Human astrocytes are only partially competent antigen presenting cells: Possible implications for lesion development in multiple sclerosis

Brain

Volumn 117, Issue 1, 1994, Pages 59-69

  Weber, Frank ^a   Meinl, Edgar ^a   Aloisi, Francesca ^d   Nevinny stickel, Claudia ^b   Albert, Ekkehard ^b   Wekerle, Hartmut ^a   Hohlfeld, Reinhard ^a,c  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

^b Laboratory for Immunogenetics   (Germany)

^c UNIVERSITY OF MUNICH   (Germany)

^d ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

Astrocyte; Autoimmunity; Multiple sclerosis; T cell

Indexed keywords

CD2 ANTIGEN; CD4 ANTIGEN; GAMMA INTERFERON; HLA ANTIGEN CLASS 1; HLA ANTIGEN CLASS 2; HLA DP ANTIGEN; HLA DQ ANTIGEN; HLA DR ANTIGEN; INTERCELLULAR ADHESION MOLECULE 1; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; TUMOR NECROSIS FACTOR ALPHA;

ANTIGEN PRESENTING CELL; ARTICLE; ASTROCYTE; AUTOIMMUNITY; CYTOTOXIC T LYMPHOCYTE; EMBRYO; HLA SYSTEM; HUMAN; HUMAN CELL; MULTIPLE SCLEROSIS; NERVE CELL CULTURE; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

ANTIGEN-PRESENTING CELLS; ANTIGENS, CD; ANTIGENS, CD2; ANTIGENS, CD58; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; ASTROCYTES; CELL ADHESION MOLECULES; CELL DIVISION; CELL LINE; EPITOPES; HLA ANTIGENS; HUMAN; INTERCELLULAR ADHESION MOLECULE-1; INTERFERON TYPE II; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; MEMBRANE GLYCOPROTEINS; MULTIPLE SCLEROSIS; RECEPTORS, IMMUNOLOGIC; SUPPORT, NON-U.S. GOV'T; T-LYMPHOCYTES; TUMOR NECROSIS FACTOR;

EID: 0028326439     PISSN: 00068950     EISSN: None     Source Type: Journal    
DOI: 10.1093/brain/117.1.59     Document Type: Article

References (42)

1. Aloisi F, Borsellino G, Samoggia P, Testa U, Chelucci C, Russo G et al. Astrocyte cultures from human embryonic brain: characterization and modulation of surface molecules by inflammatory cytokines. J Neurosci Res 1992; 32: 94-506
2. Aloisi F, Carè A, Borsellino G, Gallo P, Rosa S, Bassani A et al. Production of hemolymphopoietic cytokines (IL-6, IL-8, colony- stimulating factors) by normal human astrocytes in response to IL-1/3 and tumor necrosis factor-a. J Immunol 1992b; 149: 2358-66
3. Bignami A, Dahl D. Specificity of the glial fibrillary acidic protein for astroglia. J Histochem Cytochem 1977; 25: 466-9
4. Bretscher P. The two-signal model of lymphocyte activation twenty- one years later [see comments]. [Review] Immunol Today 1992; 13: 74-6
5. Bretscher P. Comment in: Immunol Today 1992; 13: 462
6. Caspi RR, Roberge FG, Nussenblatt RB. Organ-resident, nonlymphoid cells suppress proliferation of autoimmune T-helper lymphocytes. Science 1987; 237: 1029-32
7. Dhib-Jalbut S, Kufta CV, Flerlage M, Shimojo N, McFarland HF. Adult human glial cells can present target antigens to HLA-restricted cytotoxic T-cells. J Neuroimmunol 1990; 29: 203-11
8. Dustin ML, Rothlein R, Bhan AK, Dinarello CA, Springer TA. Induction by IL 1 and interferon-y: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1). J Immunol 1986; 137: 245-54
9. Eylar EH, Kniskem PJ, Jackson JJ. Myelin basic proteins. Methods Enzymol 1979; 32B: 323-41
10. Fabry Z, Waldschmidi MM, Moore SA, Hart MN. Antigen presentation by brain microvessel smooth muscle and endothelium. J Neuroimmunol 1990; 28: 63-71
11. Fontana A, Fierz W, Wekerle H. Astrocytes present myelin basic protein to encephalitogenic T-cell lines. Nature 1984; 307: 273-6
12. Frei K, Siepl C, Groscurth P, Bodmer S, Schwerdel C, Fontana A. Antigen presentation and tumor cytotoxicity by interferon-y-treated microglial cells. Eur J Immunol 1987; 17: 1271-8
13. Gaspari AA, Jenkins MK, Katz SI. Class U MHC-bearing kératinocytes induce antigen specific unresponsiveness in hapten-specific Thl clones. J Immunol 1988; 141: 2216-20
14. Grenier Y, Ruijs TCG, Robitaille Y, Olivier A, Antel JP. Immunohistochemical studies of adult human glial cells. J Neuroimmunol 1989; 21: 103-15
15. Hohlfeld R. Neurological autoimmune disease and the trimolecular complex of T-lymphocytes. [Review] Ann Neurol 1989; 25: 531-8
16. Hurwitz AA, Lyman WD, Guida MP, Calderon TM, Berman JW. Tumor necrosis factor a induces adhesion molecule expression on human fetal astrocytes. J Exp Med 1992; 176: 1631-6
17. Jaraquemada D, Martin R, Rosen-Bronson S, Flerlage M, McFarland HF, Long EO. HLA-DR2a is the dominant restriction molecule for the cytotoxic T cell response to myelin basic protein in DR2Dw2 individuals. J Immunol 1990; 145: 2880-5
18. Levi G, Gallo V, Ciotti MT. Bipotential precursors of putative fibrous astrocytes and oligodendrocytes in rat cerebellar cultures express distinct surface features and ‘neuron-like’ y-aminobutyric acid transport. Proc Natl Acad Sci USA 1986; 83: 1504-8
19. Linsley PS, Ledbetter JA. The role of the CD28 receptor during T cell responses to antigen. [Review] Annu Rev Immunol 1993; 11: 191-212
20. Lublin FD, Marini JC, Perreault M, Olender C, D’Imperio C, Joseph J et al. Autoimmune inflammation of astrocyte transplants. Ann Neurol 1992; 31: 519-24
21. McCarron RM, Spatz M, Kempski O, Hogan RN, Muehl L, McFarlin DE. Interaction between myelin basic protein-sensitized T lymphocytes and murine cerebral vascular endothelial cells. J Immunol 1986; 137: 3428-35
22. Male DK, Pryce G, Hughes CCW. Antigen presentation in brain: MHC induction on brain endothelium and astrocytes compared. Immunology 1987; 60: 453-9
23. Massa PT, Ter Meulen V, Fontana A. Hyperinducibility of la antigen on astrocytes correlates with strain-specific susceptibility to experimental autoimmune encephalomyelitis. Proc Natl Acad Sci USA 1987; 84: 4219-23
24. Meinl E, Weber F, Drexler K, Morelle C, Ott M, Saruhan-Direskeneli G et al. Myelin basic protein-specific T lymphocyte repertoire in multiple sclerosis: complexity of response and dominance of nested epitopes due to recruitment of multiple T cell clones. J Clin Invest. 1993; 92: 2633-43
25. Morganti-Kossmann MC, Kossmann T, Wahl SM. Cytokines and neuropathology. [Review] Trends Pharmacol Sci 1992; 13: 286-91
26. Nevinny-Stickel C, Bettinotti MD, Andreas A, Hinzpeter M, Mûhlegger K, Schmitz G et al. Nonradioactive HLA class II typing using polymerase chain reaction and digoxigenin-11 -2'-3'-dideoxy- uridinetriphosphate-labeled oligonucleotide probes. Hum Immunol 1991; 31: 7-13
27. Pette M, Fujita K, Wilkinson D, Altmann DM, Trowsdale J, Giegench G et al. Myelin autoreactivity in multiple sclerosis: recognition of myelin basic protein in the context of HLA-DR2 products by T lymphocytes of multiple sclerosis patients and healthy donors. Proc Natl Acad Sci USA 1990; 87: 7968-72
28. Pober JS, Gimbrone MA Jr, Lapierre LA, Mendrick DL, Fiers W, Rothlein R et al. Overlapping patterns of activation of human endothelial cells by interleukin 1, tumor necrosis factor, and immune interferon. J Immunol 1986; 137: 1893-6
29. Ransohoff RM, Estes ML. Astrocyte expression of major histocompatibility complex gene products in multiple sclerosis brain tissue obtained by stereotactic biopsy [published erratum appears in Arch Neurol 1992; 49: 752
30. Ransohoff RM, Estes ML. Arch Neurol 1991; 48: 1244-6
31. Risau W, Engelhardt B, Wekerle H. Immune function of the blood- brain barrier: incomplete presentation of protein (auto-)antigens by rat brain microvascular endothelium in vitro. J Cell Biol 1990; 110: 1757-66
32. Sanchez-Madrid F, Krensky AM, Ware CF, Robbins E, Strominger JL, Burakoff SJ et al. Three distinct antigens associated with human T-lymphocyte-mediated cytolysis: LFA-1, LFA-2, and LFA-3. Proc Natl Acad Sci USA 1982; 79: 7489-93
33. Schwartz RH. Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy. [Review] Cell 1992; 71: 1065-8
34. Selmaj K, Raine CS, Cannella B, Brosnan CF. Identification of lymphotoxin and tumor necrosis factor in multiple sclerosis lesions. J Clin Invest 1991; 87: 949-54
35. Sobel RA, Mitchell ME, Fondren G. Intercellular adhesion molecule-1 (ICAM-1) in cellular immune reactions in the human central nervous system. Am J Pathol 1990; 136: 1309-16
36. Springer TA. Adhesion receptors of the immune system. [Review] Nature 1990; 346: 425-34
37. Traugott U, Lebon P. Interferon-y and la antigen are present on astrocytes in active chronic multiple sclerosis lesions. J Neurol Sci 1988; 84: 257-64
38. Ullman KS, Northrop JP, Verweij CL, Crabtree GR. Transmission of signals from the T lymphocyte antigen receptor to the genes responsible for cell proliferation and immune function: the missing link. [Review] Annu Rev Immunol 1990; 8: 421-52
39. Wekerle H. Myelin specific, autoaggressive T cell clones in the normal immune repertoire: their nature and their regulation. [Review] Int Rev Immunol 1992; 9: 231-41
40. Wekerle H, Linington C, Lassmann H, Meyermann R. Cellular immune reactivity within the CNS. [Review] Trends Neurosci 1986; 9: 271-7
41. Wekerle H, Sun D, Oropeza-Wekerle RL, Meyermann R. Immune reactivity in the nervous system: modulation of T-lymphocyte activation by glial cells. [Review] J Exp Biol 1987; 132: 43-57
42. Williams K, Bar-Or A, Ulvestad E, Olivier A, Antel JP, Yong VW. Biology of adult human microglia in culture: comparisons with peripheral blood monocytes and astrocytes. J Neuropathol Exp Neurol 1992; 51: 538-49