A second ewing’s sarcoma translocation, t(21;22), fuses the EWS gene to another ETS-family transcription factor, ERG

Nature Genetics

Volumn 6, Issue 2, 1994, Pages 146-151

  Sorensen, Poul H B ^a,d   Lessnick, Stephen L ^b   Lopez Terrada, Dolores ^a   Liu, Xian F ^a   Triche, Timothy J ^a   Denny, Christopher T ^b,c  

^a CHILDREN S HOSPITAL LOS ANGELES   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d BC CHILDREN S HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CHIMERIC PROTEIN; TRANSCRIPTION FACTOR;

AMINO TERMINAL SEQUENCE; ARTICLE; CARCINOGENESIS; CHROMOSOME 22; DNA BINDING; DNA PROBE; EWING SARCOMA; GENE EXPRESSION; GENE FUSION; GENE LOCATION; GENE TRANSLOCATION; HUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SPECIES DIFFERENTIATION;

AMINO ACID SEQUENCE; BASE SEQUENCE; CHILD; CHILD, PRESCHOOL; CHROMOSOMES, HUMAN, PAIR 21; CHROMOSOMES, HUMAN, PAIR 22; CLONING, MOLECULAR; DNA-BINDING PROTEINS; EARLY GROWTH RESPONSE PROTEIN 1; FEMALE; HUMANS; IMMEDIATE-EARLY PROTEINS; KARYOTYPING; MOLECULAR SEQUENCE DATA; PRECIPITIN TESTS; PROTO-ONCOGENE PROTEIN C-FLI-1; PROTO-ONCOGENE PROTEINS; RECOMBINANT FUSION PROTEINS; RETROVIRIDAE PROTEINS, ONCOGENIC; RNA, MESSENGER; SARCOMA, EWING'S; SEQUENCE ANALYSIS, DNA; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSLOCATION, GENETIC; TUMOR CELLS, CULTURED;

EID: 0028307384     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng0294-146     Document Type: Article

References (29)

1. Solomon, E., Borrow, J. & Goddard, A. D. Chromosome aberrations and cancer. Science 254, 1153-1160 (1991).
2. Turc-Carel, C., Philip, I., Berger, M. P., Philip, T. & Lenoir, G. M. Chromosomal translocation in Ewing’s sarcoma. New Engl. J. Med. 309, 497-498 (1983).
3. Whang-Peng, J. et al. Chromosome translocation in peripheral neuroepithelioma. New Engl. J. Med. 311, 584-585 (1984).
4. Turc-Carel, C. et al. Chromosomes in Ewing’s sarcoma. I. An evaluation of 85 cases of remarkable consistency of t(11; 22)(q24; q12). Cancer Genet. Cytogenet. 32, 229-238 (1988).
5. Delattre, O. et al. Cloning of the recurrent t(11; 22) translocation of Ewing’s sarcoma & peripheral neuroepithelioma. Proc. Am. Assoc. cancer Res. 33, 604-605 (1992).
6. May, W. A. et al. Ewing sarcoma 11; 22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FL11 for transformation. Proc. natn. Acad. Sci. U. S. A. 90, 5752-5756 (1993).
7. Sorensen, P. H. B. et al. Reverse transcriptase PCR amplification of EWS/Fli-1 fusion transcripts as a diagnostic test for peripheral primitive neuroectodermal tumours of childhood. Diag. molec. Pathol. 2, 147-157 (1993).
8. Ben-David, Y., Giddens, E. B., Letwin, K. & Bernstein, A. Erythroleukemia induction by Friend murine leukemia virus: insertional activation of a new member of the ets family, Fli-1. Genes Dev. 5, 908-918 (1991).
9. Prasad, D. D. K., Rao, V. N. & Reddy, E. S. P. Structure and expression of human Fli -1 gene. Cancer Res. 52, 5833-5837 (1992).
10. Klemsz, M. J., Maki, R. A., Papyannopoulou, T., Moore, J. & Hromas, R. Characterization of the ets oncogene family member, Fli-1. J. biol. Chem. 268, 5769-5773 (1993).
11. Wasylyk, B., Hahn, S. L. & Giovane, A., The Ets family of transcription factors. Eur. J. Biochem. 211, 7-18 (1993).
12. May, W. A. et al. The Ewing’s sarcoma EWS/FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than a FLi-1. Molec. Cell. Biol. 13, 7393-7398 (1993).
13. Rao, V. N., Papas, T. S. & Reddy, S. P. ERG, a human ets-related gene on chromosome 21: alternative splicing, polyadenylation, and translation. Science 237, 635-639 (1987).
14. Lautenberger, J. A. et al. Genomic dispersal of the ets gene family during metazoan evolution. Oncogene 7, 1713-1719 (1992).
15. Wang, C.-Y., Petryniak, B., Ho, I.-C., Thompson, C. B. & Leiden, J. M. Evolutionary conserved Ets family members display distinct DNA binding specificities. J. exp. Med. 175, 1391-1399 (1992).
16. Zucman, J. et al. EWS and ATF-1 gene fusion induced by t(12; 22) translocation in malignant melanoma of soft parts. Nature Genet. 4, 341-345 (1993).
17. Nourse, J. et al. Chromosomal translocation t(1; 19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor. Cell 60, 535-545 (1990).
18. Kamps, M. P., Murre, C., Sun, X. H. & Baltimore, D. A new homeobox gene contributes the DNA binding domain of the t(1; 19) translocation protein in pre-B ALL Cell 60, 547-555 (1990).
19. Inaba, T. et al. Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia. Science 257, 531-534 (1992).
20. Magrath, I. The pathogenesis of Burkitt’s lymphoma. Adv. cancer Res. 55, 133-270 (1990).
21. Djabali, M. et al. A trithorax-like gene is interupted by chromosome 11q23 translocations in acute leukemias. Nature Genet. 2, 113-118 (1992).
22. Tkachuk, D. C., Kohler, S. & Cleary, M. L. Involvement of a homolog of drosophila trithorax by 11q23 chromosomal translocations in acute leukemias. Cell 71, 691-700 (1992).
23. Gu, Y. et al. The t(4; 11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene. Cell 71, 701-708 (1992).
24. Nakamura, T. et al. Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs. Proc. natn. Acad. Sci. U. S. A. 90, 4631-1635 (1993).
25. Domer, P. H. et al. Acute mixed lineage leukemia t(4; 11)(q21; q23) generates a MLL-AF-4 fusion product. Proc. natn. Acad. Sci. U. S. A. 90, 7884-7888 (1993).
26. Barch, M. J. The ACT Cytogenetics Laboratory Manual (Raven Press, New York, 1991).
27. Lichter, P. et al. High-resolution mapping of human chromosome 11 by in situ hybridization with cosmid clones. Science 247, 64-69 (1990).
28. Sambrook, J., Fritch, E. F. & Maniatis, T. Molecular cloning: a laboratory manual. (Cold Spring Harbor Laboratory Press, New York, 1989).
29. Smith, D. B. & Johnson, K. S. Single-step purification of polypeptides in Escherichia coli as fusions with glutathione S-transferase. Gene 67, 31-40 (1988).