Nitrobenzyl mustard quaternary salts: A new class of hypoxia-selective cytotoxins capable of releasing diffusible cytotoxins on bioreduction

International Journal of Radiation Oncology, Biology, Physics

Volumn 29, Issue 2, 1994, Pages 317-321

  Denny, William A ^a   Wilson, William R ^a   Tercel, Moana ^a   Van Zijl, Pierre ^a   Pullen, Susan M ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

Benzyl quaternary mustard; Bioreductive drug; Diffusible cytotoxin; Mechlorethamine; Spheroids

Indexed keywords

CHLORMETHINE; CHLORMETHINE DERIVATIVE; CYTOTOXIC AGENT; DIETHANOLAMINE; DIETHYLDITHIOCARBAMIC ACID; N,N BIS(2 CHLOROETHYL) N METHYL N (2 NITROBENZYL)AMMONIUM CHLORIDE; NITROBENZENE DERIVATIVE; PRODRUG; QUATERNARY AMMONIUM DERIVATIVE; SN 25246; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; CELL KILLING; CELL LINE; CELL SURVIVAL; CLONOGENIC ASSAY; CONFERENCE PAPER; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG ISOLATION; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HYPOXIC CELL; INTRAPERITONEAL DRUG ADMINISTRATION; IRRADIATION; MAXIMUM PERMISSIBLE DOSE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMAL; ANTINEOPLASTIC AGENTS; CELL HYPOXIA; DIFFUSION; MECHLORETHAMINE; MICE; NITROGEN MUSTARD COMPOUNDS; OXIDATION-REDUCTION; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TUMOR CELLS, CULTURED;

EID: 0028308246     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/0360-3016(94)90282-8     Document Type: Article

References (8)

1. Bioactivated mustards: A paradigm for hypoxia selective prodrugs of diffusible cytotoxins (HPDCs)
2. Substituent effects. 6. Charged groups: A simple extension of the Hammett equation
3. Steric effects on dehalogenation of anion radicals derived from substituted nitrobenzyl halides
4. Nitrobenzyl radical metabolites from microsomal reduction of nitrobenzyl chlorides
5. Hypoxia-selective antitumor agents. 3. Relationships between structure and cytotoxicity against cultured tumor cells for substituted N,N-bis(2-chloroethyl)anilines
6. Nitrobenzyl mustard quaternary salts: A new class of hypoxia-selective cytotoxins showing high in vitro selectivity
7. Reduction of nitromin to nitrogen mustard; unscheduled DNA synthesis in aerobic or anaerobic rat hepatocytes, JBI, BL8 and Walker carcinoma cell lines
8. Selective toxicity of nitracrine to hypoxic mammalian cells