Tryptophan depletion in normal volunteers produces selective impairments in learning and memory

Neuropharmacology

Volumn 33, Issue 3-4, 1994, Pages 575-588

  Park, S B ^a   Coull, J T ^b   McShane, R H ^a   Young, A H ^a   Sahakian, B J ^b   Robbins, T W ^b   Cowen, P J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UK   (United Kingdom)

Author keywords

5 HT; learning; memory; tryptophan depletion

Indexed keywords

PLACEBO; TRYPTOPHAN;

ADULT; AMINO ACID DEFICIENCY; AMNESIA; ARTICLE; ATTENTION; BLOOD LEVEL; CLINICAL TRIAL; COGNITION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DEPLETION; DIET; DOUBLE BLIND PROCEDURE; HUMAN; LEARNING DISORDER; MALE; MEMORY; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; SEROTONINERGIC SYSTEM; VISUAL DISCRIMINATION; VOLUNTEER;

ADULT; AMINO ACIDS; BRAIN CHEMISTRY; COGNITION; CROSS-OVER STUDIES; DISCRIMINATION (PSYCHOLOGY); HUMANS; LEARNING DISORDERS; MALE; MEMORY DISORDERS; MENTAL PROCESSES; NEUROPSYCHOLOGICAL TESTS; PATTERN RECOGNITION, VISUAL; SPACE PERCEPTION; TRYPTOPHAN;

EID: 0028307457     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/0028-3908(94)90089-2     Document Type: Article

References (62)

1. Acute tryptophan depletion blocks morphine analgesia in the cold-pressor test in humans
2. Mediation of storage and retrieval with two drugs that selectively modulate serotonergic neurotransmission
3. Enhancement of the memory of a previously learned aversive habit following pre-test administration of a variety of serotonergic antagonists in mice
4. Different temporal effects of serotonergic antagonists on passive avoidance retention
5. What is the nature of the role of the serotonergic nervous system in learning and memory: Prospects for development of an effective treatment strategy for senile dementia
6. Enhanced spatial discrimination learning in rats following 5,7-DHT-induced serotonergic deafferation of the hippocampus
7. Electrolytic, but not 5,7-dihydroxytryptamine lesions of the nucleus medianus raphe impair acquisition of a radial maze task
8. Quantified regional and laminar distribution of the serotonin innervation in the anterior half of the adult rat cerebral cortex
9. Pharmacological investigations of neurotransmitter involvement in passive avoidance responding: a review and some new results
10. Lesions of the retrosplenial cortex produce deficits in reversal learning of the rabbit nictitating membrane response Implications for potential interactions between hippocampal and cerebellar brain systems
11. Rapid depletion of serum trytophan, brain trytophan, serotonin and 5 hydroxyindolacetic acid by a trytophan-free diet
12. Error in the determination of tryptophan by the method of Denkia and Dewey A revised procedure
13. A simple apparatus for ultrafiltration of small volumes applications to the measurement of free and albumin-bound tryptophan in plasma
14. Differential effects of central serotonin manipulation on hyperactive and stereotyped behaviour
15. The mixed α1/α2 agonist clonidine has specific and non-sedative effects on tests of frontal lobe function in man
16. Diurnal variation in clinical depression and accessibility of memories of positive and negative experiences
17. Serotonin function and the mechanism of antidepressant action: Reversal of antidepressant-induced remission by rapid depletion of plasma tryptophan
18. The self-focus sentence completion task: a study of egocentricity
19. Fluoxetine enhances memory processing in mice
20. Effect of amino-acid loads on hippocampal 5-HT release in vivo evoked by electrical stimulation of the dorsal raphe nucleus and d-fenfluramine administration
21. Circuitry of primate prefrontal cortex and regulation of behaviour by representational memory
22. Topography of cognition: parallel distributed networks in primate association cortex
23. Dual pathways connecting the dorsolateral prefrontal cortex with the hippocampal formation and parahippocampal cortex in the rhesus monkey
24. Overlap of dopaminergic, adrenergic and serotonergic receptors and complemantarity of their subtypes in primate prefrontal cortex
25. 5-HT receptors and cognitive funtion
26. The effect of apomorphine and buspirone on regional cerebral blood flow during the performance of a cognitive task—measuring neuromodulatory effects of psychotropic drugs in man
27. The effects of forebrain 5-HT depletion on visual attentional performance in the rat
28. The two-period cross-over clinical trial
29. Modulation of learning and memory: effects of drugs influencing neurotransmitters
30. Behavioral aspects of serotonin-dopamine interaction in the monkey
31. Hyperresponsivity to the serotonin agonist m-chlorophenylpiperazine in Alzheimer's disease
32. Trytophan hydroxylation in mammalian systems
33. Serotonin, memory, and the aging brain
34. Some effects of frontal lobectomy in man
35. Combined cholinergic and serotonergic denervation of the forebrain produces severe deficits in a spatial learning task in the rat
36. Effects of bifemelane on discrimination learning of serotonergic-dysfunction rats
37. Enhanced passive avoidance retention following postbrain serotonergic receptor antagonist administration in middle-aged and aged rats
38. Quantified distribution of the serotonin innervation in the adult rat hippocampus
39. Planning and spatial working memory following frontal lobe lesions in Man
40. Extra-dimensional versus intradimensional set-shifting performance following frontal lobe excision, temporal lobe excision or amygdala-hippocampectomy in man
41. Spatial performance is severely impaired in rats with combined reduction of serotonergic and cholinergic transmission
42. Some limitations of indices derived from signal detection theory: evaluation of an alternative index for measuring bias in memory tasks
43. A comparative study of visuospatial memory and learning in Alzheimer type dementia and Parkinson's disease
44. The effects of nicotine on attention, information processing and short-term memory in patients with dementia of the Alzheimer type
45. Sparing of attentional relative to mnemonic function in a subgroup of patients with dementia of the Alzheimer type
46. Specific impairments in planning
47. Use of synthesis inhibitors in defining a role for biogenic amines during imipramine treatment in depressed patients
48. A test of possible cognitive and environmental influences on the mood lowering effect of trytophan depletion in normal males
49. Manipulation of serotonin protects against an hypoxiainduced deficit of a passive avoidance response in rats
50. Retrosplenial amnesia
51. Near-total loss of learning and memory as a result of combined cholinergic and serotonergic blockade in the rat
52. Zimelidine effects on memory impairment produced by ethanol
53. Neurotransmitters and memory: role of cholinergic, serotonergic and noradrenergic systems
54. Effects of scopolamine and nicotine on human rapid visual information processing performance
55. Autobiographical memory in suicide attempters
56. Tryptophan depletion causes a rapid lowering of mood in normal males
57. The effect of lowering plasma tryptophan on food selection in normal males