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5
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0024414103
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A B-Lymphocyte Activation Molecule Related to the Nerve Growth Factor Receptor and Induced by Cytokines in Carcinomas
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(1989)
EMBO J
, vol.8
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Stamenkovic1
Clark2
Seed3
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7
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0026601968
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Molecular Cloning and Expression of a New Member of the Nerve Growth Factor Receptor Family that is Characteristic for Hodgkin's Disease
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(1992)
Cell
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Dürkop1
Latza2
Hummel3
Eitelbach4
Seed5
Stein6
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8
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0025320534
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Characterization of the MRC OX40 Antigen of Activated CD4 Positive T Lymphocytes — a Molecule Related to Nerve Growth Factor Receptor
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(1990)
EMBO J
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Mallet1
Fossum2
Barclay3
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0025728020
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A new Superfamily of Cell Surface Proteins Related to the Nerve Growth Factor Receptor
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(1991)
Immunol Today
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Mallett1
Barclay2
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15
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2442571599
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Receptors and Ligands of the Nerve Growth Factor Receptor Gene Family
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in press
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(1994)
Curr Top Genet
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Loenen1
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16
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0027745154
-
CD40L: A Multi-Functional Ligand
-
of outstanding interest, Reviews the cloning of murine and human CD40L, the relationship between the two molecules and other TNF family members and reviews their biological activity on B cells, monocytes and T cells.
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(1993)
Semin Immunol
, vol.5
, pp. 401-412
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Armitage1
Maliszewski2
Alderson3
Grabstein4
Spriggs5
Fanslow6
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17
-
-
0027162651
-
CD30 Antigen, a Marker for Hodgkin's Lymphoma, is a Receptor Whose Ligand Defines an Emerging Family of Cytokines with Homology to THF
-
of outstanding interest, Descibes the cloning of CD30L and the mapping of murine and human CD30L genes to chromosomes 4 and 9833 respectively. CD30L is related to other TNF-like ligands and is shown to costimulate T-cell proliferation and inhibit the growth of Karpas 299 cells, a large cell anaplastic lymphoma line.
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(1993)
Cell
, vol.73
, pp. 1349-1360
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Smith1
Gruss2
Davis3
Anderson4
Farrah5
Baker6
Sutherland7
Brannan8
Copeland9
Jenkins10
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18
-
-
0027229134
-
Molecular and Biological Characterization of a Ligand for CD27 Defines a New Family of Cytokines with Homology to Tumor Necrosis Factor
-
of outstanding interest, Reports the cloning of a human CD27L and the chromosome mapping of its gene to 19p 13.3. CD27L is related to TNF family members and is shown to costimulate T-cell proliferation and enhance the generation of cytolytic T cells.
-
(1993)
Cell
, vol.73
, pp. 447-456
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-
Goodwin1
Alderson2
Smith3
Armitage4
Vanden-Bos5
Jerzy6
Tough7
Schoenborn8
Davis-Smith9
Hennen10
-
19
-
-
0027365746
-
Molecular Cloning of a Ligand for the Inducible T-cell Gene 4-1BB: A Member of an Emerging Family of Cytokines with Homology to Tumor Necrosis Factor
-
of outstanding interest, Describes the cloning of a murine ligand for 4-1BB.The gene encoding 4-1BBL is located on chromosome 17, distal to the genes for TNF and LTα. 4-1BBL is related to other members of the TNF family, although the degree of sequence similarity is lower than that seen between other members.
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(1993)
Eur J Immunol
, vol.23
, pp. 2631-2641
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-
Goodwin1
Din2
Davis-Smith3
Anderson4
Gimpel5
Sato6
Maliszewski7
Brannan8
Copeland9
Jenkins10
-
20
-
-
0027145632
-
Molecular Cloning and Expression of the Fas Ligand, a Novel Member of the Tumor Necrosis Factor Family
-
+ target cells, both as a membrane-associated molecule and in a soluble form in Cos cell supernatant, the latter possibly resulting from proteolytic cleavage.
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(1993)
Cell
, vol.75
, pp. 1169-1178
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Suda1
Takahashi2
Golstein3
Nagata4
-
21
-
-
0027415109
-
Lymphotoxin β, a Novel Member of the TNF Family that Forms a Heteromeric Complex with Lymphotoxin on the Cell Surface
-
of outstanding interest, Reports the cloning of LTβ (previously termed p33). Membrane-anchored LTβ associates with soluble LTα to form heterotrimeric complexes on the cell surface which do not appear to bind TNFRI or TNFRII. It is postulated that this LTα-LTβ complex may bind to an unknown receptor.
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(1993)
Cell
, vol.72
, pp. 847-856
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-
Browning1
Ngam-ek2
Lawton3
DeMarinis4
Tizard5
Chow6
Hession7
O'Brien-Greco8
Foley9
Ware10
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25
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-
0024281428
-
A Novel Form of TNF/Cachectin is a Cell Surface Cytotoxic Transmembrane Protein: Ramifications for the Complex Physiology of THF
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(1988)
Cell
, vol.53
, pp. 45-53
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Kriegler1
Perez2
De Fay3
Albert4
Lu5
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28
-
-
0027322559
-
The 26-kD Transmembrane Form of Tumor Necrosis Factor α on Activated CD4+ Cell Clones Provides a Costimulatory Signal for Human B Cell Activation
-
(1993)
J Exp Med
, vol.177
, pp. 1575-1585
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Aversa1
Punnonen2
de Vries3
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30
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-
0025165135
-
Two Tumor Necrosis Factor-Binding Proteins Purified from Human Urine. Evidence for Immunological Cross-Reactivity with Cell Surface Tumor Necrosis Factor Receptors
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(1990)
J Biol Chem
, vol.265
, pp. 1531-1536
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Engelmann1
Novick2
Wallach3
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32
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0025042313
-
CD40: A Cytokine Receptor in Search of a Ligand
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(1990)
Tissue Antigens
, vol.36
, pp. 33-36
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Clark1
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34
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0026527783
-
Differential Increase of an Alternatively Polyadenylated mRNA Species of Murine CD40 upon B Lymphocyte Activation
-
(1992)
J Immunol
, vol.148
, pp. 620-628
-
-
Tores1
Clark2
-
40
-
-
0027488595
-
The Biology of the Human Ligand for CD40
-
of outstanding interest, Summarizes the conclusions of five groups that mutation in the human CD40L gene is the underlying cause of X-linked HIGM syndrome. HIGM is characterized by elevated levels of serum Igm and a virtual absence of other Ig isotypes. Activated patient T cells either fail to express CD40L or express it in a non-functional form. B cells from HIGM patients show a normal response to recombinant ‘wild-type’ CD40L and secrete IgG, IgA and IgE when cultured in vitro with the appropriate cytokines.
-
(1993)
J Clin Immunol
, vol.13
, pp. 373-380
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Spriggs1
Fanslow2
Armitage3
Belmont4
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43
-
-
0027493906
-
In Vivo CD40-gp39 Interactions are Essential for Thymus-Dependent Humoral Immunity. II. Prolonged Suppression of the Humoral Immune Response by an Antibody to the Ligand for CD40, gp39
-
of outstanding interest, Demonstrates that the in vivo administration of a neutralizing antibody specific for murine CD40L inhibits both primary and secondary humoral responses to T-dependent antigen. These data compliment the studies on HIGM patients, 40••] in suggesting an essential requirement for CD40L in antigen-specific antibody responses.
-
(1993)
J Exp Med
, vol.178
, pp. 1567-1575
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-
Foy1
Shepherd2
Durie3
Aruffo4
Ledbetter5
Noelle6
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45
-
-
0024596722
-
A Cell-Killing Monoclonal Antibody (Anti-Fas) to a Cell Surface Antigen Co-Downregulated with the Receptor of Tumor Necrosis Factor
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(1989)
J Exp Med
, vol.169
, pp. 1747-1756
-
-
Yonehara1
Ishii2
Yonehara3
-
47
-
-
0027484072
-
Fas Transduces Activation Signals in Normal Human T Lymphocytes
-
of special interest, Demonstrates that in contrast to their apoptotic effects on cell lines, Fas antibodies can co-stimulate proliferation of freshly isolated T cells. These data suggest that the activation state of cells may dictate the outcome of signaling through Fas.
-
(1993)
J Exp Med
, vol.178
, pp. 2231-2235
-
-
Alderson1
Armitage2
Maraskovsky3
Tough4
Roux5
Schooley6
Ramsdell7
Lynch8
-
48
-
-
0026568919
-
Lymphoproliferation Disorder in Mice Explained by Defects in Fas Antigen that Mediates Apoptosis
-
of outstanding interest, Describes the chromosomal mapping of the murine Fas gene to the Ipr locus, and demonstrates that mice carrying the lpr mutation have defects in the Fas gene that prevent signal transduction by Fas antibodies.
-
(1992)
Nature
, vol.356
, pp. 314-317
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-
Watanabe-Fukunaga1
Brannan2
Copeland3
Jenkins4
Nagata5
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57
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0027473885
-
A 3-D Model for the CD40 Ligand Predicts that it is a Compact Trimer Similar to the Tumor Necrosis Factors
-
(1993)
Int Immttnol
, vol.5
, pp. 233-238
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Peitsch1
Jongeneel2
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