Treatment with oral clotrimazole blocks Ca2+-activated K+ transport and reverses erythrocyte dehydration in transgenic SAD mice. A model for therapy of sickle cell disease

Journal of Clinical Investigation

Volumn 93, Issue 4, 1994, Pages 1670-1676

  De Franceschi, L ^a   Saadane, N ^a   Trudel, M ^a   Alper, S L ^a   Brugnara, C ^a   Beuzard, Y ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

anemia; antisickling agents; hemoglobin SAD; K transport; volume regulation

Indexed keywords

CALCIMYCIN; CALCIUM ION; CLOTRIMAZOLE; HEMOGLOBIN; HEMOGLOBIN BETA CHAIN; MICONAZOLE; POTASSIUM ION;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CELL DENSITY; CONTROLLED STUDY; DEHYDRATION; ERYTHROCYTE METABOLISM; HEMATOLOGICAL PARAMETERS; HEMOGLOBIN DETERMINATION; MEAN CORPUSCULAR HEMOGLOBIN; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; POTASSIUM TRANSPORT; PRIORITY JOURNAL; SICKLE CELL ANEMIA; TRANSGENIC MOUSE; WATER CONTENT;

EID: 0028316266     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI117149     Document Type: Article

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