Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance

Biochemical Pharmacology

Volumn 47, Issue 9, 1994, Pages 1469-1479

  Brian Houston, J ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

in vitro data, predictive utility; intrinsic drug clearance; pharmacokinetics, predictive studies

Indexed keywords

ALPRENOLOL; AMINOPHENAZONE; BUTETHAL; CAFFEINE; CARBAMAZEPINE; CODEINE; DIAZEPAM; ETHENZAMIDE; ETHOXYCOUMARIN; FELODIPINE; HEPTABARB; HEXOBARBITAL; IBUPROFEN; IMIPRAMINE; LIDOCAINE; LOXTIDINE; MEPHEBARBITAL; METOPROLOL; OXODIPINE; PHENAZONE; PHENYTOIN; PROPRANOLOL; TOLBUTAMIDE;

DRUG METABOLISM; LIVER CELL; LIVER MICROSOME; LIVER PERFUSION; METABOLIC CLEARANCE RATE; NONHUMAN; PHARMACOKINETICS; PREDICTION; PRIORITY JOURNAL; REVIEW; THEORY;

ANIMAL; BIOTRANSFORMATION; IN VITRO; METABOLIC CLEARANCE RATE; MICROSOMES, LIVER; PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS;

EID: 0028342648     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(94)90520-7     Document Type: Article

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