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Volumn 35, Issue 24, 1994, Pages 4201-4204

Porphyrin-chlorambucil conjugates: Synthesis and light-induced nuclease activity

Author keywords

[No Author keywords available]

Indexed keywords

CHLORAMBUCIL; CHLORAMBUCIL DERIVATIVE; PORPHYRIN DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DNA BINDING; DNA DEGRADATION; DRUG SYNTHESIS; PHOTOCHEMISTRY;

EID: 0028340767 PISSN: 00404039 EISSN: None Source Type: Journal
DOI: 10.1016/S0040-4039(00)73151-0 Document Type: Article

Times cited : (17)

References (10)

3
- 0020445432
- Bleomycin models. Haemin?acridines which bind to DNA and cause oxygen-dependent scission
- (1982) Journal of the Chemical Society, Chemical Communications , pp. 1298
- Lown¹ Joshua²

4
- 0020577782
- Synthesis of porphyrin(Fe)-intercalators which cause DNA scission
- (1983) Tetrahedron Letters , pp. 1523
- Hashimoto¹ Lee² Shudo³ Okamoto⁴

5
- 0024573829
- Synthesis of hybrid “metalloporphyrin-ellipticine” molecules
- (1989) Tetrahedron , vol.45 , pp. 2641
- Etemad-Moghadam¹ Ding² Tadj³ Meunier⁴

6
- 0024841194
- Cytotoxic hybrid molecules ?metalloporphyrin?ellipticine? having a high affinity for DNA
- (1989) Journal of the Chemical Society, Chemical Communications , pp. 1711
- Ding¹ Etemad-Moghadam² Cros³ Auclain⁴ Meunier⁵

8
- 84912914815
- 3). 5a: δ −2.77 (2H, s), 1.92 (2H, q), 2.31 (2H, q), 2.42 (2H, t), 2.61 (2H, t), 2.7 (9H, s), 3.55 (8H, m), 4.34 (2H, t), 4.44 (2H, t), 6.59 (2H, d), 7.1 (2H, d), 7.26 (2H, d), 7.55 (6H, d), 8.1 (8H, d), 8.85 (8H, s). 5b: δ −2.78 (2H, s), 1.97 (6H, m), 2.37 (2H, t), 2.59 (2H, t), 2.7 (9H, s), 3.59 (8H, m), 4.27 (4H, t), 6.6 (2H, d), 7.1 (2H, d), 7.26 (2H, d), 7.54 (6H, d), 8.1 (8H, d), 8.85 (8H, s). 5c: δ −2.77 (2H, s), 1.76 (2H, m), 1.99 (6H, m), 2.38 (2H, t), 2.59 (2H, t), 2.7 (9H, s), 3.59 (8H, m), 4.2 (2H, t), 4.25 (2H, t), 6.6 (2H, d), 7.08 (2H, d), 7.25 (2H, d), 7.55 (6H, d), 8.1 (8H, d), 8.85 (8H, s). 5d: δ −2.75 (2H, s), 1.69 (4H, m), 1.95 (6H, m), 2.36 (2H, t), 2.58 (2H, t), 2.7 (9H, s), 3.61 (8H, m), 4.16 (2H, t), 4.23 (2H, t), 6.6 (2H, d), 7.07 (2H, d), 7.25 (2H, d), 7.54 (6H, d), 8.1 (8H, d), 8.85 (8H, s). 6: δ −2.78 [[Truncated]]

9
- 84912937507
- Quantification of DNA cleavage was done using UVP gel documentation system GDS 2000.

10
- 84912897189
- 2c This mixture was incubated for 1h at 25°C and then was irradiated (1h) with visible light (λ 〉 400 nm) by keeping the sample at a distance of 1m. from a 150 W Xe-arc lamp (UV-light was cut off using filters). The samples were analyzed by 0.8% agarose gel electrophoresis (tris-acetate buffer, pH 8) at a constant voltage. The gel was photographed after staining with ethidium bromide.

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