메뉴 건너뛰기
Bioorganic and Medicinal Chemistry Letters
Volumn 4, Issue 5, 1994, Pages 729-732
Synthesis of B-NOR-4-AZA-5α-androstane compound as 5α-reductase inhibitor
Author keywords

[No Author keywords available]
Indexed keywords

ANDROSTANE DERIVATIVE; FINASTERIDE; N BENZHYDRYL 3 OXO 4 AZA B NOR 5ALPHA ANDROSTANE 17BETA CARBOXAMIDE; STEROID 5ALPHA REDUCTASE; UNCLASSIFIED DRUG;
EID: 0028346877     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)80189-X     Document Type: Article
Times cited : (5)
References (12)
  • 5
    • 84908844923 scopus 로고    scopus 로고
    • Kojima, K.; Kurata, H.; Horikoshi, H.; Hamada, T. EP 484094A, 1992, Sankyo Co. Ltd.
  • 8
    • 84908844922 scopus 로고    scopus 로고
    • 1H-NMR.
  • 9
    • 84908844921 scopus 로고    scopus 로고
    • Stereochemistry at the C-5 position in 18a was assigned based on the NOE experiment. The NOE was observed between 5β-H and 19-methyl group in 18a.
  • 10
    • 84908844920 scopus 로고    scopus 로고
    • The undesired isomer 17b was also converted to the desired 20a: By using a similar sequence of reactions to that described for the synthesis of 20a from 18a, 17b gave 20b. Oxidation and then reduction of 20b gave 20a (35%) along with 20b (64%).
  • 11
    • 84908844919 scopus 로고    scopus 로고
    • The lactam ring of 27 was labile to the general hydrolysis condition used for the hydrolysis of 17-ester.
  • 12
    • 84908844918 scopus 로고    scopus 로고
    • The biological test method is described in reference 3.

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.