Antagonism of clonidine antinociception by buspirone and 1-(2-pyrimidinyl)-piperazine

European Journal of Pharmacology

Volumn 259, Issue 1, 1994, Pages 75-78

  Cao, Bo Jin ^a   Li, Wei Ping ^a  

^a Hunan Institute of Pharmaceutical Industry Research   (China)

Author keywords

1 PP (1 (2 pyrimidinyl) piperazine); Antinociception; Buspirone; Clonidine; 2 Adrenoceptor

Indexed keywords

1 (2 PYRIMIDINYL)PIPERAZINE; ALPHA 2 ADRENERGIC RECEPTOR; BUSPIRONE; CLONIDINE; DRUG METABOLITE;

ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DRUG ANTAGONISM; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SUBCUTANEOUS DRUG ADMINISTRATION; TAIL FLICK TEST; WRITHING TEST;

ANALGESICS; ANIMAL; ANTI-ANXIETY AGENTS; BUSPIRONE; CLONIDINE; MALE; MICE;

EID: 0028334494     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(94)90160-0     Document Type: Article

References (15)

1. 2-adrenoceptor antagonist activity of ipsapirone and gepirone mediated by their common metabolite 1-(2-pyrimidinyl)-piperazine (PmP)
2. Disposition and metabolism of buspirone and its metabolite 1-(2-pyrimidinyl)-piperazine in the rat
3. Different effects of intracerebral and systemic administration of buspirone in the forced swimming test: involvement of a metabolite
4. 1A receptor agonists in the mouse
5. 2-receptor blockade
6. Effects of buspirone and its metabolite, 1-(2-pyrimidinyl)-piperazine, on brain monoamines and their metabolites in rats
7. Pharmacological evidence for the involvement of 1-(2-pyrimidinyl)-piperazine (PmP) in the interaction of buspirine or gepirone with noradrenergic systems
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10. 2-adrenoceptor involvement in the antinociceptive action of tizanidine and clonidine in the mouse
11. 1A agonists in the learned helplessness paradigm in rats
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13. Buspirone, a new approach to the treatment of anxiety
14. 1A agonists measured with the forced swim test
15. Pharmacology of spinal adrenergic systems which modulate spinal nociceptive processing