Improved Dose Linearity of Cyclosporine Pharmacokinetics from a Microemulsion Formulation

Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists

Volumn 11, Issue 2, 1994, Pages 301-304

  Mueller, Edgar A ^a   Kovarik, John M ^a   van Bree, Johannes B ^a   Tetzloff, Wolfgang ^b   Grevel, Joachim ^c   Kutz, Klaus ^a  

^a Sandoz Pharma Ltd   (Switzerland)

^b iphar CRF Institute for Clinical Pharmacology ^*  (Germany)

^c Agriculture of Texas   (United States)

Author keywords

cyclosporine; dose proportionality; formulation; pharmacokinetics

Indexed keywords

CYCLOSPORIN A;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG FORMULATION; EMULSION; HUMAN; HUMAN EXPERIMENT; MALE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL;

ABSORPTION; ADMINISTRATION, ORAL; ADULT; BIOLOGICAL AVAILABILITY; CAPSULES; CYCLOSPORINE; DOSE-RESPONSE RELATIONSHIP, DRUG; EMULSIONS; HUMANS; MALE; RADIOIMMUNOASSAY;

EID: 0028329964     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1023/A:1018923912135     Document Type: Article

References (8)

1. Dosage forms of cyclosporine
2. Clinical pharmacokinetics of cyclosporine
3. 3H radioimmunoassay with a monoclonal antibody for monitoring cyclosporine in blood
4. On the dose dependency of cyclosporin A absorption and disposition in healthy volunteers
5. Multiexponential, multicom-partmental, and noncompartmental modeling. II. Data analysis and statistical considerations
6. Fieller's theorem vs. the delta method for significance intervals for ratios