Multiple mechanisms of resistance in a series of human testicular teratoma cell lines selected for increasing resistance to etoposide

International Journal of Cancer

Volumn 57, Issue 2, 1994, Pages 259-267

  Hosking, Louise K ^a   Whelan, Richard D H ^a   Shellard, Sharon A ^a   Davies, Sally L ^b   Hickson, Ian D ^b   Danks, Mary K ^c   Hill, Bridget T ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA TOPOISOMERASE (ATP HYDROLYSING); DOXORUBICIN; ETOPOSIDE; GLYCOPROTEIN P; VERAPAMIL; VINCRISTINE;

ARTICLE; CONTROLLED STUDY; DRUG RESISTANCE; HUMAN; HUMAN CELL; MALE; PRIORITY JOURNAL; RADIATION DOSE FRACTIONATION; TERATOMA; TESTIS TUMOR; TUMOR CELL LINE;

CARRIER PROTEINS; CELL SURVIVAL; DNA; DNA DAMAGE; DNA TOPOISOMERASES, TYPE II; DRUG RESISTANCE; ETOPOSIDE; HUMAN; MALE; MEMBRANE GLYCOPROTEINS; P-GLYCOPROTEIN; TERATOMA; TESTICULAR NEOPLASMS; TUMOR CELLS, CULTURED; VERAPAMIL; VINCRISTINE;

EID: 0028329492     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.2910570222     Document Type: Article

References (27)

1. Drug resistance associated with altered DNA topoisomerase II
2. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of proteindye binding
3. A study of the condition and mechanism of the diphenylamine reaction for the colorimetric estimation of dexyribo‐nucleic acid
4. Molecular cloning and identification of a point mutation in the topoisomerase II cDNA from an etoposide resistant Chinese hanster ovary cell line
5. Overexpression of a transporter gene in a multidrug‐resistant human lung cancer cell line
6. Growth of human tumors cell colonies from biopsies using two soft‐agar techniques
7. Single‐strand conformational polymorphims analyis of the M 170,000 isozyme of Dna topoisomerase II in human tumor cells
8. Human cells express two differentially spiced forms of topoisomerase IIβ mRNA
9. Combined modalities of resistance in estoposide‐resistant human KB cells lines
10. Relationship between topoisomerase II level and chemosensitivity in human tumor cell lines
11. Dissociation between bulk damage to Dna and the antiproliferative activity of teniposide (VM‐26) in the MCF‐7 breast tumour cell line: evidence for induction of gene‐specific damage and alterations in gene expression
12. Multidrug resistance in small cell lung cancer line: rapid selection with etoposide and differential chemosensitization with cyclosporin A
13. Interactions between antitumour agents and radiation and the expression of resistance
14. Differing patterns of cross‐resistance resulting from exposures to specific antitumour drugs or 10 radiation in vitro
15. Tumor cell resistance to etoposide (VP‐16)—a review
16. Isolation of cDNA clones encoding the β isozyme of human DNA topoisomerase II and localisation of the gene to chromosome 3p24
17. Detection of P‐glycoprotein in multidrug‐resistant cell lines by monoclonal antibodies
18. Measurement of strand breaks and cross‐links by alkaline elution
19. Differential patterns of anti‐tumour drug responses and mechanisms of resistance in a series of independently‐derived VP‐16‐resistant human tumour cell lines
20. Protein measurement with the Folin phenol reagent
21. An altered topoisomerase II α in a drug resistant small cell lung cancer cell line selected in VP‐16
22. Characterization of topo2 mutations conferring resistance to topoiomerase II targeting agents
23. Novel selection and genetic characterization of an etoposide‐resistant human leukaemic CCRF‐CEM cell tine
24. Topoisomerase II‐dependent and ‐independent mechanisms of etoposide resistance in Chinese hamster cell lines
25. Resistance to inhibitors of DNA topoisomerases
26. Characterisation of an amsacrine‐resistant line of human leukemia cells‐evidence of a drug‐resistant form of topoisomerase II