, Lynch SA, Muir J, Shoaf SE, Smoller B, Dubner R Effects of desipramine, amitriptyline, and fluoxetine on pain in diabetic neuropathy. N Engl J Med 1992; 326: 1250-1256
45. Watson CP, Evans RJ, Reed K, Merskey H, Goldsmith L, Warsh J Amitriptyline versus placebo in postherpetic neuralgia. Neurology 1982; 32: 671-673
46. Gomersall JD, Stuart A Amitriptyline in migraine prophylaxis: changes in pattern of attacks during a controlled clinical trial. J Neurol Neurosurg Psychiatry 1973; 36: 684-690
47. Couch JR, Ziegler DK, Hassanein R Amitriptyline in the prophylaxis of migraine: effectiveness and relationship of antimigraine and antidepressant effects. Neurology 1976; 26: 121-127
48. Clouse RE, Lustman PJ, Eckert TC, Ferney DM, Griffith LS Low-dose trazodone for symptomatic patients with esophageal contraction abnormalities: a double-blind, placebo-controlled trial. Gastroenterology 1987; 92: 1027-1036
49. Egbunike IG, Chaffee BJ Antidepressants in the management of chronic pain syndromes. Pharmacotherapy 1990; 10: 262-270
50. Basbaum AI, Fields HL Endogenous pain control mechanisms: review and hypothesis. Ann Neurol 1978; 4: 451-462
51. Dubner R, Bennett GJ Spinal and trigeminal mechanisms of nociception. Annu Rev Neurosci 1983; 6: 381-418
52. Max MB, Schafer SC, Culnane M, Dubner R, Gracely RH Association of pain relief with drug side effects in postherpetic neuralgia: a single-dose study of clonidine, codeine, ibuprofen, and placebo. Clin Pharmacol Ther 1988; 43: 363-371
53. Zeigler D, Lynch SA, Muir J, Benjamin J, Max MB Transdermal clonidine versus placebo in painful diabetic neuropathy. Pain 1992; 48: 403-408
54. Bigger JT Jr, Giardina EGV, Perel JM, Kantor SJ, Glassman AH Cardiac antiarrhythmic effect of imipramine hydrochloride. N Engl J Med 1977; 296: 206-208