The glomerular response to injury: Progression or resolution?

Kidney International

Volumn 45, Issue 6, 1994, Pages 1769-1782

  Johnson, R J ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COCAINE;

ADULT; CASE REPORT; DRUG ABUSE; GLOMERULOSCLEROSIS; HUMAN; IMMUNOGLOBULIN A NEPHROPATHY; PARANASAL SINUSITIS; PRIORITY JOURNAL; REVIEW;

EID: 0028338877     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1038/ki.1994.230     Document Type: Article

References (186)

1. J.W.B. Bradfield V. Cattell J. Smith The mesangial cell in glomerulonephritis Lab Invest 36 1977 487
2. R.J. Johnson R.L. Garcia P. Pritzl C.E. Alpers Platelets mediate glomerular cell proliferation in immune complex nephritis induced by anti-mesangial cell antibodies in the rat Am J Pathol 136 1990 369 374
3. R.J. Johnson P. Pritzl H. Iida C.E. Alpers Platelet-complement interactions in mesangial proliferative nephritis in the rat Am J Pathol 138 1990 313 321
4. R.J. Johnson H. Iida C.E. Alpers M.W. Majesky S.M. Schwartz P. Pritzl K. Gordon A.M. Gown Expression of smooth muscle cell phenotype by rat mesangial cells in immune complex nephritis J Clin Invest 87 1991 847 858
5. H. Iida R. Seifert C.E. Alpers R.G.K. Gronwald P.E. Phillips P. Pritzl K. Gordon A.M. Gown R. Ross D.F. Bowen-Pope R.J. Johnson Platelet-derived growth factor (PDGF) and PDGF receptor are induced in mesangial proliferative nephritis in the rat Proc Natl Acad Sci USA 88 1991 6560 6564
6. J. Floege R.J. Johnson K. Gordon H. Iida P. Pritzl A. Yoshimura C. Campbell C.E. Alpers W.G. Couser Increased synthesis of extracellular matrix in mesangial proliferative nephritis Kidney Int 40 1991 477 488
7. T. Yamamoto C.B. Wilson Complement dependence of antibody-induced mesangial cell injury in the rat J Immunol 138 1987 3758 3765
8. W.M. Bagchus J. Hoedemaeker J. Rozing W.W. Bakker Glomerulo-nephritis induced by monoclonal anti-Thy 1.1 antibodies Lab Invest 55 1986 680 687
9. P. Kurki M. Vanderlaan F. Dolbeare J. Gary E.M. Tan Expression of proliferating cell nuclear antigen (PCNA)/cyclin during the cell cycle Exp Cell Res 166 1986 209 219
10. J. Floege E. Eng B.A. Young W.G. Couser R.J. Johnson Heparin suppresses mesangial cell proliferation and matrix expansion in experimental mesangioproliferative glomerulonephritis Kidney Int 43 1993 369 380
11. J. Floege M.W. Burns C.E. Alpers A. Yoshimura P. Pritzl K. Gordon R.A. Seifert D.F. Bowen-Pope W.G. Couser R.J. Johnson Glomerular cell proliferation and PDGF expression precede glomerulosclerosis in the remnant kidney model Kidney Int 41 1992 297 309
12. M. Fukui T. Nakamura I. Ebihara I. Nagaoka Y. Tomino H. Koide Low-protein diet attenuates increased gene expression of platelet-derived growth factor and transforming growth factor-β in experimental glomerular sclerosis J Lab Clin Med 121 1993 224 234
13. T. Nakamura I. Ebihara I. Nagaoka Y. Tomino H. Koide Renal platelet-derived growth factor gene expression in NZB/W F1 mice with lupus and ddY mice with IgA nephropathy Clin Immunol Immunopathol 63 1992 173 181
14. R. Johnson H. Iida A. Yoshimura J. Floege D.F. Bowen-Pope Platelet-derived growth factor: A potentially important cytokine in glomerular disease Kidney Int 41 1992 590 594
15. B. Young R. Johnson C. Alpers E. Eng J. Floege W.G. Couser Mesangial cell (MC) proliferation precedes development of glomerulosclerosis (GS) in experimental diabetic nephropathy (DN) ( abstract ) J Am Soc Nephrol 3 1992 770
16. T. Nakamura M. Fukui I. Ebihara S. Osada I. Nagaoka Y. Tomino H. Koide mRNA expression of growth factors in glomeruli from diabetic rats Diabetes 42 1993 450 456
17. C.M. Pesce L.J. Striker E. Peten S.J. Elliot G.E. Striker Glomerulosclerosis at both early and late stages is associated with increased cell turnover in mice transgenic for growth hormone Lab Invest 65 1991 601 605
18. C.E. Alpers K.L. Hudkins A.M. Gown R.J. Johnson Enhanced expression of “muscle-specific” actin in glomerulonephritis Kidney Int 41 1992 1134 1142
19. R. Ross J. Glomset B. Kariya L. Harker A platelet-dependent serum factor that stimulates the proliferation of arterial smooth muscle cells in vitro Proc Natl Acad Sci USA 71 1974 1207 1210
20. G. Brunner H. Nguyen J. Gabrilove D.B. Rifkin L. Wilson Basic fibroblast growth expression in human bone marrow and peripheral blood cells Blood 81 1993 631 638
21. R.K. Assoian A. Komoriya C.A. Meyers D.M. Miller M.B. Sporn Transforming growth factor-β in human platelets J Biol Chem 258 1983 7155 7159
22. Y. Oka D.N. Orth Human plasma epidermal growth factor/β-urogastrone is associated with blood platelets J Clin Invest 72 1983 249 259
23. T. Nakamura K. Nawa A. Ichihara N. Kaise T. Nishino Purification and subunit structure of hepatocyte growth factor from rat platelets FEBS Lett 224 1987 311 316
24. α amino acid sequence analysis Blood 74 1989 1084 1092
25. K. Miyazono T. Okabe A. Urabe F. Takaku C.H. Heldin Purification and properties of an endothelial cell growth factor from human platelets J Biol Chem 262 1987 4098 4103
26. R.J. Johnson Platelets in inflammatory glomerular injury Semin Nephrol 11 1991 276 284
27. C.M. Hawrylowicz S.A. Santoro F.M. Platt E.R. Unanue Activated platelets expressed IL-1 activity J Immunol 143 1989 4015 4018
28. 2-purinergic receptors Am J Physiol 263 1992 F374 F383
29. N. Takuwa M. Ganz Y. Takuwa R.B. Sterzel H. Rasmussen Studies of the mitogenic effect of serotonin in rat renal mesangial cells Am J Physiol 257 1989 F431 F439
30. J. Floege E. Eng B.A. Young R.J. Johnson Factors involved in the regulation of mesangial cell proliferation in vitro and in vivo Kidney Int 43 1993 S47 S54
31. P. Duffus A. Parbtani G. Frampton J.S. Cameron Intraglomerular localization of platelet related antigens, platelet factor 4 and β-thromboglobulin in glomerulonephritis Clin Nephrol 17 1982 288 297
32. K. Miller I.G. Dresner A.F. Michael Localization of platelet antigens in human kidney disease Kidney Int 18 1980 472 479
33. R.J. Johnson S.J. Guggenheim S.J. Klebanoff R.F. Ochi A. Wass P.J. Baker M. Schulze W.G. Couser Morphologic correlates of glomerular oxidant injury induced by the myeloperoxidase-hydrogen peroxide-halide system of the neutrophil Lab Invest 58 1988 294 301
34. R.J. Johnson C.E. Alpers C. Pruchno M. Schulze P.J. Baker P. Pritzl W.G. Couser Mechanisms and kinetics for platelet and neutrophil localization in immune complex nephritis Kidney Int 36 1989 780 789
35. C.R.P. George S.I. Slichter I.J. Quadracci G.E. Striker L.A. Harker A kinetic evaluation of hemostasis in renal disease N Engl J Med 29 1974 1111 1115
36. W.F. Clark M.I. Lewis J.S. Cameron V. Parsons Intrarenal platelet consumption in the diffuse proliferative nephritis of systemic lupus erythematosus Clin Sci Mol Med 49 1975 247 252
37. A. Parbtani G. Frampton J.S. Cameron Platelet and plasma serotonin concentrations in glomerulonephritis. II Clin Nephrol 14 1980 112 123
38. G. Gabbiani M.C. Badonnel P. Vassali Experimental focal glomerular lesions elicited by insoluble immune complexes Lab Invest 32 1975 33 45
39. H. Shigematsu Y. Niwa J. Takizawa B. Akikusa Arthus-type nephritis. I. Characterization of glomerular lesions induced by insoluble and poorly soluble immune complexes Lab Invest 40 1979 492 502
40. W.F. Clark D.I. Turnbull A.A. Driedger R.M. Lindsay A.L. Linton Intrarenal insoluble immune complex formation J Clin Lab Immunol 4 1980 21 25
41. V. Cattell Focal mesangial proliferative glomerulonephritis in the rat caused by habu snake venom: The role of platelets Br J Exp Pathol 60 1979 201 208
42. V. Cattell A. Mehotra Focal mesangial proliferative glomerulonephritis in the rat caused by habu snake vemom. The effect of antiplatelet agents Br J Exp Pathol 61 1980 310 314
43. J.L. Barnes Amelioration of habu venom-induced glomerular lesions: Potential role for platelet secretory proteins J Lab Clin Med 114 1989 200 206
44. R.L. Kinlough-Rathbone J.P. Cazenave M.A. Packham J.F. Mustard Effect of inhibitors of the arachidonate pathway on the release of granule contents from rabbit platelets adherent to collagen Lab Invest 42 1980 28 34
45. J.V. Donadio K.P. Offord Reassessment of treatment results in membrano-proliferative glomerulonephritis, with emphasis on life-table analysis Am J Kidney Dis 14 1989 445 451
46. C.F. Nathan Secretory products of macrophages J Clin Invest 79 1987 319 326
47. P.J. Shultz P.E. Dicorleto B.J. Silver H.E. Abboud Mesangial cells express PDGF mRNAs and proliferate in response to PDGF Am J Physiol 255 1988 F674 F684
48. J. Floege N. Topley J. Hoppe T.B. Barrett K. Resch Mitogenic effect of platelet-derived growth factor in human glomerular mesangial cells: modulation and/or suppression by inflammatory cytokines Clin Exp Immunol 86 1991 334 341
49. K. Mackay L.J. Striker J.W. Stauffer T. Doi L.Y. Agodoa G.E. Striker Transforming growth factor-β. Murine glomerular receptors and responses of isolated glomerular cells J Clin Invest 83 1989 1160 1167
50. F. Jaffer C. Saunders P. Shultz D. Throckmorton E. Weinshell H.E. Abboud Regulation of mesangial cell growth by polypeptide mitogens Am J Pathol 135 1989 261 269
51. D.H. Lovett J.L. Ryan R.B. Sterzel Stimulation of rat mesangial cell proliferation by macrophage interleukin J Immunol 31 1983 2830 2836
52. Y. Horii A. Muraguchi M. Iwano T. Matsuda T. Hirayama H. Yamada Y. Fujii K. Dohi H. Ishikawa Y. Ohmoto K. Yoshizaki T. Hirano T. Kishimoto Involvement of IL-6 in mesangial proliferative glomerulonephritis J Immunol 143 1989 3949 3955
53. J. Floege E. Eng V. Linder C.E. Alpers B.A. Young M.A. Reidy R.J. Johnson Rat glomerular mesangial cells synthesize basic FGF: Release, upregulated synthesis and mitogenicity in mesangial proliferative glomerulonephritis J Clin Invest 90 1992 2362 2369
54. M. Ikeda U. Ikeda T. Ohara K. Takeda S. Kano Recombinant interleukin-1α inhibits the growth of rat mesangial cells in culture Clin Exp Immunol 83 1991 149 153
55. M. Ikeda U. Ikeda T. Ohara E. Kusano S. Kano Recombinant interleukin-6 inhibits the growth of rat mesangial cells in culture Am J Pathol 141 1992 334 327
56. V. Cattell P. Largen E. De Heer T. Cook Glomeruli synthesize nitrite in active Heymann nephritis: the source is infiltrating macrophages Kidney Int 40 1991 847 851
57. U.C. Garg A. Hassid Nitric oxide-generating vasodilators inhibit mitogenesis and proliferation of BALB/c 3T3 fibroblasts by a cyclic GMP-independent mechanism Biochem Biophys Res Commun 171 1990 474 479
58. W.M. Bagchus M.F. Jeunink J.D. Elema The mesangium in anti-thy 1 nephritis. Influx of macrophages, mesangial cell hyper-cellularity, and macro-molecular accumulation Am J Pathol 137 1990 215 223
59. J. Floege C.E. Alpers M.W. Burns P. Pritzl K. Gordon W.G. Couser R.J. Johnson Glomerular cells, extracellular matrix accumulation, and the development of glomerulosclerosis in the remnant kidney model Lab Invest 66 1992 485 497
60. T. Saito R.C. Atkins Contribution of mononuclear leucocytes to the progression of experimental focal glomerular sclerosis Kidney Int 37 1990 1076 1083
61. A.B. Magil A.H. Cohen Monocytes and focal glomerulosclerosis Lab Invest 61 1989 404 409
62. A.B. Magil L.D. Wadsworth M. Loewen Monocytes and human renal glomerular disease Lab Invest 44 1981 27 33
63. B. Sterzel R. Pabst The temporal relationship between glomerular cell proliferation and monocyte infiltration in experimental glomerulonephritis Virchows Arch 38 1982 337 350
64. K.J. Lavelle B.D. Durland M.N. Yum The effect of antimacrophage anti-serum on immune complex glomerulonephritis J Lab Clin Med 98 1981 195 205
65. S.R. Holdsworth T.J. Neale C.B. Wilson Abrogation of macrophage-dependent injury in experimental glomerulonephritis in the rabbit J Clin Invest 68 1981 686 698
66. G.F. Schreiner R.S. Cotran V. Pardo E.R. Unanue A mononuclear cell component in experimental immunologic glomerulonephritis J Exp Med 147 1978 369 384
67. H.Y. Lan D.J. Nikolic-Paterson M. Zarama J.L. Vannice R.C. Atkins Suppression of experimental crescentic glomerulonephritis by the interleukin-1 receptor antagonist Kidney Int 43 1993 479 485
68. J.R. Diamond G. Ding J. Frye I.P. Diamond Glomerular macrophages and the mesangial proliferative response in the experimental nephrotic syndrome Am J Pathol 141 1992 887 894
69. K. Matsumoto M. Hatano Effect of antimacrophage serum on the proliferation of glomerular cells in nephrotic serum nephritis in the rat J Clin Immunol 28 1989 39 44
70. B.J. Silver F.E. Jaffer H.E. Abboud Platelet-derived growth factor synthesis in mesangial cells: Induction by multiple peptide mitogens Proc Natl Acad Sci USA 86 1989 1056 1060
71. J. Floege E. Eng B.A. Young C.E. Alpers T.B. Barrett D.F. Bowen-Pope R.J. Johnson Infusion of PDGF or basic FGF induces selective glomerular mesangial cell proliferation and matrix accumulation in rats J Clin Invest 92 1993 2952 2962
72. V. Lindner M.A. Reidy Proliferation of smooth muscle cells after vascular injury is inhibited by an antibody against basic fibroblast growth factor Proc Natl Acad Sci USA 88 1991 3739 3743
73. R.A. Seifert C.E. Hart P.E. Phillips J.W. Forstrom R. Ross M.J. Murray D.F. Bowen-Pope Two different subunits associate to create isoform-specific platelet-derived growth factor receptors J Biol Chem 264 1989 8771 8778
74. R.A. Seifert A. Van Koppen D.F. Bowen-Pope PDGF-AB requires PDGF receptor α-subunits for high-affinity, but not for low-affinity, binding and signal transduction J Biol Chem 268 1993 4473 4480
75. H.E. Abboud Nephrology Forum: Growth factors in glomerulonephritis Kidney Int 43 1993 252 267
76. T.O. Daniel D.A. Kumjian Platelet-derived growth factor in renal development and disease Semin Nephrol 13 1993 87 95
77. R.J. Johnson J. Floege W.G. Couser C.E. Alpers Role of platelet-derived growth factor in glomerular disease J Am Soc Nephrol 4 1993 119 128
78. D.H. Lovett A. Larsen Cell cycle-dependent interleukin 1 gene expression by cultured glomerular mesangial cells J Clin Invest 82 1988 115 122
79. H.E. Abboud K.A. Woodruff S.P. Snyder L.F. Bonewald Polypeptide growth factors regulate the production of latent transforming growth factor B1 in human mesangial cells ( abstract ) J Am Soc Nephrol 2 1991 434
80. M. Marx T.O. Daniel M. Kashgarian J.A. Madri Spatial organization of the extracellular matrix modulates the expression of PDGF-receptor subunits in mesangial cells Kidney Int 43 1993 1027 1041
81. C.E. Alpers R.A. Seifert K.L. Hudkins R.J. Johnson D.F. Bowen-Pope PDGF-receptor localizes to mesangial, parietal epithelial, and interstitial cells in human and primate kidneys Kidney Int 43 1993 286 294
82. Y. Isaka Y. Fujiwara N. Ueda Y. Kaneda T. Kamada E. Imai Glomerulosclerosis induced by in vivo transfection of TGF-β or PDGF gene into the rat kidney J Clin Invest 92 1993 2597 2601
83. G. Frampton G. Hildreth B. Hartley J.S. Cameron C.H. Heldin A. Wasteson Could platelet-derived growth factor have a role in the pathogenesis of lupus nephritis Lancet 2 1988 343
84. L. Gesualdo M. Pinzani J.J. Floriano M.O. Hassan N.U. Nagy F.P. Schena S.N. Emancipator H.E. Abboud Platelet-derived growth factor expression in mesangial proliferative glomerulonephritis Lab Invest 65 1991 160 167
85. A. Yoshimura K. Gordon C.E. Alpers J. Floege P. Pritzl R. Ross W.G. Couser D.F. Bowen-Pope R.J. Johnson Demonstration of PDGF B-chain mRNA in glomeruli in mesangial proliferative nephritis by in-situ hybridization Kidney Int 40 1991 470 476
86. J.L. Barnes H.E. Abboud Temporal expression of autocrine growth factors corresponds to morphologic features of mesangial proliferation in habu snake venom (HSV) induced glomerulonephritis (GN) Am J Pathol 143 1993 1366 1376
87. F.P. Schena E. Ranieri V. Montinaro D. Bottalico L. Gesualdo Quantification of cytokine mRNA expression in human renal biopsies by reverse transcriptase-polymerase chain reaction (RT-PCR) ( abstract ) J Am Soc Nephrol 3 1992 664
88. M. Nakajima T.D. Hewitson D.C. Mathews P. Kincaid-Smith Platelet-derived growth factor mesangial deposits in mesangial IgA glomerulonephritis Nephrol Dial Transplant 6 1991 11 16
89. B. Fellstrom L. Klareskog C.H. Heldon E. Larsson L. Roonstrand L. Terracio G. Tufveson J. Wahlberg K. Rubin Platelet-derived growth factor receptors in the kidney—upregulated expression in inflammation Kidney Int 36 1989 1099 1102
90. R.J. Johnson E.W. Raines J. Floege A. Yoshimura P. Pritzl C.E. Alpers R. Ross Inhibition of mesangial cell proliferation and matrix expansion in glomerulonephritis in the rat by antibody to platelet-derived growth factor J Exp Med 175 1992 1413 1416
91. T. Doi L.J. Striker C. Quaife F.G. Conti R. Palmiter R. Behringer R. Brinster G.E. Striker Progressive glomerulosclerosis develops in transgenic mice chronically expressing growth hormone and growth hormone releasing factor but not in those expressing insulin-like growth factor-1 Am J Pathol 131 1988 398 403
92. S. Suematsu T. Matsuda K. Aozasa S. Akira N. Nakano S. Ohno J. Miyazaki K. Yamamura T. Hirano T. Kishimoto IgG1 plasmacytosis in interleukin 6 transgenic mice Proc Natl Acad Sci USA 86 1989 7547 7551
93. K. Mackay L.J. Striker C. Pinkert R.L. Brinster G.E. Striker Glomerulosclerosis and renal cysts in mice transgenic for the early region of SV40 Kidney Int 32 1987 827 838
94. J.B. Kopp M.E. Klotman S.H. Adler L.A. Bruggeman P. Dickie N.J. Marinos M. Eckhaus J.L. Bryant A.L. Notkins P.E. Klotman Progressive glomerulosclerosis and enhanced renal accumulation of basement membrane components in mice transgenic for human immunodeficiency virus type 1 genes Proc Natl Acad Sci USA 89 1992 1577 1581
95. H.I. Werber S.N. Emancipator M.L. Tykocinski J.R. Sedor The interleukin 1 gene is expressed by rat glomerular mesangial cells and is augmented in immune complex glomerulonephritis J Immunol 138 1987 3207 3212
96. D.C. Brennan M.A. Yui R.P. Wuthrich V.E. Kelley Tumor necrosis factor and IL-1 in New Zealand black/white mice. Enhanced gene expression and acceleration of renal injury J Immunol 143 1989 3470 3475
97. T. Nakamura I. Ebihara M. Fukui T. Takahashi Y. Tomino H. Koide Altered glomerular steady-state levels of tumour necrosis factor-α-mRNA during nephrotic and sclerotic phases of puromycin aminonucleoside nephrosis in rats Clin Sci 84 1993 349 356
98. A. Benigni N. Perico F. Gaspari C. Zoja L. Bellizzi M. Gabanelli G. Remuzzi Increased renal endothelin production in rats with reduced renal mass Am J Physiol 260 1991 F331 F339
99. BR) are introduced in mesangial proliferative nephritis in the rat ( abstract ) J Am Soc Nephrol 3 1992 624
100. R.B. Sterzel E. Schulze-Lohoff M. Marx Cytokines and mesangial cells Kidney Int 39 1993 S26 S31
101. K. Saito F. Shimizu T. Sato T. Oite Modulation of human mesangial cell behaviour by extracellular matrix components—the possible role of interstitial type III collagen Clin Exp Immunol 91 1993 510 515
102. 2 and prostacyclin Kidney Int 38 1990 232 239
103. P. Mene M.J. Dunn Prostaglandins and rat glomerular mesangial cell proliferation Kidney Int 37 1990 1256 1262
104. M.P. O'Donnell B.L. Kasiske Y. Kim D. Atluru W.F. Keane The mevalonate pathway: importance in mesangial cell biology and glomerular disease Miner Electrolyte Metab in press
105. M.P. O'Donnell B.L. Kasiske Y. Kim D. Atluru W.F. Keane Lovastatin inhibits proliferation of rat mesangial cells J Clin Invest 91 1993 83 87
106. G. Grandaliano P. Biswas G.G. Choudhury H.E. Abboud Simvastatin inhibits PDGF-induced DNA synthesis in human glomerular mesangial cells Kidney Int 44 1993 503 508
107. B.L. Kasiske M.P. O'Donnell M.P. Cleary W.F. Keane Treatment of hyperlipidemia reduces glomerular injury in obese Zucker rats Kidney Int 33 1988 667 672
108. R.J. Johnson J. Floege A. Yoshimura H. Iida W.G. Couser C.E. Alpers The activated mesangial cell: a glomerular “myofibroblast” J Am Soc Nephrol 2 1992 S190 S197
109. R.J. Johnson C.E. Alpers A. Yoshimura D. Lombardi P. Pritzl J. Floege S.M. Schwartz Renal injury from angiotensin II-mediated hypertension Hypertension 19 1992 464 474
110. I. Darby O. Skalli G. Gabbiani α-smooth muscle actin is transiently expressed by myofibroblasts during experimental wound healing Lab Invest 63 1990 21 29
111. D.C. Rockey C.N. Housset S.L. Friedman Activation-dependent contractility of rat hepatic lipocytes in culture and in vivo J Clin Invest 92 1993 1795 1804
112. C.E. Alpers K.L. Hudkins M. Ferguson R.J. Johnson G.C. Schatteman M. Bothwell Nerve growth factor receptor expression in fetal, mature, and diseased human kidneys Lab Invest 69 1993 703 713
113. F. Sanfilippo B.P. Croker R.R. Bollinger Fate of four cadaveric donor renal allografts with mesangial IgA deposits Transplantation 33 1982 370 376
114. E.P. Peten L.J. Striker A. Garcia-Perez G.E. Striker Studies by competitive PCR of glomerulosclerosis in growth hormone transgenic mice Kidney Int 43 1993 S55 S58
115. E.P. Peten L.J. Striker M.A. Carome S.J. Elliott C.W. Yang G.E. Striker The contribution of increased collagen synthesis to human glomerulosclerosis: A quantitative analysis of α2IV collagen mRNA expression by competitive polymerase chain reaction J Exp Med 176 1992 1571 1576
116. T. Nakamura I. Ebihara I. Shirato Y. Tomino H. Koide Modulation of basement membane component gene expression in glomeruli of aminonucleoside nephrosis Lab Invest 64 1991 640 647
117. I. Ebihara S. Suzuki T. Nakamura M. Fukui Y. Yaguchi Y. Tomino H. Koide Extracellular matrix component mRNA expression in glomeruli in experimental focal glomerulosclerosis J Am Soc Nephrol 3 1993 1387 1397
118. M.A. Carome L.J. Striker E.P. Penten J. Moore C.W. Yang W.G. Stetler-Stevenson Human glomeruli express TIMP-1 mRNA and TIMP-2 protein and mRNA Am J Physiol 264 1993 F923 F929
119. S. Tomooka W.A. Border B.C. Marshall N.A. Noble Glomerular matrix accumulation is linked to inhibition of the plasmin protease system Kidney Int 42 1992 1462 1469
120. W.A. Border S. Okuda L.R. Languino E. Ruoslahti Transforming growth factor-β regulates production of proteoglycans by mesangial cells Kidney Int 37 1990 689 695
121. S. Okuda L.R. Languino E. Ruoslahti W.A. Border Elevated expression of transforming growth factor-β and proteoglycan production in experimental glomerulonephritis J Clin Invest 86 1990 453 462
122. T. Coimbra R. Wiggins J. Woo Noh S. Merritt S.H. Phan Transforming growth factor-β production in anti-glomerular basement membrane disease in the rabbit Am J Pathol 138 1991 223 234
123. G. Ding I. Pesek-Diamond J.R. Diamond Cholesterol, macrophages, and gene expression of TGF-β1 and fibronectin during nephrosis Am J Physiol 264 1993 F577 F584
124. T. Yamamoto T. Nakamura N.A. Noble E. Ruoslahti W.A. Border Expression of transforming growth factor β is elevated in human and experimental diabetic nephropathy Proc Natl Acad Sci USA 90 1993 1814 1818
125. K. Yoshioka T. Takemura K. Murakami M. Okada S. Hino H. Miyamoto Transforming growth factor-β protein and mRNA in glomeruli in normal and diseased human kidneys Lab Invest 68 1993 164 173
126. W.A. Border S. Okuda L.R. Languino M.B. Sporn E. Ruoslahti Suppression of experimental glomerulonephritis by antiserum against transforming growth factor β1 Nature 346 1990 371 374
127. W.A. Border N.A. Noble T. Yamamoto J.R. Harper Y. Yamaguchi M.D. Pierschbacher E. Ruoslahti Natural inhibitor of transforming growth factor-β protects against scarring in experimental kidney disease Nature 360 1992 361 364
128. S. Okuda T. Nakamura T. Yamamoto E. Ruoslahti W.A. Border Dietary protein restriction rapidly reduces transforming growth factor β1 expression in experimental glomerulonephritis Proc Natl Acad Sci USA 88 1991 9765 9769
129. A. Benigni C. Zoja D. Corna S. Orisio L. Longaretti T. Bertani G. Remuzzi A specific endothelin subtype A receptor antagonist protects against injury in renal disease progression Kidney Int 44 1993 440 444
130. R.A.K. Stahl F. Thaiss G. Oberle H.M. Brecht W. Schoepee U. Wenzel U.M. Helmchen The platelet activating factor receptor antagonist WEB 2170 improves glomerular hemodynamics and morphology in a proliferative model of mesangial cell injury J Am Soc Nephrol 2 1991 37 44
131. B.A. Kiberd Interleukin-6 receptor blockage ameliorates murine lupus nephritis J Am Soc Nephrol 4 1993 58 61
132. J.J. Castellot R.L. Hoover P.A. Harper M.J. Karnovsky Heparin and glomerular epithelial cell-secreted heparin-like species inhibit mesangial-cell proliferation Am J Pathol 120 1985 427 435
133. R.C. Appel Growth inhibitory activity of atrial natriuretic factor in rat glomerular mesangial cells FEBS Lett 238 1988 135 138
134. M. Martin R. Schwinzer H. Schellekens K. Resch Glomerular mesangial cells in local inflammation. Induction of the expression of MHC Class II antigens by IFN-γ J Immunol 142 1989 1887 1894
135. Y. Kakizaki N. Kraft R.C. Atkins Differential control of mesangial cell proliferation by interferon-gamma Clin Exp Immunol 85 1991 157 163
136. G.C. Groggel M.L. Hughes Production of an inhibitor of rat mesangial cell growth by the glomerulus and its alteration in puromycin nephrosis J Am Soc Nephrol 4 1993 155 161
137. 2+-binding glycoprotein SPARC modulates cell cycle progression in bovine aortic endothelial cells Proc Natl Acad Sci USA 88 1991 2648 2652
138. S.E. Funk E.H. Sage Differential effects of SPARC and cationic SPARC peptides on DNA synthesis by endothelial cells and fibroblasts J Cell Physiol 154 1993 53 63
139. P. Hasselaar E.H. Sage SPARC antagonizes the effect of basic fibroblast growth factor on the migration of bovine aortic endothelial cells J Cell Biochem 49 1992 272 283
140. E.W. Raines T.F. Lane M. Iruela-Arispe R. Ross E.H. Sage The extra-cellular glycoprotein SPARC interacts with plateletderived growth factor (PDGF)-AB and -BB and inhibits the binding of PDGF to its receptors Proc Natl Acad Sci USA 89 1992 1281 1285
141. M.C. Raff Social controls on cell survival and cell death Nature 356 1992 397 400
142. H.Y. Lan D.J. Nikolic-Paterson R.C. Atkins Trafficking of inflammatory macrophages from the kidney to draining lymph nodes during experimental glomerulonephritis Clin Exp Immunol 92 1993 336 341
143. H.Y. Lan D.J. Nikolic-Paterson R.C. Atkins Immune events in lymphoid tissues during experimental glomerulonephritis Pathology 25 1993 159 166
144. D.H. Lovett R.J. Johnson H.P. Marti J. Martin M. Davies W.G. Couser Structural characterization of the mesangial cell type IV collagenase and enhanced expression in a model of immune complex-mediated glomerulonephritis Am J Pathol 141 1992 85 98
145. H. Iida K. Izumino M. Asaka C. Entani M. Takata R.J. Johnson Glomerulosclerosis in the rat induced by repeated immunemediated mesangial cell injury Jpn J Nephrol 35 1993 19 26
146. R.A. Stahl F. Thaiss U. Wenzel U. Helmchen Morphologic and functional consequences of immune-mediated mesangiolysis: development of chronic glomerular sclerosis J Am Soc Nephrol 2 1992 S144 S148
147. J. Floege R.J. Johnson C.E. Alpers S. Fatemi-Nainie C.A. Richardson K. Gordon W.G. Couser Visceral glomerular epithelial cells can proliferate in vivo and synthesize platelet-derived growth factor B-chain Am J Pathol 142 1993 637 650
148. J. Floege C.E. Alpers E.H. Sage P. Pritzl K. Gordon R.J. Johnson W.G. Couser Markers of complement-dependent and complement-independent glomerular visceral epithelial cell injury in vivo Lab Invest 67 1992 486 496
149. J. Floege R.J. Johnson K. Gordon A. Yoshimura C. Campbell L. Iruela-Arispe C.E. Alpers W.G. Couser Altered glomerular extracellular matrix synthesis in experimental membranous nephropathy Kidney Int 42 1992 573 585
150. H.N. Antoniades T. Galanopoulos J. Neville-Golden C.P. Kritsy S.E. Lynch Injury induces in vivo expression of platelet-derived growth factor (PDGF) and PDGF receptor mRNAs in skin epithelial cells and PDGF mRNA in connective tissue fibroblasts Proc Natl Acad Sci USA 88 1991 565 569
151. J.N. Wilcox K.M. Smith L.T. Williams S.M. Schwartz D. Gordon Platelet-derived growth factor mRNA detection in human atherosclerotic plaques by in situ hybridization J Clin Invest 82 1988 1134 1143
152. H.N. Antoniades M.A. Bravo R.E. Avila T. Galanopoulos J. Neville-Golden M. Maxwell M. Selman Platelet-derived growth factor in idiopathic pulmonary fibrosis J Clin Invest 86 1990 1055 1064
153. C. Reuterdahl A. Tingstrom L. Terracio K. Funa C. Henrik Heldin K. Rubin Characterization of platelet-derived growth factor β-receptor expressing cells in the vasculature of human rheumatoid synovium Lab Invest 64 1991 321 329
154. D.C. Rockey J.K. Boyles G. Gabbiani S.L. Friedman Rat hepatic lipocytes express smooth muscle actin upon activation in vivo and in culture J Submicrosc Cytol Pathol 24 1992 193 203
155. T. Takahara T. Kojima C. Miyabayashi K. Inoue H. Sasaki Y. Muragaki A. Ooshima Collagen production in fat storing cells after carbon tetrachloride intoxication in the rat: immunoelectron microscopic observation of type I, type III, collagens, and proly hydroxylase Lab Invest 59 1988 509 521
156. J. Mitchell J. Woodcock-Mitchell S. Reynolds R. Low K. Leslie K. Adler G. Gabbiani O. Skalli α-smooth muscle actin in parenchymal cells of bleomycin-injured rat lung Lab Invest 60 1989 643 650
157. M.A. Reidy Factors controlling smooth-muscle cell proliferation Arch Pathol Lab Med 116 1992 1276 1280
158. R. Dalchau J.W. Fabre Identification and unusual tissue distribution of the canine and human homologues of Thy-1 (0) J Exp Med 149 1979 576 591
159. D.J. O'Donoghue A. Darvill F.W. Ballardie Mesangial cell autoantigens in immunoglobulin-A nephrology and Henoch-Schönlein purpura J Clin Invest 88 1991 1522 1530
160. T. Morita J. Churg Mesangiolysis Kidney Int 24 1983 1 9
161. M.K. Chan S.Y.L. Kwan K.W. Chan C.K. Yeung Controlled trial of antiplatelet agents in mesangial IgA glomerulonephritis Am J Kidney Dis 9 1987 417 421
162. N. Ueda S. Kawaguchi Y. Niinomi T. Nonoda M. Ohnishi S. Ito T. Yasaki Effect of dipyridamole treatment on proteinuria in pediatric renal disease Nephron 44 1986 174 179
163. S. Camara J.P. De La Cruz M.A. Frutos P. Sanchez E. Lopez De Novales E. Sanchez F. Sanchez De La Cuesta Effects of dipyridamole on the short-term evolution of glomerulonephritis Nephron 58 1991 13 16
164. J. Maclouf B. Fruteau de Laclos P. Borgeat Stimulation of leukotriene biosynthesis in human blood leukocytes by platelet-derived 12-hydroperoxy-icosatetraenoic acid Proc Natl Acad Sci USA 79 1982 6042 6046
165. L. Gesualdo S. Di Paolo M. Di Cillo A. Brunaccini L. Maffione F.P. Schena Trapidil, a PDGF-receptor antagonist, inhibits human mesangial cell (HMC) proliferation ( abstract ) J Am Soc Nephrol 3 1992 453
166. A. Futamura H. Iida K. Izumino C. Entani M. Takata Effect of the platelet-derived growth factor (PDGF) antagonist trapidil on rat mesangial cell proliferation ( abstract ) J Am Soc Nephrol 3 1992 588
167. A. Bohle S. Mackensen-Haen H.V. Gise Significance of tubulointerstitial changes in the renal cortex for the excretory function and concentration ability of the kidney. A morphometric contribution Am J Nephrol 7 1987 421 443
168. D. Kees-Folts G.F. Schreiner A lipid chemotactic factor associated with proteinuria and interstitial nephritis induced by protein overload ( abstract ) J Am Soc Nephrol 2 1991 548
169. D. Seron J.S. Cameron D.O. Haskard Expression of VCAM-1 in the normal and diseased kidney Nephrol Dial Transplant 6 1991 917 922
170. R.P. Wuthrich A.M. Jevnikar F. Takei L.H. Glimcher V.E. Kelley Intracellular adhesion molecule-1 (ICAM-1) expression is upregulated in autoimmune murine lupus nephritis Am J Pathol 136 1990 441 450
171. I.W. Main D.J. Nikolic-Peterson R.C. Atkins T cells and macrophages and their role in renal injury Semin Nephrol 12 1992 395 407
172. C.M. Giachelli R. Pichler D. Lombardi D.T. Denhardt C. Alpers S. Schwartz R.J. Johnson Osteopontin expression in angiotensin II-induced tubulointerstitial nephritis Kidney Int 45 1994 515 524
173. R. Pichler C.M. Giachelli D. Lombardi J. Pippin K. Gordon C.E. Alpers S.M. Schwartz R.J. Johnson Tubulointerstitial disease in glomerulo-nephritis. Potential role of osteopontin (uropontin) Am J Pathol in press
174. J. Folkman M. Klagsbrun J. Sasse M. Wadzinski D. Ingber I. Vlodavsky A heparin-binding angiogenic protein—basic fibroblast growth factor—is stored within basement membrane Am J Pathol 130 1988 393 400
175. J.J. Castellot L.A. Pukac B.L. Caleb T.C. Wright M.J. Karnovsky Heparin selectively inhibits a protein kinase C-dependent mechanism of cell cycle progression in calf aortic smooth muscle cells J Cell Biol 109 1989 3147 3152
176. Y. Yamaguchi D.M. Mann E. Ruoslahti Negative regulation of transforming growth factor-β by the proteoglycan decorin Nature 346 1990 281 284 (Lond)
177. H.G. Rus F. Niculescu M. Nanulescu A. Cristea P. Florescu Immunohistochemical detection of the terminal C5b-9 complement complex in children with glomerular diseases Clin Exp Immunol 65 1986 66 72
178. C.E. Alpers R.A. Seifert K.L. Hudkins R.J. Johnson D.F. Bowen-Pope Developmental patterns of PDGF B-chain, PDGF-receptor, and α-actin expression in human glomerulogenesis Kidney Int 42 1992 390 399
179. L. Assad M.M. Schwartz I. Virtanen V.E. Gould Immunolocalization of tenascin and cellular fibronectins in diverse glomerulopathies Vichows Arch 63 1993 307 316 [B]
180. B.R. MacPherson K.O. Leslie K.V. Lizaso J.E. Schwartz Contractile cells of the kidney in primary glomerular disorders: An immunohistochemical study using an anti-alpha-smooth muscle actin monoclonal antibody Hum Pathol 24 1993 710 716
181. L. Fesus Biochemical events in naturally occurring forms of cell death FEBS Lett 328 1993 1 5
182. M. Lisker-Melman D. Webb A.M. Di Bisceglie C. Kassianides P. Martin V. Rustgi J.G. Waggoner Y. Park J.H. Hoofnagel Glomerulonephritis caused by chronic hepatitis B virus infection: treatment with recombinant human alpha-interferon Ann Intern Med 111 1989 479 483
183. R.J. Johnson D.R. Gretch H. Yamabe J. Hart C.E. Bacchi P. Hartwell W.G. Couser L. Corey M.H. Wener C.E. Alpers R. Willson Membranoproliferative glomerulonephritis associated with hepatitis C virus infection N Engl J Med 328 1993 465 470
184. J.R. Diamond M.J. Karnovsky Focal and segmental glomerulosclerosis: analogies to atherosclerosis Kidney Int 33 1988 917 924
185. C. Thiemermann R. Corder Is endothelin-1 the regulator of myofibroblast contraction during wound healing Lab Invest 67 1992 677 679
186. M. Simonson M.J. Dunn Endothelin-1 stimulates contraction of rat glomerular mesangial cells and potentiates β-adrenergic-mediated cyclic adenosine monophosphate accumulation J Clin Invest 85 1990 790 797