Exposure of the hydrophobic components of porcine lung surfactant to oxidant stress alters surface tension properties

Journal of Clinical Investigation

Volumn 93, Issue 6, 1994, Pages 2608-2615

  Gilliard, N ^a   Heldt, G P ^b   Loredo, J ^b   Gasser, H ^c   Redl, H ^c   Merritt, T A ^d   Spragg, R G ^b,e  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c LUDWIG BOLTZMANN INSTITUTE FOR EXPERIMENTAL AND CLINICAL TRAUMATOLOGY   (Austria)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

Author keywords

dipalmitoylphosphatidylcholine; oxidants; phospholipids; pulmonary surfactants; respiratory distress syndrome, adult

Indexed keywords

ALKADIENE; ALPHA TOCOPHEROL; COPPER CHLORIDE; DIPALMITOYLPHOSPHATIDYLCHOLINE; FERROUS CHLORIDE; HYDROGEN PEROXIDE; LUNG SURFACTANT; OXYGEN RADICAL; PALMITIC ACID; PHOSPHOLIPID DERIVATIVE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; THIOL GROUP; TYLOXAPOL; UNSATURATED FATTY ACID;

ANIMAL EXPERIMENT; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; FETUS; HYDROPHOBICITY; LIPID COMPOSITION; LIPID PEROXIDATION; LUNG ALVEOLUS SURFACE TENSION; LUNG COMPLIANCE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RABBIT; SWINE;

EID: 0028307155     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI117273     Document Type: Article

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