Diuretic therapy for hypertension and the risk of primary cardiac arrest

New England Journal of Medicine

Volumn 330, Issue 26, 1994, Pages 1852-1857

  Siscovick, David S ^a,b   Raghunathan, T E ^b   Psaty, Bruce M ^a,b   Koepsell, Thomas D ^a,b   Wicklund, Kristine G ^a   Lin, Xihong ^b   Cobb, Leonard ^a   Rautaharju, Pentti M ^c   Copass, Michael K ^a   Wagner, Edward H ^b,d  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c UNIVERSITY OF ALBERTA   (Canada)

^d CENTER FOR HEALTH STUDIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIHYPERTENSIVE AGENT; ATENOLOL; CAPTOPRIL; CHLORTALIDONE; CLONIDINE; DILTIAZEM; ENALAPRIL; HYDRALAZINE; HYDROCHLOROTHIAZIDE; HYDROCHLOROTHIAZIDE PLUS TRIAMTERENE; LISINOPRIL; METHYLDOPA; METOPROLOL; NADOLOL; NIFEDIPINE; POTASSIUM SPARING DIURETIC AGENT; PRAZOSIN; PROPRANOLOL DERIVATIVE; RESERPINE; THIAZIDE DIURETIC AGENT; TRIAMTERENE; VERAPAMIL;

ADULT; AGED; AMBULATORY CARE; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE ASSOCIATION; DOSE RESPONSE; DRUG MEGADOSE; FEMALE; HEALTH MAINTENANCE ORGANIZATION; HEART ARREST; HUMAN; HYPERTENSION; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR; SUDDEN DEATH;

AGED; BENZOTHIADIAZINES; CASE-CONTROL STUDIES; CONFIDENCE INTERVALS; DEATH, SUDDEN, CARDIAC; DIURETICS; FEMALE; HEART ARREST; HUMANS; HYPERTENSION; MALE; MIDDLE AGED; ODDS RATIO; POTASSIUM; REGRESSION ANALYSIS; RISK; SODIUM CHLORIDE SYMPORTER INHIBITORS;

EID: 0028321729     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJM199406303302603     Document Type: Article

References (31)

1. Multiple Risk Factor Intervention Trial Research Group. Multiple Risk Factor Intervention Trial: risk factor changes and mortality results. JAMA 1982; 248: 1465-1477
2. Multiple Risk Factor Intervention Trial Research Group. Baseline rest electrocardiographic abnormalities, antihypertensive treatment, and mortality in the Multiple Risk Factor Intervention Trial. Am J Cardiol 1985; 55: 1-15
3. Kuller LH, Hulley SB, Cohen JD, Neaton J Unexpected effects of treating hypertension in men with electrocardiographic abnormalities: a critical analysis. Circulation 1986; 73: 114-123
4. Kuller L, Farrier N, Caggiula A, Borhani N, Dunkle S Relationship of diuretic therapy and serum magnesium levels among participants in the Multiple Risk Factor Intervention Trial. Am J Epidemiol 1985; 122: 1045-1059
5. MacMahon SW, Cutler JA, Furberg CD, Payne GH The effects of drug treatment for hypertension on morbidity and mortality from cardiovascular disease: a review of randomized controlled trials. Prog Cardiovasc Dis 1986; 29: Suppl 1: 99-118
6. Collins R, Peto R, MacMahon S, Blood pressure, stroke, and coronary heart disease. Part 2, short-term reductions in blood pressure: overview of randomised drug trials in their epidemiologic context. Lancet 1990; 335: 827-838
7. SHEP Cooperative Research Group. Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension: final results of the Systolic Hypertension in the Elderly Program (SHEP). JAMA 1991; 265: 3255-3264
8. Dahlof B, Lindholm LH, Hansson L, Schersten B, Ekbom T, Wester P-O Morbidity and mortality in the Swedish Trial in Old Patients with Hypertension (STOP-Hypertension). Lancet 1991; 338: 1281-1285
9. MRC Working PartyMedical Research Council trial of treatment of hypertension in older adults: principal results. BMJ 1992; 304: 405-412
10. Elmfeldt D, Berglund G, Wedel H, Wilhelmsen L Incidence and importance of metabolic side-effects during antihypertensive therapy. Acta Med Scand Suppl 1983; 672: 79-83
11. Medical Research Council Working Party on Mild to Moderate Hypertension. Ventricular extrasystoles during thiazide treatment: substudy of MRC mild hypertension trial. BMJ 1983; 287: 1249-1253
12. Fisch CH Relation of electrolyte disturbances to cardiac arrhythmias. Circulation 1973; 47: 408-419
13. Carlsen JE, Kober L, Torp-Pedersen C, Johansen P Relation between dose of bendrofluazide, antihypertensive effect, and adverse biochemical effects. BMJ 1990; 300: 975-978
14. Dorup I, Skajaa K, Clausen T, Kjeldsen K Reduced concentrations of potassium, magnesium, and sodium-potassium pumps in human skeletal muscle during treatment with diuretics. BMJ 1988; 296: 455-458
15. Siegel D, Hulley SB, Black DM, Diuretics, serum and intracellular electrolyte levels, and ventricular arrhythmias in hypertensive men. JAMA 1992; 267: 1083-1089
16. Hollifield JW Potassium and magnesium abnormalities: diuretics and arrhythmias in hypertension. Am J Med 1984; 77: Suppl 5A: 28-32
17. Hollifield JW Electrolyte disarray and cardiovascular disease. Am J Cardiol 1989; 63: 21B-26B
18. Martin BJ, Milligan K Diuretic-associated hypomagnesemia in the elderly. Arch Intern Med 1987; 147: 1768-1771
19. Nomenclature and criteria for diagnosis of ischemic heart disease: Report of the Joint International Society and Federation of Cardiology/World Health Organization Task Force on Standardization of Clinical Nomenclature. Circulation 1979; 59: 607-609
20. Siscovick DS Challenges in cardiac arrest research: data collection to assess outcomes. Ann Emerg Med 1993; 22: 92-98
21. Psaty BM, Koepsell TD, LoGerfo JP, Wagner EH, Inui TS β-Blockers and primary prevention of coronary heart disease in patients with high blood pressure. JAMA 1989; 261: 2087-2094
22. Blackburn H, Keys A, Simonson E, Rautaharju P, Punsar S The electrocardiogram in population studies: a classification system. Circulation 1960; 21: 1160-1175
23. Rautaharju PM, Warren JW, Jain U, Wolf HK, Nielsen CL Cardiac infarction injury score: an electrocardiographic coding scheme for ischemic heart disease. Circulation 1981; 64: 249-256
24. Little RJ, Rubin DB. Statistical analysis with missing data. New York: John Wiley, 1987.
25. Spence JD, Wong DG, Lindsay RM Effects of triamterene and amiloride on urinary sediment in hypertensive patients taking hydrochlorothiazide. Lancet 1985; 2: 73-75
26. Widmann L, Dyckner T, Wester P-O Effects of triamterene on serum and skeletal muscle electrolytes in diuretic-treated patients. Eur J Clin Pharmacol 1988; 33: 577-579
27. Andersson P-O, H-Andersen H, Hagman A, Henning R Potassium sparing by amiloride during thiazide therapy in hypertension. Clin Pharmacol Ther 1984; 36: 197-200
28. Farnett L, Mulrow CD, Linn WD, Lucey CR, Tuley MR The J-curve phenomenon and the treatment of hypertension: is there a point beyond which pressure reduction is dangerous? JAMA 1991; 265: 489-495
29. McCloskey LW, Psaty BM, Koepsell TD, Aagaard GN Level of blood pressure and risk of myocardial infarction among treated hypertensive patients. Arch Intern Med 1992; 152: 513-520
30. Dyckner T Serum magnesium in acute myocardial infarction: relation to arrhythmias. Acta Med Scand 1980; 207: 59-66
31. The fifth report of the Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure (JNC V). Arch Intern Med 1993; 153: 154-183