Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic

Cell

Volumn 77, Issue 2, 1994, Pages 175-178

  Gibbs, Jackson B ^a   Oliff, Allen ^a   Kohl, Nancy E ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B 581; BZA 5B; CYCLIC GMP PHOSPHODIESTERASE; CYTOSTATIC AGENT; DIMETHYLALLYLTRANSFERASE; FARNESYL TRANS TRANSFERASE; GUANINE NUCLEOTIDE BINDING PROTEIN; L 731734; MANUMYCIN; PHOSPHORYLASE KINASE; PRODRUG; PROTEIN FARNESYLTRANSFERASE INHIBITOR; RAS PROTEIN; SQUALENE SYNTHASE; TRANSDUCIN; TRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; CANCER INHIBITION; CELL TRANSFORMATION; COLON CANCER; DRUG CYTOTOXICITY; DRUG EFFICACY; GENE MUTATION; HUMAN; NONHUMAN; ONCOGENE RAS; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN PROCESSING; SHORT SURVEY; SIGNAL TRANSDUCTION;

EID: 0028331587     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(94)90308-5     Document Type: Short Survey

References (26)

1. Post-translational modifications of p21rho proteins.
2. Proteins regulating Ras and its relatives
3. Mad Bet for Rab
4. Farnesylation of YDJ1p is required for function at elevated growth temperatures in Saccharomyces cerevisiae.
5. Protein Isoprenylation and Methylation at Carboxyl-Terminal Cysteine Residues
6. Protein prenylation: more than just glue?
7. Prenyl group identification of rap2 proteins: a ras superfamily member other than ras that is farnesylated.
8. A novel yeast mutant defective in the processing of ras proteins: assessment of the effect of the mutation on processing steps.
9. Peptidomimetic inhibitors of Ras farnesylation and function in whole cells.
10. Prevention of orthotopic human lung cancer growth by intratracheal instillation of a retroviral antisense K-ras construct.
11. Ras C-terminal processing enzymes—New drug targets?
12. Pharmacological probes of Ras function.
13. Prenyl proteins in eukaryotic cells: a new type of membrane anchor
14. All ras proteins are polyisoprenylated but only some are palmitoylated
15. Farnesylcysteine, a constituent of the alpha and beta subunits of rabbit skeletal muscle phosphorylase kinase: localization by conversion to S-ethylcysteine and by tandem mass spectrometry.
16. Benzodiazepine peptidomimetics: potent inhibitors of Ras farnesylation in animal cells
17. Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor
18. Function and Regulation of RAS
19. Posttranslational modification of proteins by isoprenoids in mammalian cells.
20. Posttranslational processing of the ras superfamily of small GTP-binding proteins.
21. Potent inhibition of human tumor p21ras farnesyltransferase by A1A2-lacking p21ras CA1A2X peptidomimetics.
22. RAM, a gene of yeast required for a functional modification of RAS proteins and for production of mating pheromone a-factor
23. Protein Prenylation: Genes, Enzymes, Targets, and Functions
24. Altered growth of human colon cancer cell lines disrupted at activated Ki-ras
25. Inhibitors of ras farnesyltransferases
26. Genetic evidence for in vivo cross-specificity of the CaaX-box protein prenyltransferases farnesyltransferase and geranylgeranyltransferase-I in Saccharomyces cerevisiae.