Induction of Apoptotic DNA Fragmentation and Cell Death in Hl-60 Human Promyelocytic Leukemia Cells by Pharmacological Inhibitors of Protein Kinase C

Cancer Research

Volumn 54, Issue 7, 1994, Pages 1707-1714

  Jarvis, W David ^a   Turner, Amy J ^a   Povirk, Lawrence F ^a   Traylor, Rebecca S ^a   Grant, Steven ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; CALPHOSTIN C; CHELERYTHRINE; DNA; DNA FRAGMENT; GOSSYPOL; HYPERICIN; N (2 GUANIDINOETHYL) 5 ISOQUINOLINESULFONAMIDE; PROTEIN KINASE C; STAUROSPORINE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL DEATH; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL STRAIN HL 60; CONTROLLED STUDY; DNA DAMAGE; DNA STRAND BREAKAGE; ENZYME INHIBITION; HUMAN; HUMAN CELL; NORTHERN BLOTTING; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; ALKALOIDS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BENZOPHENANTHRIDINES; CELL DIFFERENTIATION; CELL LINE; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DNA DAMAGE; DNA, NEOPLASM; ENZYME INHIBITORS; GOSSYPOL; HUMANS; ISOQUINOLINES; LEUKEMIA, PROMYELOCYTIC, ACUTE; NAPHTHALENES; PERYLENE; PHENANTHRIDINES; PIPERAZINES; POLYCYCLIC COMPOUNDS; PROTEIN KINASE C; STAUROSPORINE; TIME FACTORS; TUMOR CELLS, CULTURED;

EID: 0028316195     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article

References (65)

1. Nishizuka, Y. The family of protein kinase C for signal transduction. JAMA, 262: 1826-1833, 1989.
2. Craven, P.A. and DeRubertis, D. Role of activation of protein kinase C in the stimulation of colonic epithelial proliferation by unsaturated fatty acids. Gastroenterology, 95: 676-685, 1988.
3. Brach, M.A. Herrmann, F. and Kufe, D.W. Activation of the AP-1 transcription factor by arabinofuranosylcytosine in myeloid leukemia cells. Blood, 79: 728-734, 1992.
4. Rahmsdorf, H.J. and Herrlich, P. Regulation of gene expression by tumor promotors. Pharmacol. Ther. 48: 157-188, 1990.
5. Berridge, M.J. Inositol triphosphate and diacylglycerol: two interacting second messengers. Annu. Rev. Biochem. 56: 159-193, 1987.
6. Nishizuka, Y. The molecular heterogeneity of protein kinase C and its implications for cellular regulation. Nature (Lond.), 334: 661-665, 1988.
7. Katayama, N. Minami, N. and Shirakawa, S. Putative involvement of protein kinase C in proliferation of human myeloid progenitor cells. Blood, 73: 123-129, 1989.
8. Tohda, S. Nara, N. Inai, Y. and Aoki, N. Effect of protein kinase inhibitors on the proliferation of leukemic cells stimulated by granulocyte colony-stimulating factor, granulocyte-macrophage colony-stimulating factor, or interleukin-3. Leukemia (Baltimore), 5: 813-814, 1991.
9. Barendsen, N. Mueller, M. and Chen, B. Inhibition of TPA-induced monocytic differentiation of THP-1 human monocytic leukemia cells by staurosporine, a potent protein kinase inhibitor. Leuk. Res. 14: 467-474, 1990.
10. Hass, R. Pfannkuche, H. Kharbanda, S. Gunji, H. Meyer, G. Hartman, A. Hidaka, A. Resch, K. Kufe, D. and Goppet-Strube, M. Protein kinase C activation and proto-oncogcne expression in differentiation/retrodifferentiation of human U-937 leukemia cells. Cell Growth & Differ. 2: 541-548, 1991.
11. Kaufman, S.H. Induction by endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note. Cancer Res. 49: 5870-5878, 1989.
12. Wyllie, A.H. The significance of apoptosis. Int. Rev. Cytol. 68: 251-306, 1980.
13. Gaido, M.L. and Cidlowski, J.A. Identification, purification, and characterization of a calcium-dependent endonuclease (NUC18) from apoptotic rat thymocytes; NUC18 is not histone H.B.J. Biol. Chem. 266: 18580-18585, 1991.
14. Wyllie, A.H. Cell death: a new classification separating apoptosis from necrosis. In: I.D. Bowen and R.A. Lockshin (eds.), Cell Death in Biology and Pathology, pp. 9-34. London: Chapman & Hall, 1981.
15. +2 requirements and sensitivity to cyclosporine A.J. Immunol. 142: 4085-4092, 1989.
16. Ojeda, F. Guarda, M.I. Maldonato, C. and Folch, H. Protein kinase C involvement in thymocyte apoptosis induced by hydrocortisone. Cell. Immunol. 125: 535-539, 1990.
17. McConkey, D.J. Hartzell, P. Jondal, M. and Arrenius, S. Inhibition of DNA fragmentation in thymocytes and isolated thymocyte nuclei by agents that stimulate protein kinase C.J. Biol. Chem. 264: 13399-13402, 1989.
18. Lotem, J. Cragoe, E.J. and Sachs, L. Rescue from programmed cell death in leukemia and normal cells. Blood, 78: 953-960, 1991.
19. Grant, S. Jarvis, W.D. Swerdlow, P.S. Turner, A.J. Traylor, R.S. Wallace, H.J. Lin, P.S. Pettit, G.R. and Gewirtz, D.A. Potentiation of the activity of l-/β-D-arabinofuranosycytosine by the macrocyclic lactone PK-C activator bryostatin 1 is associated with enhanced fragmentation of mature DNA. Cancer Res. 52: 6270-6278, 1992.
20. Cotter, T.G. Lennon, S.V. Clynn, J.M. and Green, D.R. Microfilament-disrupting agents prevent the formation of apoptotic bodies in tumor cells undergoing apoptosis. Cancer Res. 52: 997-1005, 1992.
21. Bertrand, R. Solary, E. Kohn, K.W. and Pommier, Y. Staurosporine may activate a common final pathway to apoptosis. Proc. Am. Assoc. Cancer Res. 34: 1735, 1993.
22. Forbes, I.J. Zalewski, P.D. Grannakis, C. Cowled, P.A. Induction of apoptosis in chronic lymphocytic leukemia cells and its prevention by phorbol diester. Exp. Cell Res. 198: 367-371, 1992.
23. Herbert, J.M. Augereau, J.M. Gleye, J. Maffrand, J.P. Chelerythrine is a potent and specific inhibitor of protein kinase C. Biochem. Biophys. Res. Commun. 172: 993-999, 1990.
24. Hidaka, H. Inagaki, M. Kawamoto, S. Sasski, Y. Isoquinoline sulfonamides, novel potent inhibitors of cyclic nucleotide protein kinase and protein kinase C. Biochemistry, 23: 5036-5041, 1984.
25. Takahashi, I. Nakanishi, S. Hobayashi, E. Nakano, H. Suzuki, K. Tamaoki, T. Hypericin and pseudohypericin specifically inhibit protein kinase C: possible relation to their antiretroviral activity. Biochem. Biophys. Res. Commun. 165: 1207-1212, 1989.
26. Pelosin, J.M. Keramidos, M. Souvignet, C. and Chambaz, E.M. Differential inhibition of protein kinase C subtypes. Biochem. Biophys. Res. Commun. 169: 1040-1048, 1984.
27. Kobayashi, E. et al. Calphostin C (UCN-1028C), a novel microbial compound and highly potent and specific inhibitor of protein kinase C. Biochem. Biophys. Res. Commun. 159: 548-553, 1989.
28. Schachtcle, C. Seifert, R. and Osswald, H. Stimulus-dependent inhibition of platelet aggregation by the protein kinase C inhibitors polymixin, H-7, and staurosporine. Biochem. Biophys. Res. Commun. 151: 542-547, 1988.
29. Nakadate, T. Jeng, A.Y. and Blumberg, P.M. Comparison of protein kinase C functional assays to clarify mechanisms of inhibitor action. Biochem. Pharmacol. 37: 1541-1542, 1988.
30. Gallegher, R. Collins, S. Trujillo, J. McCredie, K. Ahearn, M. Tsai, S. Metzgar, R. Aulakh, G. Ting, R. Ruscetti, F. and Gallo, R. Characterization of the continuous differentiating myeloid cell line (HL-60) from a patient with acute promyelocyte leukemia. Blood, 54: 713-733, 1979.
31. Bruas R.F. Miller, F.D. Merriman, R.L. Howbert, J.J. Heath, W.F. Kobayashi, E. Takahashi, I. Tamaoki, T. and Nakano, H. Inhibition of protein kinase C by calphostin C is light-dependent. Biochem. Biophys. Res. Commun. 176: 288-293, 1991.
32. Cesarone, C. Bolognesi, C. and Santi, L. Improved microfluorometry DNA determination in biological material using Hoechst 33258. Anal. Biochem. 100: 118-197, 1979.
33. Jarvis, W.D. Gewirtz, D.A. Povirk, L.R. Turner, A.J. Traylor, R.S. Pettit, G.R. and Grant, S. Modulation of 1-β-D-arabinofuranosylcytosine-induced apoptosis in human promyelocytic leukemia cells by bryostatin 1 and other activators of protein kinase C. Biochem. Pharmacol. in press, 1994.
34. Grant, S. Boise, L.L. Westin, E.L. Howe, C.S.W. Pettit, G.R. Turner, A.J. and McCrady, C.A. In vitro effects of bryostatin 1 on the metabolism and cytotoxicity of l-/3-r>arabinofuranosylcytosine in human leukemia cells. Biochem. Pharmacol. 42: 853-867, 1991.
35. Lotem, J. Sachs, L. Regulation by bcl-2, c-myc, and p. 3 of susceptibility to induction of apoptosis by heat shock and cancer chemotherapy compounds in differentiation-competent and defective myeloid leukemia cells. Cell Growth & Differ. 4: 41-47, 1993.
36. Miyashita, T. and Reed, J.C. Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line. Blood, 81: 151-157, 1993.
37. Chirgwin, J. Przybala, H. McDonald, R. and Rutter, W. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry, 18: 5294-5299, 1979.
38. Boise, L.H. Grant, S. and Westin, E.H. Altered expression of c-myb in a subclone of HL-60 that exhibits reversible differentiation. Cell Growth & Differ. 3: 53-61, 1992.
39. Barry, M.A. Reynolds, J.E. and Eastman, A. Etoposide-induced apoptosis in HL-60 human leukemia cells is associated with intracellular acidification. Cancer Res. 53: 2349-2357, 1993.
40. 2+-dependent endodeoxyribonuclease from calf thymus chromatin. J. Biochem. 89: 143-152, 1981.
41. 1 arrest. J. Clin. Invest. 89: 954-960, 1992.
42. Martin, S.J. Beardley, J.G. and Cotter, T.G. HL-60 cells induced to differentiation toward neutrophils subsequently die via apoptosis. Clin. Exp. Immunol. 79: 448-453, 1990.
43. Griffin, J. Munroe, D. Major, P. and Kufe, D. Induction of differentiation of human myeloid leukemia cells by inhibitors of DNA synthesis. Exp. Hematol. 10: 774-781, 1982.
44. McConkey, D.J. Arrenuis, S. and Jondal, M. Agents that elevate cAMP stimulate DNA fragmentation in thymocytes. J. Immunol. 145: 1227-1230, 1990.
45. Gorczyca, W. Gong, J. Ardelt, B. Traganos, F. and Darzunkiewicz, Z. The cell cycle related differences in susceptibility of HL-60 cells to apoptosis induced by various antitumor agents. Cancer Res. 53: 3186-3192, 1993.
46. Traganos, E. Knulti-Hotz, J. Hotz, M. Gorczyca, W. Ardelt, B. and Darzunkiewicz, Z. The protein kinase C inhibitor H7 blocks normal human lymphocyte stimulation and induced apoptosis of both normal lymphocytes and MOLT-4 leukemia cells. Int. J. Oncol. 2: 47-59, 1993.
47. Falcieri, E. Martelli, A.M. Bareggi, R. Cataldi, A. and Cocco, L. The protein kinase C inhibitor staurosporine induces morphological changes typical of apoptosis in MOLT-4 cells without concomitant DNA fragmentation. Biochem. Biophys. Res. Commun. 193: 19-25, 1993.
48. DeWitte, P. Agostinis, P. VanLint, J. Merlevede, W. and Vandenheede, J.R. Inhibition of epidermal growth factor receptor tyrosine kinase activity by hypericin. Biochem. Pharmacol. 46: 1929-1936, 1993.
49. Matsui, T. Nakao, Y. Koizumi, T. Katakami, Y. and Fujita, T. Inhibition of phorbol ester-induced phenotypic differentiation of HL-60 cells by l-(isoquinolinylsulfonyl)-2-methylpiperazine, a protein kinase inhibitor. Cancer Res. 46: 583-587, 1986.
50. Merrill, A.H. Sereni, A.M. Stevens, V.L. Hannun, Y. Bell, R.M. and Kinjade, J.M. Inhibition of phorbol diester-dependent differentiation of human leukemic (HL-60) cells by sphingosine and other long-chain sphingoid bases. J. Biol. Chem. 261: 12610-12615, 1986.
51. Solary, E. Betrand, R. Kohn, K.W. and Pommier, Y. Differential induction of apoptosis in undifferentiated and differentiated HL-60 cells by DNA topoisomerases I and II inhibitors. Blood, 81: 1359-1368, 1993.
52. Nunez, G. London, L. Hockenberg, D. Alexander, M. McKearn, J. and Korsmeyer, S.S. Deregulated bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines. J. Immunol. 144: 3607-3610, 1990.
53. McDonnell, T.J. Tronscosco, P. Brisbay, S.M. Logothetis, C. Chung, L.K.W. Hsieh, J.T. Tu, S.M. and Campbell, M.L. Expression of the protooncogene bcl-2 in the prostate and its association with the emergence of androgen-independent prostate cancer. Cancer Res. 52: 6940-6944, 1992.
54. Miyashita, T. and Reed, J.C. Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line. Blood, 81: 151-157, 1993.
55. Walton, M.I. Whysong, D. O'Connor, P.M. Hockenbery, D. Korsmeyer, S.J. and Kohn, K.W. Constitutive expression of human bcl-2 modulates nitrogen mustard and camptothecin induced apoptosis. Cancer Res. 53: 1853-1861, 1993.
56. Bhalla, K. Ibrado, A.M. Tourkina, E. Tang, C. Maloney, M.E. and Huang, Y. Taxol induces internucleosomal DNA fragmentation associated with programmed cell death in human myeloid leukemia cells. Leukemia (Baltimore), 7: 563-568, 1993.
57. Bhalla, K. Tang, C. Ibrado, A.M. Grant, S. Tourkina, E. Holladay, C. Hughes, M. Mahoney, M.E. and Huang, Y. Granulocyte-macrophage colony stimulating factor/ interleukin-3 fusion protein (PIXY 321) enhances high dose ara-C induced programmed cell death or apoptosis in human myeloid leukemia cells. Blood, 80: 2883-2890, 1992.
58. May, W.S. Tyler, P.G. Armstrong, D.K. and Davidson, N.E. Role for serine phosphorylation of Bcl-2 in an anti-apoptotic signaling pathway triggered by IL-3, erythropoietin, and bryostatin 1. Blood, 82 (Supplement 1): 1738, 1993.
59. Brown, D.G. Sun, X.M. and Cohen, G.M. Dexamethasone-induced apoptosis involves cleavage of DNA to large fragments prior to internuceosomal fragmentation. J. Biol. Chem. 268: 3037-3039, 1993.
60. +-exchange. J. Biol. Chem. 259: 7057-7060, 1984.
61. Alnemri, E.S. and Litwack, G. Activation of internucleosomal DNA cleavage in human CEM lymphocytes by glucocorticoids and novobiocin. J. Biol. Chem. 265: 17323-17333, 1990.
62. Jarvis, W.D. Kolesnick, R.N. Fornari, F.A. Traylor, R.S. Gewirtz, D.A. and Grant, S. Induction of apoptotic cell death by sphingomyelinase and ceramide in a variety of mammalian cells. Proc. Natl. Acad. Sci. USA, 91: 73-77, 1994.
63. Dive, C. Evans, C.A. Lynch, P.J. Musk, P. and Whetton, A.D. The role of protein kinase C in the suppression of apoptosis by \-abl in hematopoietic cells. Proc. Am. Assoc. Cancer Res. 34: 516, 1993.
64. Sato, W. Yusa, K. Naito, M. and Tsurro, T. Staurosporine, a potent inhibitor of c-kinase, enhances drug accumulation in multidrug-resistant cells. Biochem. Biophys. Res. 173: 1252-1257, 1990.
65. Laredo, J. Demur, C. Muller, C. Saivin, S. Cassar, G. Bousquet, C. Dastugue, N. Jeffrezou J.P. Colombres, O. and Laurent, G. Effects of H7 and staurosporine on the proliferation and self-renewal of acute myeloid leukemia progenitors. Leukemia (Baltimore), 7: 813-820, 1993.