-
3
-
-
0025948534
-
Comparison of the effects of various typical and atypical antipsychotic drugs on the suppressant action of 2-methylserotonin on medial prefrontal cortical cells in the rat
-
(1991)
Synapse
, vol.8
, pp. 155-161
-
-
Ashby, C.R.1
Miabe, Y.2
Edwards, E.3
Wang, R.Y.4
-
8
-
-
84936010542
-
-
Blum PS, Davis CB (1988) Effect of risperidone (R 64 766) on presynaptic dopamine receptors in the neostriatum of the rat. Janssen Biological Research Report 010, N 64755
-
-
-
-
12
-
-
84936030317
-
-
Bowden CR, Voina SJ (1988) Effects of R 64 766, haloperidol hydrochloride and clozapine on fasting plasma prolactin, insuline, corticosterone and glucose concentrations in normal rats. Janssen Biological Research Report 004, N 59594
-
-
-
-
18
-
-
0027475985
-
Canadian multicenter placebo-controlled study of fixed doses of risperidone and haloperidol in the treatment of chronic schizophrenic patients
-
(1993)
J Clin Psychopharmacol
, vol.13
, pp. 25-40
-
-
Chouinard, G.1
Jones, B.2
Remington, G.3
Bloom, D.4
Addington, D.5
MacEwan, G.W.6
Labelle, A.7
Beauclair, L.8
Arnott, W.A.9
-
22
-
-
0027193007
-
Effects of atypical antipsychotic agents on social behavior in rodents
-
(1993)
Pharmacology Biochemistry and Behavior
, vol.45
, pp. 9-17
-
-
Corbet, R.1
Hartman, H.2
Kerman, L.L.3
Woods, A.T.4
Strupczewski, J.T.5
Helsley, G.C.6
Conway, P.C.7
Dunn, R.W.8
-
26
-
-
84936035563
-
-
D'Aubioul J, Van Gerven W, Wouters L, Xhonneux R (1985) Cardiovascular and behavioural effects of R 64 766 (0.08 mg.kg−1, orally) in conscious dogs. Janssen Preclinical Research Report R 64 766/1, N 43655
-
-
-
-
27
-
-
84936041632
-
-
D'Aubioul J, Van Gerven W, Wouters L, Xhonneux R (1986) The effects of R 64 766 (0.31 mg.kg−1, orally) on ECG, heart rate and behaviour in conscious dogs. Janssen Preclinical Research Report R 64 766/7, N 51935
-
-
-
-
28
-
-
84936002141
-
-
D'Aubioul J, Van Gerven W, Wouters L, Xhonneux R (1989) Cardiovascular and behavioural effects of R 64 766 (0.08 mg.kg−1, orally) in conscious dogs, chronically medicated with the compound. Janssen Preclinical Research Report R 64 766/20, N 64850
-
-
-
-
29
-
-
0016191010
-
A multicentric evaluation of pimozide (OrapR) in patients who usually would take tranquilizers
-
(1974)
Acta Psychiatr Belg
, vol.74
, pp. 653-660
-
-
Deberdt, R.1
-
30
-
-
0017074454
-
Pipamperone (Dipiperon) in the treatment of behaviour disorders. A large-scale multicentre evaluation
-
(1976)
Acta Psychiatr Belg
, vol.76
, pp. 157-166
-
-
Deberdt, R.1
-
32
-
-
84936057694
-
-
De Coster R, Coussement W, Van Cauteren H, Goeminne N (1991) Effects of daily oral administration of risperidone for 6 weeks on serum prolactin, LH and testosterone levels in rats. Janssen Preclinical Research Report R 64 766/33, N 84177
-
-
-
-
33
-
-
0006584351
-
The effects of a novel 5-HT3 antagonist, ondansetron, in schizophrenia: results from uncontrolled trials
-
H.Y., Meltzer, Raven, New York
-
(1991)
Novel antipsychotic drugs
, pp. 225-232
-
-
De Veaugh-Geiss, J.1
McBain, S.2
Cooksey, P.3
Bell, J.M.4
-
36
-
-
84936007676
-
-
Dugovic C, Van Wassenhove JJH, Van Den Broeck W, Clincke GHC (1992) Comparative study on the effects of haloperidol, bromperidol, and risperidone on sleep-wakefulness and ECoG power spectra in the rat. Janssen Preclinical Research Report R 64 766, N 91966
-
-
-
-
37
-
-
84935999556
-
-
Ellenbroek B (1988) The paw test: an animal model with predictive validity. In: Animal models for schizophrenia and neuroleptic drug action (Chapter 7). Ph. D. Thesis, Krips Repro Meppel, pp 230–275
-
-
-
-
39
-
-
0025925148
-
Multiple human D5 dopamine receptor genes: a functional receptor and two pseudogenes
-
(1991)
Physiol Pharmacol Phys
, vol.88
, pp. 9175-9179
-
-
Grandy, D.K.1
Zhang, Y.2
Bouvier, C.3
Zhou, Q-Y4
Johnson, R.A.5
Allen, L.6
Buck, K.7
Bunzow, J.R.8
Salon, J.9
Civelli, O.10
-
43
-
-
0025242104
-
The effect of serotonergic agents on haloperidol-induced catalepsy
-
(1990)
Life Sci
, vol.47
, pp. 1609-1615
-
-
Hicks, P.B.1
-
48
-
-
0023623799
-
The development of new antipsychotic drugs: towards a new strategy in the management of chronic psychoses
-
(1987)
J Drug Ther Res
, vol.12
, pp. 324-328
-
-
Janssen, P.A.J.1
-
49
-
-
84935994799
-
-
Janssen PAJ, Awouters FHL (1993) Is it possible to predict the clinical effects of neuroleptics from animal data? V. From haloperidol and pipamperone to risperidone. Arzneimittelforschung (in press)
-
-
-
-
55
-
-
84936030065
-
-
Janssens WJ, Schuurkes JAJ, Ghoos ECR, Van Nueten JM (1988) The pharmacological profile of risperidone (R 64 766) on peripheral tissues. Janssen Preclinical Research Report R 64 766/18, N 62360
-
-
-
-
59
-
-
84936006046
-
-
Lavrijsen K, Van Houdt J, Van Dyck D, Heykants J (1989) Study on the induction and/or inhibition potential of risperidone towards drug-metabolizing enzymes in the liver of male Wistar rats. Janssen Preclinical Research Report R 64 766/21, N 69384
-
-
-
-
60
-
-
84936004456
-
-
Lavrijsen K, Meuldermans W, Heykants J (1993) In vitro inhibition study in human liver microsomes to investigate the interaction potential of various drugs with the metabolism of risperidone. Janssen Preclinical Research Report R 64 766/FK 1257
-
-
-
-
67
-
-
84936020355
-
-
Leysen JE, Gys L, Heylen L, Gommeren W (1991) In vitro receptor binding and neurotransmitter uptake inhibition profile of R 64 766, R 76 477, R 78 543 and R 78 544. Janssen Preclinical Research Report R 64 766/28, R 76 477/, R 78 543/, R 78 544/, N 79120
-
-
-
-
69
-
-
0027396727
-
Comparison of in vitro binding properties of a series of dopamine antagonists and agonists for cloned human dopamine D2S and D2L receptors and for D2 receptors in rat striatal and mesolimbic tissues, using [125I]2′-iodospiperone
-
(1993)
Psychopharmacology
, vol.110
, pp. 27-36
-
-
Leysen, J.E.1
Gommeren, W.2
Wynants, J.3
Mertens, J.4
Luyten, W.H.M.L.5
Pauwels, P.J.6
Ewert, M.7
Seeburg, P.8
-
73
-
-
1842598607
-
Behandlung von Schlafstörungen bei älteren Patienten
-
(1987)
Therapiewoche
, vol.37
, pp. 2484-2487
-
-
Malsch, U.1
-
75
-
-
0026366885
-
Application of drug discrimination with drugs of abuse to develop new therapeutic agents
-
R.A., Glennon, et al., Proceedings of the International Drug Discrimination Symposium, Noordwijkerhout, The Netherlands, June 25–27, 1990, Research Monograph, 116, National Institute on Drug Abuse, Rockville, Maryland, USA
-
(1991)
Drug discrimination: applications to drug abuse research
, pp. 307-323
-
-
Meert, T.F.1
-
80
-
-
84936001078
-
-
Megens AAHP, Awouters FHL (1993) In vivo pharmacological profile of 9-hydroxyrisperidone, the major metabolite of the novel antipsychotic risperidone: comparison with risperidone and haloperidol. Janssen Preclinical Research Report R 64 766, N 96295
-
-
-
-
81
-
-
84936056468
-
-
Megens AAHP, Canters LLJ (1988) Absence of gastrointestinal motor stimulating or inhibiting properties of risperidone in the phenol red and charcoal tests in rats. Janssen Preclinical Research Report R 64 766/19, N 62363
-
-
-
-
84
-
-
84936012518
-
-
Megens AAHP, Awouters FHL, Niemegeers CJE (1988b) Complementary study on the pharmacology of risperidone in mice and rats. Janssen Preclinical Research Report R 64 766/16, N 62321
-
-
-
-
89
-
-
84936015204
-
-
Megens AAHP, Vermeire J, Artois K, Hens K, Awouters FHL (1993a) The new antipsychotic risperidone is devoid of local irritating and anesthetic activity on rabbit cornea and fails to affect nerve conduction from rat tail. Janssen Preclinical Research Report R 64 766, N 94702
-
-
-
-
90
-
-
84936049026
-
-
Megens AAHP, Hendrickx H, Awouters FHL (1993b) Risperidone is devoid of interaction with the convulsant pentylenetetrazole in rats. Janssen Preclinical Research Report R 64 766, N 94704
-
-
-
-
103
-
-
0021245210
-
Neuroleptic affinities for human brain receptors and their use in predicting adverse effects
-
(1984)
J Clin Psychiatry
, vol.45
, pp. 331-336
-
-
Richelson, E.1
-
110
-
-
84910584321
-
Receptor feedback and dopamine turnover in CNS
-
L.L., Iversen, S.D., Iversen, S.H., Snyder, Plenum, New York
-
(1975)
Handbook of psychopharmacology, vol 6
, pp. 127-177
-
-
Sedvall, G.1
-
117
-
-
0001054442
-
Modulation of dopaminergic neurotransmission by 5HT2 antagonism
-
R., Paoletti, P., Saxena, P., Vanhoutte, Kluwer, Dordrecht, The Netherlands
-
(1993)
2nd Serotonin from Cell Biology to Pharmacology and Therapeutics
-
-
Svensson, T.H.1
Nomikos, G.G.2
Andersson, J.L.3
-
120
-
-
84936001722
-
-
Van Beijsterveldt LEC, Geerts RJF, Leysen JE, Megens AAHP, Van den Eynde HMJ, Meuldermans WEG, Heykants JJP (1993) The regional brain distribution of risperidone and its active metabolite 9-hydroxy-risperidone in the rat. Psychopharmacology (in press)
-
-
-
-
121
-
-
84936013866
-
-
Van Cauteren H, Lampo A, Megens A, Meuldermans W (1992) Expert report on the toxicological, pharmacodynamic and pharmacokinetic documentation on risperidone. Janssen Research Expert Report on R 64 766, N 84308
-
-
-
-
122
-
-
84936043678
-
-
Van de Water A, Wouters L, Xhonneux R, Reneman RS (1985) The cardiac and haemodynamic effects of cumulative intravenous administrations of R 64 766 in closed-chest anaesthetized mongrel dogs. Janssen Preclinical Research Report R 64 766/2, N 45495
-
-
-
-
123
-
-
84936044813
-
-
Van de Water A, Xhonneux R, De Clerck F (1992) Analysis of the effects of risperidone on the electrocardiogram and the overall behaviour of awake Beagle dogs: a randomised, placebo-controlled comparison with chlorpromazine. Janssen Preclinical Research Report R 64 766, N 91564
-
-
-
|