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Volumn 264, Issue 5163, 1994, Pages 1319-1322

Prevention of lipopolysaccharide-induced lethal toxicity by tyrosine kinase inhibitors

Author keywords

[No Author keywords available]

Indexed keywords

LIPOPOLYSACCHARIDE; NITRIC OXIDE; PROTEIN KINASE INHIBITOR; PROTEIN TYROSINE KINASE; TUMOR NECROSIS FACTOR ALPHA; TYRPHOSTIN;

EID: 0028343059     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.8191285     Document Type: Article
Times cited : (333)

References (43)
  • 2
    • 0019906260 scopus 로고
    • E. J. Ziegler, ibid 307, 1225 (1982); R. L. Greenman et al., J. Am. Med. Assoc 266, 1097 (1991).
    • (1982) N. Engl. J. Med. , vol.307 , pp. 1225
    • Ziegler, E.J.1
  • 3
    • 0025917510 scopus 로고
    • E. J. Ziegler, ibid 307, 1225 (1982); R. L. Greenman et al., J. Am. Med. Assoc 266, 1097 (1991).
    • (1991) J. Am. Med. Assoc , vol.266 , pp. 1097
    • Greenman, R.L.1
  • 5
    • 0014533039 scopus 로고
    • C. A. Geunter, V. Florica, B. J. Hinshaw, J. Appl. Physiol. 26, 780 (1969); C. R. Raetz, Annu. Rev. Biochem. 59, 124 (1990).
    • (1990) Annu. Rev. Biochem. , vol.59 , pp. 124
    • Raetz, C.R.1
  • 7
    • 0023706894 scopus 로고
    • A. H. Ding et al., J. Immunol. 141, 2407 (1988); X. Zang and D. C. Morrison, J. Exp. Med. 177, 511 (1993).
    • (1988) J. Immunol. , vol.141 , pp. 2407
    • Ding, A.H.1
  • 8
    • 0027499515 scopus 로고
    • A. H. Ding et al., J. Immunol. 141, 2407 (1988); X. Zang and D. C. Morrison, J. Exp. Med. 177, 511 (1993).
    • (1993) J. Exp. Med. , vol.177 , pp. 511
    • Zang, X.1    Morrison, D.C.2
  • 9
    • 0344140225 scopus 로고
    • S. Okusawa et al., J. Clin. Invest. 81, 1162 (1988); B. Everaedt, P. Broukaet, A. Shaw, W. Fiers, Biochem. Biophys. Res. Commun. 163, 378 (1989).
    • (1988) J. Clin. Invest. , vol.81 , pp. 1162
    • Okusawa, S.1
  • 11
    • 0027297663 scopus 로고
    • K. Pfeffer et al. Cell 73, 457 (1993); J. Rothe et al., Nature 364, 798 (1993).
    • (1993) Cell , vol.73 , pp. 457
    • Pfeffer, K.1
  • 12
    • 0027327619 scopus 로고
    • K. Pfeffer et al. Cell 73, 457 (1993); J. Rothe et al., Nature 364, 798 (1993).
    • (1993) Nature , vol.364 , pp. 798
    • Rothe, J.1
  • 14
    • 0025225333 scopus 로고
    • K. Ohlsson et al., Nature 348, 550 (1990).
    • (1990) Nature , vol.348 , pp. 550
    • Ohlsson, K.1
  • 18
    • 84901964444 scopus 로고
    • M. Kohmo et al., Biochem. J. 267, 91 (1990); A. V. Hoffbrand and R. G. Wickremasinghe, Blood 75, 88 (1990); I. Victor et al., J. Biol. Chem. 268, 18994 (1993).
    • (1990) Biochem. J. , vol.267 , pp. 91
    • Kohmo, M.1
  • 19
    • 84901965506 scopus 로고
    • M. Kohmo et al., Biochem. J. 267, 91 (1990); A. V. Hoffbrand and R. G. Wickremasinghe, Blood 75, 88 (1990); I. Victor et al., J. Biol. Chem. 268, 18994 (1993).
    • (1990) Blood , vol.75 , pp. 88
    • Hoffbrand, A.V.1    Wickremasinghe, R.G.2
  • 20
    • 0027209271 scopus 로고
    • M. Kohmo et al., Biochem. J. 267, 91 (1990); A. V. Hoffbrand and R. G. Wickremasinghe, Blood 75, 88 (1990); I. Victor et al., J. Biol. Chem. 268, 18994 (1993).
    • (1993) J. Biol. Chem. , vol.268 , pp. 18994
    • Victor, I.1
  • 21
    • 0026530158 scopus 로고
    • E. Munoz et al., Eur. J. Immunol. 22, 1391 (1992); G. R. Guy et al., J. Biol. Chem. 266, 14343 (1991).
    • (1992) Eur. J. Immunol. , vol.22 , pp. 1391
    • Munoz, E.1
  • 22
    • 0026329119 scopus 로고
    • E. Munoz et al., Eur. J. Immunol. 22, 1391 (1992); G. R. Guy et al., J. Biol. Chem. 266, 14343 (1991).
    • (1991) J. Biol. Chem. , vol.266 , pp. 14343
    • Guy, G.R.1
  • 24
    • 0026458235 scopus 로고
    • P. Yaish, A. Gazit, C. Gilon, A. Levitzki, Science 242, 933 (1988); A. Levitzki, FASEB J. 6, 3275 (1992).
    • (1992) FASEB J. , vol.6 , pp. 3275
    • Levitzki, A.1
  • 28
    • 0025195627 scopus 로고
    • R. G. Kilbourn et al., Proc. Natl. Acad. Sci. U.S.A. 87, 3629 (1990); R. G. Kilbourn and O. W. Griffith, J. Natl. Cancer Inst. 84, 827 (1992).
    • (1990) Proc. Natl. Acad. Sci. U.S.A. , vol.87 , pp. 3629
    • Kilbourn, R.G.1
  • 30
    • 0027325770 scopus 로고
    • Z. Dong et al., J. Immunol. 151, 2717 (1993); N. Marczin et al., Am. J. Physiol. 265, H110 (1993).
    • (1993) J. Immunol. , vol.151 , pp. 2717
    • Dong, Z.1
  • 31
    • 0027325770 scopus 로고
    • Z. Dong et al., J. Immunol. 151, 2717 (1993); N. Marczin et al., Am. J. Physiol. 265, H110 (1993).
    • (1993) Am. J. Physiol. , vol.265
    • Marczin, N.1
  • 32
    • 0024434810 scopus 로고    scopus 로고
    • unpublished results
    • F. Bohmer et al., unpublished results; A. Gazit et al., J. Med. Chem. 32, 2344 (1989); unpublished experiments.
    • Bohmer, F.1
  • 33
    • 0024434810 scopus 로고    scopus 로고
    • unpublished experiments
    • F. Bohmer et al., unpublished results; A. Gazit et al., J. Med. Chem. 32, 2344 (1989); unpublished experiments.
    • (1989) J. Med. Chem. , vol.32 , pp. 2344
    • Gazit, A.1
  • 34
    • 0021139773 scopus 로고
    • 2. Nonadherent cells were removed, and complete medium (RPMI 1640 containing heat-inactivated newborn calf serum) was added. After incubation of macrophage monolayers for 20 hours, tyrphostins were added at a final concentration of 20 μM followed 2 hours later by the addition of E. coli 055:B5 LPS (10 μg/ml). Endotoxin (Sigma) was prepared by phenol extraction. After incubation for 6 hours, supernatants were collected and the concentration of TNF-α was determined with an ELISA kit (Endogen). The results are expressed as the mean of two determinators; deviations from the mean did not exceed 8%.
    • (1984) J. Biol. Chem. , vol.259 , pp. 4305
    • Tsunawaki, S.1    Nathan, C.F.2
  • 35
    • 84901964433 scopus 로고    scopus 로고
    • note
    • - production seems to depend on the method of macrophage preparation, whereas maximal LPS does not depend on the preparation.
  • 37
    • 84901964434 scopus 로고    scopus 로고
    • note
    • The tyrphostins AG 490 and AG 556 were found to be more active in inhibiting TNF-α cytotoxicity in vitro (two- to threefold). This finding suggests that different sets of PTKs mediate the effects of LPS and TNF-α and, therefore, that different families of tyrphostins will be effective against these two agents.
  • 38
    • 0026659881 scopus 로고
    • S. L. Weinstein et al., J. Biol. Chem. 267, 14955 (1993); Z. Dong et al., J. Exp. Med. 177, 1071 (1993).
    • (1993) J. Biol. Chem. , vol.267 , pp. 14955
    • Weinstein, S.L.1
  • 39
    • 0027474842 scopus 로고
    • S. L. Weinstein et al., J. Biol. Chem. 267, 14955 (1993); Z. Dong et al., J. Exp. Med. 177, 1071 (1993).
    • (1993) J. Exp. Med. , vol.177 , pp. 1071
    • Dong, Z.1
  • 42
    • 84901964435 scopus 로고    scopus 로고
    • note
    • 6 U/mg (Reportech, Rocky Hill, NJ) at 0.0, 0.2, and 0.5 ng/ml with and without 10 μM tyrphostin. After incubation for 18 hours, the supernatants were aspirated, the monolayers were washed twice with PBS, and 200 μl of neutral red solution (0.02%) was added. After incubation for 2 hours, cells were washed out and the dye that had been absorbed by the live cells was extracted upon the addition of 200 μl of Sorenson buffer containing 50% ethanol. The concentration of the dye was determined by an ELISA autoreader with a 550-nm filter.
  • 43
    • 84901964436 scopus 로고    scopus 로고
    • note
    • We thank M. Collazo from SUGEN, Inc. (Redwood City, CA) for helping in the preparation of this manuscript.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.