Accelerated in vitro apoptosis of lymphocytes from patients with systemic lupus erythematosus

Journal of Immunology

Volumn 152, Issue 7, 1994, Pages 3685-3692

  Emlen, Woodruff ^a   Niebur, JoAnn ^a   Kadera, Richard ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS ANTIGEN; CORTICOSTEROID; CYTOTOXIC AGENT;

ADULT; ANTIGEN ANTIBODY COMPLEX; APOPTOSIS; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CORTICOSTEROID THERAPY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GEL ELECTROPHORESIS; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IN VITRO STUDY; LYMPHOCYTE; NUCLEOSOME; PATHOGENESIS; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SYSTEMIC LUPUS ERYTHEMATOSUS;

ADULT; APOPTOSIS; ARTHRITIS, RHEUMATOID; DNA DAMAGE; FEMALE; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC; LYMPHOCYTES; MIDDLE AGED; NUCLEOSOMES;

EID: 0028330345     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Emlen, W., D. S. Pisetsky, and R. P. Taylor. 1986. Antibodies to DNA: a perspective. Arthritis Rheum. 29:1417.
2. Carson, D. A. 1991. The specificity of anti-DNA antibodies in systemic lupus erythematosus. J. Immunol. 146:1-2.
3. Shlomchik, M., M. Mascelli, H. Shan, M. Z. Radic, D. Pisetsky, A. Marshak-Rothstein, and M. Weigert. 1990. Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation. J. Exp. Med. 171:265.
4. Marion, T. N., A. L. M. Bothwell, D. E. Briles, and C. A. Janeway, Jr. 1989. IgG anti-DNA autoantibodies within an individual autoimmune mouse are the products of clonal selection. J. Immunol. 142: 4269.
5. Portanova, J. P., J. C. Cheronis, J. K. Blodgett, and B. L. Kotzin. 1990. Histone autoantigens in murine lupus: definition of a major epitope within an accessible region of chromatin. J. Immunol. 144: 4633.
6. Tan, E. M. 1989. Antinuclear antibodies: diagnostic markers for autoimmune diseases and probes for cell biology. Adv. Immunol. 444: 93.
7. Emlen, W. 1993. Immune complexes in SLE. In Dubois' Systemic Lupus Erythematosus. B. H. Hahn and D. J. Wallace, eds. Lea & Febiger, Philadelphia, pp. 100-107.
8. Koffler, D., V. Agnello, R. Thorburn, and H. G. Kunkel. 1971. Systemic lupus erythematosus: prototype of immune complex nephritis in man. J. Exp. Med. 134:1695.
9. Mannik, M. 1987. Immune complexes In Systemic Lupus Erythematosus. R. G. Lahita, ed. Wiley, New York, pp. 333-351.
10. Franêk, F., and J. Dolniková. 1991. Nucleosomes occurring in protein-free hybridoma cell culture. Evidence for programmed cell death. FEBS Lett. 284:285-287.
11. Bell, D. A., B. Morrison, and P. VandenBygaart. 1990. Immunogenic DNA-related factors. Nucleosomes spontaneously released from normal murine lymphoid cells stimulate proliferation and immunoglobulin synthesis of normal mouse lymphocytes. J. Clin. Invest. 85:1487.
12. Arends, M. J., R. G. Morris, and A. H. Wyllie. 1990. Apoptosis. The role of the endonuclease. Am. J. Pathol. 136:593.
13. Duvall, E., and A. H. Wyllie. 1986. Death and the cell. Immunol. Today 7:115.
14. Green, D. R., and T. G. Cotter. 1992. Apoptosis in the immune system. Semin. Immunol. 4:355.
15. Fadok, V. J., D. R. Voelker, P. A. Campbell, J. J. Cohen, D. L. Bratton, and P. M. Henson. 1992. Exposure of phosphatidyl serine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages. J. Immunol. 148:2207.
16. Savill, J., N. Dransfield Hogg, and C. Haslett. 1990. Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosis. Nature 343:170.
17. Emlen, W. 1992. Binding of apoptotic cells by human macrophages. Arthritis Rheum. 35:S167.
18. Emlen, W., V. M. Holers, W. P. Aiend, and B. L. Kotzin. 1992. Regulation of nuclear antigen expression on the cell surface of human monocytes. J. Immunol. 148:3042.
19. Watanabe-Fukunaga, R., C, I. Brannan, N. G. Copeland, N. A. Jenkins, and S. Nagata. 1992. Lympho-proliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 356:314-317.
20. Adachi, M., R. Watanabe-Fukunaga, and S. Nagata. 1993. Aberrant transcription caused by the insertion of an early transposable element in an intron of the fas antigen gene of lpr mice. Proc. Natl. Acad. Sci. USA 90:1756-1760.
21. Cohen, P. L., and R. A. Eisenberg. 1992. The lpr and gld genes in systemic autoimmunity: life and death in the Fas lane. Immunol. Today 13:427.
22. VanHouten, N., and R. C. Budd. 1992. Accelerated programmed cell death of MRL-lpr/lpr T lymphocytes. J. Immunol. 149:2513.
23. Liang, M. H., S. A. Socher, M. G. Larson, and P. H. Schur. 1989. Reliability and validity of six systems for the clinical assessment of disease activity in SLE. Arthritis Rheum. 32:1107.
24. Duke, R. C., and J. J. Cohen. 1992. Cell death and apoptosis. In Current Protocols in Immunology. J. E. Coligan, A. M. Kruisbeek, D. H. Margulies, E. M. Shevach, and W. Strober, eds. Greene Publishing Associates, Brooklyn, NY, p. 3.17.1.
25. Nicoletti, I., G. Migliorati, M. C. Pagliacci, F. Grignani, and C. Riccardi. 1991. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J. Immunol. Methods 139:271.
26. Collins, M. K. L., J. Marvel, P. Malde, and A. Lopez-Rivas. 1992. Interleukin-3 protects murine bone marrow cells from apoptosis induced by DNA damaging agents. J. Exp. Med. 176:1043-1051.
27. Kornberg, R. D., J. W. LaPointe, and Y. Lorch. 1989. Preparation of nucleosomes and chromatin. Methods Enzymol. 170:3.
28. Kotzin, B. L., J. A. Lafferty, J. P. Portanova, R. L. Rubin, and E. M. Tan. 1984. Monoclonal anti-histone autoantibodies derived from murine models of lupus. J. Immunol. 133:2554-2559.
29. Cohen, J. J., and R. C. Duke. 1984. Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death. J. Immunol. 132:38.
30. Collins, R. J., B. V. Harmon, T. Souvlis, J. H. Pope, and J. F. R. Kerr. 1991. Effects of cycloheximide on B-chronic lymphocytic leukaemic and normal lymphocytes in vitro: induction of apoptosis. Br. J. Cancer 64:518-522.
31. Martin, S. J., S. V. Lennon, A. M. Bohman, and T. G. Cotter. 1990. Induction of apoptosis (programmed cell death) in human leukemic HL-60 cells by inhibition of RNA or protein synthesis. J. Immunol. 145:1859-1867.
32. Mountz, J. D., J. Wu, J. Zhang, J. He, and T. Zhou. 1993. Correction of autoimmune disease in fas-transgenic MRL-lpr/lpr mice. J. Immunol. 150:172A.
33. Illera, V. A., C. E. Perandones, L. L. Stunz, D. A. Mower, Jr. and R. F. Ashman. 1993. Apoptosis in splenic B lymphocytes. Regulation by protein kinase C and IL-4. J. Immunol. 151:2965-2973.
34. Perandones, C. E., V. A. Illera, D. Peckham, L. L. Stunz, and R. F. Ashman. 1993. Regulation of apoptosis in vitro in mature murine spleen T cells. J. Immunol 151:3521-3529.
35. Glinski, W., M. E. Gershwin, D. R. Budman, and A. D. Steinberg. 1976. Study of lymphocyte subpopulations in normal humans and patients with systemic lupus erythematosus by fractionation of peripheral blood lymphocytes on a discontinuous Ficoll gradient. Clin. Exp. Immunol. 26:228.
36. Ginsburg, W. W., F. D. Finkelman, and P. E. Lipsky. 1976. Circulating and pokeweed mitogen-induced immunoglobulin-secreting cells in systemic lupus erythematosus. Clin. Exp. Immunol. 35:76-88.
37. Sakane, T., N. Suzuki, S. Takada, Y. Ueda, Y. Murakawa, T. Tsuchida, Y. Yamauchi, and T. Kishimoto. 1988. B cell hyper-activity and its relation to distinct clinical features and the degree of disease activity in patients with systemic lupus erythematosus. Arthritis Rheum. 31:80-87.
38. Kabelitz, D., T. Pohl, and K. Pechhold. 1993. Activation-induced cell death (apoptosis) of mature peripheral T lymphocytes. Immunol. Today 14:338.
39. Shi, Y., M. G. Szalay, L. Paskar, M. Boyer, B. Singh, and D. R. Green. 1990. Activation-induced cell death in T cell hybridomas is due to apoptosis: morpholic aspects and DNA fragmentation. J. Immunol. 144:3226.