Alzheimer's disease and soluble Aβ

Neurobiology of Aging

Volumn 15, Issue 2, 1994, Pages 143-152

  Wisniewski, T ^a   Ghiso, J ^a   Frangione, B ^a  

^a NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Alzheimer's disease; Amyloid; Apolipoprotein E; Soluble amyloid ; amyloid precursor protein

Indexed keywords

AMYLOID BETA PROTEIN; APOLIPOPROTEIN E;

AGING; ALZHEIMER DISEASE; AMYLOIDOSIS; ARTICLE; HUMAN; MUTATION; PRIORITY JOURNAL; PROTEIN STRUCTURE;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN; HUMAN; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0028314088     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/0197-4580(94)90105-8     Document Type: Article

References (133)

1. Immunochemical identification of the serine protease inhibitor α 1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease
2. Uber eine eigenartige Erkrankung der Hirnrinde
3. Beta-amyloid protein immunoreactivity in muscle of patients with inclusion-body myositis
4. About the presence of paired helical filaments in dystrophic neurites participating in plaque formation
5. Solution conformations and aggregational properties of synthetic amyloid β-peptides of Alzheimer's disease
6. The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects
7. Neuropathological staging of Alzheimer-related changes correlates with psychometrically assessed intellectual status
8. Assembly and aggregation properties of synthetic Alzheimer's A4/β amyloid peptide analogs
9. Generation of β-amyloid in the secretory pathway in neuronal and non-neuronal cells
10. Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production
11. Release of excess amyloid β protein from a mutant amyloid β protein precursor
12. Chloroquine inhibits intracellular degradation but not secretion of Alzheimer β/A4 amyloid precursor protein
13. Alzheimer's disease from the perspective of the systemic and localized forms of amyloidosis
14. In vitro formation of amyloid fibrils from two synthetic peptides of different lengths homologous to Alzheimer's disease β-protein
15. Biology of disease: Human amyloidosis, Alzheimer disease and related disorders
16. SP-40,40 is a constituent of Alzheimer's amyloid
17. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
18. Isolation and characterization of amyloid P component from Alzheimer's disease and other types of cerebral amyloidosis
19. Clinicopathologic studies in dementia: Nondemented subjects with pathologically confirmed Alzheimer's disease
20. Quantitative histological studies on the aged human brain. I. Senile plaques and neurofibrillary tangles in senile dementia
21. A novel mRNA of the A4 amyloid precursor gene coding for a possibly secreted protein
22. Neuropathological changes in scrapie and Alzheimer's disease are associated with increased expression of apolipoprotein E and cathepsin D in astrocytes
23. Immunodetection of the amyloid P component in Alzheimer's disease
24. Identification transmembrane orientation and biogenesis of the amyloid A4 precursor of Alzheimer's disease
25. Membrane insertion prevents aggregation of precursor fragments containing the β/A4 sequence of Alzheimer's disease
26. The sequence of neuroimmunological events in cerebral amyloid plaque formation in Alzheimer's disease
27. Cleavage of amyloid β peptide during constitutive processing of its precursor
28. Potentially amyloidogenic, carboxyl-terminal derivatives of the amyloid protein precursor
29. Comparative analysis of human and Dutch-type Alzheimer β-amyloid peptides by infrared spectroscopy and circular dichroism
30. Alzheimer's disease and Dutch variant: Opposing faces of a single coin
31. Fibril formation by primate, rodent, and Dutch-hemorrhage analogues of Alzheimer amyloid β-protein
32. Alzheimer β/A4 amyloid precursor protein: Evidence for putative amyloidogenic fragment
33. Beta protein precursor expression in human platelets and a megakaryocyte cell line
34. Macrophage apolipoprotein synthesis and endoneurial distribution as a response to segmental demyelination
35. The cerebrospinal fluid soluble form of Alzheimer's amyloid β is complexed to SP-40,40 (Apo J), an inhibitor of the complement membrane attack complex
36. A 109-amino acid C-terminal fragment of Alzheimer's disease amyloid precursor protein contains a sequence, - RHDS - , that promotes cell adhesion
37. Down patients: Extracellular preamyloid deposits precede neuritic degeneration and senile plaques
38. Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein
39. Expression of β amyloid protein precursor mRNAs; recognition of a novel alternatively spliced form and quantitation in Alzheimer's disease using PCR
40. Processing of the amyloid protein precursor to potentially amyloidogenic derivatives
41. Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease
42. Abnormal phosphorylation of the microtubule-associated protein tau in Alzheimer cytoskeletal pathology
43. Beta-amyloid protein and a 3-kDa fragment are derived by distinct cellular mechanisms
44. Targeting of cell-surface β-amyloid precursor protein to lysosomes: Alternative processing into amyloid-bearing fragments
45. Amyloid β-peptide is produced by cultured cells during normal metabolism
46. Presenile dementia and cerebral hemorrhage linked to a mutation at codon 692 of the β-amyloid precursor protein gene
47. Substitutions of hydrophobic amino acids reduce the amyloidogenicity of Alzheimer's disease βA4 peptides
48. Amyloidosis
49. Alz-50 antibody recognizes Alzheimer's related neuronal changes
50. Morphology and distribution of plaque and related deposits in the brains of Alzheimer's disease and control cases
51. A novel species specific RNA related to alternatively spliced amyloid precursor protein mRNAs
52. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
53. Production and characterization of monoclonal antibodies reactive to synthetic cerebrovascular amyloid peptide
54. Synthetic peptide homologous to β protein from Alzheimer disease forms amyloid-like fibrils in vitro
55. Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity
56. Identification and differential expression of a novel alternative splice isoform of the βA4 amyloid precursor protein (APP) mRNA in leukocytes and brain microglial cells
57. Is β-amyloid neurotoxic?
58. A68: A major subunit of paired helical filaments and derivatized forms of normal tau
59. The Pre A4695 precursor protein of Alzheimer's disease A4 amyloid is encoded by 16 exons
60. Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type
61. Apolipoprotein E: Cholersterol transport protein with an expanding role in cell biology
62. Cerebral amyloidosis, aging and Alzheimer's disease: A contribution from studies on Down's syndrome
63. Secretase, Alzheimer's amyloid protein precursor secreting enzyme is not sequence-specific
64. Amyloid plaque core protein in Alzheimer disease and Down syndrome
65. Abnormal and deficient processing of β-amyloid precursor protein in familial Alzheimer's disease lymphoblastoid cells
66. Distribution of clusterin in Alzheimer brain tissue
67. Peptide compositions of the cerebrovascular and senile plaque core amyloid deposits of Alzheimer's disease
68. Morphological study of amyloid fibrils and preamyloid deposits in the brain with Alzheimer's disease
69. 1-antichymotrypsin and amyloid production in the brain in Alzheimer's disease
70. Age-related changes in the density and morphology of plaques and neurofibrillary tangles in Down syndrome brain
71. Kinetic analysis of amyloid fibril polymerization in vitro
72. High affinity interactions between the Alzheimer's β-amyloid precursor proteins and the basement membrane form of heparan sulfate proteoglycan
73. Perlecan, the large low-density proteoglycan of basement membranes - structure and variant forms
74. Alzheimer β/A4 amyloid precursor protein in human brain Aging-associated increases in holoprotein and in a proteolytic fragment
75. The Alzheimer amyloid precursor protein
76. Distribution of the protease inhibitor α1-antichymotrypsin in cerebral and systemic amyloid
77. A new A4 amyloid mRNA contains a domain homologous to serine protease inhibitors
78. Differences between vascular and plaque core amyloid in Alzheimer's disease
79. Expression of a normal and variant Alzheimer's β-protein gene in amyloid of hereditary cerebral hemorrhage, Dutch type: DNA and protein diagnostic assays
80. A special type of senile plaque, possibly an initial stage
81. Alzheimer's disease: A description of the structural lesions
82. Molecular biology of prion diseases
83. Proteolytic processing of human amyloid β protein precursor in insect cells
84. Molecular cloning and characterization of a cDNA encoding the neuritic plaque amyloid peptides
85. Structural alterations in the peptide backbone of β-amyloid core protein may account for its deposition and stability in Alzheimer's disease
86. The pathogenesis of artheroslerosis: A perspective for the 1990s
87. Correlation between scores for dementia and counts of “senile plaques” in cerebral gray matter of elderly subjects
88. Amyloid A4 protein and its precursor in Down's syndrome and Alzheimer's dsease
89. Association of apolipoprotein E allele E4 with late-onset familial and sporadic Alzheimer's disease
90. The molecular pathology of Alzheimer's disease
91. Isolation of low-molecular-weight proteins from amyloid plaque fibers in Alzheimer's disease
92. Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids
93. Production of the Alzheimer amyloid β protein by normal proteolytic processing
94. Evidence that β-amyloid protein in Alzheimer's disease is not derived by normal processing
95. Beta amyloid precursor protein cleavage by a membrane-bound protease
96. Sulphated glycosaminoglycans: A common constituent of all amyloids?
97. Immunolocalization of heparan sulfate proteoglycans to “primitive plaques” and multi-core prion positive plaques in familial dementia
98. Apolipoprotein E: High-avidity binding to β-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease
99. Preamyloid deposits in the cerebral cortex of patients with Alzheimer's disease and nondemented individuals
100. A comparative study of amyloid formation and resorption using immunoelectron microscopy
101. Identification of a stable fragment of the Alzheimer amyloid precursor containing the β-protein in brain microvessels
102. Protease inhibitor domain encoded by an amyloid precursor mRNA associated with Alzheimer's disease
103. Amyloid B-protein gene: cDNA, mRNA distribution and genetic linkage near the Alzheimer locus
104. Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment
105. Parenchymal preamyloid and amyloid deposits in the brains of patients with hereditary cerebral hemorrhage with amyloidosis Dutch type
106. Hereditary cerebral hemorrhage with amyloidosis in patients of Dutch origin is related to Alzheimer disease
107. Protease nexin-II (amyloid β-protein precursor): A platelet α granule protein
108. Secretion of the β/A4 amyloid precursor protein
109. Identification, biogenesis and localizaton of precursors of Alzheimer's disease A4 amyloid protein
110. Plaques, tangles and dementia, a quantitative study
111. Aged dogs: An animal model to study β-protein amyloidogenesis
112. Reexamination of the pathogenesis of the senile plaque
113. Neurofibrillary pathology in subacute sclerosing panencephalitis
114. Alzheimer neurofibrillary tangles in diseases other than senile and presenile dementia
115. Apolipoprotein E: Binding to soluble Alzheimer's β-amyloid
116. Molecular Biology of Alzheimer's amyloid - Dutch variant
117. Apolipoprotein E: A pathologic chaperone protein in patients with cerebral and systemic amyloid
118. Peptides homologous to the amyloid protein of Alzheimer's disease containing a glutamine for glutamic acid substitution have accelerated amyloid fibril formation
119. CSF inhibits Alzheimer B-amyloid fibril formation in vitro
120. A neuronal antigen in the brains of Alzheimer patients
121. Neuritic plaques and cerebrovascular amyloid in Alzheimer disease are antigenically related
122. A variety of cerebral amyloid deposits in the brains of the Alzheimer-type dementia demonstrated by β protein immunostaining
123. Genomic organization of the human amyloid-protein precursor gene
124. The ultrastructural localization of sulfated proteoglycans is identical in the amyloids of Alzheimer's disease and AA, AL, senile cardiac and medullary carcinoma-associated amyloidosis
125. The apolipoprotein ϵ4 allele in patients with Alzheimer's disease
126. Apolipoprotein E polymorphism and Alzheimer's disease
127. Apolipoprotein E ϵ4 allele distributions in late-onset Alzheimer's disease and in other amyloid-forming diseases
128. Genetic associations with human longevity at the APOE and ACE loci
129. Binding of human apolipoprotein E to synthetic amyloid β peptide: Isoform-specific effects and implications for late-onset Alzheimer disease
130. A high frequency of apolipoprotein E4 isoprotein in Japanese patients with late-onset nonfamilial Alzheimer's disease
131. Characterization of β-amyloid peptide from human cerebrospinal fluid
132. Blood-brain barrier transport of circulating Alzheimer's amyloid β