Antitumor bisdioxopiperazines inhibit yeast DNA topoisomerase II by trapping the enzyme in the form of a closed protein clamp

Proceedings of the National Academy of Sciences of the United States of America

Volumn 91, Issue 5, 1994, Pages 1781-1785

  Roca, Joaquim ^a   Ishida, Ryoji ^b   Berger, James M ^a   Andoh, Toshiwo ^b   Wang, James C ^a  

^a HARVARD UNIVERSITY   (United States)

^b AICHI CANCER CENTER HOSPITAL   (Japan)

Author keywords

bis(2,6 dioxopiperazines); drug design; enzyme mechanism

Indexed keywords

2,3 BIS(3,5 DIOXO 1 PIPERAZINYL)BUTANE; ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATE; ADENYLYLIMIDODIPHOSPHATE; CIRCULAR DNA; DNA TOPOISOMERASE (ATP HYDROLYSING); PIPERAZINEDIONE; PROTEINASE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DNA PROTEIN COMPLEX; DRUG EFFECT; ENZYME DEGRADATION; ENZYME INHIBITION; NONHUMAN; PRIORITY JOURNAL; YEAST;

EUKARYOTA; STAPHYLOCOCCUS AUREUS;

EID: 0028345406     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.91.5.1781     Document Type: Article

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