Effects of transforming growth factor β on bone nodule formation and expression of bone morphogenetic protein 2, osteocalcin, osteopontin, alkaline phosphatase, and type I collagen mRNA in long‐term cultures of fetal rat calvarial osteoblasts

Journal of Bone and Mineral Research

Volumn 9, Issue 6, 1994, Pages 855-863

  Harris, S E ^a   Bonewald, L F ^b   Harris, M A ^a   Sabatini, M ^c   Dallas, S ^a   Feng, J Q ^a   Ghosh Choudhury N ^a   Wozney, J ^d   Mundy, G R ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b SOUTH TEXAS VETERANS HEALTH CARE SYSTEM   (United States)

^c INSTITUT DE RECHERCHES SERVIER   (France)

^d Genetics Institute Cambridge   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; ASCORBIC ACID; BONE MORPHOGENETIC PROTEIN; COLLAGEN TYPE 1; GLYCEROL 2 PHOSPHATE; MESSENGER RNA; OSTEOCALCIN; OSTEOPONTIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ARTICLE; BONE GROWTH; CALVARIA; CELL DIFFERENTIATION; CELL PROLIFERATION; FETUS; GROWTH REGULATION; NONHUMAN; OSSIFICATION; OSTEOBLAST; PROTEIN SYNTHESIS; RAT;

ALKALINE PHOSPHATASE; ANIMAL; BLOTTING, NORTHERN; BONE AND BONES; BONE DEVELOPMENT; BONE MORPHOGENETIC PROTEINS; CELL DIFFERENTIATION; CELLS, CULTURED; COLLAGEN; OSTEOBLASTS; OSTEOCALCIN; PROTEINS; RATS; RNA, MESSENGER; SIALOGLYCOPROTEINS; SUPPORT, U.S. GOV'T, NON-P.H.S.; SUPPORT, U.S. GOV'T, P.H.S.; TRANSFORMING GROWTH FACTOR BETA;

EID: 0028341364     PISSN: 08840431     EISSN: 15234681     Source Type: Journal    
DOI: 10.1002/jbmr.5650090611     Document Type: Article

References (33)

1. In vivo stimulation of bone formation by transforming growth factor‐beta
2. In vivo effects of human recombinant transforming growth factor‐beta on bone turnover in normal mice
3. Stimulation of bone formation in vivo by transforming growth factor‐beta—remodeling of woven bone and lack of inhibition by indomethacin
4. Effects of transforming growth factor beta on osteoblastic osteosarcoma cells
5. Type B transforming growth factor inhibits proliferation and expression of alkaline phosphatase in murine osteoblasts‐like cells
6. The use of osteosarcoma cells to characterize factors which regulate bone cell function
7. 3 on differentiation of a human osteosarcoma (MG‐63)
8. Transforming growth factor beta is a bifunctional regulator of replication and collagen synthesis in osteoblast‐enriched cell cultures from fetal rat bone
9. 1
10. Transforming growth factor beta stimulates bone matrix apposition and bone cell replication in cultured fetal rat calvariae
11. Growth factors in bone matrix
12. Modulation of transforming growth factor beta activity in bone cultures by osteotropic hormones
13. Mineralized bone nodules formed in vivo from enzymatically released rat calvaria cell populations
14. Relationship of cell growth to the regulation of tissue‐specific gene expression during osteoblast differentiation
15. Pleiotropic effects of vitamin‐D on osteoblast gene expression are related to the proliferative and differentiated state of the bone cell phenotype—dependency upon basal levels of gene expression, duration of exposure, and bone matrix competency in normal rat osteoblast cultures
16. Factors that promote progressive development of the osteoblast phenotype in cultured fetal rat calvaria cells
17. Ultrastructural analysis of bone nodules formed in vitro from isolated fetal rat calvarial cells
18. Effects of transforming growth factor β and epidermal growth factor on cell proliferation and the formation of bone nodules in isolated fetal rat calvaria cells
19. Expression of bone morphogenetic protein messenger RNA in prolonged cultures of fetal rat calvarial cells
20. Characterization of the hamster DDT1 cell aFGF/HBGF 1 gene and cDNA and its modulation by steroids
21. Gla‐containing proteins of bone
22. 3‐mediated transcriptional activation
23. Chemotactic response of osteoblast‐like cells to TGF‐β
24. 3‐induced inhibition of bone nodule formation in long term cultures of fetal rat calvarial cells
25. TGFβ stimulation and inhibition of cell proliferation: New mechanistic insights
26. Growth inhibition by TGFβ linked to suppression of retinoblastoma protein phosphorylation
27. 1 induces bone closure of skull defects
28. Transforming growth factor‐β and the initiation of chondrogenesis and osteogenesis in the rat femur
29. Recombinant human bone morphogenetic protein‐2 stimulates osteoblastic maturation and inhibits myogenic differentiation in vitro
30. Novel regulators of bone formation: Molecular clones and activities
31. Purification and characterization of other distinct bone‐inducing factors
32. Identification of transforming growth factor β family members present in bone‐inductive protein purified from bovine bone
33. Expression of bone morphogenetic protein (BMPs) during differentiation of fetal rat calvarial cells osteoblasts in vitro