-
9
-
-
0026342111
-
Leukocyte-Endothelial Cell Recognition: Three (or More) Steps to Specificity and Diversity
-
(1991)
Cell
, vol.67
, pp. 1033-1036
-
-
Butcher1
-
10
-
-
0025854524
-
Leukocytes Roll on a Selectin at Physiologic Flow Rates: Distinction from and Prerequisite for Adhesion Through Imegrins
-
(1991)
Cell
, vol.65
, pp. 859-873
-
-
Lawrence1
Springer2
-
11
-
-
0027178531
-
Rapid G Protein-regulated Acti- vation Event Involved in Lymphocyte Binding to High Endothelial Venules
-
of outstanding interest, This report examines the effect of pertussis toxin, an inhibitor of G protein mediated signal transduction, on lymphocyte interactions with Peyers patch HEV in vivo. Pretreated cells show the same overall frequency of interaction as controls, but stable adhesion is largely prevented, with most cells exhibiting a typical rolling interaction. These data strongly support the validity of the multistep hypothesis of leukocyte extravasation for lymphocytes, as well as neutrophils. Moreover, this report was the first demonstration that the in vivo triggering of lymphocyte secondary adhesion to EC involves G protein coupled receptors.
-
(1993)
J Exp Med
, vol.178
, pp. 367-372
-
-
Bargatze1
Sprcher2
-
12
-
-
0027207679
-
MAdCAM-1 Has Homology to Immunoglobulin and Mucin-Like Adhesion Receptors and to IgAl
-
of outstanding interest, Cloning of the mucosal addressin (MAdCAM-1), a tissue-selective endothelial adhesion molecule for lymphocytes, reveals this important molecule to be encoded by a member of the Ig gene superfamily containing three Ig-like domains-the amino terminal domain most homologous to the first domain of the vascular adhesion proteins ICAM-1 and VCAM-I, the second domain most homologous to the fifth domain of VCAM-1, and the membrane proximal domain homologous to the third (Ca2) constant region Ig loop of IgAl. Between the proximal IgAl-like and middle VCAM-1-like domains is a serine/threonine-rich mucin-like region, which can be modified with O-linked oligosaccharide ligands for L-Selectin [17of outstanding interest]
-
(1993)
Nature
, vol.363
, pp. 461-464
-
-
Briskin1
McEvoy2
Butcher3
-
13
-
-
0027237424
-
α 4β7 Inte-grin Mediates Lymphocyte Binding to the Mucosal Vascular Ad dressin MAdCAM-1
-
of outstanding interest, This paper presents data indicating that a407-integrin is a primary lymphocyte ligand for the vascular adhesion molecule MAdCAM-1. The related a4p1 heterodimer does not mediate MAdCAM-1 binding, even after Mnz-induced integrin activation. The a407 heterodimer mediates binding of resting lymphoid cells to MAdCAM-1, but binding is enhanced with integrin activation. It also interacts with the α4β1-ligand VCAM-1, but this activity is more dependent on integrin activation than its interaction with MAdCAM-1. On cells expressing both a4 heterodimers, a4D1 appears to be the dominant VCAM-1-binding integrin. MAdCAM-1 is therefore a preferential EC counter-receptor for a407, and this homing receptor-EC ligand pair probably plays a major role in the regulation of tissue-selective lymphocyte homing to mucosal sites.
-
(1993)
Cell
, vol.74
, pp. 185-195
-
-
Berlin1
Berg2
Briskin3
Andrew4
Kilshaw5
Holzmann6
Weissman7
Hamann8
-
14
-
-
0028181865
-
The Role of a4 Integrins in Lymphocyte Homing to Mucosal Tissues In Vivo
-
of outstanding interest, This paper provides in vivo support for the hypothesis that ot407 and MAdCAM-1 play a major role in the mediation of lymphocyte homing to mucosal sites. MAb against mousse a4-integrin chains, a407 combinatorial determinants, and 07-integrin chains, as well as an antiMAdCAM-1 mAb, significantly inhibit lymphocyte and lymphoblast migration to Peyer's patch and intestine, but not PLN. Anti-VCAM-1 mAbs and the CS-1 fragment of fibronectin had no effect on mucosal homing in vivo. An anti-L-selectin mAb also significantly inhibited lymphocyte homing to Peyer's patch (but not lymphoblast homing to non-Peyer's patch intestine), in keeping with the hypothesis that L-selectin may be important in virgin lymphocyte homing to mucosal secondary lymphoid tissues [17of outstanding interest].
-
(1994)
J Immunol
, vol.152
, pp. 3282-3293
-
-
Hamann1
Andrews2
Jablonski-Westrich3
Holzmann4
-
15
-
-
0027178702
-
L-Selectin Can Mediate Leukocyte Rolling in Untreated Mesenteric Venules in Vivo Independent of E- or P-Selectin
-
of special interest, This paper demonstrates that L-selectin can mediate ‘rolling’ on endothelium in a lectin domain dependent manner. L-selectin transfectants of the pre-B cell line 300.19 (which does not express oligosaccharide ligands for either E- or P-selectin), but not control transfectants, roll on mesenteric venular endothelium in vivo, and this rolling interaction is completely abolished using blocking L-selectin-specific mAbs.
-
(1993)
Blood
, vol.82
, pp. 1632-1638
-
-
Ley1
Tedder2
Kansas3
-
16
-
-
0027212673
-
L-Selectin Mediates Neutrophil Rolling in Inflamed Venules Through Sialyl Lewis X-Dependent and -Independent Recognition Pathways
-
of special interest, Similar to [15of special interest], L-selectvn transfectants of the pre-B cell line Ll-2 roll in vivo in a lectin-domain dependent manner. This paper goes on to present evidence suggesting that rolling efficiency is increased on cells (like normal neutrophils, but not lymphocytes) which express L-selectin molecules post-translationally modified with sialyl Lewis X (E- and P-selectin-binding oligosaccharides), presumably this increased rollingefficiency is achieved by allowing L-selectin loth to bind its own oligosaccharide ligand(s) on EC, and simultaneously present oligosaccharide ligands to the vascular selectctivs.
-
(1993)
Blood
, vol.82
, pp. 182-191
-
-
Von Andrian1
Chambers2
Berg3
Michie4
Brown5
Karolak6
Ramezani7
Berger8
Arfors9
Butcher10
-
17
-
-
0027756971
-
L-Selectin Mediated Lymphocyte Rolling on MAdCAM-1.
-
of outstanding interest, MAdCAM-1, the mucosa-selective vascular counter-receptor for the lymphocyte homing receptor HR a407, can be modified with functional L-selectin-binding oligosaccharides in mesenteric lymph node and Peyer's patch, but not intestinal lamina propria. This modification, which would allow dual recognition of MAdCAM-1 molecules by cells expressing both L-selectin and ct4s7, might act to increase the homing efficiency of double positive virgin lymphocyte homing to mucosal secondary lymphoid tissues (see text and Fig. 2).
-
(1993)
Nature
, vol.366
, pp. 695
-
-
Berg1
McEvoy2
Berlin3
Bargatze4
Butcher5
-
18
-
-
0027742870
-
The Human Peripheral Lymph Node Vascular Addressin. An Indrrcible Endothelial Antigen Involved in Lymphocyte Homing
-
of special interest, MAb MECA-79 had been previously shown to delineate L-selectin glycoprotein ligands in both the mouse and human systems [4]. This paper demonstrates high intensity, constitutive MECA-79 reactivity with PLN HEV, and shows that MECA-79 significantly blocks lymphocyte binding to these HEV in the in vitro (Stamper-Woodruff) cryostat-section adhesion assay. Low intensity, constitutive MECA-79 reactivity is present on appendix HEV, but MECA-79 does not significantly block lymphocyte binding to these HEV. ECs in teritary sites are largely non-reactive with MECA-79 under resting conditions. These observations appear analogous to what has been observed in the mouse system [17••], and support the hypothesis that L-selectin-mediated interactions are quantitatively most important in PLN extravasation. However, MECA-79-defined PNAd molecules appear to be more readily induced at sites of chronic inflammation in man than in the [[Truncated]]
-
(1993)
Am J Pathol
, vol.143
, pp. 1688-1698
-
-
Michie1
Streeter2
Bolt3
Butcher4
Picker5
-
19
-
-
0027232583
-
Molecular Mechanisms Underlying Lymphocyte Recirculation III. Characterization of the LECAM-1 (L-Scicctin)Dependent Adhesion Pathway in Rats
-
of outstanding interest, These workers use a recombinant L-selectvn-Ig chimeric molecule as an immunohistological probe for L-selectvn ligands in the rat system. This L-selectin chimera delineates L-selectin binding oligosaccharides on PLN HEV and capillary endothelium in the renal medulla. NonEC staining is also detected in renal (distal) tubular epithelium, and a variety of sites in the CNS. The physiological significance of this non-EC reactivity is uncertain. Used in immunoprecipitation studies, the chimeric L-selectin/Ig detects multiple sulfated species from PLN HEV cells (55, 65, 120, 190, and 250-kIra).
-
(1993)
J Immunol
, vol.150
, pp. 1735-1745
-
-
Tamatani1
Kuida2
Watanabe3
Koike4
Miyasaka5
-
20
-
-
0027262235
-
Control of Lymphocyte Homing in Man: I. Differential Regulation of the Peripheral Lymph Node Homing Receptor L-Selectin on T Cells During the Virgin to Memory Transition
-
of outstanding interest, This paper first describes and validates multiparameter flow cytometric criteria for identifying T cells undergoing the virgin to memory/effector transition in secondary lymphoid tissues. Using these criteria, the regulation of L-selectin during this differentiative process is examined in various secondary lymphoid tissues. The results indicate that L-selectin is preserved on memory/effector T cells produced in PIN, but selectively downregulated in mucosal sites, particularly the appendix. This paper goes on to demonstrate that various immune cytokines can influence L-selectvn expression on virgin T cells activated in vitro. Together with data in its companion paper on the skin-selective homing receptor CIA [26of outstanding interest], these results confirm theimportance of local microenvironments in the generation of memory/effector cell homing heterogenity.
-
(1993)
J Immunol
, vol.150
, pp. 1105-1121
-
-
Picker1
Treer2
Ferguson-Darnell3
Collins4
Buck5
Tersptappen6
-
21
-
-
0026776328
-
An Endothelial Ligand for L-Selectin Is a Novel Mucin-like Molecule
-
of outstanding interest, The molecular cloning of sgp50 (GlyCAM-1), one of the high affinity PLN HEV glycoprotein ligands for L :selectin identified with a mouse L-selectin-Ig chimera, reveals a mucin-like molecule with a high degree of predominantly O-linked glycosylation (approcimately 70% molecular weight). Expression of GlyCAM-1 message was found to be highly specific to PLN and MLN HEV. The physiological participation of this ligand versus other L :selectin binding glycoproteins in lymphocyte interactions with PLN and mesenteric lymph node HEV remains to be determined, particularly in view of the observation that GIyCAM-1 lacks a transmembrane region and appears to be rapidly shed in vitro.
-
(1992)
Cell
, vol.69
, pp. 927-938
-
-
Lasky1
Singer2
Dowbenko3
Imai4
Henzel5
Grimley6
Fennie7
Gillett8
Watson9
Rosen10
-
22
-
-
0027496220
-
Binding of L-Selectin to the Vascular Sialomucin CD34
-
of outstanding interest, The molecular cloning of sgp90, a second high affinity PLN HEV glycoprotein ligand for L-selectvn identified with a mouse L-seeectvn-Ig chimera, reveals identity with the protein backbone of the sialomucin CD34. Although best known for its expression on hematopoietic progenitors, CD34 is expressed on ECs in a wide variety of tissues, and when decorated with appropriate oligosaccharides has the capacity to be an L :selectin ligand. Again, the relative physiologic role of CD34 versus other PIN HEV L-selectin lil ands in lymphocyte homing remains to be determined.
-
(1993)
Science
, vol.262
, pp. 436-438
-
-
Baumhueter1
Singer2
Henzel3
Hemmerich4
Renz5
Rosen6
Lasky7
-
25
-
-
0028307598
-
Differential Expression of Lyrnphocyte Homing Receptors by Human Memory/Effector T Cells in Pulmonary vs. Cutaneous Immune Effector Sites
-
+. α4β7-integrin expression was diminished in both skin and lung, suggesting this homing receptor does not have a key role in determining localization specificity in these sites. induction of a rapid upregulation of pulmonary inflammation via intrabronchial allergen challenge in asthmatic patients tended to decrease localization specificity, resulting in a more general importation of memory/effector subsets. Taken together, these results support the hypothesis that lymphocyte [[Truncated]]
-
(1994)
Eur J Immunol
-
-
Picker1
Martin2
Trumble3
Newman4
Collins5
Bergstresser6
Leung7
-
26
-
-
0027211784
-
Control of Lymphocyte Homing in Man: II. Differential Regulation of the T Cell Skin-Selective Homing Receptor CIA
-
of outstanding interest, Using the same flow cytometry techniques described in, 20of outstanding interest], this paper follows the induction of the skin-selective homing receptor CIA during the virgin to memory/effector T cell transition in secondary lymphoidtissues. CIA is upregulated on over 50'16 of memory/effector T cells differentiating in PLN, but only 5-1096 of those in appendix. Tonsil and MIN show intermediate levels of CLA induction. As was the case with L-selectin [22], mitogen stimulation of naive cells in vitro in the presence of certain cytokines recapitulated this differential regulation. In the discussion, this paper presents a model of microenvironmental regulation of memory/effector T cell homing heterogeneity.
-
(1993)
J Immunol
, vol.150
, pp. 1122-1136
-
-
Picker1
Treer2
Ferguson-Darnell3
Collins4
Bergstresser5
-
33
-
-
0027255804
-
A Major Portion of Polymorphonu clear Leukocyte and T Lymphocyte Migration to Arthritic Joints in the Rat is Via LEA-1/MAC-1-Independent Mechanisms
-
of special interest, This study examines the contribution of 02-integrins (LEA-1 and MAC-1) to both polymorphonuclear cell and T cell homing to inflamed (arthritic) joints versus skin in the rat. With regard to T cell homing, the presented data demonstrate that T cell migration to skin is much more dependent on β2-integrins than to arthritic joints. These results indicate differential, microenvironment-dependent -involvement of even ‘general’ adhesion molecules like the β2-integrins in lymphocyte homing.
-
(1993)
Clin Immuno Immungpaib
, vol.67
, pp. 257-263
-
-
Issekutz1
Issekutz2
-
35
-
-
0026504051
-
Lymphocyte Adhesion Through Very Late Antigen 4: Evidence for a Novel Binding Site in the Alternatively Spliced Domain of Vascular Cell Adhesion Molecule 1 and an Additional a4 Integrin Counter-Receptor on Stimulated Endothelium
-
(1992)
J Fxp Med
, vol.175
, pp. 1433-1442
-
-
Vonderheide1
Springer2
-
36
-
-
0027848540
-
ICAM-3 Expression on Endothelium in Lymphoid Malignancy
-
of special interest, ICAM-3, a third Ig superfamily ligand for LFA-1 (αLβ2-integrin), is shown in this report to be expressed on the microvasculature in a high percentage of lymphoid neoplasms, indicating its inducibility on ECs in at least some circumstances. ICAM-3, therefore, joins ICAM-1 and -2 as a potential participant in 02-integrin-dependent lymphocyte homing phenomena.
-
(1993)
Am J Patbol
, vol.143
, pp. 1040-1043
-
-
Doussis-Anagnostopoulou1
Kaklamanis2
Cordell3
Jones4
Turley5
Pulford6
Simmons7
Mason8
Gatter9
-
37
-
-
0026757630
-
A 90Kilodalton Endothelial Cell Molecule Mediating Lymphocyte Binding in Humans
-
of outstanding interest, This report describes a novel 90kDa EC adhesion molecule (VAP-1) defined by mAb 1132. This anti-VAP-1 mAb strongly stains HEV in PLN, tonsil, and chronically inflamed synovium, and blocks lymphocyte binding to HEV in these sites in Stamper-Woodruff binding assays. Moreover, immunoafnity-isolated VAP-1 mediates lymphocyte binding when adsorbed onto glass. Limited amino acid sequence analysis of VAP-1 failed to reveal homology with any known adhesion molecule. Further characterization of VAP-1 expression patterns, including its inducibility in inflammatory sites, is reported in [38].
-
(1992)
Science
, vol.257
, pp. 1407-1409
-
-
Salmi1
Jalkanen2
-
38
-
-
0027368071
-
Induction and Function of Vascular Adhesion Protein-1 at Sites of Inflammation
-
(1993)
J Exp Med
, vol.178
, pp. 2255-2260
-
-
Salmi1
Kalimo2
Jalkanen3
-
39
-
-
0027440443
-
Lymphocyte-Vascular Adhesion Protein-2 Is a Novel 70kIYa Molecule Involved in Lympho cyte Adhesion to Vascular Endothelium
-
+ T cells). The involvement of LVAP-2 in lymphocyte-EC interaction is inferred from the ability of mAb 4G4 to consistently block about 25x6 of lymphocyte binding to HUVECs in static assays
-
(1993)
J Immunol
, vol.151
, pp. 4228-4238
-
-
Airas1
Salmi2
Jalkanen3
-
40
-
-
0027976481
-
Skin Disease-Related T Cells Bind to Endothelial Sclectins Expression of Cutaneous Lymphocyte Antigen (CIA) Predictls E-Selectin But Not Predictls E-Selectin Binding
-
+ and CIA — clones bound similarly to P-selectin. These results provide further support for the association of CIA and T cell homing to skin, and indicate the existence of P-selectin ligands on T cells that are distinct from the major E-selectin ligand(s) defined by the anti-CLA mAb HECA-452.
-
(1994)
European Journal of Immunology
, vol.24
, pp. 205-210
-
-
Rossiter1
van Reijsen2
Mudde3
Kalthoff4
Bruijnzeel Koomen5
Picker6
Kipper7
-
45
-
-
0026161899
-
Biology of the RANTES/SIS Cytokine Family
-
(1991)
Cytokine
, vol.3
, pp. 1-18
-
-
Schall1
-
50
-
-
0027509103
-
T-cell Adhesion Induced by Proteoglycan-Immobilized Cytokine MIP-1β
-
of special interest, This paper demonstrates the possibility that soluble chemokines such as MIP-1βcould be immobilized on the EC surface by binding proteoglycans, and thereby be in ‘position’ to trigger secondary adhesion during lymphocyte extravasation
-
(1993)
Nature
, vol.361
, pp. 79-82
-
-
Tanaka1
Adams2
Hubscher3
Hirano4
Siebenlist5
Shaw6
-
51
-
-
0027462365
-
Molecular Cloning, Functional Expression, and Signaling Characteristics of a C-C Chemokine Receptor
-
of special interest, These workers report the molecular cloning of a cell surface receptor which binds with varying affinities to C-C chemokines MIP-αand β, MCP-1 and RANTES. The cloned gene encodes a seven tranmembrune-spanning receptor that belongs to the superfamily of G protein-linked receptors with similar structure. Despite homology with a previously cloned C-X-C chemokine receptor, the C-X-C chemokine IL-8 does not bind this new receptor. Characterization of these receptors will be critical in the evaluation of the role played by the different chemokines in lymphocyte homing.
-
(1993)
Cell
, vol.72
, pp. 415-425
-
-
Neote1
DeGregorio2
Mak3
Horuk4
Schall5
-
53
-
-
0027359207
-
Coordinate Expression of P1 and 02 Integrin ‘Activation’ Epitopes During T Cell Responses in Secondary Lymphoid Tissue
-
of special interest, The conformational changes responsible for the increased ligandbinding capabilities of ‘activated’ integrins are associated with the creation of neoepitopes that are recognizable by mAbs. These neoepitope-specific mAbs can therefore serve as ‘reporters’ of integrin activation. This study examines the reactivity of two such reporter mAbs, 15/7 and 24, against 01 and P2-integrins, respectively, on T cells in human secondary lymphoid tissue. The results demonstrate the coordinate activation of β1- and β2-integrins on T cells undergoing the virgin to memory/effector transition, and on a subset of activated memory/effector T cells. These data provide the first evidence of integrin activation during in vivo immune reponses, and suggest that integrins act to ‘tether’ T cells to the local microenvironment during periods of activation.
-
(1993)
Eur j Immunol
, vol.23
, pp. 2751-2757
-
-
Picker1
Treer2
Nguyen3
Terstappen4
Hogg5
Yednock6
-
54
-
-
0025730216
-
Lymphocyte Interactions with Extracellular Matrix
-
(1991)
FASEB J
, vol.5
, pp. 2292-2299
-
-
Shimizu1
Shaw2
-
58
-
-
0027324601
-
Integrin αeβ7 Mediates Adhesion of T Lymphocytes to Epithelial Cells.
-
of special interest, The selective expression of ae57-integrin on intraepithelial and lamina propria T cells in mucosal sites has strongly suggested that it has a unique microenvironment-specific function, but the nature of this function has been mysterious. This paper and [59•] offer a clue to this mystery by demonstrating that aej37 mediates adhesion of T cells to mucosal epithelial cells, a finding that strongly suggests that αeβ7 serves as a post-extravasation localization receptor responsible for the selective retention of positive T cells in mucosal epithelia.
-
(1993)
J Immunol
, vol.150
, pp. 3459-3470
-
-
Cepek1
Parker2
Madara3
Brenner4
-
59
-
-
0027416258
-
Intestinal Intraepithelial Lymphocytes Bind to Colon Cancer Cells by HML-1 and CDl la
-
of special interest, This paper reports additional data supporting a role for αϵβ7-integrin in lymphocyte adhesion to mucosal epithelial cells (see [60•]).
-
(1993)
Cancer Res
, vol.53
, pp. 1608-1611
-
-
Roberts1
O'Connell2
Ebert3
-
60
-
-
0027371220
-
The Peyer's Patch High Endothelial Receptor for Lymphocytes, the Mueosal Vascular Addressin, is Induced on a Murinc Endothelial Cell Line by Tumor Necrosis Factor-α and IL-1
-
(1993)
J Immunol
, vol.151
, pp. 5239-5250
-
-
Sikorsk1
Hallmann2
Berg3
Butcher4
-
63
-
-
0027525639
-
Heterogeneity of Dermal Microvascular Endothelial Cell Antigen Expression and Cytokine Responsiveness In Situ and in Cell Culture
-
of special interest, Most of the work examining cytokine regulation of adhesion molecule expression on ECs has been done with ECs obtained from the large venules of the umbilical cord (HUVEC), and many investigators have developed models of lymphocyte extravasation based on direct extrapolation of these data to microvascular EC in different tissues. This paper, and 162,641 provide data indicating that HUVECs are not always representative of microvascular ECs. These workers compared the cytokine reponsiveness of HUVECs, cultured dermal microvascular ECs, and dermal ECs in organ culture with regard to expression of VCAM-1 and E-selectin. In general, dermal microvascular ECs were found to express more E-selectin and less VCAM-1 than analogously treated HUVECs.
-
(1993)
J Immunol
, vol.151
, pp. 5062-5072
-
-
Petzelbauer1
Bender2
Wilson3
Pober4
-
65
-
-
0017092799
-
Migration of Lymphoblasts to the Small Intestine II. Divergent Migration of Mesenteric and Peripheral Immunoblasts to Sites of Inflammation in the Mouse
-
(1976)
Cell Immunol
, vol.27
, pp. 36-46
-
-
Rose1
Parrott2
Bruce3
|
